Recent Developments in Nanoparticle Formulations for Resveratrol Encapsulation as an Anticancer Agent

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(1), P. 126 - 126

Published: Jan. 18, 2024

Resveratrol is a polyphenolic compound that has gained considerable attention in the past decade due to its multifaceted therapeutic potential, including anti-inflammatory and anticancer properties. However, efficacy impeded by low water solubility, dose-limiting toxicity, bioavailability, rapid hepatic metabolism. To overcome these hurdles, various nanoparticles such as organic inorganic nanoparticles, liposomes, polymeric dendrimers, solid lipid gold zinc oxide zeolitic imidazolate frameworks, carbon nanotubes, bioactive glass mesoporous were employed deliver resveratrol, enhancing against types of cancer. Resveratrol-loaded nanoparticle or resveratrol-conjugated administration exhibits excellent potency compared free resveratrol. This review highlights latest developments nanoparticle-based delivery systems for focusing on potential limitations associated with compound’s bioavailability effectiveness.

Language: Английский

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A Comprehensive Review on Exploring the Potential of Phytochemicals and Biogenic Nanoparticles for the Treatment of Antimicrobial-Resistant Pathogenic Bacteria

Current Microbiology, Journal Year: 2025, Volume and Issue: 82(2)

Published: Jan. 18, 2025

Language: Английский

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Green Extraction of Plant Materials Using Supercritical CO2: Insights into Methods, Analysis, and Bioactivity

Plants, Journal Year: 2024, Volume and Issue: 13(16), P. 2295 - 2295

Published: Aug. 18, 2024

In recent years, the supercritical CO

Language: Английский

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Experimental and Numerical Modeling of Magnetic Drug Targeting: Can We Trust Particle-Based Models?

IEEE journal on multiscale and multiphysics computational techniques, Journal Year: 2025, Volume and Issue: 10, P. 69 - 84

Published: Jan. 1, 2025

The development of trustworthy simulation models is crucial for planning drug administration in magnetic targeting (MDT) interventions future cancer treatment. In the MDT therapy, bound to nanoparticles, which act as carriers and are guided through cardiovascular system into tumor region using an external field. Thus, modeling represents a multiphysical problem can be approached either by particle-based or concentration-based models. this paper, both approaches implemented COMSOL Multiphysics typical scenario, verified measurements, compared among each other. Two different particle concentrations with without applied field Halbach array consisting five permanent magnets tube flow laminar velocity were investigated. Within scope, analytical model calculating response detection nanoparticles commercial susceptometer derived, too. Considering two investigated shows considerably better agreement experimental results spatial resolution reduced due limited number considered particles resulting inaccurate response. Overall, high new publications need research interdisciplinary improve therapeutic success.

Language: Английский

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Inhibition of Kinase Activity and In Vitro Downregulation of the Protein Kinases in Lung Cancer and Cervical Cancer Cell Lines and the Identified Known Anticancer Compounds of Ziziphus mucronata

Plants, Journal Year: 2025, Volume and Issue: 14(3), P. 395 - 395

Published: Jan. 28, 2025

Plants have long been used as sources of natural compounds with therapeutic benefits, providing molecules capable inhibiting multiple kinases. Many medicinal plants are recognized for their anticancer properties and may offer ways to mitigate the adverse effects conventional cancer treatments. In this study, potential Ziziphus mucronata methanol extract a kinase inhibitor was assessed using MTT assay, universal human phosphokinase antibody array, along GC-MS analysis volatile compounds. The assay revealed strong cytotoxicity in A549 cells, an IC50 31.25 µg/mL, while HeLa cells showed weaker 125 µg/mL. comparison, paclitaxel exhibited potent inhibitory on (IC50 µg/mL) moderate inhibition 65 µg/mL). Enzyme activity, measured by ADP production ADP-Glo indicated that inhibited protein activity both after 24 h treatment. Additionally, which includes 44 pre-spotted kinases, downregulated phosphorylated kinases cell lines. Some affected such TOR, Fyn, HcK, Fgr, STAT5b, PLC-γ1, p38α, ERK1/2, AMPKA, Akt1/2, GSK-3α/β, MSK1/2, CREB, RSK1/2/3, STAT5a critical regulators various cellular processes, including apoptosis, differentiation, proliferation. findings study suggest from Z. capacity regulate highlighting significant growth inhibitors cells.

Language: Английский

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Exploring the anticancer potential of extracts and compounds from the heartwood of Cotinus coggygria Scop. wild growing in Serbia

BMC Complementary Medicine and Therapies, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 4, 2025

Cotinus coggygria has a long history of use in traditional medicine Europe and Asia. The aim study was to explore the cytotoxicity extracts (EE-ethanol, MME-methylene chloride/methanol, WE-water) compounds (butin, butein, fisetin, sulfuretin, taxifolin, eriodictyol, fustin, cotinignan A, sulfuretin auronol, 3-O-methylepifustin, 3-O-methylfustin, sitosterol-3-O-β-D-glucoside) isolated from C. coggygria. Mechanisms anticancer effects three extracts, butin, were examined. Compounds EE using silica gel column chromatography semipreparative HPLC. Structure elucidation performed NMR spectroscopy. Cytotoxicity evaluated MTT assay. on cell cycle death investigated by flow cytometry. antimigration examined scratch assay, while expression MMP2, MMP9, VEGFA measured quantitative real time PCR. antioxidant epitaxifolin, auronol found for first showed selective against HeLa, MDA-MB-231, HL-60, K562, A375, PC-3, DU 145 cells. HeLa cells most sensitive MME (IC50 value 47.45 µg/mL), leukemia K562 HL-60 values range 31.04 44.57 µg/mL). Butein exerted strong MDA-MB-231 8.66 µM, 13.91 22.36 µM). EE, fisetin highly when compared with normal fibroblasts MRC-5 (selectivity index: 4.01, 5.15, 6.17, 7.05, > 4.41, respectively). high selectivity cytotoxic activity 9.91 6.61). Three initiated apoptosis activating caspase-8 caspase-9. inhibited migration. MME, cytoprotective fibroblasts. This research might suggest promising underscores need additional assess their potential cancer prevention therapy.

Language: Английский

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Molecular docking, dynamics simulations, and in vivo studies of gallic acid in adenine-induced chronic kidney disease: targeting KIM-1 and NGAL

Journal of Computer-Aided Molecular Design, Journal Year: 2025, Volume and Issue: 39(1)

Published: March 15, 2025

Language: Английский

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An In Vitro Examination of Whether Kratom Extracts Enhance the Cytotoxicity of Low-Dose Doxorubicin against A549 Human Lung Cancer Cells

Molecules, Journal Year: 2024, Volume and Issue: 29(6), P. 1404 - 1404

Published: March 21, 2024

Doxorubicin is an effective chemotherapeutic agent in the treatment of solid hematological and non-hematological carcinoma. However, its long-term usage could result side effects, such as cardiomyopathy, chronic heart failure, neurotoxicity cancer cell resistance. In this study, we reported sensitivity enhancement A549 human lung cells on doxorubicin at a low dose (0.1 ppm) combination with 10–60 ppm crude alkaloid extracts derived from leaves Kratom (Mitragyna speciosa (Korth.) Havil. Rubiaceae). lines were insensitive to extract containing mitragynine (MG) (4–5%), while these moderately inhibited by 40–45% MG (IC50 48–55 ppm). The was found inhibit via apoptosis suggested higher relative fluorescence intensity Annexin compared that propidium iodide (PI), i.e., positive negative PI. sensitized 1.3 2.4 times, induced 2.6- 3.4-fold increase sensitivity. calculated index (CI) for 0.6 0.3, respectively, showing potential synergistic combinations reduce level dosage used chemotherapy. addition, effect cytotoxic activity provides insights into plausibility non-alkaloids influence biological activities Kratom.

Language: Английский

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The neuroprotective potential of phytochemicals in traumatic brain injury: mechanistic insights and pharmacological implications

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 4, 2024

Traumatic brain injury (TBI) leads to damage, comprising both immediate primary damage and a subsequent cascade of secondary mechanisms. The results in localized while the initiates inflammatory responses, followed by disruption blood-brain barrier, infiltration peripheral blood cells, edema, release various immune mediators, including chemotactic factors interleukins. TBI disrupts molecular signaling, cell structures, functions. In addition physical tissue such as axonal injuries, contusions, haemorrhages, interferes with functioning, impacting cognition, decision-making, memory, attention, speech capabilities. Despite deep understanding pathophysiology TBI, an intensive effort evaluate underlying mechanisms effective therapeutic interventions is imperative manage repercussions TBI. Studies have commenced explore potential employing natural compounds for These are characterized their low toxicity limited interactions conventional drugs. Moreover, many demonstrate capacity target aspects process. While our there urgent need mitigate its consequences. Here, we aimed summarize mechanism action role phytochemicals against progression. This review discusses implications phytonutrients addresses consequences addition, highlighted roles emerging promising candidates intervention highlights neuroprotective mechanistic approach. Furthermore, efforts focused on mechanisms, providing better therapeutics.

Language: Английский

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Phytochemicals as Immunomodulatory Molecules in Cancer Therapeutics

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(12), P. 1652 - 1652

Published: Nov. 26, 2023

Phytochemicals are natural plant-derived products that provide significant nutrition, essential biomolecules, and flavor as part of our diet. They have long been known to confer protection against several diseases via their anti-inflammatory, immune-regulatory, anti-microbial, other properties. Deciphering the role phytochemicals in prevention, inhibition, treatment cancer—unrestrained cell proliferation due loss tight regulation on growth replication—has focus recent research. Particularly, immunomodulatory phytochemicals, which is pivotal unchecked metastasis, has recently studied extensively. The immune system a critical component tumor microenvironment, it plays roles both preventing promoting oncogenesis. Immunomodulation includes stimulation, amplification, or inactivation some stage(s) response. demonstrated regulation, such macrophage migration, nitric oxide synthase lymphocyte, T-cell, cytokine killer augmentation, NFκB, TNF, apoptosis regulation. There dearth extensive accounts effects cancer; thus, we compiled these with mechanistic aspects dietary cancer, highlighting promising candidates ongoing clinical trials immunotherapeutic strategies mitigate

Language: Английский

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