Association between triglyceride-glucose related indices with the all-cause and cause-specific mortality among the population with metabolic syndrome

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: April 24, 2024

Abstract Background Triglyceride-glucose (TyG) index has been determined to play a role in the onset of metabolic syndrome (MetS). Whether TyG and with combination obesity indicators are associated clinical outcomes MetS population remains unknown. Method Participants were extracted from multiple cycles National Health Nutrition Examination Survey (NHANES) between 1999 2018 years. Three constructed including index, combining waist circumference (TyG-WC), waist-to-height ratio (TyG-WHtR). The was defined according Cholesterol Education Program (NCPE) Adult Treatment Panel III. Kaplan-Meier (KM) curves, restricted cubic splines (RCS), Cox proportional hazard model used evaluate associations TyG-related indices mortality population. sensitive analyses performed check robustness main findings. Results There 10,734 participants included this study, 5,570 females 5,164 males. median age study 59 years old. multivariate regression showed high levels significantly all-cause [TyG index: adjusted (aHR): 1.36, 95%confidence interval (CI): 1.18–1.56, p < 0.001; TyG-WHtR aHR = 1.29, 95%CI: 1.13–1.47, 0.001]. Meanwhile, TyG-WC cardiovascular (TyG-WC: 1.45, 1.13–1.85, 0.004; TyG-WHtR: 1.50 1.17–1.92, 0.002). consistent significant correlations diabetes (TyG: 4.06, 2.81–5.87, TyG-WC: 2.55, 1.82–3.58, 2.53 1.81–3.54, 0.001). RCS curves non-linear trend (p for nonlinearity 0.004 0.001, respectively). supported positive Conclusion Our highlights value predicting survival would be surrogate biomarkers follow-up

Language: Английский

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The Link between NAFLD and Metabolic Syndrome

Diagnostics, Journal Year: 2023, Volume and Issue: 13(4), P. 614 - 614

Published: Feb. 7, 2023

Metabolic syndrome (MetS) is characterized by an association of cardiovascular and diabetes mellitus type 2 risk factors. Although the definition MetS slightly differs depending on society that described it, its central diagnostic criteria include impaired fasting glucose, low HDL-cholesterol, elevated triglycerides levels high blood pressure. Insulin resistance (IR) believed to be main cause connected level visceral or intra-abdominal adipose tissue, which could assessed either calculating body mass index measuring waist circumference. Most recent studies revealed IR may also present in non-obese patients, considered adiposity effector MetS’ pathology. Visceral strongly linked with hepatic fatty infiltration known as non-alcoholic liver disease (NAFLD), therefore, acids parenchyma indirectly MetS, being both a consequence this syndrome. Taking into consideration pandemic obesity tendency drift towards progressively earlier onset due Western lifestyle, it leads increased NAFLD incidence. Novel therapeutic resources are lifestyle intervention physical activity, Mediterranean diet, surgical respective metabolic bariatric surgery drugs such SGLT-2i, GLP-1 Ra vitamin E. early diagnosis important easily available tools non-invasive tools: clinical laboratory variables (serum biomarkers): AST platelet ratio index, fibrosis-4, Fibrosis Score, BARD fibro test, enhanced fibrosis; imaging-based biomarkers: Controlled attenuation parameter, magnetic resonance imaging proton-density fat fraction, transient elastography (TE) vibration controlled TE, acoustic radiation force impulse imaging, shear wave elastography, elastography; possibility prevent complications, respectively, fibrosis, hepato-cellular carcinoma cirrhosis can develop end-stage disease.

Language: Английский

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Association between triglyceride-glucose related indices and all-cause and cardiovascular mortality among the population with cardiovascular-kidney-metabolic syndrome stage 0–3: a cohort study

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 28, 2025

Cardiovascular-Kidney-Metabolic (CKM) syndrome typically commences with the interaction of insulin resistance (IR), excessive or dysfunctional obesity, and consequent systemic inflammatory response oxidative stress. The relationship between triglyceride-glucose (TyG) index TyG-related indices that may simply assess IR as well mortality risk in CKM population, remains ambiguous. This study included 6,383 participants from National Health Nutrition Examination Survey (NHANES) 2009–2018. TyG index, TyG-waist-to-height ratio (TyG-WHtR), TyG-waist circumference (TyG-WC), TyG-body mass (TyG-BMI) were developed. Cox proportional hazards models, smooth curve fitting, two-stage models employed to examine association all-cause cardiovascular population. Subgroup analyses tests conducted evaluate within various demographics. In survey-weighted multifactorial regression analyses, a significant positive existed TyG, indices, both mortality, except for which did not demonstrate link mortality. Of these TyG-WC exhibited strongest correlation hazard (HR) 1.50 95% confidence interval (CI) 1.18–1.92, followed by TyG-WHtR (HR: 1.45, 95%CI 1.13–1.85). demonstrated 1.85, CI 1.19–2.86), index(HR: 1.83, 1.21–2.78). An L-shaped was identified TyG-WHtR, TyG-BMI, during examination nonlinear relationships (both P log-likelihood < 0.05). TyG-WC, TyG-BMI more pronounced those stages 1 3 (P value 0.05, Our emphasizes individuals 0–3. Individuals should be vigilant abnormal alterations indices.

Language: Английский

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Relationship between Atherogenic Dyslipidaemia and Lipid Triad and Scales That Assess Insulin Resistance

Nutrients, Journal Year: 2023, Volume and Issue: 15(9), P. 2105 - 2105

Published: April 27, 2023

Background: Atherogenic dyslipidaemia (AD) and lipid triad (LT) are characterised by high triglyceride levels together with low HDL normal or LDL cholesterol favoured a persistent state of insulin resistance (IR), which increases the release free fatty acids from abdominal adipose tissue. This alteration in profile favours accelerated development atherosclerosis, is most important cause morbidity mortality all countries developed developing world. One elements that plays major role genesis AD IR. The aim this study was to determine relationship between variables assess atherogenic risk (AD LT) scales presenting resistance. Methods: A descriptive cross-sectional 418,343 workers conducted evaluate triad; three (Triglycerides/HDL, TyG index, METS-IR) established. usefulness IR for predicting LT calculated applying ROC curves, obtaining area under curve (AUC) cut-off points their sensitivity, specificity, Youden index. Multivariate analysis performed binary logistic regression. Results: prevalence high-risk values much higher people compared those without. curves present us an AUC two dyslipidaemias studied figures ranging 0.856 0.991, implies results good/very good. Conclusions: assessed revealed, mean triad. make it possible adequately classify presence LT. highest presented triglycerides/HDL scale, result close 1. METS-IR recommended formula estimate

Language: Английский

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Effects of dietary polyphenol curcumin supplementation on metabolic, inflammatory, and oxidative stress indices in patients with metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: July 14, 2023

Objective The aim was to conduct a systematic review and meta-analysis for assessing the effectiveness safety of dietary polyphenol curcumin supplement on metabolic, inflammatory, oxidative stress indices in patients with metabolic syndrome (MetS). Methods A comprehensive search clinical trials conducted following scientific databases: PubMed, SCOPUS, Cochrane Library, EMBASE, Web Science, China Biological Medicine. Randomized controlled (RCTs) evaluating efficacy MetS were identified. random-effects performed using inverse variance, expressed as mean difference (MD) 95% confidence interval (CI). markers that evaluated present study included waist circumference (WC), fasting blood sugar (FBS), systolic pressure (SBP), diastolic (DBP), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), tumor necrosis factor-a (TNF-a), interleukin 6 (IL-6), C-reactive protein (CRP), ultrasensitive c-reactive (hsCRP), malondialdehyde (MDA). By employing tool, RCTs assessed bias risk. Results total 785 participants from 13 included, intervention durations ranging 4 12 weeks. Compared control group, group had positive effects WC (MD = -2.16, CI: -3.78 -0.54, p 0.009, seven studies), FBS -8.6, -15.45 -1.75, 0.01, nine DBP -2.8, -4.53 - 1.06, 0.002, five HDL-C 4.98, 2.58 7.38, &lt; 0.0001, eight TNF-a -12.97, -18.37 -7.57, 0.00001, two CRP 1.24, -1.71 -0.77, MDA -2.35, -4.47 -0.24, 0.03, three studies). These improvements statistically significant. Meanwhile, there no significant improvement SBP -4.82, -9.98 0.35, 0.07, six TG 1.28, -3.75 6.30, 0.62, IL-6 -1.5, -3.97 0.97, 0.23, or hsCRP -1.10, -4.35 2.16, 0.51, FBS, SBP, HDL-C, IL-6, CRP, hsCRP, relatively high heterogeneity. Conclusion Curcumin exhibited promising potential enhancing associated syndrome, including inflammation. However, additional studies are required confirm such findings since evidence is limited has Systematic registration https://www.crd.york.ac.uk/prospero , identifier CRD42022362553.

Language: Английский

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Association between estimated glucose disposal rate and cardiovascular mortality across the spectrum of glucose tolerance in the US population

Diabetes Obesity and Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 18, 2024

Abstract Aims To determine if estimated glucose disposal rate (eGDR) can predict cardiovascular disease mortality risk at different levels of glycaemic tolerance. Materials and Methods The eGDR 11 656 individuals aged 45–79 years from the National Health Nutrition Examination Survey cycles 1999 to 2010 were analysed. Associations between all‐cause examined using Cox proportional hazards Fine Gray models, respectively. Results After a median follow‐up 12.8 years, total 2852 participants died, with 777 those deaths attributed causes. When comparing values ≤4 mg/kg/min falling within ranges 4–6, 6–8 >8 mg/kg/min, it was found that latter groups exhibited lower hazard ratios for both (0.61 [0.52–0.72], 0.61 [0.52–0.72] 0.46 [0.39–0.55]) (0.44 [0.33–0.57], 0.45 [0.34–0.59] 0.30 [0.23–0.40]). A U‐shaped relationship observed, an inflection point 9.54 mg/kg/min. Conclusions In general population, association reduced independently significant, contributing identification high tolerances.

Language: Английский

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From adiposity to steatosis: metabolic dysfunction-associated steatotic liver disease, a hepatic expression of metabolic syndrome – current insights and future directions

Clinical Diabetes and Endocrinology, Journal Year: 2024, Volume and Issue: 10(1)

Published: Dec. 2, 2024

Language: Английский

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Body Mass Index and Waist Circumference as Predictors of Above-Average Increased Cardiovascular Risk Assessed by the SCORE2 and SCORE2-OP Calculators and the Proposition of New Optimal Cut-Off Values: Cross-Sectional Single-Center Study

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(7), P. 1931 - 1931

Published: March 27, 2024

Background: Obesity has been perceived as one of the important cardiovascular risk factors, but SCORE2 calculators used in clinical practice do not include most popular parameters assessed for body composition: mass index (BMI) and waist circumference (WC). The objective this research was to determine which aforementioned variables is a more reliable predictor an above-average increased gender age (ICVR). Methods: Data from 2061 patients were analyzed; 10-year events by tables, correlations with BMI WC analyzed. Results: independently predicted ICVR (OR 1.10–1.27). In males, accurate (AUC = 0.816); however, females, it 0.739). A novel threshold (27.6 kg/m2) suggested, increases disease 3.3–5.3 times depending on gender; same holds true (93 cm women 99 men; 3.8–4.8-fold higher risk). Conclusions: Despite their heterogeneity, are effective predictors, especially males females; therefore, needed them future models predicting unfavorable cardiometabolic events.

Language: Английский

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The Effect of a Program to Improve Adherence to the Mediterranean Diet on Cardiometabolic Parameters in 7034 Spanish Workers

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 1082 - 1082

Published: April 7, 2024

Background: Cardiovascular and metabolic diseases include a large group of pathologies constitute one the most serious chronic health problems facing 21st century, with high rates morbidity mortality worldwide. Unhealthy diets influence development these pathologies. The Mediterranean diet can be an important part in treatment diseases. objective this study was to assess effect program that aims increase adherence on improvement different cardiometabolic risk parameters. Methods: A prospective intervention carried out 7034 Spanish workers. Prior intervention, 22 scales were evaluated. Participants informed both orally writing characteristics benefits given website Ministry Health, Consumption Social Welfare Spain, which provides advice nutrition. Adherence reinforced by sending monthly SMS their mobile phones. After six months follow-up, re-evaluated changes. Means standard deviations calculated using Student’s t test analyse quantitative variables. Prevalence Chi-square when variables qualitative. Results: All studied decreased after implementing improve enhance diet. number losses sample very low, standing at 4.31%. Conclusions: is effective reducing all cardiovascular mean values prevalence analysed led lower implementation We observed significant positive difference age sexes. have obtained insulin resistance index, especially SPISE-IR data we not found previous publications. Easy access Internet new information communication technologies facilitate reduce losses.

Language: Английский

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Surrogate indices of insulin resistance using the Matsuda index as reference in adult men—a computational approach

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: April 23, 2024

Background Overweight and obesity, high blood pressure, hyperglycemia, hyperlipidemia, insulin resistance (IR) are strongly associated with non-communicable diseases (NCDs), including type 2 diabetes, cardiovascular disease, stroke, cancer. Different surrogate indices of IR derived validated the euglycemic–hyperinsulinemic clamp (EHC) test. Thus, using a computational approach to predict Matsuda index as reference, this study aimed determine optimal cutoff value diagnosis accuracy for in non-diabetic young adult men. Methods A cross-sectional descriptive was carried out 93 men (ages 18–31). Serum levels glucose were analyzed fasting state during an oral tolerance test (OGTT). Additionally, clinical, biochemical, hormonal, anthropometric characteristics body composition (DEXA) determined. The evaluate diagnostic difference parameters examined, well other statistical tools make output robust. Results highest sensitivity specificity at value, respectively, established Homeostasis model assessment (HOMA-IR) (0.91; 0.98; 3.40), Quantitative check (QUICKI) (0.98; 0.96; 0.33), triglyceride-glucose (TyG)-waist circumference (TyG-WC) (1.00; 1.00; 427.77), TyG-body mass (TyG-BMI) 132.44), TyG-waist-to-height ratio (TyG-WHtR) 2.48), waist-to-height (WHtR) 0.53), waist (WC) 92.63), (BMI) 28.69), total fat percentage (TFM) (%) 31.07), android (AF) 40.33), lipid accumulation product (LAP) (0.84; 45.49), leptin 16.08), leptin/adiponectin (LAR) 1.17), 16.01). Conclusions used be preventive healthcare.

Language: Английский

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