Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A State-of-the-Art Review

Journal of Obesity & Metabolic Syndrome, Journal Year: 2023, Volume and Issue: 32(3), P. 197 - 213

Published: Sept. 13, 2023

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the latest term for associated with metabolic syndrome. MASLD most common cause of chronic and leading liver-related morbidity mortality. It important that all stakeholders be involved in tackling public health threat obesity obesity-related diseases, including MASLD. A simple clear assessment referral pathway using non-invasive tests essential to ensure patients severe are identified referred specialist care, while less remain primary where they best managed. While lifestyle intervention cornerstone management MASLD, cardiovascular risk must properly assessed managed because No pharmacological agent has been approved treatment but novel anti-hyperglycemic drugs appear have benefit. Medications used diabetes other conditions may need adjusted as progresses cirrhosis, especially decompensated cirrhosis. Based on tests, concepts compensated advanced clinically significant portal hypertension provide a practical approach stratifying according complications can help manage such patients. Finally, prevention sarcopenia should considered

Language: Английский

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The role of the Mediterranean diet in reducing the risk of cognitive impairement, dementia, and Alzheimer’s disease: a meta-analysis

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 11, 2025

Abstract Age-related cognitive impairment and dementia pose a significant global health, social, economic challenge. While Alzheimer’s disease (AD) has historically been viewed as the leading cause of dementia, recent evidence reveals considerable impact vascular (VCID), which now accounts for nearly half all cases. The Mediterranean diet—characterized by high consumption fruits, vegetables, whole grains, fish, olive oil—has widely recognized its cardiovascular benefits may also reduce risk decline dementia. To investigate protective effects diet on we conducted systematic literature review using PubMed, Web Science, Google Scholar, focusing studies published between 2000 2024. included in meta-nalysis examined adherence to incidence AD. We applied random-effects model calculate pooled hazard ratios (HRs) with 95% confidence intervals (CIs) assessed heterogeneity through I -square statistics. Forest plots, funnel Z -score plots were used visualize study outcomes. Of 324 full-text records reviewed, 23 met inclusion criteria. combined HR among those adhering was 0.82 (95% CI 0.75–0.89); 0.89 0.83–0.95); AD, 0.70 0.60–0.82), indicating substantial effects. Significant observed across studies, though suggested sufficient sample sizes support reliable conclusions each condition. In conclusion, this meta-analysis confirms that is associated an 11–30% reduction age-related disorders, including impairment, These findings underscore diet’s potential central element neuroprotective public health strategies mitigate promote healthier aging.

Language: Английский

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The role of nutrition in the prevention of sarcopenia

American Journal of Clinical Nutrition, Journal Year: 2023, Volume and Issue: 118(5), P. 852 - 864

Published: Aug. 30, 2023

Sarcopenia is a common skeletal muscle disorder characterized by loss of mass and impaired function that associated with poor health outcomes. Although nutrition considered an important factor in the etiology sarcopenia, preventive potential diet, specifically extent to which differences habitual patterns diet and/or nutrient intakes impact risk its development, poorly understood. This narrative review research evidence on dietary mid- (<60 y) young-older (60-70 adulthood evaluate how they relate age-related changes function. A key finding was current adult sarcopenia older age limited fragmented, different outcomes reported across studies (for example, lean mass, strength) few reporting links incident diagnosed sarcopenia. As these are not interchangeable, it challenges collation evidence, leaving many gaps understanding. There also information about (<70 longitudinal repeated assessments enable definition cumulative exposures adulthood. However, despite limitations, findings from already provide reasonably consistent messages benefits diets higher quality earlier for later physical performance, although whole-diet intervention trials urgently needed understand their potential. In comparison, there little individual nutrients need be addressed future research, may sufficient data promote more widely - healthier adulthood, known range outcomes, linked effective preservation

Language: Английский

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Association between oxidative balance score and sarcopenia in US adults: NHANES 2011–2018

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: April 24, 2024

Sarcopenia, a condition characterized by diminished skeletal muscle mass, strength, and function, accompanied inflammation oxidative stress, remains an area of limited exploration concerning its correlation with the Oxidative Balance Score (OBS).

Language: Английский

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The impact of the Mediterranean diet on immune function in older adults

Aging Clinical and Experimental Research, Journal Year: 2024, Volume and Issue: 36(1)

Published: May 23, 2024

Abstract Diet is one of the lifestyle factors that most amenable to intervention, and has a substantial effect on potential for successful aging mitigation risk disease. Good nutrition pillar healthy aging, large body evidence attests benefits Mediterranean diet quality process. The comprises wide range nutrients which, both individually collectively, exert positive effects immunity, in part mediated by gut microbiota. In this article, we review how its beneficial are We certain key components dietary pattern, including vitamins, zinc, selenium, polyphenols. Overall, existing convincingly demonstrates Mediterreanean affects immune health maintaining weight reducing metabolic cardiovascular diseases; inflammation promoting microbiota profile.

Language: Английский

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Vitamin D and Colorectal Cancer Prevention: Immunological Mechanisms, Inflammatory Pathways, and Nutritional Implications

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1351 - 1351

Published: April 15, 2025

Vitamin D plays a crucial role in the regulation of immune system, with immunomodulatory effects that are key prevention colorectal cancer (CRC). Over past decades, research has shown this steroid hormone impacts much more than bone health, significantly influencing responses. enhances organ functions such as spleen and lymph nodes, boosts T-cell activity, which is essential defending body against tumors. Additionally, vitamin mitigates inflammatory responses closely linked to development, reducing inflammation contributes CRC. It acts via receptors (VDRs) expressed on cells, modulating Adequate levels influence gene expression related cell proliferation, inhibiting tumor development. also activates mechanisms suppress survival, migration, metastasis. Low have been associated an increased risk CRC, deficiency correlating higher disease incidence. Lifestyle factors, diet high red meat calories but low fiber, fruits, vegetables, well physical inactivity, contribute CRC risk. Insufficient calcium intake occurrence poorer clinical outcomes. Maintaining optimal adequate dietary preventing improving patient prognosis. This review explores summarizes findings from randomized trials assessing supplementation

Language: Английский

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Obesity and malnutrition in children and adults: A clinical review

Obesity Pillars, Journal Year: 2023, Volume and Issue: 8, P. 100087 - 100087

Published: Sept. 7, 2023

In the U.S., children and adults are consuming more low-nutrient foods with added sugar excess fats as compared to healthy, high-quality calories micronutrients. This diet is increasing prevalence of malnutrition nutritional deficiencies, despite high calorie intake. a review common micronutrient risk factors for malnutrition, dietary plans, health consequences in obesity U.S.

Language: Английский

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Scientific evidence supporting the newly developed one-health labeling tool “Med-Index”: an umbrella systematic review on health benefits of mediterranean diet principles and adherence in a planeterranean perspective

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Oct. 26, 2023

Med-Index is a one-health front-of-pack (FOP) label, based on Mediterranean diet (MedDiet) principles, developed to summarize information about the nutritional properties and related-health benefits of any food as well its sustainable production processes, associated company's social responsibility parameters in new "Planeterranean" perspective. Thus, can be adopted by European region authority worldwide; this achieved consumption cooking locally available sourced foods that respect MedDiet both terms healthy nutrition production. The huge body scientific evidence health model principles requires comprehensive framework encompass reliability robustness tool. A systematic review was carried out examine association between human adherence patterns upon which "Med-Index" tool subsequently developed.

Language: Английский

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Accounting Gut Microbiota as the Mediator of Beneficial Effects of Dietary (Poly)phenols on Skeletal Muscle in Aging

Nutrients, Journal Year: 2023, Volume and Issue: 15(10), P. 2367 - 2367

Published: May 18, 2023

Sarcopenia, the age-related loss of muscle mass and function increasing risk disability adverse outcomes in older people, is substantially influenced by dietary habits. Several studies from animal models aging wasting indicate that intake specific polyphenol compounds can be associated with myoprotective effects, improvements strength performance. Such findings have also been confirmed a smaller number human studies. However, gut lumen, polyphenols undergo extensive biotransformation microbiota into wide range bioactive compounds, which contribute to bioactivity on skeletal muscle. Thus, beneficial effects may consistently vary across individuals, depending composition metabolic functionality bacterial communities. The understanding such variability has recently improved. For example, resveratrol urolithin interaction produce different biological according metabotype. In frequently characterized dysbiosis, overrepresentation opportunistic pathogens, increased inter-individual variability, actions phenolic at level. These interactions should taken great consideration for designing effective nutritional strategies counteract sarcopenia.

Language: Английский

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Systematic review of mediterranean diet interventions in menopausal women

AIMS Public Health, Journal Year: 2024, Volume and Issue: 11(1), P. 110 - 129

Published: Jan. 1, 2024

<abstract> <p>The increasing lifespan of women and their extended time spent in menopause pose significant challenges for health care systems, primarily due to the impacts postmenopausal estrogen deficiency aging on health. Menopause's onset is linked a heightened prevalence obesity, metabolic syndrome, cardiovascular disease, osteoporosis. Diet particularly relevant during given its impact quality life longevity modifiability. Because Mediterranean diet currently regarded as one healthiest dietary models world, aim this systematic review was assess current evidence regarding effectiveness studies an intervention menopausal women. A intervention-based involving among performed Scopus, PubMed, Web Science. The results seven that met inclusion criteria suggests adherence can have beneficial women's health, including reductions weight, blood pressure, ω6: ω3 ratio, triglycerides, total cholesterol, LDL levels. Those seem be public interventions aimed at improving life.</p> </abstract>

Language: Английский

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