Diversity of Culture Microorganisms from Portuguese Sweet Cherries DOI Creative Commons
Ana C. Gonçalves, Amílcar Falcão, Gilberto Alves

et al.

Life, Journal Year: 2023, Volume and Issue: 13(12), P. 2323 - 2323

Published: Dec. 11, 2023

Consumers today seek safe functional foods with proven health-promoting properties. Current evidence shows that a healthy diet can effectively alleviate oxidative stress levels and reduce inflammatory markers, thereby preventing the occurrence of many types cancer, hypertension, cardiovascular neurological pathologies. Nevertheless, as fruits vegetables are mainly consumed fresh, they serve vectors for transmission pathogenic microorganisms associated various disease outbreaks. As result, there has been surge in interest microbiome vegetables. Therefore, given growing sweet cherries, since their microbial communities have largely ignored, primary purpose this study is to investigate culturome at maturity stages first time. A total 55 were isolated from cherry fruit, comprising 23 bacteria 32 fungi species. Subsequently, selected isolates molecularly identified by amplifying 16S rRNA gene ITS region. Furthermore, it was observed became more diverse fruit matured. The most abundant taxa included Pseudomonas Ralstonia among bacteria, Metschnikowia, Aureobasidium, Hanseniaspora fungi.

Language: Английский

Immunomodulatory Activity of Cytokines in Hypertension: A Vascular Perspective DOI
Rinaldo Rodrigues dos Passos, Cintia Vieira dos Santos, Fernanda Priviero

et al.

Hypertension, Journal Year: 2024, Volume and Issue: 81(7), P. 1411 - 1423

Published: April 30, 2024

Cytokines play a crucial role in the structure and function of blood vessels hypertension. Hypertension damages by mechanisms linked to shear forces, activation renin-angiotensin-aldosterone sympathetic nervous systems, oxidative stress, proinflammatory milieu that lead generation neoantigens damage-associated molecular patterns, ultimately triggering release numerous cytokines. Damage-associated patterns are recognized PRRs (pattern recognition receptors) activate inflammatory endothelial cells, smooth muscle perivascular nerves, adipose tissue. Activated vascular cells also cytokines express factors attract macrophages, dendritic lymphocytes vessels. differentiated T into Th1, Th17, Th22 secondary lymphoid organs migrate vessels, releasing specific further contribute dysfunction remodeling. This chronic inflammation alters profile making them dysfunctional. Here, we provide an overview how hypertension impacting vasculature. Furthermore, explore clinical perspectives about modulation as potential therapeutic intervention specifically target hypertension-linked dysfunction.

Language: Английский

Citations

17
Exploring the Antioxidant, Antidiabetic, and Antimicrobial Capacity of Phenolics from Blueberries and Sweet Cherries DOI Creative Commons
Ana C. Gonçalves, Ana R. Nunes, Sara Meirinho

et al.

Applied Sciences, Journal Year: 2023, Volume and Issue: 13(10), P. 6348 - 6348

Published: May 22, 2023

(1) Background: Nowadays, special attention has been paid to red and purple fruits, including blueberries sweet cherries, since they are highly attractive consumers due their organoleptic properties, standing out vibrant colours flavour, nutritional value. (2) Methods: The present study evaluated the phenolic profile of phenolic-enriched extracts from cherries explored antioxidant potential against DPPH, superoxide nitric oxide radicals, ferric species, inhibit α-glucosidase enzyme. Furthermore, antimicrobial activity was also determined by microdilution method four Gram-positive strains (Enterococcus faecalis ATCC 29212, Bacillus cereus 11778, Listeria monocytogenes LMG 16779, Staphylococcus aureus 25923) five Gram-negative (Salmonella enterica subsp. 13311 serovar Typhimurium, Klebsiella pneumoniae 13883, Proteus mirabilis CECT 170, Serratia marcescens 159, Acinetobacter baumannii 1025). (3) Results: By chromatographic techniques, eight anthocyanins were detected in blueberry coloured fraction total extract, cherry extract fraction, while quercetin aglycone chlorogenic acids dominant non-coloured compounds respectively. All demonstrated significant as well ability enzyme development various microorganisms. (4) Conclusion: obtained data evidence promising biological being correlated with presence compounds.

Language: Английский

Citations

13
Phenolic Compounds from Cherries and Berries for Chronic Disease Management and Cardiovascular Risk Reduction DOI Open Access
Filomena Carvalho, Radhia Aitfella Lahlou, Luís R. Silva

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1597 - 1597

Published: May 23, 2024

Cardiovascular diseases (CVDs) are a leading cause of mortality worldwide. Therefore, there is increasing interest in dietary interventions to reduce risk factors associated with these conditions. Cherries and berries rich sources bioactive compounds have attracted attention for their potential cardiovascular benefits. This review summarises the current research on effects cherry berry consumption health, including vivo studies clinical trials. These red fruits phenolic compounds, such as anthocyanins flavonoids, which multiple properties. properties include antioxidant, anti-inflammatory, vasodilatory effects. Studies suggest that regular may inflammation oxidative stress, lower blood pressure, improved lipid profiles, enhanced endothelial function. However, interpreting findings establishing optimal dosages challenge due variability fruit composition, processing methods, study design. Despite limitations, evidence highlights cherries components preventive strategies against CVD. Further needed maximise health benefits improve practice.

Language: Английский

Citations

4
Efecto del consumo de polifenoles sobre biomarcadores de inflamación y endotoxemia en personas con obesidad: una revisión sistemática. DOI Creative Commons
Luz Adriana López González, Clara Helena González-Correa, Elcy Yaned Astudillo Muñoz

et al.

Nutrición clínica y dietética hospitalaria/Nutrición clínica, dietética hospitalaria, Journal Year: 2025, Volume and Issue: 45(1)

Published: Feb. 3, 2025

Introducción: las enfermedades crónicas han aumentado a nivel mundial debido al estilo de vida y otros factores como el tabaquismo, alcohol, la obesidad, comida ultraprocesada baja en fibra, carente frutas verduras, etc. La evidencia científica respalda uso polifenoles dietarios agentes preventivos terapéuticos que podrían ayudar con carga estas patologías modulando respuesta inflamatoria endotoxemia. Objetivo: evaluar los efectos del consumo sobre parámetros relacionados biomarcadores inflamatorios endotoxemia, perfiles glucémicos peso personas esta condición. Metodología: Se realizó búsqueda ensayos clínicos aleatorizados bases datos PubMed, Science Direct, Ovid Ebsco. accedió estudios adultos obesos publicados entre enero 2019 hasta marzo 2024 evaluaran efecto inflamación (FNTα, PCR hs, IL6 e IL10) endotoxemia (LPS). Resultados: incluyeron 11 506 participantes. evidenció 73% más sensibles disminución fueron PCR, FNTα. Con relación lipoproteína fijadora lipopolisacáridos aumentó 30% grupo intervención no se afectaron. glicemia disminuyó promedio 15% mantuvo estable lo indica puedan ser, además, coadyuvantes manejo peso. Discusión: tolerancia modulación pero requieren estudios. Conclusión: fitonutrientes son sustancias prometedoras inflamación, pacientes obesidad.

Citations

0
Assessing the Role of Dark Sweet Cherry (Prunus avium L.) Consumption on Cognitive Function, Neuropeptides, and Circadian Rhythm in Obesity: Results from a Randomized Controlled Trial DOI Open Access
Shirley Arbizu,

Susanne U. Mertens-Talcott,

Stephen T. Talcott

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 784 - 784

Published: Feb. 24, 2025

Background/Objectives: Obesity is linked to a higher risk of cognitive impairment. The objective this single blind randomized trial was evaluate the impact dark sweet cherry (DSC) intake on function in obese adults. Methods: Participants (body mass index (BMI): 30-40 kg/m2, >18 years, without chronic diseases and/or antibiotic use) consumed 200 mL DSC drink with 3 g powder (n = 19) or an isocaloric placebo 21) twice daily for 30 days. Cognitive assessed at Day 1 (D1) and (D30) using standardized tests NeuroTracker (NT) 3D training program. Blood biomarkers related health (neurotensin, substance p, oxytocin) circadian rhythm (melatonin cortisol) were D1 D30 Luminex multiplex bead-based immunoassay. Results: supplementation significantly improved working memory concentration, as indicated by scores digit span forward (DSF, p 0.006) backward (DSB, 0.01) tests. However, processing speed, sustained attention, visual spatial skills, through trail making (TMT) symbol substitution (DSST) tests, well performance (VCP) evaluated NT program, showed no significant differences between groups. Neurotensin, associated deficits, increased both groups but only group (p 0.007). Similarly, melatonin groups, reaching significance 0.02), it correlated positively IFNγ, suggesting compensatory response inflammation. Conclusions: These findings suggest may enhance specific functions Further clinical trials are needed confirm these results.

Language: Английский

Citations

0
Health Benefits of (Poly)phenols from Cherries: A Review of Clinical Trials DOI Creative Commons
Alessandro Colletti, Giancarlo Cravotto,

Anna Meo

et al.

Nutraceuticals, Journal Year: 2025, Volume and Issue: 5(2), P. 12 - 12

Published: April 25, 2025

Cherries are well known to be a rich source of (poly)phenols, especially anthocyanins, with exhibited antioxidant and anti-inflammatory properties. The aim this review is describe the effects cherry extract observed in clinical trials respective tolerability indications, highlighting differences efficacy depending on type extract, cherry, formulation, dosage used. In particular, supplementation standardized tart extracts has been shown improve different markers human health, exercise performance, quality sleep. Most studies conducted date have reported total (poly)phenol anthocyanin doses administered that were contained extracts, which ranged from 143 2140 mg/day 15 547 mg/day, respectively, as duration treatments, acute 84 days. Although currently prescribed dietary supplements several areas medicine, further investigations mechanisms action long-term randomized (RCTs) required order validate safety applications. addition, real challenge for next few years standardization cherry’s (poly)phenolic fractions. context, optimization extraction procedure downstream processing represents key point reliable active guiding principles formulation food supplements. fact, due methods cherries, relative closely related specific profile obtained, cannot extrapolated literature. Future research should include an analysis reporting content analytical used quantify individual contents.

Language: Английский

Citations

0
Bioactive Potential of Sweet Cherry (Prunus avium L.) Waste: Antioxidant and Anti-Inflammatory Properties for Sustainable Applications DOI Creative Commons
Luisa Frusciante,

Collins Nyaberi Nyong’a,

Alfonso Trezza

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(9), P. 1523 - 1523

Published: April 26, 2025

This study presents an innovative approach to the sustainable valorization of industrial sweet cherry (Prunus avium L.) waste from Vignola Region, Italy, transforming what is typically discarded into a high-value bioactive resource. Unlike conventional extractions, our hydroethanolic extract (VCE) was obtained entire waste, including pericarp, pulp, and stone, as generated by processing. full-fruit extraction strategy represents novel efficient use agricultural by-products, aligning with circular bioeconomy principles. Sweet cherries are known for their phenolic richness, spectrophotometric assays (TPC, TFC, reducing power, DPPH, ABTS) confirmed extract’s antioxidant capacity. In vitro studies using RAW 264.7 macrophages revealed no cytotoxic effects (MTT assay), along significant anti-inflammatory activity, evidenced reduced ROS NO production downregulation iNOS COX-2. Western blotting showed inhibition NF-κB nuclear translocation MAPK pathway signaling. Additionally, agarose gel electrophoresis protection against oxidative DNA damage. UPLC-MS/MS analysis identified sakuranetin, aequinetin, dihydrowogonin most representative compounds in VCE. Molecular docking simulations strong specific binding affinities these p65 key targets. These findings highlight whole waste—including pit—as potent source promising nutraceutical pharmaceutical applications.

Language: Английский

Citations

0
Interferon gamma in the pathogenesis of hypertension − recent insights DOI Creative Commons
Lance Benson, Shengyu Mu

Current Opinion in Nephrology & Hypertension, Journal Year: 2024, Volume and Issue: 33(2), P. 154 - 160

Published: Jan. 2, 2024

The mounting body of evidence underscores the pivotal role interferon gamma (IFNγ) in pathogenesis hypertension, prompting exploration mechanisms by which this cytokine fosters a pro-inflammatory immune milieu, subsequently exacerbating hypertension. In review, we delve into recent preclinical and clinical studies from past two years to elucidate how IFNγ participates progression

Language: Английский

Citations

3
Phenolic Compounds from Cherries and Berries for Chronic Disease Management and Cardiovascular Risk Reduction DOI Open Access
Filomena Carvalho, Radhia Aitfella Lahlou, Luís R. Silva

et al.

Published: April 17, 2024

Cardiovascular diseases (CVDs) a leading cause of mortality worldwide. Therefore, there is in-creasing interest in dietary interventions to reduce risk factors associated with these conditions. Cherries and berries are rich sources bioactive compounds have attracted attention for their potential cardiovascular benefits. This review summarizes the current research on effects cherries consumption health, including vivo studies clinical trials. These red fruits phenolic compounds, such as anthocyanins flavonoids, which multiple properties. properties include antioxidant, anti-inflammatory, vasodilatory effects. Studies suggest that regular may reducing in-flammation oxidative stress, lower blood pressure, improved lipid profiles, enhanced endothelial function. However, interpreting findings establishing optimal dosages challenge due variability fruit composition, processing methods, study design. Despite limitations, evidence highlights components preventive strategies against CVD. Further needed maximize health benefits improve practice.

Language: Английский

Citations

3
Ingredients, structure and reconstitution properties of instant powder foods and the potential for healthy product development: a comprehensive review DOI
Yi Ren,

Fuhuai Jia,

Duo Li

et al.

Food & Function, Journal Year: 2023, Volume and Issue: 15(1), P. 37 - 61

Published: Nov. 22, 2023

Instant foods are widely presented in powder forms across different food segments, which potentially can be formulated with functional or beneficial compounds to provide health benefits. Many reconstituted instant form colloidal suspensions complex structures. However, designing could challenging due the structural complexity and high flexibility formulation. This review proposed a new classification method for according solubility of ingredients structure products. containing insoluble discussed. It summarised challenges current advances treatments, reconstitution improvement, influences on texture facilitate product design related industries. The characteristics incorporation main benefits development were reviewed. Different products vary significantly ratios macronutrients. macronutrients have limited water. After being by water, components dispersed swell dispersions structures textures. Soluble components, dissolve continuous phase, may dispersing process influence solution environment. destabilising factors Both particle molecular structuring strategies been developed improve wettability prevent formation lumps and, therefore, properties. Various types based healthy exhibit positive effects prevention non-communicable diseases overall health. Less processed materials by-products often chosen enhance contents dietary fibre phenolic compounds. enrichment compounds, fibres and/or probiotics tend simultaneous plant-based formulation must tailored desired property.

Language: Английский

Citations

6