Applied Sciences,
Journal Year:
2024,
Volume and Issue:
14(9), P. 3882 - 3882
Published: May 1, 2024
Weight
loss
solutions
are
on
the
rise,
and
there
is
growing
interest
in
natural
alternatives
to
pharmaceuticals
market,
which
not
devoid
of
relevant
side
effects.
To
this
end,
objective
current
study
was
assess
effects
a
botanical-based
blend
comprised
lemon
verbena
hibiscus
extracts
weight
management,
body
fat,
appetite,
lipid,
glucose
profiles
an
overweight
population
for
90
days.
The
volunteers
presented
significant
absence
diet
(approximately
3
kg,
−3.4%
total
weight),
coincided
with
decreased
fat
(−1.7%,
equivalent
almost
6%
decrease
compared
initial
value).
Body
assessed
by
anthropometry,
electrical
bioimpedance
DEXA
scans.
Cholesterol
levels
were
also
significantly
7%
decrease).
Satiety
assessment
revealed
that
product
contributed
increased
feeling
fullness
satisfaction
after
meal
placebo
group,
could
contribute
observed.
Blood
blood
pressure
remained
unchanged,
expected
as
normoglycemic
their
healthy
range.
In
conclusion,
daily
supplementation
contributes
individuals
diet,
while
affecting
other
parameters
This
be
candidate
alternative
or
add-on
products
part
lifestyle.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(3), P. 1379 - 1379
Published: Feb. 6, 2025
Atherosclerosis,
a
chronic
inflammatory
disease
characterized
by
the
accumulation
of
lipids
and
immune
cells
within
arterial
walls,
remains
leading
cause
cardiovascular
morbidity
mortality
worldwide.
Oxidative
stress
inflammation
are
central
to
its
pathogenesis,
driving
endothelial
dysfunction,
foam
cell
formation,
plaque
instability.
Emerging
evidence
highlights
potential
bioactive
compounds
with
antioxidant
anti-inflammatory
properties
mitigate
these
processes
promote
vascular
health.
This
review
explores
mechanisms
through
which
compounds-such
as
polyphenols,
carotenoids,
flavonoids,
omega-3
fatty
acids,
coenzyme
Q10,
other
natural
compounds-modulate
oxidative
in
atherosclerosis.
It
examines
their
effects
on
key
molecular
pathways,
including
inhibition
reactive
oxygen
species
(ROS)
production,
suppression
nuclear
factor-κB
(NF-κB),
modulation
cytokines.
By
integrating
current
knowledge,
this
underscores
therapeutic
dietary
supplemental
complementary
strategies
for
managing
atherosclerosis,
paving
way
future
research
clinical
applications.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(7), P. 1071 - 1071
Published: April 5, 2024
Obesity
remains
a
significant
global
health
challenge,
with
bariatric
surgery
remaining
as
one
of
the
most
effective
treatments
for
severe
obesity
and
its
related
comorbidities.
This
review
highlights
multifaceted
impact
beyond
mere
physical
restriction
or
nutrient
malabsorption,
underscoring
importance
gut
microbiome
neurohormonal
signals
in
mediating
profound
effects
on
weight
loss
behavior
modification.
The
various
procedures,
such
Roux-en-Y
gastric
bypass
(RYGB)
sleeve
gastrectomy
(SG),
act
through
distinct
mechanisms
to
alter
microbiome,
subsequently
impacting
metabolic
health,
energy
balance,
food
reward
behaviors.
Emerging
evidence
has
shown
that
induces
changes
composition
notably
altering
Firmicutes/Bacteroidetes
ratio
enhancing
populations
beneficial
bacteria
Akkermansia.
These
microbiota
shifts
have
far-reaching
influencing
dopamine-mediated
pathways
brain
modulating
secretion
action
key
hormones
including
ghrelin,
leptin,
GLP-1,
PYY,
CCK.
resultant
dopamine
signaling
hormone
levels
contribute
reduced
hedonic
eating,
enhanced
satiety,
improved
outcomes.
Further,
post-bariatric
surgical
satiation
targets
are
part
mediated
by
byproducts
like
short-chain
fatty
acids
(SCFAs)
bile
acids,
which
play
pivotal
role
metabolism
expenditure
reducing
obesity-associated
inflammation,
well
pathways,
potentially
contributing
regulation
body
reduction
eating
Overall,
better
understanding
these
opens
door
developing
non-surgical
interventions
replicate
signaling,
regulation,
offering
new
avenues
treatment.
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(2), P. 329 - 329
Published: Jan. 31, 2025
Nutrition,
the
gut
microbiota
and
immunity
are
all
important
factors
in
maintenance
of
health.
However,
there
is
a
growing
realization
complex
interplay
between
these
elements
coalescing
nutrition-gut
microbiota-immunity
axis.
This
regulatory
axis
critical
for
health
with
disruption
being
implicated
broad
range
diseases,
including
autoimmune
disorders,
allergies
mental
disorders.
new
perspective
continues
to
underpin
number
innovative
therapeutic
strategies
targeting
different
this
treat
relevant
diseases.
review
describes
inter-relationships
nutrition,
immunity.
It
then
details
several
human
diseases
where
has
been
identified
presents
examples
how
various
may
be
targeted
therapeutically
as
alternate
treatment
The
gastrointestinal
tract
is
inhabited
by
the
gut
microbiota.
main
phyla
are
Firmicutes
and
Bacteroidetes.
In
non-alcoholic
fatty
liver
disease,
now
renamed
metabolic
dysfunction-associated
disease
(MAFLD),
an
increase
in
Bacteroidetes
abundance
promotes
its
pathogenesis
evolution
into
steatohepatitis,
cirrhosis
hepatocellular
carcinoma.
For
this
reason,
early
treatment
necessary
to
disfavor
progression.
aim
of
present
narrative
review
evaluate
different
therapeutic
approaches
MAFLD.
most
important
for
MAFLD
lifestyle
changes.
regard,
Mediterranean
diet
could
be
considered
gold
standard
prevention
contrast,
a
Western
should
discouraged.
Probiotics
fecal
microbiota
transplantation
seem
valid,
safe,
effective
alternatives
treatment.
However,
more
studies
with
longer
follow
up
larger
cohort
patients
needed
underline
ap-proaches
contrasting
Nutrients,
Journal Year:
2024,
Volume and Issue:
17(1), P. 143 - 143
Published: Dec. 31, 2024
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
is
a
major
contributor
to
liver-related
morbidity,
cardiovascular
disease,
and
metabolic
complications.
Lifestyle
interventions,
including
diet
exercise,
are
first
line
in
treating
MASLD.
Dietary
approaches
such
as
the
low-glycemic-index
Mediterranean
diet,
ketogenic
intermittent
fasting,
high
fiber
diets
have
demonstrated
potential
addressing
dysfunction
underlying
this
condition.
The
development
progression
of
MASLD
closely
associated
with
taxonomic
shifts
gut
microbial
communities,
relationship
well-documented
literature.
Given
importance
primary
treatment
for
MASLD,
it
important
understand
how
microbiota
their
byproducts
mediate
favorable
outcomes
induced
by
healthy
dietary
patterns.
Conversely,
changes
conferred
unhealthy
patterns
Western
may
induce
dysbiosis
influence
through
promoting
hepatic
inflammation,
up-regulating
lipogenesis,
dysregulating
bile
acid
metabolism,
increasing
insulin
resistance,
causing
oxidative
damage
hepatocytes.
Although
emerging
evidence
has
identified
links
between
microbiota,
significant
gaps
remain
understanding
specific
roles,
metabolite
pathways,
host
interactions,
causal
relationships.
Therefore,
review
aims
provide
mechanistic
insights
into
role
microbiota-mediated
processes
analysis
both
contribution
pathophysiology.
By
better
elucidating
interplay
nutrients,
processes,
onset
work
identify
new
opportunities
targeted
interventions
treat
efficiently.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(16), P. 9026 - 9026
Published: Aug. 20, 2024
Colorectal
cancer
(CRC)
continues
to
be
a
significant
contributor
global
morbidity
and
mortality.
Emerging
evidence
indicates
that
disturbances
in
gut
microbial
composition,
the
formation
of
reactive
oxygen
species
(ROS),
resulting
inflammation
can
lead
DNA
damage,
driving
pathogenesis
progression
CRC.
Notably,
bacterial
metabolites
either
protect
against
or
contribute
oxidative
stress
by
modulating
activity
antioxidant
enzymes
influencing
signaling
pathways
govern
ROS-induced
inflammation.
Additionally,
microbiota
byproducts,
when
supplemented
through
probiotics,
affect
tumor
microenvironments
enhance
treatment
efficacy
selectively
mediate
destruction
CRC
cells.
This
review
aims
discuss
mechanisms
which
taxonomical
shifts
related
such
as
short-chain
fatty
acids,
secondary
bile
trimethylamine-N-oxide
influence
ROS
concentrations
safeguard
promote
onset
inflammation-mediated
we
focus
on
role
probiotic
ROS-mediated
both
status
inflammation,
Nrf2-Keap1,
NF-κB,
NLRP3
mitigate
carcinogenesis.
Overall,
deeper
understanding
may
aid
delaying
preventing
offer
new
avenues
for
adjunct,
CRC-specific
therapeutic
interventions
immunotherapy.
Foods,
Journal Year:
2024,
Volume and Issue:
13(22), P. 3529 - 3529
Published: Nov. 5, 2024
Obesity
is
a
pandemic
currently
affecting
the
world's
population
that
decreases
quality
of
life
and
promotes
development
chronic
non-communicable
diseases.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(11), P. 2614 - 2614
Published: June 2, 2024
Neurodegenerative
diseases
(NDs),
characterized
by
progressive
degeneration
and
death
of
neurons,
are
strongly
related
to
aging,
the
number
people
with
NDs
will
continue
rise.
Alzheimer’s
disease
(AD)
Parkinson’s
(PD)
most
common
NDs,
current
treatments
offer
no
cure.
A
growing
body
research
shows
that
AD
especially
PD
intricately
intestinal
health
gut
microbiome
both
can
spread
retrogradely
from
brain.
Zeolites
a
large
family
minerals
built
[SiO4]4−
[AlO4]5−
tetrahedrons
joined
shared
oxygen
atoms
forming
three-dimensional
microporous
structure
holding
water
molecules
ions.
The
widespread
used
zeolite
is
clinoptilolite,
additionally,
mechanically
activated
clinoptilolites
further
improved
beneficial
effects.
review
describes
discusses
numerous
positive
effects
clinoptilolite
its
forms
on
microbiome,
as
well
their
detoxifying,
antioxidative,
immunostimulatory,
anti-inflammatory
effects,
relevant
treatment
PD.
direct
pathology
in
vitro
vivo
also
reviewed,
use
zeolites
biosensors
delivery
systems
