Endometriosis: A Comprehensive Analysis of the Pathophysiology, Treatment, and Nutritional Aspects, and Its Repercussions on the Quality of Life of Patients

Biomedicines, Journal Year: 2024, Volume and Issue: 12(7), P. 1476 - 1476

Published: July 4, 2024

Endometriosis is a chronic proinflammatory pathology characterized by the growth of tissue similar to endometrium outside uterus, affecting approximately 5 15% women worldwide. Suffering from endometriosis entails complex pathophysiological process, significantly impacting quality life and reproductive function affected women; therefore, it must be addressed in personalized comprehensive manner, as its management requires multidisciplinary approach. This article aims conduct literature review endometriosis, not only condition but also significant factor social, nutritional, mental well-being those who experience it. Emphasis placed on importance understanding assessing impact provide better more approach, integrating various alternatives strategic treatments for factors involved development. The aim complete overview pathophysiology patients, well current treatment options, both pharmacological alternative, order broaden perspective improve care patients with this disease.

Language: Английский

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Natural Chemical Constituents and Polymer Used in to Reduce PCOS Pain

Journal for Research in Applied Sciences and Biotechnology, Journal Year: 2025, Volume and Issue: 4(1), P. 88 - 99

Published: Feb. 26, 2025

The complex metabolic and endocrine disorder known as polycystic ovarian syndrome (PCOS) is characterised by anovulation, infertility, obesity, insulin resistance, ovaries. Factors that predispose women to encompass dietary lifestyle decisions, environmental pollutants, genetic predisposition, gut dysbiosis, alterations in neuroendocrine function, excess adiposity. Hyperinsulinemia, oxidative stress, hyperandrogenism, inadequate folliculogenesis, irregular menstrual periods are symptoms may arise from these variables, potentially contributing an escalation of syndrome. Pathogenic dysbiosis the microbiota have a role aetiology (PCOS). Immature oocytes, inflammation, resveratrol pathological features PCOS be ameliorated supplementation with natural compounds such polyphenols, quercetin, resveratrol, flavonoids, vitamin C, gamma-linolenic acid, piperine, omega-3 fatty acids, along semi-synthetic polymers. This review encapsulates current understanding efficacy chemical treatment PCOS.

Language: Английский

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Exploring regional influences on bioactive components in tea leaves and their effect on sensory quality

Journal of Food Composition and Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 107683 - 107683

Published: April 1, 2025

Language: Английский

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Enhanced Endometrial Receptivity via Epigallocatechin Gallate (EGCG)-Loaded Menstrual Blood-Derived Exosomes

Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 103801 - 103801

Published: April 1, 2025

Language: Английский

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Polycystic Ovary Syndrome Pathophysiology: Integrating Systemic, CNS and Circadian Processes

Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(1), P. 24 - 24

Published: Jan. 18, 2024

The conceptualization of polycystic ovary syndrome (PCOS) has primarily focused on hormonal alterations driven by changes within the hypothalamus and ovarian granulosa cells, with treatment contraceptive pill weight loss. However, a growing body data implicates wider systemic central nervous system (CNS) in pathoetiology pathophysiology PCOS, consequent implications for targeted treatments. It is proposed that there significant role night-time interactions factors acting to regulate whether rising level cortisol over night during morning awakening response (CAR) able induce nuclear translocation glucocorticoid receptor (GR), thereby influencing how immune glial systems cellular function preparation coming day. Factors affording protection PCOS also inhibit GR including gut microbiome-derived butyrate, pineal/local melatonin as well regulated bcl2-associated athanogene (BAG)-1. A pathophysiological attributed aryl hydrocarbon (AhR), which shows heightened levels activity PCOS. AhR activated ligands many processes, white adipocyte-derived kynurenine, implicating obesity occurring ovaries. activation consequences physiological hypothalamic paraventricular nucleus, cells adipocytes, partly mediated upregulation mitochondrial N-acetylserotonin/melatonin ratio, decreasing availability whilst increasing local stress plasticity nucleus. This article reviews detail CNS highlighting pineal melatonergic pathway, nucleus tanycytes/astrocytes, hypothalamus-pituitary-adrenal (HPA) axis pathophysiology. integrates wide array previously disparate biological underpinnings associates other currently classified medical conditions, such depression, bipolar disorder, type 1 diabetes mellitus autism spectrum. Numerous future research are detailed.

Language: Английский

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Empowering Strategies for Lifestyle Interventions, Diet Modifications, and Environmental Practices for Uterine Fibroid Prevention; Unveiling the LIFE UP Awareness

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 807 - 807

Published: March 12, 2024

Uterine fibroids (UFs) are the most common prevalent benign tumor among women of reproductive age, disproportionately affecting color. This paper introduces an innovative management strategy for UFs, emphasizing curbing disease prevention and progression. Traditionally, medical intervention is deferred until advanced stages, necessitating invasive surgeries such as hysterectomy or myomectomy, leading to high recurrence rates increased healthcare costs. The strategy, outlined in this review, emphasizes UF named LIFE UP awareness—standing Lifestyle Interventions, Food Modifications, Environmental Practices Prevention. These cost-effective, safe, accessible measures hold potential prevent improve overall health, reduce need procedures, generate substantial cost savings both individuals systems. review underscores importance a proactive method, paving way future research policy initiatives domain.

Language: Английский

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Evidence-Based Approach for Secondary Prevention of Uterine Fibroids (The ESCAPE Approach)

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15972 - 15972

Published: Nov. 4, 2023

Uterine fibroids (UFs) are common tumors in women of reproductive age. It is imperative to comprehend UFs’ associated risk factors facilitate early detection and prevention. Simple relying on surgical/pharmacological treatment advanced disease not only highly expensive, but it also deprives patients good quality life (QOL). Unfortunately, even if the discovered early, no medical intervention traditionally initiated until burden becomes high, then surgical performed. Furthermore, after myomectomy, recurrence rate UFs extremely high with need for additional surgeries other interventions. This confused approach invasive costly an overall negative impact women’s health. Secondary prevention management slow down its progression or halt completely. The current watchful observation considered a major missed opportunity literature. aim this article present named ESCAPE (Evidence-Based Approach Prevention) UF management. comprises simple, inexpensive, safe steps that can arrest development UFs, promote health, decrease number unnecessary surgeries, save billions health care systems’ dollars worldwide.

Language: Английский

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Chronic Kidney Disease: Interaction of Adiponectin Gene Polymorphisms and Diabetes

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 8128 - 8128

Published: May 1, 2023

Adiponectin is an adipokine multipeptide hormone with insulin-sensitizing; anti-atherosclerotic; and anti-inflammatory properties. Chronic kidney disease (CKD) may be associated low adiponectin. The adiponectin gene ADIPOQ thought to the only major responsible for plasma levels; which are diabetes diabetic nephropathy. purpose of this study was investigate association between polymorphism CKD. In addition; combined effects levels total urinary arsenic blood cadmium on CKD were also explored. This included 215 patients 423 age-sex matched controls. polymorphisms determined using Agena Bioscience Mass ARRAY System. species measured. rs182052 GA/AA genotype had a marginally lower odds ratio (OR) than GG genotype. OR (95% confidence interval; CI) 16.33 (5.72-46.66) in subjects carrying compared non-diabetes genotype; interaction term p = 0.015; synergy index 6.64 (1.81-24.36) after multivariate adjustment. A significant rs1501299 risk increased adjustment 0.31 (0.11-0.86) multiplicative 0.001. These results suggest that genotypes significantly modify but not

Language: Английский

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Assessing the Protective Role of Epigallocatechin Gallate (EGCG) against Water-Pipe Smoke-Induced Toxicity: A Comparative Study on Gene Expression and Histopathology

Molecules, Journal Year: 2023, Volume and Issue: 28(22), P. 7502 - 7502

Published: Nov. 9, 2023

Exposure to water-pipe smoking, whether flavored or unflavored, has been shown instigate inflammation and oxidative stress in BALB/c mice. This consequently results alterations the expression of inflammatory markers antioxidant genes. study aimed scrutinize impact Epigallocatechin gallate (EGCG)-a key active component green tea-on mice exposed smoke. The experimental setup included a control group, smoke (FWP) an unflavored (UFWP) EGCG-treated groups (FWP + EGCG UFWP EGCG). Expression levels IL-6, IL1B, TNF-α, CAT, GPXI, MT-I, MT-II, SOD-I, SOD-II, SOD-III were evaluated lung, liver, kidney tissues. Histopathological changes also assessed. findings revealed that manifested significant decline genes compared FWP groups. insinuates holds capacity alleviate damaging effects smoke-induced stress. Moreover, enhancements histopathological features observed groups, signifying protective effect against tissue damage induced by smoking. These underscore potential as agent adverse By curbing stress, may aid prevention mitigation smoking-associated diseases.

Language: Английский

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The Role of Nutrition in Pathogenesis of Uterine Fibroids

Nutrients, Journal Year: 2023, Volume and Issue: 15(23), P. 4984 - 4984

Published: Dec. 1, 2023

Uterine fibroids are benign tumors that arise from the smooth muscle tissue of uterus and most common in women. Due to their high prevalence, costs for health care system substantial impact on women’s quality life, they a significant public concern. Previous literature diet occurrence, growth symptoms is limited. Recently, many papers have been written this topic. A scoping review PubMed Cochrane databases was performed using following keywords: uterine fibroids, antioxidants, diet, vegetarian, vegetables, fruits, meat soy foods, dairy products, tea, vitamin D, C, ascorbic acid. Preliminary research has shown beneficial effect vegetable fruit consumption occurrence fibroids. relationship between hypovitaminosis D an increased risk also demonstrated. Studies epigallocatechin gallate showed its apoptosis-promoting antifibrinolytic fibroid cells. Initial results promising, but further randomized trials needed draw firm conclusions about effects nutrients

Language: Английский

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