Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: March 11, 2024

Abstract Diet, serving as a vital source of nutrients, exerts profound influence on human health and disease progression. Recently, dietary interventions have emerged promising adjunctive treatment strategies not only for cancer but also neurodegenerative diseases, autoimmune cardiovascular metabolic disorders. These demonstrated substantial potential in modulating metabolism, trajectory, therapeutic responses. Metabolic reprogramming is hallmark malignant progression, deeper understanding this phenomenon tumors its effects immune regulation significant challenge that impedes eradication. Dietary intake, key environmental factor, can tumor metabolism. Emerging evidence indicates might affect the nutrient availability tumors, thereby increasing efficacy treatments. However, intricate interplay between pathogenesis other diseases complex. Despite encouraging results, mechanisms underlying diet-based remain largely unexplored, often resulting underutilization management. In review, we aim to illuminate various interventions, including calorie restriction, fasting-mimicking diet, ketogenic protein restriction high-salt high-fat high-fiber aforementioned diseases. We explore multifaceted impacts these encompassing their immunomodulatory effects, biological impacts, molecular mechanisms. This review offers valuable insights into application therapies

Language: Английский

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Glycolipid Metabolic Disorders, Metainflammation, Oxidative Stress, and Cardiovascular Diseases: Unraveling Pathways

Biology, Journal Year: 2024, Volume and Issue: 13(7), P. 519 - 519

Published: July 12, 2024

Glycolipid metabolic disorders (GLMDs) are various resulting from dysregulation in glycolipid levels, consequently leading to an increased risk of obesity, diabetes, liver dysfunction, neuromuscular complications, and cardiorenal vascular diseases (CRVDs). In patients with GLMDs, excess caloric intake a lack physical activity may contribute oxidative stress (OxS) systemic inflammation. This study aimed review the connection between GLMD, OxS, metainflammation, onset CRVD. GLMD is due causing dysfunction synthesis, breakdown, absorption glucose lipids body, excessive ectopic accumulation these molecules. mainly neuroendocrine dysregulation, insulin resistance, metainflammation. many inflammatory markers defense cells play vital role related tissues organs, such as blood vessels, pancreatic islets, liver, muscle, kidneys, adipocytes, promoting lesions that affect interconnected organs through their signaling pathways. Advanced glycation end products, ATP-binding cassette transporter 1, Glucagon-like peptide-1, Toll-like receptor-4, sphingosine-1-phosphate (S1P) crucial since they glucolipid metabolism. The consequences this system organ damage morbidity mortality.

Language: Английский

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Reply to Najjar, R.S. Comment on “Dyńka et al. The Ketogenic Diet and Cardiovascular Diseases. Nutrients 2023, 15, 3368”

Nutrients, Journal Year: 2023, Volume and Issue: 15(20), P. 4312 - 4312

Published: Oct. 10, 2023

We thank Dr. Najjar for his interest [...]

Language: Английский

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The ketogenic diet does not improve cardiac function and blunts glucose oxidation in ischaemic heart failure

Cardiovascular Research, Journal Year: 2024, Volume and Issue: 120(10), P. 1126 - 1137

Published: April 29, 2024

Cardiac energy metabolism is perturbed in ischaemic heart failure and characterized by a shift from mitochondrial oxidative to glycolysis. Notably, the failing relies more on ketones for than healthy heart, an adaptive mechanism that improves energy-starved status of heart. However, whether this can be implemented therapeutically remains unknown. Therefore, our aim was determine if increasing ketone delivery via ketogenic diet improve outcomes failure.

Language: Английский

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ω-6 and ω-3 Polyunsaturated Fatty Acids: Inflammation, Obesity and Foods of Animal Resources

Food Science of Animal Resources, Journal Year: 2024, Volume and Issue: 44(5), P. 988 - 1010

Published: July 31, 2024

Obesity, as defined by the World Health Organization (WHO), is excessive fat accumulation that can pose health risks and a disorder of energy homeostasis system. In typical westernized diets, ω-6 polyunsaturated fatty acids (PUFAs) vastly exceed amount ω-3 PUFAs, with ω-6/ω-3 ratios ranging from 10:1 to 25:1. such arachidonic acid (AA), have pro-inflammatory effects increase obesity. On other hand, including eicosapentaenoic (EPA) docosahexaenoic (DHA), anti-inflammatory anti-obesity effects. LA (linoleic acid) ALA (alpha-linolenic are synthesized in almost all higher plants, algae, some fungi. However, humans animals, they essential (EFA) must be consumed through diet or supplementation. Therefore, balancing LA/ALA for obesity prevention human health. Monogastric animals pigs chickens produce meat eggs fortified PUFAs controlling dietary (FA). Additionally, ruminant feeder cattle lactating dairy cows opt feed supplementation sources rumen-protected microencapsulated pasture finishing. This method conjugated linoleic (CLA) meat, milk, cheese. A high ratio associated pro-inflammation obesity, whereas balanced reduces inflammation probiotics containing lactic bacteria necessary, which converting into functional metabolites HYA (10-hydroxy-cis-12-octadecenoic CLA.

Language: Английский

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β‐Hydroxybutyrate enhances chondrocyte mitophagy and reduces cartilage degeneration in osteoarthritis via the HCAR2/AMPK/PINK1/Parkin pathway

Aging Cell, Journal Year: 2024, Volume and Issue: 23(11)

Published: Aug. 9, 2024

Abstract Osteoarthritis (OA) is widely recognized as the prevailing joint disease associated with aging. The ketogenic diet (KD) has been postulated to impede advancement of various inflammatory ailments. β‐Hydroxybutyrate (βOHB), a prominent constituent ketone bodies, recently proposed possess crucial signaling capabilities. In this study, we propose explore role and mechanism βOHB in OA. Tissue staining factor assay were employed evaluate impacts KD on OA rats. oxidative stress conditions chondrocytes induced using tert‐butyl hydroperoxide (TBHP). mechanisms determined siRNA hydroxycarboxylic acid receptor 2 (HCAR2), antagonist adenosine monophosphate‐activated protein kinase (AMPK), inhibitor mitophagy. administration demonstrated reduction pathological damage cartilage, well decrease plasma levels factors. Furthermore, it resulted an increase concentration blood synovial fluid. vitro experiments showed that facilitated mitophagy triphosphate production. Besides, mitigated chondrocyte senescence, factors secretion, extracellular matrix degradation, apoptosis by TBHP. Subsequent investigations indicated protective effects no longer observed following knockdown HCAR2, AMPK, or Moreover, vivo studies suggested played targeting HCAR2‐AMPK‐PINK1 axis. conclusion, enhanced through HCAR2/AMPK/PINK1/Parkin pathway, offering potential therapeutic approach for treatment

Language: Английский

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Associations of Dietary and Lifestyle Components with Atrial Fibrillation

Nutrients, Journal Year: 2024, Volume and Issue: 16(3), P. 456 - 456

Published: Feb. 5, 2024

Atrial fibrillation (AF) is a prevalent cardiac arrhythmia that still remains significant health concern, especially due to its consequences, including stroke and heart failure. This review explores the intricate interplay between AF, lifestyle choices, dietary habits. It particularly focused on findings from diverse studies about non-pharmacological methods of managing AF. Moreover, purpose elucidate implementation changes such as physical activity or proper diet choices in integrated treatment strategy patients with

Language: Английский

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Dietary Influence on Drug Efficacy: A Comprehensive Review of Ketogenic Diet–Pharmacotherapy Interactions

Nutrients, Journal Year: 2024, Volume and Issue: 16(8), P. 1213 - 1213

Published: April 19, 2024

It is widely acknowledged that the ketogenic diet (KD) has positive physiological effects as well therapeutic benefits, particularly in treatment of chronic diseases. Maintaining nutritional ketosis utmost importance KD, it provides numerous health advantages such an enhanced lipid profile, heightened insulin sensitivity, decreased blood glucose levels, and modulation diverse neurotransmitters. Nevertheless, integration KD with pharmacotherapeutic regimens necessitates careful consideration. Due to changes their absorption, distribution, metabolism, or elimination, can impact pharmacokinetics various medications, including anti-diabetic, anti-epileptic, cardiovascular drugs. Furthermore, which characterised by intake meals rich fats, potential specific medications high lipophilicity, hence enhancing absorption bioavailability. However, pharmacodynamic aspects conjunction pharmaceutical interventions, provide either advantageous detrimental synergistic outcomes. Therefore, important consider pharmacokinetic interactions may arise between This assessment essential not only for ensuring patients' compliance but also optimising overall outcome, mitigating adverse reactions. highlights significance necessity tailoring pharmacological dietetic therapies order enhance effectiveness safety this comprehensive approach managing

Language: Английский

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An unexpected role for the ketogenic diet in triggering tumor metastasis by modulating BACH1-mediated transcription

Science Advances, Journal Year: 2024, Volume and Issue: 10(23)

Published: June 5, 2024

We have found that the ketogenic (Keto) diet is able to, unexpectedly, promote metastatic potential of cancer cells in complementary mouse models. Notably, Keto diet–induced tumor metastasis dependent on BTB domain and CNC homolog 1 (BACH1) its up-regulation pro-metastatic targets, including cell migration–inducing hyaluronidase 1, response to diet. By contrast, upon genetic knockout or pharmacological inhibition endogenous BACH1, diet–mediated activation those targets largely diminished, effects are completely abolished. Mechanistically, administration diet, levels activating transcription factor 4 (ATF4) markedly induced. Through direct interaction with ATF4 recruited target promoters enhances BACH1-mediated transcriptional activation. Together, these data implicate a distinct regulatory program BACH1 for induced by Our study also raises health risk human patients cancer.

Language: Английский

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Changes in the chronic and postprandial blood lipid profiles of trained competitive cyclists and triathletes following a ketogenic diet: a randomized crossover trial

BMC Sports Science Medicine and Rehabilitation, Journal Year: 2024, Volume and Issue: 16(1)

Published: Jan. 16, 2024

Abstract Background The ketogenic diet (KD) is the most popular carbohydrate restriction strategy for endurance athletes. However, because primary goal of employing KD to gain a competitive advantage in competition, athletes may be less concerned with influence on their cardiometabolic health; particularly blood lipid profiles. Thus, purpose this study was examine chronic and postprandial alterations following two-week ad libitum compared an high-carbohydrate (HCD) athletes’ habitual (HD) group trained cyclists triathletes. Methods Six triathletes (female: 4, male: 2; age: 37.2 ± 12.2) completed randomized crossover trial, which required them follow HCD order after HD. Fasting lipids were collected HD two-weeks conditions. Postprandial responses test meal reflective assigned at end each condition. Results total cholesterol (TC) significantly higher ( p < 0.001) = 0.006). incremental area under curve triglycerides (TRG), TRG:HDL ratio, VLDL-C (all meals but LDL-C LDL:HDL ratio lower 0.001). Conclusions Trained demonstrate increased TC response or Endurance contemplating should consider potential these alterations, future research focus determine if changes manifest shifts. Trial registration ClinicalTrials.gov Identifier: NCT04097171 (11 October 2019).

Language: Английский

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