The Crosstalk between Gut Microbiota and Nervous System: A Bidirectional Interaction between Microorganisms and Metabolome

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 10322 - 10322

Published: June 19, 2023

Several studies have shown that the gut microbiota influences behavior and, in turn, changes immune system associated with symptoms of depression or anxiety disorder may be mirrored by corresponding microbiota. Although composition/function intestinal appears to affect central nervous (CNS) activities through multiple mechanisms, accurate epidemiological evidence clearly explains connection between CNS pathology and dysbiosis is not yet available. The enteric (ENS) a separate branch autonomic (ANS) largest part peripheral (PNS). It composed vast complex network neurons which communicate via several neuromodulators neurotransmitters, like those found CNS. Interestingly, despite its tight connections both PNS ANS, ENS also capable some independent activities. This concept, together suggested role played microorganisms metabolome onset progression neurological (neurodegenerative, autoimmune) psychopathological (depression, disorders, autism) diseases, large number investigations exploring functional physiopathological implications microbiota/brain axis.

Language: Английский

---

Probiotics’ Effects in the Treatment of Anxiety and Depression: A Comprehensive Review of 2014–2023 Clinical Trials

Microorganisms, Journal Year: 2024, Volume and Issue: 12(2), P. 411 - 411

Published: Feb. 19, 2024

Changes in the gut microbiome can affect cognitive and psychological functions via microbiota-gut-brain (MGB) axis. Probiotic supplements are thought to have largely positive effects on mental health when taken sufficient amounts; however, despite extensive research having been conducted, there is a lack of consistent findings probiotics anxiety depression associated alterations. The aim our study systematically review most recent literature last 10 years order clarify whether could actually improve symptoms. Our results indicate that majority suggests beneficial role treatment anxiety, existence substantial number less findings. Given probiotics' potential offer novel, personalized options for mood disorders, further, better targeted psychiatric populations needed address concerns about exact mechanisms probiotics, dosing, timing treatment, possible differences outcomes depending severity depression.

Language: Английский

---

Unravelling the complexities of depression with medical intelligence: exploring the interplay of genetics, hormones, and brain function

Complex & Intelligent Systems, Journal Year: 2024, Volume and Issue: 10(4), P. 5883 - 5915

Published: April 4, 2024

Abstract Depression is a multifactorial disease with unknown etiology affecting globally. It’s the second most significant reason for infirmity in 2020, about 50 million people worldwide, 80% living developing nations. Recently, surge depression research has been witnessed, resulting multitude of emerging techniques developed prediction, evaluation, detection, classification, localization, and treatment. The main purpose this study to determine volume conducted on different aspects such as genetics, proteins, hormones, oxidative stress, inflammation, mitochondrial dysfunction, associations other mental disorders like anxiety stress using traditional medical intelligence (medical AI). In addition, it also designs comprehensive survey treatment planning, genetic predisposition, along future recommendations. This work designed through methods, including systematic mapping process, literature review, network visualization. we used VOSviewer software some authentic databases Google Scholar, Scopus, PubMed, Web Science data collection, analysis, designing picture study. We analyzed 60 articles related intelligence, 47 from machine learning 513,767 subjects (mean ± SD = 10,931.212 35,624.372) 13 deep 37,917 3159.75 6285.57). Additionally, found that stressors impact brain's cognitive autonomic functioning, increased production catecholamine, decreased cholinergic glucocorticoid activity, cortisol. These factors lead chronic inflammation hinder normal leading depression, anxiety, cardiovascular disorders. brain, reactive oxygen species (ROS) by IL-6 stimulation cytochrome c oxidase inhibited nitric oxide, potent inhibitor. Proteins, lipids, phosphorylation enzymes, mtDNA are further disposed impairment mitochondria. Consequently, dysfunction exacerbates impairs DNA (mtDNA) or deletions mtDNA, increases intracellular Ca 2+ levels, changes fission/fusion morphology, lastly leads neuronal death. highlights multidisciplinary approaches intelligence. It will open new way technologies.

Language: Английский

---

The influence of the gut-brain axis on anxiety and depression: A review of the literature on the use of probiotics

Journal of Traditional and Complementary Medicine, Journal Year: 2024, Volume and Issue: 14(3), P. 237 - 255

Published: March 21, 2024

This review aims to argue how using probiotics can improve anxiety and depressive behaviour without adverse effects, also exploring the impact of postbiotics on it. Specifically, have drawn more attention as effective alternative treatments, considering rising cost antidepressant anti-anxiety drugs high risk side effects. Depression disorders are among most common mental illnesses in world's population, characterised by low mood, poor general interest, cognitive or motor dysfunction. Thus, this study analyzed published literature anxiety, depression, probiotic supplementation from PubMed Scopus, focusing last twenty years. focused effect health they because their extensive clinical applications positive various diseases. Numerous studies demonstrated gut microbiota might be critical for mood regulation affect host regulating gut-brain axis. By comparing different works analysed, it was possible identify a strategy which selected employed and, at same time, assess optimised postbiotics, an innovation well-being humans.

Language: Английский

---

Mind, Mood and Microbiota—Gut–Brain Axis in Psychiatric Disorders

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3340 - 3340

Published: March 15, 2024

Psychiatric disorders represent a primary source of disability worldwide, manifesting as disturbances in individuals’ cognitive processes, emotional regulation, and behavioral patterns. In the quest to discover novel therapies expand boundaries neuropharmacology, studies from field have highlighted gut microbiota’s role modulating these disorders. These alterations may influence brain’s processes through brain–gut axis, multifaceted bidirectional system that establishes connection between enteric central nervous systems. Thus, probiotic prebiotic supplements are meant overall health play an insightful alleviating psychiatric symptoms, such templates major depressive disorder, anxiety, or schizophrenia. Moreover, administration psychotropic drugs has been revealed induce specific changes microbiome’s diversity, suggesting their potential utility combating bacterial infections. This review emphasizes intricate correlations microbiota, mentioning promising approaches regard modulation treatments, well antimicrobial effects medication.

Language: Английский

---

Probiotics: health benefits, microencapsulation, and viability, combination with natural compounds, and applications in foods

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106253 - 106253

Published: Feb. 1, 2025

Language: Английский

---

Bifidobacteria with indole-3-lactic acid-producing capacity exhibit psychobiotic potential via reducing neuroinflammation

Cell Reports Medicine, Journal Year: 2024, Volume and Issue: 5(11), P. 101798 - 101798

Published: Oct. 30, 2024

Language: Английский

---

Mood and microbes: a comprehensive review of intestinal microbiota’s impact on depression

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 9, 2024

Depression is considered a multifaceted and intricate mental disorder of growing concern due to its significant impact on global health issues. The human gut microbiota, also known as the “second brain,” has an important role in CNS by regulating it through chemical, immunological, hormonal, neurological processes. Various studies have found bidirectional link between brain gut, emphasizing onset depression therapies. biological molecular processes underlying microbiota are required, association may represent novel study. However, profound insights into stratification diversity still uncommon. This article investigates emerging evidence bacterial relationship brain’s system potential pathogenicity relevance. interplay immune system, nervous neurotransmitter synthesis, neuroplasticity transitions widely studied. consequences stress, dietary fibers, probiotics, prebiotics, antibiotics GB axis being Multiple revealed this led development effective microbiota-based drugs for both prevention treatment. Therefore, results support hypothesis that influences provide promising area research improved knowledge etiology disease future

Language: Английский

---

Strain-specific effects of probiotics on depression and anxiety: a meta-analysis

Gut Pathogens, Journal Year: 2024, Volume and Issue: 16(1)

Published: Sept. 8, 2024

Depression and anxiety are pervasive mental health disorders with substantial global burdens. Probiotics, live microorganisms known for their benefits, have emerged as a potential therapeutic intervention these conditions. This systematic review meta-analysis aim to evaluate the strain-specific effects of probiotics on relieving depressive symptoms while elucidating underlying mechanisms.

Language: Английский

---

Probiotics in Depression Management: Efficacy, Mechanisms and Future Directions

Progress In Microbes & Molecular Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 15, 2025

Depression affects approximately 280 million people worldwide, representing a significant public health burden. It is characterized by persistent sadness, anhedonia, fatigue, sleep disturbances, cognitive dysfunction, and in severe cases, suicidal ideation. The pathophysiology often attributed to neurotransmitter imbalances, hypothalamic-pituitary-adrenal (HPA) axis inflammation. Recently, the gut-brain has garnered attention for its role mood regulation, suggesting that probiotic supplementation may influence depressive symptoms through gut microbiome modulation. Therefore, this review examines recent findings research gaps regarding efficacy of probiotics managing clinically diagnosed depression. Emerging demonstrates daily from 3×109 CFU 9×1011 four eight weeks combination with antidepressants effective improving symptoms. Effective formulations commonly included Bifidobacteria, Lactobacilli, Lactococcus lactis, Streptococcus thermophilus. Nevertheless, remain, particularly concerning mechanistic pathways, comparative effectiveness, impact across different demographics probiotics. Furthermore, long-term effects use antidepressants, their reducing antidepressant side effects, combined psychotherapy are largely understudied. Addressing these standardized methodologies will enhance evaluations strains optimize microbiome-based treatment regimens, ultimately improve mental outcomes depression management. Graphical abstract. Summary future directions determine

Language: Английский

---