Salvia deserti Decne., an endemic and rare subshrub from Arabian desert: antidiabetic and antihyperlipidemic effects of leaf hydroethanolic extracts

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 10, 2025

Introduction Diabetes is a major health issue that has reached alarming levels worldwide. Although their effectiveness, the antidiabetic drugs have many side effects such as cardiovascular diseases, kidney failure, and hepatic complications. Many plant species of genus Salvia L. “Arabian desert sage” ( deserti ) should began to be focus phytochemical bioactivity studies. Methods The study aims investigate, first-ever, antihyperlipidemic leaf hydroethanolic extract S. deserti, an endemic rare subshrub from Arabian desert. A single intraperitoneal injection alloxan monohydrate (160 mg/kg) was used induce type-2 diabetes. Development diabetes confirmed by measuring blood glucose collected tail vein after 72 h injection. Oral administration extracts at 200 400 mg/kg for 14 days were tested on alloxan-induced diabetic mice animals divided into 6 groups each. identity phenolic compounds S . conducted through HPLC-Electrospray Ionization-Mass Spectrometry (LC-ESI-MS) analyses. Results significantly decreased restored renal function reducing ALT, AST, ALP, GGT, LDH, urea creatinine. An improved lipid profile revealed reduced TC, TG LDL coupled with increased level HDL also observed. Moreover, treatment relieved oxidative stress (reduction MDA H 2 O activity antioxidant enzymes SOD, CAT GPx. presence several (derivatives ferulic, coumaric, caffeic acids, among other derivatives) could least in part explain obtained data empower use source bioactive ingredients antioxidant, properties. Discussion Our research unveiled potential effectively manage its associated dyslipidemia improving status, recovery liver functions presumably increasing insulin secretion sensitivity peripheral tissues insulin.

Language: Английский

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Biological Applications of Acacia Gums (AGs) SME on Breast Cancer Cell Lines

Published: Jan. 1, 2025

Language: Английский

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Preventive and Therapeutic Effects of Baicalein, Galangin, and Isorhamnetin in Chronic Liver Diseases: A Narrative Review

Molecules, Journal Year: 2025, Volume and Issue: 30(6), P. 1253 - 1253

Published: March 11, 2025

Chronic liver diseases (CLDs), including fatty disease, fibrosis, and cirrhosis, pose significant global health challenges due to the limitedness of therapeutic options. Flavonoids, a class polyphenolic compounds mainly contained in natural sources foods Mediterranean diet, have emerged as potential candidates for protection their anti-inflammatory, antioxidant, anti-fibrotic properties. Baicalein, derived from Scutellaria baicalensis, exhibits hepatoprotective effects by attenuating oxidative stress, inhibiting fibrogenesis, modulating lipid metabolism. Galangin, flavonoid Alpinia officinarum, has demonstrated anti-inflammatory properties, while isorhamnetin, methylated found various fruits herbs, been shown possess qualities, it reduces stress mitigates inflammation CLDs. This narrative review highlights preventive these three flavonoids, emphasizing role promising agents managing CLDs guiding future research.

Language: Английский

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Computational investigation of Y. aloifolia variegate as anti-Human Immunodeficiency Virus (HIV) targeting HIV-1 protease: A multiscale in-silico exploration

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2024, Volume and Issue: 11, P. 100451 - 100451

Published: June 1, 2024

Human Immunodeficiency Virus (HIV) is a global challenge for the health sector due to absence of definitive cure. More than 38 million people are affected by disease worldwide, with approximately 1.5 new cases reported annually. This situation has spurred continued efforts in searching drug candidates. Meanwhile, rutin, luteolin, and quercetin compounds known efficacy treating infectious diseases. The have also been detected Yucca aloifolia (絲蘭) variegate L. Therefore, this study aimed conduct computational investigation utilizing multiscale silico exploration assess potential Y. as an anti-HIV agent targeting HIV-1 Protease (H1P). For study, three-dimensional structure H1P (PDB: 5V4Y) was retrieved prepared using YASARA Structure. binding pockets were identified Cavity Plus server, ligands obtained from leaves alcohol extract. Furthermore, molecular docking conducted Structure predict energies, followed QSAR analysis activity prediction. Density Functional Theory (DFT) performed stability reactivity, while toxicity evaluated ProTox 3.0. Molecular dynamics (MD) simulation Mechanics Poisson–Boltzmann Surface Area (MM-PBSA) calculation further analysis. results showed that Ramachandran plot indicated favorable residue distribution based on evaluation enzyme preparation quality. sites, cavity no.2 showing highest druggability. rutin isorhamnetin-3-O-rutinoside top binders H1P, energies. Moreover, post-docking produced specific interactions between receptor. PASS prediction (narcissin) inhibitors. DFT assessed stability, comparable values investigated compounds. Toxicity suggested both be non-toxic. Finally, MD demonstrated superior affinity compared control drug, grl-09510. Rutin, hecogenin, inhibitors through study. Docking simulations had most interactions, only rutin-H1P complex stable, signifying development. Rutin promising lead inhibition its strong binding, predicted safety properties, underscoring need wet lab validation.

Language: Английский

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Isorhamnetin alleviates cisplatin-induced acute kidney injury via enhancing fatty acid oxidation

Free Radical Biology and Medicine, Journal Year: 2023, Volume and Issue: 212, P. 22 - 33

Published: Dec. 13, 2023

Language: Английский

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Waste-to-value: Guidelines for the potential applications of Prosopis juliflora

Bioresource Technology Reports, Journal Year: 2023, Volume and Issue: 24, P. 101678 - 101678

Published: Nov. 1, 2023

Language: Английский

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Combined Microbial Fermentation Converts Bioactive Compounds in Nitraria tangutorum Bobrov Fruit and Displays Its Antidiabetic Potential

Published: March 21, 2024

Nitraria tangutorum Bobrov is a berry shrub with white flowers and red fruits, which grows in the deserts Tibetan Plateau, Mongolia, western China. Its fruit N. (NTF) contains various bioactive compounds, anti-fatigue, anti-inflammatory, neuroprotective functions. However, high saccharide content of NTF makes it unsuitable for diabetic patients. In this study, we fermented to obtain juice (NTJ), residue (NTR), are suitable diabetics consume. We characterized compounds NTF, NTR, NTJ, found that fermentation increased diversity greatly reduced sucrose, glucose, fructose while generating trehalose, has potential manage blood glucose levels. Further, NTJ displays anti-diabetic due properties. This study provides basis further clinical research on NTJ's function humans.

Language: Английский

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Comprehensive investigation on non-volatile and volatile flavor compounds in different varieties of rose tea by UPLC-Q-TOF-MS/MS-based metabolomics and GC-IMS, GC-MS

Journal of Food Composition and Analysis, Journal Year: 2024, Volume and Issue: unknown, P. 106708 - 106708

Published: Sept. 1, 2024

Language: Английский

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Sea buckthorn plant as a functional food ingredient, with antioxidant and anti-inflammatory properties [pdf]

Acta Scientiarum Polonorum Technologia Alimentaria, Journal Year: 2023, Volume and Issue: 22(4), P. 477 - 496

Published: Dec. 30, 2023

Plants with valuable health properties, rich in a spectrum of compounds various biological activities, have long been focus interest researchers and the food industry.Undoubtedly, it is great challenge for science to compose an innovative product functional status, managing combine as many advantages particular plant preparation possible obtain that satisfies requirements specific group consumers.This article provides brief overview current information on status sea buckthorn (Hippophae rhamnoides L.) ingredient, well its interesting activity.Sea very terms content substances high nutritional value, which recently makes area growing scientific industrial interest.This due broad extremely phytochemical composition extensive pharmacological activity, especially antioxidant anti-inflammatory activity.The above-mentioned preparations make good candidate ingredient can be used products produced support modern industry technologies.

Language: Английский

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Contribution of Phenolic Compounds to the Antioxidant Activity of Leaf and Flower Extracts of Sinapis pubescens L. subsp. pubescens (Brassicaceae)

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: 21(5)

Published: March 16, 2024

Within a study focused on Sinapis pubescens subsp. wild from Sicily (Italy), an edible species still unexplored, our earlier published work has demonstrated good in vitro antioxidant properties for the flower and leaf hydroalcoholic extracts, exhibiting quite different qualitative-quantitative phenolic profiles. Herein, further research was designed to elucidate role played by compounds mechanisms highlighted extracts. To achieve this goal, crude extracts were subjected liquid-liquid partitioning with solvents of increasing polarity; then, fractions investigated their using assays. For both flowers leaves, ethyl acetate exhibited best activity DPPH reducing power assays, followed n-butanol. The total content determination indicated these as phenolic-rich ones, which characterized HPLC-PDA/ESI-MS analysis. Conversely, did not show any chelating activity, more hydrophobic ones.

Language: Английский

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