Gut microbiota modulate intestinal inflammation by endoplasmic reticulum stress-autophagy-cell death signaling axis DOI Creative Commons
Fei He, Yi Zheng, Mabrouk Elsabagh

et al.

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: May 1, 2025

The intestinal tract, a complex organ responsible for nutrient absorption and digestion, relies heavily on balanced gut microbiome to maintain its integrity. Disruptions this delicate microbial ecosystem can lead inflammation, hallmark of inflammatory bowel disease (IBD). While the role in IBD is increasingly recognized, underlying mechanisms, particularly those involving endoplasmic reticulum (ER) stress, autophagy, cell death, remain incompletely understood. ER cellular response various stressors, trigger inflammation death. Autophagy, degradation process, either alleviate or exacerbate stress-induced depending specific context. influence both stress autophagy pathways, further complicating interplay between these processes. This review delves into intricate relationship context inflammation. By exploring molecular mechanisms interactions, we aim provide comprehensive theoretical framework developing novel therapeutic strategies IBD. A deeper understanding stress-autophagy axis, microbial-ER microbial-autophagy axis may pave way targeted interventions restore health mitigate impact

Language: Английский

The Role of Gut Dysbiosis in the Loss of Intestinal Immune Cell Functions and Viral Pathogenesis DOI Creative Commons
Farzaneh Fakharian,

Siva Thirugnanam,

David A. Welsh

et al.

Microorganisms, Journal Year: 2023, Volume and Issue: 11(7), P. 1849 - 1849

Published: July 21, 2023

The gut microbiome plays a critical role in maintaining overall health and immune function. However, dysbiosis, an imbalance composition, can have profound effects on various aspects of human health, including susceptibility to viral infections. Despite numerous studies investigating the influence infections microbiome, impact dysbiosis infection pathogenesis remains relatively understudied. clinical variability observed SARS-CoV-2 seasonal influenza infections, presence natural HIV suppressors, suggests that host-intrinsic factors, may contribute pathogenesis. has been shown host system by regulating intestinal homeostasis through interactions with cells. This review aims enhance our understanding how perturb mucosal cells, affecting response Specifically, we focus exploring between gamma delta (γδ) T cells microbes context inflammatory examine highlighting disease outcomes. Furthermore, discuss emerging evidence potential future directions for modulation therapy

Language: Английский

Citations

43
Research advance about plant polysaccharide prebiotics, benefit for probiotics on gut homeostasis modulation DOI
Xiaoqi Liu,

Shengpeng Su,

Jiaying Yao

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 59, P. 103831 - 103831

Published: March 1, 2024

Language: Английский

Citations

21
Causal relationship between gut microbiota and gastrointestinal diseases: a mendelian randomization study DOI Creative Commons
Kaiwen Wu, Qiang Luo, Ye Liu

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 23, 2024

Abstract Background Recent research increasingly highlights a strong correlation between gut microbiota and the risk of gastrointestinal diseases. However, whether this relationship is causal or merely coincidental remains uncertain. To address this, Mendelian randomization (MR) analysis was undertaken to explore connections prevalent Methods Genome-wide association study (GWAS) summary statistics for microbiota, encompassing diverse range 211 taxa (131 genera, 35 families, 20 orders, 16 classes, 9 phyla), were sourced from comprehensive MiBioGen study. Genetic associations with 22 diseases gathered UK Biobank, FinnGen study, various extensive GWAS studies. MR meticulously conducted assess genetically predicted these validate reliability our findings, sensitivity analyses tests heterogeneity systematically performed. Results The yielded significant evidence 251 relationships This included 98 upper diseases, 81 lower 54 hepatobiliary 18 pancreatic Notably, particularly evident in belonging genera Ruminococcus Eubacterium . Further reinforced robustness results. Conclusions findings indicate potential genetic predisposition linking These insights pave way designing future clinical trials focusing on microbiome-related interventions, including use microbiome-dependent metabolites, potentially treat manage their associated factors.

Language: Английский

Citations

17
Chitosan and its derivatives: A novel approach to gut microbiota modulation and immune system enhancement DOI
Great Iruoghene Edo, Alice Njolke Mafe,

Ali B. M. Ali

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 289, P. 138633 - 138633

Published: Dec. 13, 2024

Language: Английский

Citations

10
Intestinal Dysbiosis: Microbial Imbalance Impacts on Colorectal Cancer Initiation, Progression and Disease Mitigation DOI Creative Commons
Mary Garvey

Biomedicines, Journal Year: 2024, Volume and Issue: 12(4), P. 740 - 740

Published: March 26, 2024

The human gastrointestinal tract houses a diverse range of microbial species that play an integral part in many biological functions. Several preclinical studies using germ-free mice models have demonstrated the gut microbiome profoundly influences carcinogenesis and progression. Colorectal cancer appears to be associated with dysbiosis involving certain bacterial species, including F. nucleatum, pks+ E. coli, B. fragilis, virome commensals also disrupted patients. A toward these pro-carcinogenic increases significantly CRC patients, reduced numbers preventative Clostridium butyicum, Roseburia, Bifidobacterium evident. There is correlation between infection CRC. particular, strongly where it therapeutic resistance poor outcomes carcinogenic mode action pathogenic bacteria result genotoxicity, epigenetic alterations, ROS generation, pro-inflammatory activity. aim this review discuss their impact on colorectal terms disease initiation, progression, metastasis. potential anticancer peptides as agents or adjuvants discussed, novel treatment options are required combat high levels current pharmaceutical options.

Language: Английский

Citations

9
Interactions between Gut Microbiota and Natural Bioactive Polysaccharides in Metabolic Diseases: Review DOI Open Access
Yu Pi,

Miaoyu Fang,

Yanpin Li

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2838 - 2838

Published: Aug. 24, 2024

The gut microbiota constitutes a complex ecosystem, comprising trillions of microbes that have co-evolved with their host over hundreds millions years. Over the past decade, growing body knowledge has underscored intricate connections among diet, microbiota, and human health. Bioactive polysaccharides (BPs) from natural sources like medicinal plants, seaweeds, fungi diverse biological functions including antioxidant, immunoregulatory, metabolic activities. Their effects are closely tied to which metabolizes BPs into health-influencing compounds. Understanding how interact is critical for harnessing potential health benefits. This review provides an overview focusing on its role in diseases obesity, type II diabetes mellitus, non-alcoholic fatty liver disease, cardiovascular diseases. It explores basic characteristics several impact microbiota. Given significance health, we summarize these BPs, particularly terms immunoregulatory activities, blood sugar, hypolipidemic effect, thus providing valuable reference understanding benefits treating These properties make promising agents preventing comprehensive mechanisms by exert through opens new avenues developing targeted therapies improve

Language: Английский

Citations

9
Cancer, deuterium, and gut microbes: A novel perspective DOI Creative Commons
Stephanie Seneff, Anthony M. Kyriakopoulos

Endocrine and Metabolic Science, Journal Year: 2025, Volume and Issue: unknown, P. 100215 - 100215

Published: Jan. 1, 2025

Citations

1
Taurine prevents mitochondrial dysfunction and protects mitochondria from reactive oxygen species and deuterium toxicity DOI Creative Commons
Stephanie Seneff, Anthony M. Kyriakopoulos

Amino Acids, Journal Year: 2025, Volume and Issue: 57(1)

Published: Jan. 10, 2025

Abstract Taurine, although not a coding amino acid, is the most common free acid in body. Taurine has multiple and complex functions protecting mitochondria against oxidative-nitrosative stress. In this comprehensive review paper, we introduce novel potential role for taurine from deuterium (heavy hydrogen) toxicity. This can be of crucial impact to either normal or cancer cells that have highly different mitochondrial redox status. Deuterium an isotope hydrogen with neutron as well proton, making it about twice heavy hydrogen. We first explain important gut microbiome sulfomucin barrier play management. describe synergistic effects protect deleterious accumulation mitochondria, which disrupts ATP synthesis by ATPase pumps. Moreover, taurine’s derivatives, N-chlorotaurine (NCT) N-bromotaurine (NBrT), produced through spontaneous reaction hypochlorite hypobromite, fascinating regulatory roles oxidative stress beyond. how could potentially alleviate stress, primarily metabolic collaboration among various microflora produce depleted nutrients water, way leaky barrier, inflammatory bowel disease, colon cancer.

Language: Английский

Citations

1
Imbalance of gut microbiota is involved in the development of chronic obstructive pulmonary disease: A review DOI Open Access
Wei Song, Yuanyi Yue, Qiang Zhang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115150 - 115150

Published: July 8, 2023

Chronic obstructive pulmonary disease (COPD) is a common chronic characterized by airway inflammation and remodeling, which seriously endangers human health. Recent developments in genomics metabolomics have revealed the roles of gut microbiota its metabolites COPD. Dysbiosis directly increases permeability, thereby promoting translocation pathological bacteria. The associated may influence development progression COPD modulating immunity inflammation. Furthermore, systemic hypoxia oxidative stress that occur also be involved intestinal dysfunction. cross-talk between lungs known as gut–lung axis; however, an overview mechanism lacking. This review highlights critical complex interplay immune responses axis, further explores possible links lungs, summarizes new interventions through diet, probiotics, vitamins, fecal transplantation, are to

Language: Английский

Citations

18
Alleviating Pyroptosis of Intestinal Epithelial Cells to Restore Mucosal Integrity in Ulcerative Colitis by Targeting Delivery of 4-Octyl-Itaconate DOI
Wenying Li, Dong Chen,

Yanmei Zhu

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(26), P. 16658 - 16673

Published: June 22, 2024

Current therapies primarily targeting inflammation often fail to address the root relationship between intestinal mucosal integrity and resulting dysregulated cell death ensuing in ulcerative colitis (UC). First, UC tissues from human mice models this article both emphasize crucial role of Gasdermin E (GSDME)-mediated pyroptosis epithelial cells (IECs) as it contributes by releasing proinflammatory cytokines, thereby compromising barrier. Then, 4-octyl-itaconate (4-OI), exhibiting potential for anti-inflammatory activity inhibiting pyroptosis, was encapsulated butyrate-modified liposome (4-OI/BLipo) target delivery IECs. In brief, 4-OI/BLipo exhibited preferential accumulation inflamed colonic epithelium, attributed over 95% butyrate being produced absorbed colon. As expected, epithelium barriers were restored significantly alleviating GSDME-mediated colitis. Accordingly, permeability IECs restored, inflammation, balance gut flora reprogrammed, which offers a hopeful approach effective management UC.

Language: Английский

Citations

8