Experience with the use of undenatured type II collagen in patients with stage III knee osteoarthritis: a multicenter, prospective, double-blind, placebo-controlled, randomized trial

Terapevticheskii arkhiv, Journal Year: 2025, Volume and Issue: 97(1), P. 54 - 64

Published: Feb. 20, 2025

Introduction. Current strategies for treating osteoarthritis (OA) are based on a multimodal approach that includes pharmacological and non-pharmacological methods. Undenatured chicken collagen type II (NK2) is considered safe effective maintaining joint health can be used alone combined with drugs OA treatment. Aim. To further evaluate the efficacy of combination Artneo containing NK2 in patients stage III knee compared placebo multicenter, prospective, double-blind, placebo-controlled, randomized trial. Materials The study included 212 from 12 centers Russian Federation, whom 50 had radiological OA: 41 (82.0%) females 9 (18.0%) males aged 44 to 75. Using interactive web response system (IWRS), population was into two groups: Group 1 (Artneo group) 28 receiving drug capsule once day 180 days, 2 (placebo 22 drug-matched presentation same regimen as 1. effectiveness therapy assessed by change pain using Visual Analog Scale, WOMAC index, KOOS, EQ-5D quality life questionnaire, need non-steroidal anti-inflammatory drugs. All complete blood count, urinalysis, chemistry, ultrasonic examination target joint. Results. A trial demonstrated significantly superior all studied parameters, improved clinical manifestations reduced stiffness, function life, good safety profile. Conclusion. showed high general patients, including those OA.

Language: Английский

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Chondrocyte Homeostasis and Differentiation: Transcriptional Control and Signaling in Healthy and Osteoarthritic Conditions

Life, Journal Year: 2023, Volume and Issue: 13(7), P. 1460 - 1460

Published: June 28, 2023

Chondrocytes are the main cell type in articular cartilage. They embedded an avascular, abundant, and specialized extracellular matrix (ECM). responsible for synthesis turnover of ECM, which major macromolecular components collagen, proteoglycans, non-collagen proteins. The crosstalk between chondrocytes ECM plays several relevant roles regulation phenotype. live avascular environment healthy cartilage with a low oxygen supply. Although adapted to anaerobic conditions, many their metabolic functions oxygen-dependent, most is supplied by synovial fluid. This review focuses on transcription control signaling chondrocyte differentiation, homeostasis, senescence, death changes that occur osteoarthritis. effects chondroitin sulfate other molecules as anti-inflammatory agents also approached analyzed.

Language: Английский

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Pharmaceutical Applications of Biomass Polymers: Review of Current Research and Perspectives

Polymers, Journal Year: 2024, Volume and Issue: 16(9), P. 1182 - 1182

Published: April 23, 2024

Polymers derived from natural biomass have emerged as a valuable resource in the field of biomedicine due to their versatility. Polysaccharides, peptides, proteins, and lignin demonstrated promising results various applications, including drug delivery design. However, several challenges need be addressed realize full potential these polymers. The current paper provides comprehensive overview latest research perspectives this area, with particular focus on developing effective methods efficient systems. This review aims offer insights into opportunities associated use polymers provide roadmap for future field.

Language: Английский

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Impact of Collagen Peptide Supplementation in Combination with Long-Term Physical Training on Strength, Musculotendinous Remodeling, Functional Recovery, and Body Composition in Healthy Adults: A Systematic Review with Meta-analysis

Sports Medicine, Journal Year: 2024, Volume and Issue: 54(11), P. 2865 - 2888

Published: July 26, 2024

Abstract Introduction Over the past decade, collagen peptide (CP) supplements have received considerable attention in sports nutrition research. These shown promising results improving personal health, enhancing athletic performance, and preventing injuries some but not all studies. Objective A systematic review meta-analysis of randomized controlled trials (RCTs) has been conducted to investigate effects long-term daily supplementation on strength, musculotendinous adaptation, functional recovery, body composition healthy adults, both with without concurrent exercise interventions over several weeks. Methods The PRISMA PERSiST guidelines were followed for this literature review, which was December 2023 using PubMed, Scopus, CINAHL, SPORTDiscus databases. Eligible studies included healthy, normal overweight adults 17 years age who engaged a minimum 8 weeks (except one 3-week trial only maximal strength). Studies examining recovery-related outcomes also eligible if they 1-week period exercise. Methodological study quality assessed PEDro scale. random-effects model standardized mean differences (SMD) change scores chosen calculate overall effect sizes. Results Nineteen comprising 768 participants meta-analysis. indicate statistically significant favor CP intake regarding fat-free mass (FFM) (SMD 0.48, p < 0.01), tendon morphology 0.67, muscle architecture 0.39, strength 0.19, 48 h recovery reactive following exercise-induced damage 0.43, = 0.045). GRADE approach revealed moderate certainty evidence composition, very low mechanical properties, remaining. Conclusion This represents first comprehensive investigation into combined regular physical training various aspects musculoskeletal health adults. findings significant, though certainty, improvements (FFM), morphology, mass, damage. However, further research is required fully understand mechanisms underlying these effects, particularly properties short-term adaptations exercise, as observed outcomes. Overall, appears beneficial adjunct performance Open Science Framework (Registration DOI: https://doi.org/10.17605/OSF.IO/WCF4Y ).

Language: Английский

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Efficacy and safety of collagen derivatives for osteoarthritis: A trial sequential meta-analysis

Osteoarthritis and Cartilage, Journal Year: 2024, Volume and Issue: 32(5), P. 574 - 584

Published: Jan. 11, 2024

Language: Английский

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Efficacy, safety and prospects of using a combination of native type II collagen, methylsulfonylmethane, boswellic acids, vitamin C and vitamin D₃ in knee osteoarthritis: a resolution of the Expert panel

Terapevticheskii arkhiv, Journal Year: 2024, Volume and Issue: 96(1), P. 68 - 74

Published: Jan. 25, 2024

A meeting of the Expert Council on September 9, 2023 considered last challenges in treatment osteoarthritis (OA) including OA comorbid patients. Leading experts rheumatology, traumatology and other relevant disciplines participated meeting. The key goal was discussion potential application a combination undenatured (native) type II collagen, methylsulfonylmethane, boswellic acids, vitamins C D (Artneo complex) as part complex therapy. concluded that Artneo for stage I–III knee patients is not just non-inferior comparison with chondroitin sulfate glucosamine hydrochloride but excels it decrease magnetic resonance imaging synovitis markers dynamics Lequesne index severity. proven efficacy favorable safety profile 6-months course deserve attention medical community active implementation into ambulatory practice, first all, mild or moderate and/or burdened comorbidities.

Language: Английский

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Unlocking the Potential of Marine Sidestreams in the Blue Economy: Lessons Learned from the EcoeFISHent Project on Fish Collagen

Marine Biotechnology, Journal Year: 2025, Volume and Issue: 27(2)

Published: March 13, 2025

Abstract This review provides a general overview of collagen structure, biosynthesis, and biological properties, with particular focus on marine sources, especially fisheries discards by-catches. Additionally, well-documented applications are presented, special emphasis not only its final use but also the processes enabling sustainable safe recovery from materials that would otherwise go to waste. Particular attention is given extraction process, highlighting key aspects essential for industrialization fish sidestreams, such as hygiene standards, adherence good manufacturing practices, ensuring minimal environmental impact. In this context, EcoeFISHent projects have provided valuable insights, aiming create replicable, systemic, territorial clusters based multi-circular economy industrial symbiosis. The main goal project increase monetary income certain categories, fishery aquaculture activities, through valorization underutilized biomass.

Language: Английский

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Polysulfone membranes functionalized with Ni-ZnO and sustainable eggshell: High performance and flux recovery during protein filtration

Journal of Water Process Engineering, Journal Year: 2025, Volume and Issue: 72, P. 107535 - 107535

Published: March 27, 2025

Language: Английский

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Harnessing Marine Bioactive Compounds: In Silico Insights into Therapeutics for Rheumatoid Arthritis and Major Depressive Disorder

Computational Biology and Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108452 - 108452

Published: April 1, 2025

Language: Английский

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Undenatured type II collagen for knee osteoarthritis

Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)

Published: April 20, 2025

Knee Osteoarthritis (OA) leads to significant pain and reduced function affects patients' overall quality of life (QoL). Conservative modalities are the first line management, resorting surgery only if they fail. However, these have limitations, do not address underlying cause knee OA. The use nutraceuticals, including native/undenatured type II collagen (UC-2), has evolved shown promise in conservative management This article highlights mechanism action, qualitatively presents pre-clinical, clinical on-going scientific literature exploring safety efficacy UC-2 for A search was performed using multiple databases (PubMed, Web Science, Embase Scopus) employing terms OA articles published English language, while adhering Preferred Reporting Items Systematic Reviews Meta-Analysis (PRISMA) guidelines. All pre-clinical studies utilizing were included. Studies alone or focusing on excluded. Twelve (3 studies, 8 1 study with both component) met our pre-defined inclusion criteria, included this review. acts via a specific immune mediated mechanism, known as oral tolerance, which can lead inflammation enhanced cartilage repair joint. In addition, administration (40 mg daily) is safe efficacious short- mid-term, reducing pain, improving function, range motion (ROM) QoL. Nonetheless, more adequately powered, prospective, multi-center, non-randomized randomized controlled trials longer follow-up warranted establish long-term patients justify its routine use.

Language: Английский

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