The footprint of gut microbiota in gallbladder cancer: a mechanistic review

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: May 7, 2024

Gallbladder cancer (GBC) is the most common malignant tumor of biliary system with worst prognosis. Even after radical surgery, majority patients GBC have difficulty achieving a clinical cure. The risk recurrence remains more than 65%, and overall 5-year survival rate less 5%. gut microbiota refers to variety microorganisms living in human intestine, including bacteria, viruses fungi, which profoundly affect host state general health, disease even cancer. Over past few decades, substantial evidence has supported that plays critical role promoting progression GBC. In this review, we summarize functions, molecular mechanisms recent advances intestinal We focus on driving bacteria pivotal pathways, such as virulence factors, metabolites derived from chronic inflammatory responses ecological niche remodeling. Additionally, emphasize high level correlation between especially EBV Candida spp., general, review not only provides solid theoretical basis for close relationship but also highlights potential research directions further future.

Language: Английский

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Review article: The complex interplay between diet and Escherichia coli in inflammatory bowel disease

Alimentary Pharmacology & Therapeutics, Journal Year: 2023, Volume and Issue: 58(10), P. 984 - 1004

Published: Sept. 28, 2023

Summary Background Although no causative microbe has been yet identified or successfully targeted in the treatment of inflammatory bowel disease (IBD), role Escherichia coli pathogenesis Crohn's attracted considerable interest. Aim In this review, we present a literature overview interactions between diet and E. other Proteobacteria aetiology, outcomes management IBD suggest future research directions. Methods An extensive search was performed to identify vitro studies animal models that explored mechanisms by which dietary components can interact with initiate propagate gut inflammation. We also effect therapies have on levels patients IBD. Results Preclinical data Western its influence abundance, colonisation phenotypic behaviour gut, may turn contribute contrast, Mediterranean specific fibres abrogate these effects protect from There are limited clinical trials, mostly during exclusive enteral nutrition, findings often challenging observations preclinical research. Data ulcerative colitis sparse. Conclusions some trial certain promote Well‐designed trials required before recommendations for be made.

Language: Английский

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Ketogenic diet and β-hydroxybutyrate in osteoporosis: current progress and controversy

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 23, 2025

Diet has been proven to have significant impacts on the pathogenesis and treatment of osteoporosis. This review attempts elucidate current progress controversy surrounding ketogenic diet (KD) β-hydroxybutyrate (BHB) in osteoporosis offers a novel perspective prevention The broadly used epilepsy, diabetes, obesity, certain neoplasms by triggering ketone bodies, mainly BHB. However, most osteoporosis-related clinical preclinical studies, demonstrated detrimental effects inhibiting bone accumulation damaging microarchitecture. In contrast, BHB is thought ameliorate promoting osteoblastogenesis osteoclastogenesis. main purpose this summarize research hope that more basic experiments will focus similarities differences between

Language: Английский

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Association between avoidant/restrictive food intake disorder risk, dietary attitudes and behaviors among Chinese patients with inflammatory bowel disease: a cross-sectional study

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 6, 2025

Restrictive eating behaviors are common among patients with inflammatory bowel disease (IBD), which may develop nutritional and/or quality of life impairments into avoidant/restrictive food intake disorder (ARFID). The objective this study is to estimate the prevalence and characteristics ARFID in Chinese IBD, investigate current perceptions dietary without ARFID. A cross-sectional was conducted gastroenterology clinics four tertiary hospitals China. Patients IBD were asked complete a structured questionnaire including demographic characteristics, attitudes behaviors. diagnosis established using version Nine-Item Avoidant/Restrictive Food Intake Disorder Screen questionnaire. total 483 completed questionnaires, 20.3% met clinical criteria for average score 21.9 (interquartile range = 17.0-26.0). Multivariable binary logistic regression results showed that Crohn's (OR 0.483, 95%CI 0.280-0.835; p 0.009), being an active state 0.220, 0.123-0.392; < 0.001), holding regarding symptom control 2.431, 1.299-4.548; 0.005), reporting specific history 27.158, 3.679-200.456; 0.001) significant more likely suffer from problem IBD. incidence particularly high disease, during relapse, those who hold restrictive or have diets. Therefore, it imperative prioritize routine screening early identification ARFID, especially high-risk populations, future research practice. ChiCTR2100051539, on 26 September 2021.

Language: Английский

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The Role of Ultra-Processed Foods in Inflammation and Aging

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Processed foods are that undergo physical, chemical, or biological processes to enhance durability, extend shelf life, improve taste and texture, alter nutritional content, facilitate consumption. While traditional processed preserved packaged through methods such as canning salting, ultra-processed (UPFs) industrially produced formulations ready-to-eat ready-to-heat typically contain little no whole food ingredients. Recent evidence suggests the adverse health effects of UPFs may not only be due nutrients they provide but also non-nutritive components their impact on gut health. Diets rich in associated with cellular changes leading oxidative stress, which turn contributes inflammation aging processes. In this context, reducing consumption UPFs, limiting refined carbohydrates, modifying meal timing frequency recommended for improving

Language: Английский

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Diets for inflammatory bowel disease: impact on microbiome and immunomodulatory microbial metabolites

Exploration of Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Diet plays a complex role in the management of inflammatory bowel disease (IBD), significantly influencing microbiome and metabolome. Three key metabolites implicated IBD are short chain fatty acids, bile acids tryptophan, all which can be modulated through diet. This study analyses impact various diets on these metabolites. Despite anti-inflammatory effects their levels do not increase during successful remission with exclusive enteral nutrition. Additionally, changes tryptophan non-specific across different diets, suggesting metabolic shifts secondary to dietary efficacy IBD. Dietary therapies vary individuals, as established may produce desired variability is further compounded by differences immune responses influenced genetic factors duration. Furthermore, inflammation symptom resolution always coincide, revealing discrepancy impacts These limitations highlight need for deeper understanding interconnectedness heterogeneity, effects, microbiome, influence mucosal system develop more personalised therapies. While no single diet universally effective patients, future research should focus establishing rigid definition interventions long-term clinical outcomes.

Language: Английский

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Plasma Metabolite Profiles Linked to EAT‐Lancet Diet and Risk of Inflammatory Bowel Disease: A Prospective Cohort Study From UK Biobank

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

ABSTRACT The EAT‐Lancet Commission recommends a sustainable, health‐focused diet, but its impact on inflammatory bowel disease (IBD) and metabolic mechanisms remains unclear. This study explores the association between diet IBD risk. We included 187 558 participants from UK Biobank, free at baseline. Dietary intake was assessed using validated 24‐h dietary recall, an score calculated. Incident cases were identified through primary care, hospital data, death registries. Cox proportional hazards models used to estimate hazard ratios (HRs) 95% confidence intervals (CIs). Over mean follow‐up of 13.15 years, 571 Crohn's (CD) 1066 ulcerative colitis (UC) recorded. HRs per 1‐point increase in 0.95 (95% CI: 0.91–0.98) for IBD, 0.91–1.00) UC, 0.93 0.87–0.98) CD. Seven metabolites as mediators, accounting 10.7% association. Greater adherence associated with trend toward reduced risk, mediating this These findings emphasize nutritional relevance reducing

Language: Английский

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Dietary inflammatory potential, genetic predisposition, and incidence of Crohn’s disease and ulcerative colitis

Nutrition & Metabolism, Journal Year: 2025, Volume and Issue: 22(1)

Published: May 1, 2025

Language: Английский

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Effects of Mediterranean Diet, Curcumin, and Resveratrol on Mild-to-Moderate Active Ulcerative Colitis: A Multicenter Randomized Clinical Trial

Nutrients, Journal Year: 2024, Volume and Issue: 16(10), P. 1504 - 1504

Published: May 16, 2024

This study aimed to investigate the effects of Mediterranean diet (MD), combined with curcumin and resveratrol supplementation, on disease activity, serum inflammatory markers, quality life in patients mild-to-moderate active ulcerative colitis (UC). was designed as a prospective multicenter three-arm randomized controlled trial. Participants were MD, MD + curcumin, groups. All participants placed for 8 weeks. The group also received 1600 mg/day whereas 500 supplementation Anthropometric measurements, Truelove–Witts Index, Short Form-36, Inflammatory Bowel Disease Questionnaire, Diet Adherence Scale (MEDAS), laboratory tests performed at baseline postintervention. Within-group comparisons showed that interventions effective reducing activity inflammation improving individuals UC (p < 0.05). Between-group revealed no significant difference all parameters except pain subparameter SF-36 MEDAS score is an safe intervention be used clinical practice UC.

Language: Английский

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Association of diet and outdoor time with inflammatory bowel disease: a multicenter case-control study using propensity matching analysis in China

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: June 17, 2024

Objective To investigate the association between dietary and some other environmental factors risk of inflammatory bowel diseases (IBD) in Chinese population. Materials methods A multicenter case-control study was conducted involving 11 hospitals across China. total 1,230 subjects were enrolled consecutively, diet factor questionnaires collected. IBD patients matched with healthy controls (HC) using propensity-score matching (PSM) at a 1:1 ratio caliper value 0.02. Multivariate conditional logistic regression analyses performed to evaluate associations diet, factors, IBD. Results Moderate alcohol milk consumption, as well daily intake fresh fruit, protective for both Crohn's disease (CD) ulcerative colitis (UC). Conversely, consumption eggs chocolate increased Outdoor time more than 25% day only CD. In eastern regions China, CD had higher egg less outdoor time, while UC consumed chocolate. from urban areas or per capita monthly income eggs, Conclusions This reveals an specific foods, emergence The findings emphasize importance balanced sufficient activities, tailored prevention strategies considering regional variations.

Language: Английский

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