Toxicology and Environmental Health Sciences, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 20, 2024
Language: Английский
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(6), P. 718 - 718
Published: May 27, 2024
Secondary metabolites, polyphenols, are widespread in the entire kingdom of plants. They contain one or more hydroxyl groups that have a variety biological functions natural environment. These uses include polyphenols food, beauty products, dietary supplements, and medicinal products grown rapidly during past 20 years. Antimicrobial described together with their sources, classes, subclasses. Polyphenols found different such as dark chocolate, olive oil, red wine, almonds, cashews, walnuts, berries, green tea, apples, artichokes, mushrooms, etc. Examples benefits antiallergic, antioxidant, anticancer agents, anti-inflammatory, antihypertensive, antimicrobe properties. From these classes helpful for growth internal functional systems human body, providing healthy fats, vitamins, minerals, lowering risk cardiovascular diseases, improving brain health, rebooting our cellular microbiome health by mitochondrial uncoupling. Among various (curcumin, naringenin, quercetin, catechin, etc.) primarily antimicrobial activities discussed along possible future applications. For agents to be proven safe, adverse impacts must substantiated reliable scientific research well vitro vivo clinical data. Future may influenced this evaluation.
Language: Английский
Citations
20
Food Chemistry, Journal Year: 2024, Volume and Issue: 452, P. 139459 - 139459
Published: April 24, 2024
Language: Английский
Citations
11
LWT, Journal Year: 2023, Volume and Issue: 189, P. 115482 - 115482
Published: Nov. 1, 2023
The consumption of kombucha drinks has remarkably grown during the last decade and, besides traditional ingredients such as tea leaves, alternative raw materials with interesting functional properties are being proposed. aim this study was to obtain kombuchas enriched in phenolic compounds and a high antioxidant activity using fruits instead determine optimal fermentation time. fruit-based were prepared cherry, plum, apricot, strawberry, persimmon, grape, orange, or pomegranate three different microbial consortia (SCOBYs/SCs). pH, carbohydrate, ethanol, levels, vitro capacity determined along process (21 days). obtained products showed safe pH values (2.5–4.2) suitable ethanol levels (<1.2%). Their carbohydrate content almost half that commercial kombucha. fermentative microorganisms increased total (TPC) radical scavenging (TEAC) all preparations, differences found depending on SC used. Maximum TPC TEAC observed strawberry (up 13.7 mg/100 mL 2.05 μmol/mL, respectively). results fruits, mainly strawberries, could be used activity.
Language: Английский
Citations
20
Published: April 8, 2024
Rheumatoid arthritis (RA) is a complex illness with both hereditary and environmental compo-nents. Globally, in 2019, 18 million people had RA. RA characterised by persistent inflammation of the synovial membrane that lines joints, cartilage loss, bone erosion. Phenolic molecules are most prevalent secondary metabolites plants, diverse spectrum biological ac-tions benefit functional meals nutraceuticals. These compounds have received lot at-tention recently because they antioxidant, anti-inflammatory, immunomodulatory, anti-rheumatoid activity modulating tumour necrosis factor, mitogen-activated protein kinase, nu-clear factor kappa-light-chain-enhancer activated B cells, c-Jun N-terminal kinases, as well other preventative properties. This article discusses dietary polyphenols, their pharmacological properties, innovative delivery technologies for treatment RA, focus on possible activities. Nonetheless, commercialization polyphenols may be achievable only after confirming safety profile completing successful clinical trials.
Language: Английский
Citations
5
Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 131 - 169
Published: Jan. 1, 2025
Language: Английский
Citations
0
Food Chemistry X, Journal Year: 2025, Volume and Issue: unknown, P. 102459 - 102459
Published: April 1, 2025
Language: Английский
Citations
0
Nutrients, Journal Year: 2024, Volume and Issue: 16(9), P. 1361 - 1361
Published: April 30, 2024
Currently, a clear interest has been given to berries due their richness in active metabolites, including anthocyanins and non-coloured phenolics. Therefore, the main aim of present work is investigate phenolic profile, antioxidant abilities, antiproliferative effects on normal human dermal fibroblasts (NHDF) colon carcinoma cell line (Caco-2) cells phenolic-rich extracts from three red fruits highly appreciated by consumers: two species blackberries (Rubus fruticosus Rubus ulmifolius) one mulberry (Morus nigra). A total 19 different phenolics were identified quantified HPLC-DAD-ESI/MSn HPLC-DAD, respectively. Focusing biological potential extracts, all them revealed notable scavenging abilities. Concerning properties, R. presented cytotoxic selectivity for Caco-2 compared NHDF cells. To deeper explore potential, combinations with positive controls (ascorbic acid 5-fluorouracil) also conducted. Finally, obtained data are another piece evidence that combination natural plants may reduce clinical therapy costs possible toxicity chemical drugs.
Language: Английский
Citations
3
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(5), P. 590 - 590
Published: May 6, 2024
Rheumatoid arthritis (RA) is a complex illness with both hereditary and environmental components. Globally, in 2019, 18 million people had RA. RA characterized by persistent inflammation of the synovial membrane that lines joints, cartilage loss, bone erosion. Phenolic molecules are most prevalent secondary metabolites plants, diverse spectrum biological actions benefit functional meals nutraceuticals. These compounds have received lot attention recently because they antioxidant, anti-inflammatory, immunomodulatory, anti-rheumatoid activity modulating tumor necrosis factor, mitogen-activated protein kinase, nuclear factor kappa-light-chain-enhancer activated B cells, c-Jun N-terminal kinases, as well other preventative properties. This article discusses dietary polyphenols, their pharmacological properties, innovative delivery technologies for treatment RA, focus on possible activities. Nonetheless, commercialization polyphenols may be achievable only after confirming safety profile completing successful clinical trials.
Language: Английский
Citations
2
Applied Sciences, Journal Year: 2023, Volume and Issue: 13(14), P. 8410 - 8410
Published: July 20, 2023
Hybrid materials, composed of organic and inorganic components at the nanometer or molecular level, have emerged as a promising material class forefront technological progress. Their potential applications in biological medical fields garnered significant interest, particularly context incorporating antioxidant compounds. This study focuses on synthesis characterization sol–gel-derived hybrid material, consisting silica (S), polyethylene glycol (P), flavonoid quercetin (Q). By varying concentrations Q P, structural properties SPQ systems were investigated. Structural analysis using Fourier-transform infrared (FT-IR) solid-state nuclear magnetic resonance (NMR) spectroscopies provided insights into composition morphology, giving information about interactions between phases. Additionally, vitro release revealed controlled over time, demonstrating that materials possess suitable application for drug delivery.
Language: Английский
Citations
6
Environmental Nanotechnology Monitoring & Management, Journal Year: 2024, Volume and Issue: unknown, P. 101011 - 101011
Published: Sept. 1, 2024
Language: Английский
Citations
0