Lentinula edodes as a Source of Bioactive Compounds with Therapeutical Potential in Intestinal Inflammation and Colorectal Cancer

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3320 - 3320

Published: April 2, 2025

Inflammatory bowel disease (IBD), including Crohn's (CD) and ulcerative colitis (UC), is a rising global health issue. Chronic intestinal inflammation an important risk factor for colorectal cancer (CRC). Despite significant progress in IBD CRC treatment, numerous patients remain resistant to standard pharmacotherapy or experience severe side effects that prevent them from continuing treatment. There evidence suggesting bioactive substances Lentinula edodes have immunomodulatory anticancer properties. This fungus currently classified as functional food, considering its beneficial on human special nutritional value. Studies conducted vitro animal models demonstrated L. compounds, particular glucans, anti-inflammatory antioxidant effects, induce apoptosis of cells, reduce tumor angiogenesis, restore gut microbiome heterogeneity improve barrier dysfunction. Moreover, clinical trials confirmed these compounds combined with chemotherapy effect improving the prognosis patients. In addition, glucans increase microbial diversity enhance interferon (IFN)-γ production by immune cells. Future studies must be focused understanding pathways mechanisms associated observed effects. both randomized long-term follow-up are needed confirm their effectiveness treatment CRC.

Language: Английский

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Protect Effects of Perilla Seed Extract and Its Active Ingredient Luteolin Against Inflammatory Bowel Disease Model via the PI3K/AKT Signal Pathway In Vivo and In Vitro

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3564 - 3564

Published: April 10, 2025

The purpose of this study was to investigate the anti-inflammatory effects Perilla Seed Extract (PSE) and its active ingredient on Inflammatory Bowel Disease (IBD) in vitro vivo. Thirty-two C57/BL mice were randomly divided into four groups (n = 8): control group (CON), PBS group, LPS (LPS 3.5 mg/kg given intraperitoneally [ip] day 7 only), PSE (100 orally daily + ip at 7). Mice euthanized 24 h after administration. MODE-K cells five groups: (50 μg/mL for 2 h), (low dose, 25 LPS; middle 50 high 100 LPS). In vivo, compared with CON revealed a significant decrease villus length-to-crypt depth ratio (p < 0.01) goblet cell density per unit area 0.01). Conversely, administration resulted increase significantly increased ROS content 0.01), secretion inflammatory cytokines IL-6 TNF-α mRNA expressions HO-1 decreased Occludin Claudin1 contrast, treatment led marked levels along reduction factors TNF-α(p 0.05), as well Concurrently, 0.05) vitro, also reversed LPS-induced inflammation, oxidation tight junction-related factors. Network pharmacology identified 97 potential targets treating IBD, while transcriptomics analysis 342 differentially expressed genes (DEGs). indicated that pathways included PI3K-Akt signaling pathway, MAPK TNF which PI3K-AKT pathway may represent primary mechanism. an vivo setting, protein expression p-PI3K/PI3K p-AKT1/AKT1 blocked chemical composition analyzed using UPLC-MS/MS, six components including luteolin (content 0.41%), rosmarinic acid 0.27%), α-linolenic 1.2%), oleic 0.2%). Molecular docking found could establish stable binding eight targets, cells. summary, demonstrates efficacy against IBD progression by enhancing intestinal barrier function inhibiting responses oxidative stress via PI3K/AKT luteolin's inhibition AKT1 phosphorylation appears play particularly crucial role therapeutic

Language: Английский

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Niga-ichigoside F1 alleviates DSS-induced ulcerative colitis by inhibiting the NF-κB pathway

Food Bioscience, Journal Year: 2024, Volume and Issue: 62, P. 104834 - 104834

Published: July 29, 2024

Language: Английский

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Effects of Centella asiatica-isolated pectic polysaccharide on dextran sulfate sodium-induced colitis

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 285, P. 138237 - 138237

Published: Nov. 30, 2024

Language: Английский

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Nutrition, Nutraceuticals and Bioactive Compounds in the Prevention and Fight against Inflammation

Nutrients, Journal Year: 2023, Volume and Issue: 15(11), P. 2629 - 2629

Published: June 5, 2023

Chronic low-grade systemic inflammation is a key factor involved in the pathogenesis of many diseases and their complications (Figure 1) [...].

Language: Английский

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The Potential of Natural Oils to Improve Inflammatory Bowel Disease

Nutrients, Journal Year: 2023, Volume and Issue: 15(11), P. 2606 - 2606

Published: June 1, 2023

Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disorder that includes ulcerative colitis (UC) and Crohn’s (CD), the exact cause of which still unknown. Numerous studies have confirmed diet one major environmental factors associated with IBD, as it can regulate gut microbiota reduce inflammation oxidative stress. Since consumption oil essential in diet, improving IBD through has potential. In this article, we first briefly reviewed current treatment methods for introduce role natural oils diseases. We then focused on recent discovery prevention summarized their main mechanisms action. The results showed anti-inflammatory activity derived from different plants animals been validated various experimental animal models. These are capable homeostasis models multiple mechanisms, including modulation microbiota, protection barrier, reduction colonic inflammation, improvement stress levels intestine, regulation immune homeostasis. Therefore, dietary or topical use may potential therapeutic effects IBD. However, currently, only few clinical trials support aforementioned conclusions. This review emphasized positive encouraged more to provide reliable evidence human by functional substances.

Language: Английский

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Drosophila: An Important Model for Exploring the Pathways of Inflammatory Bowel Disease (IBD) in the Intestinal Tract

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12742 - 12742

Published: Nov. 27, 2024

Inflammatory bowel disease (IBD) is a chronic and recurring lifelong condition, the exact etiology of which remains obscure. However, an increasing corpus research underscores pivotal role cellular signaling pathways in both instigation management intestinal inflammation. Drosophila, owing to its prodigious offspring, abbreviated life cycle, conservation with mammals, among other advantages, has become model organism for IBD research. This review will expound on feasibility utilizing Drosophila as model, comparing architecture that inflammatory responses, pathways. Furthermore, it deliberate natural products across various biological models pathways, elucidating viability fruit flies modus operandi context IBD.

Language: Английский

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Silkworm pupa protein peptide improved DSS-induced colitis in C57BL/6 mice through the MAPK/NF-κB signaling pathway

Journal of Functional Foods, Journal Year: 2023, Volume and Issue: 110, P. 105852 - 105852

Published: Oct. 19, 2023

Numerous studies have revealed the multifunctional activities of silkworm pupa peptides (SPP). In this study, we investigated protective effects SPP on dextran sulfate sodium (DSS)-induced colitis in mice. The results showed that improved clinical symptoms mice, including increased colon length, slowed weight loss, and reduced disease activity index (DAI) scores. Furthermore, significantly alleviated DSS-induced colonic injury by reducing expression myeloperoxidase (MPO) tissues, enhancing mucin secretion colon, decreasing cell apoptosis. also mitigated severity modulating serum inflammatory factors improving oxidative stress levels. Western blot analysis suppressed activation MAPK NF-κB signaling pathways. conclusion, protected against mice apoptosis, attenuating responses, levels, potentially through inhibition

Language: Английский

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Silkworm pupa peptide ameliorates dextrose sodium sulfate-induced colitis by enhancing gut barriers and modifying gut flora

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown

Published: April 1, 2024

The anti-inflammatory properties of silkworm pupa peptide (SPP) have been recognized for their potential benefits in colitis treatment. However, the underlying mechanism SPP animal models remains unclear. objective our work was to investigate improving effect and action on a mouse model dextrose sodium sulfate (DSS)-induced colitis. findings suggested that effectively eased ulcerative (UC) symptoms mice by decreasing disease activity index, ameliorating histopathological injury, serum colonic markers inflammation. In addition, research demonstrated restored intestinal barrier function increasing production tight junction proteins such as zonula occludens-1 (ZO-1), claudin-1, claudin-3, occludin, adherens protein E-cadherin1. Further, supplementation enhanced concentration short-chain fatty acids positively altered makeup gut bacteria mice's gut. These underscore SPP's ability slow progression point its possible use functional component dietary supplements prevention early-stage

Language: Английский

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Aloe-emodin alleviates inflammatory bowel disease in mice by modulating intestinal microbiome homeostasis via the IL-4/IL-13 axis

Heliyon, Journal Year: 2024, Volume and Issue: 10(15), P. e34932 - e34932

Published: July 22, 2024

Inflammatory bowel disease (IBD) is a global health concern. Aloe-emodin (AE) has diverse pharmacological benefits, including anti-inflammatory effects. However, its role in IBD remains unclear, prompting our investigation of regulatory effects and mechanisms an mouse model.

Language: Английский

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