ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: June 2, 2023

Some patients remain unwell for months after "recovering" from acute COVID-19. They develop persistent fatigue, cognitive problems, headaches, disrupted sleep, myalgias and arthralgias, post-exertional malaise, orthostatic intolerance other symptoms that greatly interfere with their ability to function can leave some people housebound disabled. The illness (Long COVID) is similar myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) as well persisting illnesses follow a wide variety of infectious agents following major traumatic injury. Together, these are projected cost the U.S. trillions dollars. In this review, we first compare ME/CFS Long COVID, noting considerable similarities few differences. We then in extensive detail underlying pathophysiology two conditions, focusing on abnormalities central autonomic nervous system, lungs, heart, vasculature, immune gut microbiome, energy metabolism redox balance. This comparison highlights how strong evidence each abnormality, illness, helps set priorities future investigation. review provides current road map literature biology both illnesses.

Language: Английский

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The plasma metabolome of long COVID patients two years after infection

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Aug. 1, 2023

Abstract One of the major challenges currently faced by global health systems is prolonged COVID-19 syndrome (also known as “long COVID”) which has emerged a consequence SARS-CoV-2 epidemic. It estimated that at least 30% patients who have had will develop long COVID. In this study, our goal was to assess plasma metabolome in total 100 samples collected from healthy controls, patients, and COVID recruited Mexico between 2020 2022. A targeted metabolomics approach using combination LC–MS/MS FIA MS/MS performed quantify 108 metabolites. IL-17 leptin were measured immunoenzymatic assay. The comparison paired COVID-19/long revealed 53 metabolites statistically different. Compared 27 remained dysregulated even after two years. Post-COVID-19 displayed heterogeneous metabolic profile. Lactic acid, lactate/pyruvate ratio, ornithine/citrulline arginine identified most relevant for distinguishing with more complicated evolution. Additionally, levels significantly increased these patients. Mitochondrial dysfunction, redox state imbalance, impaired energy metabolism, chronic immune dysregulation are likely be main hallmarks years acute infection.

Language: Английский

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Diet for the prevention and management of sarcopenia

Metabolism, Journal Year: 2023, Volume and Issue: 146, P. 155637 - 155637

Published: June 21, 2023

Sarcopenia is a geriatric condition characterized by progressive loss of skeletal muscle mass and strength, with an increased risk adverse health outcomes (e.g., falls, disability, institutionalization, reduced quality life, mortality). Pharmacological remedies are currently unavailable for preventing the development sarcopenia, halting its progression, or impeding negative outcomes. The most effective strategies to contrast sarcopenia rely on adoption healthier lifestyle behaviors, including adherence high-quality diets regular physical activity. In this review, role nutrition in prevention management summarized. Special attention given current "blockbuster" dietary regimes agents used counteract age-related wasting, together their putative mechanisms action. Issues related design implementation nutritional discussed, focus unanswered questions appropriate timing interventions preserve function into old age. A brief description also provided new technologies that can facilitate personalized plans sarcopenia.

Language: Английский

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L-arginine metabolism as pivotal interface of mutual host–microbe interactions in the gut

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)

Published: June 26, 2023

L-arginine (L-arg) is a versatile amino acid and central intestinal metabolite in mammalian microbial organisms. Thus, L-arg participates as precursor of multiple metabolic pathways the regulation cell division growth. It also serves source carbon, nitrogen, energy or substrate for protein synthesis. Consequently, can simultaneously modify immune functions, intraluminal metabolism, microbiota, pathogenesis. While dietary intake, turnover de novo synthesis usually supply sufficient amounts, expression several key enzymes metabolism change rapidly dramatically following inflammation, sepsis, injury. availability be restricted due to increased catabolism, transforming into an essential acid. Here, we review enzymatic cells their role function, colonization resistance, pathogenesis gut.

Language: Английский

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The knowns and unknowns of long COVID-19: from mechanisms to therapeutical approaches

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 4, 2024

The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has been defined as the greatest global health and socioeconomic crisis of modern times. While most people recover after being infected with virus, a significant proportion them continue to experience issues weeks, months even years acute infection SARS-CoV-2. This persistence clinical symptoms in individuals for at least three onset or emergence new lasting more than two months, without any other explanation alternative diagnosis have named long COVID, long-haul post-COVID-19 conditions, chronic post-acute sequelae (PASC). Long COVID characterized constellation disorders that vary widely their manifestations. Further, mechanisms underlying are not fully understood, which hamper efficient treatment options. review describes predictors common related COVID's effects on central peripheral nervous system organs tissues. Furthermore, transcriptional markers, molecular signaling pathways risk factors such sex, age, pre-existing condition, hospitalization during phase COVID-19, vaccination, lifestyle presented. Finally, recommendations patient rehabilitation management, well therapeutical approaches discussed. Understanding complexity this disease, its across multiple organ systems overlapping pathologies possible paramount developing diagnostic tools treatments.

Language: Английский

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Vitamin C as Scavenger of Reactive Oxygen Species during Healing after Myocardial Infarction

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3114 - 3114

Published: March 7, 2024

Currently, coronary artery bypass and reperfusion therapies are considered the gold standard in long-term treatments to restore heart function after acute myocardial infarction. As a drawback of these restoring strategies, an ischemic insult sudden oxygen exposure lead exacerbated synthesis additional reactive oxidative species persistence increased oxidation levels. Attempts based on antioxidant treatment have failed achieve effective therapy for cardiovascular disease patients. The controversial use vitamin C as clinical practice is comprehensively systematized discussed this review. dose-dependent adsorption release kinetics mechanism complex; however, review may provide holistic perspective its potential preventive supplement and/or combined precise targeted therapeutics management therapy.

Language: Английский

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Long COVID: Clinical Framing, Biomarkers, and Therapeutic Approaches

Journal of Personalized Medicine, Journal Year: 2023, Volume and Issue: 13(2), P. 334 - 334

Published: Feb. 15, 2023

More than two years after the onset of COVID-19 pandemic, healthcare providers are facing an emergency within emergency, so-called long COVID or post-COVID-19 syndrome (PCS). Patients diagnosed with PCS develop extended range persistent symptoms and/or complications from COVID-19. The risk factors and clinical manifestations many various. Advanced age, sex/gender, pre-existing conditions certainly influence pathogenesis course this syndrome. However, absence precise diagnostic prognostic biomarkers may further complicate management patients. This review aimed to summarize recent evidence on influencing PCS, possible biomarkers, therapeutic approaches. Older patients recovered approximately one month earlier younger patients, higher rates symptoms. Fatigue during acute phase appears be important factor for symptom persistence. Female sex, older active smoking associated a developing PCS. incidence cognitive decline death in controls. Complementary alternative medicine improvement symptoms, particularly fatigue. heterogeneous nature post-COVID complexity who often polytreated due concomitant conditions, suggest holistic integrated approach provide useful guidance treatment overall COVID.

Language: Английский

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Malnutrition in COVID-19 survivors: prevalence and risk factors

Aging Clinical and Experimental Research, Journal Year: 2023, Volume and Issue: 35(10), P. 2257 - 2265

Published: Sept. 4, 2023

Nutritional status is a critical factor throughout COVID-19 disease course. Malnutrition associated with poor outcomes in hospitalized patients.

Language: Английский

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The Effectiveness of L-arginine in Clinical Conditions Associated with Hypoxia

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 8205 - 8205

Published: May 3, 2023

The review summarises the data of last 50 years on effectiveness amino acid L-arginine in therapeutic practice conditions accompanied by different-origin hypoxia. aim this was to analyse literature and our research role nitric oxide modulation individual physiological reactivity considers possibility eliminating methodological conflicts case L-arginine, which can be solved taking into account (or hypoxia resistance factor). Considerable attention is paid genetic epigenetic mechanisms adaptation different models. article presents clinical cardiovascular system diseases (hypertension, atherosclerosis, coronary heart disease, etc.) stress disorders associated with these diseases. a generalised analysis techniques, use athletes, ambiguous NO physiology pathology hypoxic states shown via synthesis. Data protective effects formation high sportsmen are demonstrated. demonstrates favourable effect supplementation its application depending mitochondrial oxidative phosphorylation processes biochemical indices groups individuals low capacity In initial anti-hypoxic reserves, achieved blockade NO-dependent biosynthesis pathways. Therefore, tasks experiments consequences treatment should include component basic level reactivity.

Language: Английский

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Cardiovascular and haematological pathology in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): A role for viruses

Blood Reviews, Journal Year: 2023, Volume and Issue: 60, P. 101075 - 101075

Published: March 20, 2023

ME/CFS is a debilitating chronic condition that often develops after viral or bacterial infection. Insight from the study of Long COVID/Post Acute Sequelae COVID-19 (PASC), post-viral syndrome associated with SARS-CoV-2 infection, might prove to be useful for understanding pathophysiological mechanisms ME/CFS. Disease presentation similar between two conditions, and subset COVID patients meet diagnostic criteria Since characterized by significant vascular pathology – including endothelial dysfunction, coagulopathy, dysregulation question whether not same biological abnormalities are significance in arises. Cardiac have while now been documented cohorts, recent studies demonstrating major deficits cerebral blood flow, hence dysregulation. A growing body research accompanied platelet hyperactivation, anomalous clotting, procoagulant phenotype, dysfunction. Endothelial damage dysregulated clotting can impair substance exchange tissues, result hypoperfusion, which may contribute manifestation certain symptoms. Here we review literature summarize cardiovascular haematological findings condition, and, this context, briefly discuss potential role previously-implicated pathogens. Overall, cardiac present within cohorts. While atherosclerotic heart disease significantly ME/CFS, suboptimal function defined reduced output, impaired are, these do appear influenced deconditioning. Rather, dysfunction (autonomic) nervous system. Plenty recently published hyperactivity as well processes. It particular importance determine what extent symptom severity, if systems targeted therapeutic purposes. Viral reservoirs herpesviruses exist most likely directly indirectly. This highlights studying functioning, vasculature, coagulation system

Language: Английский

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