Association Between Vitamin D and COVID-19–Related Outcomes: An Umbrella Review of Meta-Analyses

Nutrition Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

COVID-19 remains globally pandemic, and although several meta-analyses have explored the association between vitamin D relative to clinical outcomes, a unified view has not yet emerged. To summarize evidence for associations levels COVID-19-related outcomes assess strength validity of these associations. PubMed, Embase, Web Science, Scopus, Cochrane Database Systematic Reviews databases were searched from January 1, 2020, June 15, 2024. Two reviewers independently extracted data assessed study quality. Low increased risk infection by 1.26- 2.18-fold, severe illness 1.50- 5.57-fold, intensive care unit (ICU) admission more than 2-fold, death 1.22- 4.15-fold. In addition, patients with deficiency had an average increase in length hospital stay 0.54 days compared high levels. Overall, supplementation may reduce severity (eg, ICU admissions, need mechanical ventilation) shorter but nonsignificant effect on mortality rates. there significant differences individuals testing positive those negative (mean difference [MD] = -3.22 ng mL-1; 95% CI, -5.18 -1.25), cases mild (MD -4.60 -5.49 -3.71), nonsurvivors survivors -6.59 CI: -8.94 -4.24). are associated higher rates, disease, rates among COVID-19, whereas patients' disease severity. The beneficial effects remain be further explored, however, higher-quality, randomized controlled studies. Nonetheless, caution is warranted because methodological quality most level very low. PROSPERO registration No. CRD42022385036.

Language: Английский

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Changes and clinical significance of serum vitamin A, 25-(OH)D3, TG2, IL-4 and IL-13 levels in children with eczema

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: Feb. 8, 2025

Language: Английский

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Vitamin D Status and Incidence of SARS-CoV-2 Reinfections in the Borriana COVID-19 Cohort: A Population-Based Prospective Cohort Study

Tropical Medicine and Infectious Disease, Journal Year: 2025, Volume and Issue: 10(4), P. 98 - 98

Published: April 6, 2025

A deficient vitamin D (VitD) status has been associated with SARS-CoV-2 infections, severity, and mortality. However, this related to reinfections studied little. Our aim was quantify the risk of considering VitD before reinfection. We performed a population-based prospective cohort study in Borriana (Valencia Community, Spain) during 2020-2023, measuring 25-hydroxyvitamin [25(OH)D] levels by electrochemiluminescence. Cox proportional hazards models were employed. Of total 644 cases confirmed laboratory tests, 378 (58.9%) included our study, an average age 38.8 years; 241 females (63.8%), 127 occurred (33.6%). reinfection incidence rates per 1000 person-days 0.50 for (<20 ng/mL), insufficient (20-29 0.37 sufficient (≥30 ng/mL). Compared status, adjusted hazard ratios 1.79 (95% confidence interval [CI] 0.89-3.59) 1.59 CI 1.06-2.38) significant inverse dose-response (p = 0.02). These results can help improve nutritional actions against reinfections. suggest that lower than 30 ng/mL showed higher Achieving maintaining is recommended prevent

Language: Английский

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A Comprehensive Review of the Global Epidemiology, Clinical Management, Socio-Economic Impacts, and National Responses to Long COVID with Future Research Directions

Diagnostics, Journal Year: 2024, Volume and Issue: 14(11), P. 1168 - 1168

Published: May 31, 2024

Long COVID, characterized by a persistent symptom spectrum following SARS-CoV-2 infection, poses significant health, social, and economic challenges. This review aims to consolidate knowledge on its epidemiology, clinical features, underlying mechanisms guide global responses;

Language: Английский

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TLR10 overexpression modulates immune response in A549 lung epithelial cells challenged with SARS-CoV-2 S and N proteins

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 20, 2025

Toll-like receptors (TLRs) play an important role in the recognition of viral particles and activation innate immune system, but their SARS-CoV-2 infection is still poorly characterized. In present study, we investigated receptor 10 (TLR10) modulating response during infection. The results showed that overexpression TLR10 A549 lung epithelial cells, immunostimulated with proteins S N mainly downregulated proinflammatory cytokines interferons affected gene expression cocultured THP-1 monocytes. Our suggest could mediate extent by downregulating release inflammatory chemokines such as CXCL10 , IL6 IL8 IFNβ . Modulation have implications for treatment patients severe COVID-19, whom excessive inflammation leading to development acute respiratory distress syndrome (ARDS) a key feature. However, further research needed fully understand impact on antiviral overall balance

Language: Английский

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Long COVID and gut microbiome: insights into pathogenesis and therapeutics

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 24, 2025

Post-acute coronavirus disease 2019 syndrome (PACS), following severe acute respiratory 2 (SARS-CoV-2) infection or (COVID-19), is typically characterized by long-term debilitating symptoms affecting multiple organs and systems. Unfortunately, there currently a lack of effective treatment strategies. Altered gut microbiome has been proposed as one the plausible mechanisms involved in pathogenesis PACS; extensive studies have emerged to bridge gap between persistent dysbiosis microbiome. Recent clinical trials indicated that modulation using probiotics, prebiotics, fecal microbiota transplantation (FMT) led improvements related PACS, including fatigue, memory loss, difficulty concentration, gastrointestinal upset, disturbances sleep mood. In this review, we highlight latest evidence on key microbial alterations observed well use microbiome-based therapeutics managing PACS symptoms. These novel findings altogether shed light other chronic conditions.

Language: Английский

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Long COVID: current research and future directions

Infectious Diseases & Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Abstract Long coronavirus disease (COVID) is defined as the continuation or development of new symptoms three months after severe acute respiratory syndrome 2 (SARS-CoV-2) infection, and that last for at least two months, with no other explanation their cause. This includes various clinical manifestations affect multiple organ systems, such complications in respiratory, cardiovascular, neurological, musculoskeletal systems. The most commonly reported include fatigue, cognitive dysfunction, dyspnea, chest pain; however, prevalence severity these vary greatly among individuals. underlying mechanisms long COVID are complex multifaceted, encompassing viral persistence, immune system mitochondrial abnormalities, endothelial impairment, alterations microbiome. Further, has imposed a significant burden on individuals, healthcare economy by impairing an individual’s quality life functional capacity, thereby increasing costs demand care rehabilitation services. review summarizes definition, phenotypes, mechanisms, current treatment advancements highlights specific research directions future investigation.

Language: Английский

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Association of zinc deficiency and clinical symptoms, inflammatory markers, severity of COVID-19 in hospitalized children

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 25, 2025

Introduction Zinc plays an important role in the functioning of immune system. deficiency leads to increased susceptibility inflammatory and infectious diseases. There are few studies investigating zinc development progression COVID-19 children, their findings remain inconsistent. This study aimed determine levels children with assess association symptoms, inflammation markers, disease progression. Methods A prospective cohort included hospitalized patients under 18 years who had a confirmed diagnosis SARS-CoV-2 infection. Serum concentrations were measured using colorimetric method. Based on levels, divided into two groups: first group below 10.7 μmol/L, indicating deficiency, while second above which was considered within optimal range. Results In total, 140 examined. identified 40 (28.6%), found 100 (71.4%). status did not depend age children. Among symptoms acute infection, showed trend toward more frequent fever occurrences ( p = 0.0654). No significant impact observed severity or duration hospitalization. Children higher median values neutrophil-to-lymphocyte ratio (NLR) (1.84 vs. 1.09, 0.0010), C-reactive protein (CRP) (9.65 3.96 mg/L, 0.0053), fibrinogen (2.88 2.07 g/L, 0.0057) compared those adequate levels. Additionally, percentage NLR greater than 4, elevated CRP, zinc-deficient 0.0017, 0.0107, 0.0338, respectively). Conclusion 28.6% dependent age. hypozincemia including CRP.

Language: Английский

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The Link between Inflammation, Lipid Derivatives, and Microbiota Metabolites in COVID-19 Patients: Implications on Eating Behaviors and Nutritional Status

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7899 - 7899

Published: July 19, 2024

Extreme inflammation that continues even after infections can lead to a cytokine storm. In recent times, one of the most common causes storm activation has been SARS-CoV-2 infection. A leads dysregulation and excessive stimulation immune system, producing symptoms typical post-COVID syndrome, including chronic fatigue, shortness breath, joint pain, trouble concentrating (known as “brain fog”), direct organ damage in heart, lungs, kidneys, brain. This work summarizes current knowledge regarding related Additionally, changes lipid metabolism microbiota composition under influence COVID-19, along with possible underlying mechanisms, are described. Finally, this text explores potential health implications eating behaviors nutritional status COVID-19 patients. Although research on is still ongoing, there convincing evidence suggesting severe inflammatory responses during acute phase may long-term consequences. Understanding these links key developing treatment strategies supporting patients

Language: Английский

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Addressing Post-Acute COVID-19 Syndrome in Cancer Patients, from Visceral Obesity and Myosteatosis to Systemic Inflammation: Implications in Cardio-Onco-Metabolism

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1650 - 1650

Published: July 24, 2024

Cardiovascular disease and cancer are the two leading causes of morbidity mortality in world. The emerging field cardio-oncology described several shared risk factors that predispose patients to both cardiovascular cancer. Post-acute COVID-19 syndrome is a chronic condition occurs many who have experienced SARS-CoV-2 infection, mainly based on fatigue, sedentary lifestyle, cramps, breathing difficulties, reduced lung performance. exposes increased visceral adiposity, insulin resistance, myosteatosis, white adipose tissue content (surrounded by M1 macrophages characterized Th1/Th17 phenotype), which increases recurrence. In this review, main metabolic affections post-acute at low high cardiomyopathies will be summarized. Furthermore, non-pharmacological strategies aimed reducing atherosclerotic cardiac provided, especially through anti-inflammatory nutrition with glycemic index, appropriate physical activity, immune-modulating bioactivities able reduce obesity improving insulin-related signaling myocardial metabolism.

Language: Английский

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