International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(14), P. 11667 - 11667
Published: July 19, 2023
Cervi
cornu
extracts
have
been
used
in
traditional
medicine
for
the
treatment
of
various
disorders,
including
osteoporosis.
However,
since
it
is
not
easy
to
separate
active
ingredients,
limited
research
has
conducted
on
their
functional
properties.
In
this
study,
we
extracted
low-molecular-weight
(843
Da)
collagen
NP-2007
from
cervi
by
enzyme
hydrolyzation
enhance
absorption
and
evaluated
therapeutic
effect
monosodium
iodoacetate-induced
rat
osteoarthritis
(OA)
model.
was
orally
administered
at
50,
100,
200
mg/kg
21
days.
We
showed
that
production
matrix
metalloproteinase-2,
-3,
-9,
decreased
after
treatment.
The
levels
tumor
necrosis
factor
(TNF)-α,
interleukin
(IL)-1β,
IL-6,
prostaglandin
E2
were
also
reduced
NP-2007.
Furthermore,
administration
resulted
effective
preservation
both
synovial
membrane
knee
cartilage
significantly
transformation
fibrous
tissue.
verified
nitric
oxide
pro-inflammatory
cytokines
TNF-α,
IL-1β,
IL-6
lipopolysaccharides-stimulated
RAW
264.7
cells
regulation
NF-kB
MAPK
signaling
pathways.
This
study
indicates
can
alleviate
symptoms
be
applied
as
a
novel
OA
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(22), P. 3807 - 3807
Published: Nov. 6, 2024
Deer
bone
is
rich
in
proteins
and
free
amino
acids,
offering
high
nutritional
value
benefits
such
as
strengthening
bones
antioxidant
properties.
However,
the
development
utilization
of
deer
resources
are
limited,
safety
evaluation
health
foods
incomplete.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(16), P. 3589 - 3589
Published: Aug. 16, 2023
This
study
investigated
whether
oral
supplementation
with
protease-soluble
chicken
type
II
collagen
(PSCC-II)
mitigates
the
progression
of
anterior
cruciate
ligament
transection
(ACLT)–induced
osteoarthritis
(OA)
in
rats.
Eight-week-old
male
Wistar
rats
were
randomly
assigned
to
following
groups:
control,
sham,
ACLT,
group
A
(ACLT
+
pepsin-soluble
(C-II)
I
collagen),
B
Amano
M–soluble
C-II
C
high-dose
and
D
unproteolyzed
C-II).
Various
methods
employed
analyze
knee
joint:
nociceptive
tests,
microcomputed
tomography,
histopathology,
immunohistochemistry.
Rats
treated
any
form
had
significant
reductions
pain
sensitivity
cartilage
degradation.
Groups
that
received
PSCC-II
treatment
effectively
mitigated
ACLT-induced
effects
OA
concerning
cancellous
bone
volume,
trabecular
number,
separation
compared
ACLT
alone
group.
Furthermore,
suppressed
effects,
such
as
downregulation
upregulation
matrix
metalloproteinase-13,
tumor
necrosis
factor-α,
interleukin-1β.
These
results
indicate
retains
protective
traditional
undenatured
provide
superior
benefits
for
management.
encompass
relief,
anti-inflammatory
protection
bone.
Cervi
cornu
has
been
extensively
used
in
traditional
medicine
as
an
antioxidant
and
for
the
treatment
of
various
disorders,
including
osteoporosis.
However,
since
it
is
not
easy
to
separate
active
ingredient,
absorption
performed
well.
In
this
study,
we
extracted
low
molecular
weight
(843Da)
collagen
NP-2007
from
cervi
by
enzyme
hydrolyzation,
evaluated
therapeutic
effect
a
monosodium
iodoacetate
(MIA)-induced
rat
osteoarthritis
model,
identified
their
mechanisms.
was
orally
administered
at
50,
100,
200
mg/kg
21
d.
Efficacy
based
on
serum
parameters,
inflammatory
mediators,
mor-phological
histopathological
analyses
knee
joints.
Production
matrix
metalloproteinases,
MMP-2,
MMP-3,
MMP-9,
higher
MIA-treated
rats;
however,
these
levels
decreased
after
treatment.
Serum
tumor
necrosis
factor-α,
interleukin
(IL)-1β,
IL-6,
prostaglandin
E2
were
lower
group
than
MIA
group.
Furthermore,
administration
resulted
effective
preservation
both
synovial
membrane
cartilage,
significantly
transformation
fibrous
tissue.
This
study
indicates
that
can
prevent
alleviate
symptoms
have
applications
novel
arthritis
The
master
molecular
regulators
and
mechanisms
determining
longevity
health
span
include
nitric
oxide
(NO)
superoxide
anion
radicals
(SOR).
L-arginine,
the
NO
synthase
(NOS)
substrate,
can
restore
a
healthy
ratio
between
dangerous
SOR
protective
radical
to
promote
aging.
Antioxidant
supplementation
orchestrates
protection
against
oxidative
stress
damage—L-arginine
antioxidants
such
as
vitamin
C
increase
production
bioavailability.
Uncoupling
of
generation
with
appearance
be
induced
by
asymmetric
dimethylarginine
(ADMA).
L-arginine
displace
ADMA
from
site
formation
if
sufficient
amounts
amino
acid
are
available.
Antioxidants
ascorbic
acids
scavenge
bioavailability
NO.
topics
this
review
complex
interactions
antioxidant
agents
which
determine
bioactivity
age-related
degeneration.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(14), P. 11667 - 11667
Published: July 19, 2023
Cervi
cornu
extracts
have
been
used
in
traditional
medicine
for
the
treatment
of
various
disorders,
including
osteoporosis.
However,
since
it
is
not
easy
to
separate
active
ingredients,
limited
research
has
conducted
on
their
functional
properties.
In
this
study,
we
extracted
low-molecular-weight
(843
Da)
collagen
NP-2007
from
cervi
by
enzyme
hydrolyzation
enhance
absorption
and
evaluated
therapeutic
effect
monosodium
iodoacetate-induced
rat
osteoarthritis
(OA)
model.
was
orally
administered
at
50,
100,
200
mg/kg
21
days.
We
showed
that
production
matrix
metalloproteinase-2,
-3,
-9,
decreased
after
treatment.
The
levels
tumor
necrosis
factor
(TNF)-α,
interleukin
(IL)-1β,
IL-6,
prostaglandin
E2
were
also
reduced
NP-2007.
Furthermore,
administration
resulted
effective
preservation
both
synovial
membrane
knee
cartilage
significantly
transformation
fibrous
tissue.
verified
nitric
oxide
pro-inflammatory
cytokines
TNF-α,
IL-1β,
IL-6
lipopolysaccharides-stimulated
RAW
264.7
cells
regulation
NF-kB
MAPK
signaling
pathways.
This
study
indicates
can
alleviate
symptoms
be
applied
as
a
novel
OA
