The role of colonic microbiota amino acid metabolism in gut health regulation

Cell Insight, Journal Year: 2025, Volume and Issue: unknown, P. 100227 - 100227

Published: Jan. 1, 2025

The human gut microbiota plays a critical role in maintaining host homeostasis through metabolic activities. Among these, amino acid (AA) metabolism by the large intestine is highly heterogeneous and relevant to health. Despite increasing interest, microbial AA remains relatively unexplored. This review highlights recent advances colonic metabolism, including auxotrophies, synthesis, dissimilatory metabolites, their implications health, focusing on major gastrointestinal diseases colorectal cancer, inflammatory bowel disease, irritable syndrome.

Language: Английский

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Energy metabolism and the intestinal barrier: implications for understanding and managing intestinal diseases

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 31, 2025

The interplay between energy metabolism and the gut barrier is crucial for maintaining intestinal physiological homeostasis. Energy perform distinct yet complementary roles that uphold ecological equilibrium. Disruptions in can compromise integrity of barrier; example, inactivation AMPK pathway may lead to reduced expression proteins associated with tight junctions. Conversely, impairment result metabolic dysregulation, such as alterations microbiota impede production short-chain fatty acids (SCFAs), which are essential substrates metabolism. This disruption affect modify gut's hypoxic environment. Imbalances these systems have been onset various diseases. Research indicates dietary interventions, a low FODMAP diet, enhance colonization probiotics improve fermentation SCFAs. Pharmacological strategies elevate SCFA levels activate rectify abnormalities review provides comprehensive summary recent advancements elucidating interactions barrier.

Language: Английский

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Effects of fructan and gluten on gut microbiota in individuals with self-reported non-celiac gluten/wheat sensitivity—a randomised controlled crossover trial

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 4, 2024

Language: Английский

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The effects of low FODMAP diet on gut microbiota regulation: A systematic review and meta‐analysis

Journal of Food Science, Journal Year: 2025, Volume and Issue: 90(3)

Published: March 1, 2025

Abstract This systematic review and meta‐analysis aimed to evaluate the effects of a low FODMAP (fermentable oligosaccharides, disaccharides, monosaccharides, polyols) diet on gut microbiota regulation. A comprehensive literature search was conducted in PubMed, Cochrane Library, Web Science, Embase, CNKI (China National Knowledge Infrastructure), Wanfang Data databases. Randomized controlled trials (RCTs) comparing diets with normal were included. The primary outcome effect intestinal flora. standardized mean difference (SMD) 95% confidence intervals (CI) calculated using random‐effects model. Heterogeneity assessed I 2 statistic, publication bias evaluated funnel plots Egger's test. Ten RCTs involving 590 participants included analysis. showed significant positive flora compared (SMD = 0.33, CI [0.01, 0.64], p 0.003). Substantial heterogeneity observed ( 67.5%). Subgroup analysis irritable bowel syndrome (IBS) patients revealed no between 0.08, [−0.17, 0.32], 0.306), 17.0%). No detected (Egger's test, 0.328). suggests that may have However, appears be less pronounced IBS patients. Further high‐quality studies are needed confirm these findings explore long‐term impact health across various gastrointestinal disorders.

Language: Английский

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Therapeutic effects of a Low FODMAP Diet on anxiety in irritable bowel syndrome patients

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Background Individuals with Irritable Bowel Diseases (IBS) have a higher risk of mental disorders. However, management on IBS still focuses gastrointestinal symptoms, often ignoring psychological comorbidities, which might lead to suboptimal therapeutic outcomes. The purpose the study was investigate current state treatment at our center and further explore whether dietary intervention could alleviate anxiety burden.Methods We prospectively enrolled two cohorts patients. first one an observational that designed assess prevalence status treatment. other conducted efficacy low FODMAP diet (LFD). Finally, stool samples were collected before after LFD analyzed by 16s rRNA sequencing.Results Anxiety present in approximately 60% patients cohort but consistently ignored conventional therapy. positively correlated discomfort syndromes. Rifaximin only effective drug among standard options. one-month greatly both abdominal disorders Though α- β-diversity gut bacteria similar between responders non-responders, composition dominate significantly different. At genus level, exhibited abundances Klebsiella, Parabacteroides, Lactobacillus compared non-responders.Conclusions is common patients, yet it frequently neglected emerges as promising approach, potentially exerting its benefits through specific microbiota.

Language: Английский

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Exploration of differential responses to FODMAPs and gluten in people with irritable bowel syndrome- a double-blind randomized cross-over challenge study

Metabolomics, Journal Year: 2024, Volume and Issue: 20(2)

Published: Feb. 12, 2024

Abstract Introduction There is large variation in response to diet irritable bowel syndrome (IBS) and determinants for differential are poorly understood. Objectives Our aim was investigate clinical molecular responses provocation with fermentable oligo-, di-, monosaccharides, polyols (FODMAPs) gluten individuals IBS. Methods Data were used from a crossover study week-long interventions either FODMAPs, or placebo. The also included rapid test. Molecular data consisted of fecal microbiota, short chain fatty acids, untargeted plasma metabolomics. IBS symptoms evaluated the severity scoring system. modelled against baseline questionnaire data, using Random Forest (RF; regression clustering), Parallel Factor Analysis (PARAFAC), univariate methods. Results Regression classification RF models general low predictive power (Q 2 ≤ 0.22, rate < 0.73). Out 864 clustering models, only had significant associations clusters (0.69 CR 0.73, p 0.05), but no measures. Similarly, PARAFAC revealed clear association between metabolome symptoms. Conclusion Differential FODMAPs exposures could not be explained despite extensive exploration different analytical approaches. trial registered at www.clinicaltrials.gov as NCT03653689 31/08/2018.

Language: Английский

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The Low-FODMAP Diet, IBS, and BCFAs: Exploring the Positive, Negative, and Less Desirable Aspects—A Literature Review

Microorganisms, Journal Year: 2023, Volume and Issue: 11(10), P. 2387 - 2387

Published: Sept. 25, 2023

The literature about the association of branched short-chain fatty acids (BCFAs) and irritable bowel syndrome (IBS) is limited. BCFAs, bacterial products catabolism branched-chain amino acids, are proposed as markers for colonic protein fermentation. IBS a gastrointestinal disorder characterized by low-grade inflammation intestinal dysbiosis. low-FODMAP diet (LFD) has increasingly been applied first-line therapy managing symptoms, although it decreases production (SCFA), well known their anti-inflammatory action. In parallel, high consumption increases BCFAs. Protein fermentation alters microbiome through nitrogenous metabolites production, detrimental effects on barrier promoting inflammation. Purpose: This review aims to explore role BCFAs gut in patients with impact LFD production. Methods: A search was carried out using combination terms scientific databases. Results: included studies have contradictory findings how affect health patients. Conclusions: Although evidence suggests that may play protective inflammation, other associated Further research needed order clarify composition and, consequently, implicated pathogenesis or symptoms management LFD+.

Language: Английский

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Effects of Short-Term Gluten-Free Diet on Cardiovascular Biomarkers and Quality of Life in Healthy Individuals: A Prospective Interventional Study

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2265 - 2265

Published: July 13, 2024

Introduction: The exposome concept includes nutrition as it significantly influences human health, impacting the onset and progression of diseases. Gluten-containing wheat products are an essential source energy for world’s population. However, a rising number non-celiac healthy individuals tend to reduce or completely avoid gluten-containing cereals health reasons. Aim Methods: This prospective interventional study aimed investigate whether short-term gluten avoidance improves cardiovascular endpoints quality life (QoL) in volunteers. A cohort 27 participants followed strict gluten-free diet (GFD) four weeks. Endothelial function measured by flow-mediated vasodilation (FMD), blood testing, plasma proteomics (Olink®) QoL World Health Organisation Quality-of-Life (WHOQOL) survey were investigated. Results: GFD resulted decreased leucocyte count C-reactive protein levels along with trend reduced inflammation biomarkers determined proteomics. positive indicated improvement FMD, whereas other remained unchanged. In addition, no was observed. Conclusion: individuals, demonstrated anti-inflammatory effects but did not result overall enhanced life.

Language: Английский

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Celiac Disease: The Importance of Studying the Duodenal Mucosa-Associated Microbiota

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1649 - 1649

Published: May 27, 2024

There is increasing evidence indicating that changes in both the composition and functionality of intestinal microbiome are closely associated with development several chronic inflammatory diseases, celiac disease (CeD) being particularly noteworthy. Thanks to advent culture-independent methodologies, ability identify quantify diverse microbial communities residing within human body has been significantly improved. However, context CeD, a notable challenge lies characterizing specific microbiota present on mucosal surfaces intestine, rather than relying solely fecal samples, which may not fully represent relevant populations. Currently, our comprehension functional importance mucosa-associated (MAM) CeD remains an ongoing field research because limited number available studies have reported few sometimes contradictory results. MAM plays crucial role progression potentially acting as trigger modulator immune response mucosa, given its proximity epithelial cells direct interaction. According this background, review aims consolidate existing literature specifically focused CeD. By elucidating complex interplay between host system gut microbiota, we aim pave way for new interventions based novel therapeutic targets diagnostic biomarkers

Language: Английский

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DIETA LOW FODMAPS: OPÇÃO DE TRATAMENTO NÃO FARMACOLÓGICO NA SÍNDROME DO INTESTINO IRRITÁVEL

Brazilian Journal of Implantology and Health Sciences, Journal Year: 2023, Volume and Issue: 5(5), P. 6287 - 6303

Published: Dec. 24, 2023

A síndrome do intestino irritável (SII) emerge como uma condição extenuante, amplamente disseminada em escala global, gerando impactos significativos na qualidade de vida dos indivíduos e nos custos associados à saúde pública. Tendo vista que o padrão alimentar exerce influência significativa modulação da microbiota intestinal, é possível inferir a intervenção dieta alternativa viável para tratamento SII. Dessa forma, objetivo deste estudo foi avaliar impacto baixa FODMAPS no Trata-se revisão integrativa literatura eficácia adoção Síndrome Intestino Irritável. low FODMAPs tem se destacado abordagem promissora manejo Irritável (SII). Ao restringir ingestão determinados carboidratos fermentáveis, essa estratégia busca aliviar os sintomas gastrointestinais incômodos SII, dor abdominal, distensão irregularidades intestinais. Embora apresente benefícios notáveis, são necessárias pesquisas adicionais compreender completamente seus efeitos longo prazo otimizar suas diretrizes, contribuindo assim gestão mais eficaz

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