Polyphenols: immunonutrients tipping the balance of immunometabolism in chronic diseases

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 15, 2024

Mounting evidence progressively appreciates the vital interplay between immunity and metabolism in a wide array of immunometabolic chronic disorders, both autoimmune non-autoimmune mediated. The immune system regulates functioning cellular within organs like brain, pancreas and/or adipose tissue by sensing adapting to fluctuations microenvironment’s nutrients, thereby reshaping metabolic pathways that greatly impact pro- or anti-inflammatory immunophenotype. While it is agreed relies on an adequate nutritional status function properly, we are only just starting understand how supply single combined all them termed immunonutrients, can steer cells towards less inflamed, tolerogenic Polyphenols, class secondary metabolites abundant Mediterranean foods, pharmacologically active natural products with outstanding immunomodulatory actions. Upon binding range receptors highly expressed (e.g. AhR, RAR, RLR), they act through mitochondria-centered multi-modal approach. First , polyphenols activate nutrient via stress-response pathways, essential for responses. Second regulate mammalian target rapamycin (mTOR)/AMP-activated protein kinase (AMPK) balance well-tolerated caloric restriction mimetics. Third interfere assembly NLR family pyrin domain containing 3 (NLRP3) endoplasmic reticulum-mitochondria contact sites, inhibiting its activation while improving mitochondrial biogenesis autophagosome-lysosome fusion. Finally chromatin remodeling coordinates epigenetic reprogramming. This work moves beyond well-documented antioxidant properties polyphenols, offering new insights into multifaceted nature these compounds. It proposes mechanistical appraisal regulatory which modulate response, alleviating low-grade inflammation. Furthermore, draws parallels pharmacological interventions polyphenol-based immunonutrition their modes immunomodulation across spectrum socioeconomically impactful diseases such as Multiple Sclerosis, Diabetes (type 1 2) even Alzheimer’s disease. Lastly, discusses existing challenges thwart translation polyphenols-based immunonutritional long-term clinical studies. Overcoming limitations will undoubtedly pave way precision nutrition protocols provide personalized guidance tailored plans.

Language: Английский

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Protective Effects of Sulforaphane Preventing Inflammation and Oxidative Stress to Enhance Metabolic Health: A Narrative Review

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 428 - 428

Published: Jan. 24, 2025

The worldwide obesity epidemic has led to a drastic increase in diabetes and cardiovascular disease younger generations. Further, maintaining metabolic health during aging is frequently challenge due poor diets decreased mobility. In this setting, bioactive nutrients that are naturally occurring antioxidants, such as sulforaphane (SFN), of high nutritional interest. SFN, compound present cruciferous vegetables, molecule protects cells from cytotoxic damage mitigates oxidative stress, protecting against disease. It exerts its action through the activation transcription factor nuclear erythroid 2-related 2 (Nrf2). Many studies have been performed animals humans evaluate effects on cancer, brain health, neurodegenerative disorders. However, fewer clinical insulin resistance development type mellitus (T2DM) across lifespan. Given that, some parts world, particularly Europe, population growing older at significant rate, it crucial promote healthy habits (healthy foods, dietary pattern, precision nutrition, physical activity) an early stage life lifespan avoid debilitating conditions adulthood aging. Thus, narrative review, we discuss protective SFN supplementation inflammatory stress pathways relate them

Language: Английский

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Sulforaphane-mediated immune regulation through inhibition of NF-kB and MAPK signaling pathways in human dendritic cells

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 117056 - 117056

Published: June 29, 2024

Inflammation and immune responses are intricately intertwined processes crucial for maintaining homeostasis combating against pathogens. These involve complex signaling pathways, notably the Nuclear Factor kappa-light-chain-enhancer of activated B-cells (NF-κB) Mitogen-Activated Protein Kinase (MAPK) which play roles. Sulforaphane (SFN), a nutraceutic, has emerged as potential regulator NF-κB MAPK exhibiting anti-inflammatory properties. However, limited knowledge exists regarding SFN's effects on cell modulation. This study aimed to assess immunomodulatory capacity SFN pretreatment in human dendritic cells (DCs), followed by exposure chronic inflammatory environment induced lipopolysaccharide. was found inhibit resulting phenotypic changes DCs characterized slight reduction expression surface markers, well decrease TNF-α/IL-10 ratio. Additionally, enhanced proliferation Treg-cells promoted production IL-10 before environment. Furthermore, these were be influenced inhibition pathways (specifically p38 JNK), suggesting that may role regulation differentiation adaptive (proliferation T- IL-10-producing regulatory-cells), prior pretreatment. Our findings suggest induce regulatory response inhibiting an could considered promising strategy utilizing functional foods protect inflammation develop immunoregulatory interventions.

Language: Английский

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Effect of resveratrol on sperm motility in subjects affected by idiopathic asthenozoospermia: an in vitro study

Tissue and Cell, Journal Year: 2025, Volume and Issue: 95, P. 102857 - 102857

Published: March 16, 2025

Language: Английский

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Funkcionalna aktivnost neutrofila u krvi i imunološkog statusa junica pod utjecajem probiotika

Veterinarska stanica, Journal Year: 2024, Volume and Issue: 56(1), P. 29 - 38

Published: June 19, 2024

The article is devoted to the effect of probiotics on animal body. purpose study individual strains functional activity blood neutrophils and parts immune system cattle Various are widely used in husbandry make it possible modernize existing regimens. task finding new approaches optimizing beneficial flora body extremely relevant. use livestock production a cost-effective solution. It has been established that Lactobacillus spp. Bacillus sb. accompanied by activation natural resistance mechanisms. Probiotics also help improve status, mainly due humoral component, tend optimize microbiocenosis colon, have positive increasing productivity. results comprehensive studies state defense systems their changes under influence drug expand deepen data homeostasis animals.

Language: Английский

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Modulation of the Immune Response to Allergies Using Alternative Functional Foods

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 25(1), P. 467 - 467

Published: Dec. 29, 2023

Modulation of the allergic immune response through alternative therapies is a field study that aims to address reactions differently from traditional approaches. These encompass utilization natural functional foods, which have been observed exert an influence on response, thus mitigating severity allergies. Indeed, some studies suggest incorporation these nutraceuticals can regulate function, leading reduction in histamine release and subsequent alleviation symptoms. Moreover, certain herbs dietary supplements, such as curcumin, are believed possess anti-inflammatory properties, may serve moderate responses. Although results remain somewhat mixed require further research, exhibit potential impact thereby providing complementary options conventional treatments. Therefore, this review, we aim provide updated account foods capable modulating In sense, review delves into sourced plants (phytochemicals), animals, marine algae. Emphasis placed their application treatment disorders. It also provides overview how be effectively utilized foods. Additionally, it explores molecular mechanisms scientific validity various bioactive compounds management

Language: Английский

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Combating Hot Corrosion of Metallic Substrate by Nano-Coating

BENTHAM SCIENCE PUBLISHERS eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 75 - 103

Published: July 30, 2024

Corrosion of metallic materials poses a serious threat to the efficiency manufacturing and construction industries. To overcome this, various surface modification techniques are employed. But, protection by nano-coating is gaining great potential owing its numerous benefits. These include hardness, high-resistance against hot corrosion, high wear resistance, adhesive strength. Additionally, nano-coatings can be deposited in thinner smoother thicknesses, allowing for increased efficiency, more flexible equipment design, smaller carbon footprints, lower operating maintenance costs. Hence, aim this chapter provide an overview corrosion performance ceramic, metallic, nanocomposite coatings on substrate. In addition, role nanocoating combat substrate explored. Finally, diverse applications different fields including aircraft, automobile, marine, defense, electronic, medical industries discussed. 

Language: Английский

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Harnessing Β-Glucan Conjugated Quercetin Nanocomplex to Function as a Promising Anti-Inflammatory Agent Via Macrophage-Targeted Delivery

Published: Jan. 1, 2024

Language: Английский

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Harnessing β-glucan conjugated quercetin nanocomplex to function as a promising anti-inflammatory agent via macrophage-targeted delivery

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 349, P. 122952 - 122952

Published: Nov. 14, 2024

Language: Английский

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Neuroinflammation and Oxidative Stress in Individuals Affected by DiGeorge Syndrome

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 4242 - 4242

Published: Feb. 20, 2023

DiGeorge syndrome (DGS) is a rare genetic disease caused by microdeletions of the 22q11.2 region (DGS1). A haploinsufficiency at 10p level has been proposed also as DGS cause (DGS2). Clinical manifestations are variable. The most frequent features thymic hypoplasia or aplasia with consequent immune deficiency, cardiac malformations, hypoparathyroidism, facial and palatine abnormalities, variable degrees cognitive impairment psychiatric disorders. specific aim this descriptive report to discuss correlation between oxidative stress neuroinflammation in patients region. deleted chromosomic maps various genes involved mitochondrial metabolisms, such DGCR8 TXNRD2, that could lead reactive oxygen species (ROS) increased production antioxidant depletion. Furthermore, levels ROS mitochondria would destruction projection neurons cerebral cortex neurocognitive impairment. Finally, increase modified protein belonging family sulfoxide compounds hexoses, acting inhibitors IV V complex, result direct overproduction. Neuroinflammation individuals be directly related development syndrome's characteristic In psychotic disorders, manifestation DGS, Th-17, Th-1 Th-2 cells elevation proinflammatory cytokine IL-6 IL1β. anxiety both CD3 CD4 increased. Some autism spectrum disorders (ASDs) have an augmented cytokines IL-12, IL-1β, while IFNγ anti-inflammatory IL-10 seem reduced. Other data altered synaptic plasticity conclusion, use antioxidants for restoring functionality useful tool protect cortical connectivity behavior.

Language: Английский

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