Nutritional Strategies for Battling Obesity-Linked Liver Disease: the Role of Medical Nutritional Therapy in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Management

Current Obesity Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 11, 2025

This narrative review explores the role of Medical Nutritional Therapy (MNT) in managing Metabolic-Associated Steatotic Liver Disease (MASLD), previously known as nonalcoholic fatty liver disease. It aims to examine effectiveness specific nutritional strategies preventing and treating this obesity-linked Emerging evidence underscores benefits Mediterranean diet, low-carbohydrate diets, intermittent fasting reducing fat, improving insulin sensitivity, mitigating inflammation. Supplementing with vitamin E, omega-3 acids, silymarin can potentially reduce fibrosis promote health. MNT is a key intervention for MASLD management, emphasizing dietary patterns, caloric restriction, nutraceutical supplementation. Integrating these lifestyle modifications, including regular physical activity, offers comprehensive approach metabolic outcomes patients MASLD. Further research needed refine personalize therapeutic interventions.

Language: Английский

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Dietary Interventions and Physical Activity as Crucial Factors in the Prevention and Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 217 - 217

Published: Jan. 16, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic worldwide and affects nearly 30% of adult population 10% pediatric population. It estimated that this number will double by 2030. MASLD one leading causes hepatocellular carcinoma, cirrhosis, transplantation, as well a significant risk factor for cardiovascular mortality. Due to ever-increasing patients, long-term asymptomatic course disease, serious complications, lack preventive programs, insufficient awareness among patients doctors themselves, growing interdisciplinary problem real challenge modern medicine. The main cause an inappropriate lifestyle—inadequate nutrition physical activity, which lead various components metabolic syndrome. Lifestyle changes—appropriate diet, weight reduction, systematic activity—are also basis prevention treatment MASLD. Hence, in recent years, so much importance has been attached lifestyle medicine, non-pharmacological diseases. narrative review presents possible therapeutic options management best documented available diets used were discussed, focusing on benefits drawbacks Mediterranean, high-protein, ketogenic, intermittent fasting diets. In addition, recommendations regarding activity are summarized.

Language: Английский

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Unlocking the potential: very-low-energy ketogenic therapy in obesity-related disorders

Food and Agricultural Immunology, Journal Year: 2025, Volume and Issue: 36(1)

Published: Jan. 16, 2025

The Very Low-Energy Ketogenic Therapy (VLEKT) is a structured, multi-phase dietary regimen characterized by carbohydrate intake of less than 50 g/day and daily caloric fewer 800 kcal, which induces ketosis facilitates significant weight loss. Evidence suggests that this nutritional therapy can improve glycemic control, lipid profiles, blood pressure, making it promising option for managing type 2 diabetes (T2D) reducing cardiovascular risk. These benefits are achieved through reductions in triglycerides low-density lipoprotein cholesterol (LDL-c), alongside increases high-density (HDL-c). However, the effects VLEKT on metabolism remain controversial. review emphasizes urgent need further research to validate long-term safety efficacy VLEKT. It also highlights critical role personalized plans, supervised healthcare professionals, optimize health outcomes address individual patient needs.

Language: Английский

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Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Children with Obesity: An Obesity Medicine Association (OMA) and Expert Joint Perspective 2025

Obesity Pillars, Journal Year: 2025, Volume and Issue: 14, P. 100164 - 100164

Published: Feb. 1, 2025

This Obesity Medicine Association (OMA) Expert Joint Perspective examines steatotic liver disease (SLD), which is composed of metabolic dysfunction-associated (MASLD), and steatohepatitis (MASH) in children with obesity. The prevalence obesity increasing, rates have tripled since 1963 from 5 % to now 19 US affected 2018. MASLD, the most common seen children, can be a precursor development Type 2 Diabetes (T2DM) primary reason for transplant listing young adults. We must vigilant prevention treatment MASLD childhood prevent further progression. joint clinical perspective based upon scientific evidence, peer expertise. medical literature was reviewed via PubMed search appropriate articles were included this review. work formulated collaboration eight hepatologists/gastroenterologists expertise two physicians OMA. authors who are experts field, determined sentinel questions often asked by clinicians regarding They created consensus guideline on screening, diagnosis, associated children. comorbidity increasing problem that needs addressed urgently. It well known chronic continue these diseases as adults, leads reduced life expectancy, quality life, healthcare financial burden. paper recommend healthy weight reduction not only through lifestyle modification but pharmacotherapy bariatric surgery. Therefore, guidance reviews available therapies achieve reverse progressive fibrosis, disease.

Language: Английский

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Gender Differences in Liver Steatosis and Fibrosis in Overweight and Obese Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease before and after 8 Weeks of Very Low-Calorie Ketogenic Diet

Nutrients, Journal Year: 2024, Volume and Issue: 16(10), P. 1408 - 1408

Published: May 8, 2024

Obesity and metabolic syndrome are linked to steatotic liver disease (SLD), the most common form of chronic disease. Lifestyle modifications dieting strategies that can prevent dysfunction-associated (MASLD). The very low-calorie ketogenic diet (VLCKD) is a helpful treatment for MASLD has been recommended people affected by obesity; we evaluated effect gender on steatosis fibrosis in cohort 112 overweight or obese patients undergoing an eight-week with VLCKD. Differences between genders terms anthropometric measures, body composition, indicators were examined before, during, after nutritional intervention. At baseline, there significant differences men women parameters, blood pressure, Homeostatic Model Assessment Insulin Resistance (HOMA-IR), fasting insulin, hepatic markers, lipid profile. Men had considerably higher levels (measured CAP) stiffness E) under basal conditions than women. After VLCKD, reductions both controlled attenuation parameter (CAP), weight, mass index (BMI), waist circumference, systolic diastolic insulin resistance, fat (FM), free (FFM), glucose, glycated hemoglobin (HbA1c), triglycerides, total cholesterol, low-density lipoprotein (LDL) alanine transaminase (ALT), gamma-glutamyl transferase (γGT), uric acid levels. Only men, stiffness, aspartate aminotransferase (AST), creatinine, C-reactive protein (CRP) significantly decreased. Moreover, greater steatosis: male featured increase 23.96 points Fibroscan CAP. exhibited women, these persist despite These gender-specific variations could be caused hormonal factors, suggesting different therapeutic might required depending gender.

Language: Английский

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Ketogenic Diet in Steatotic Liver Disease: A Metabolic Approach to Hepatic Health

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1269 - 1269

Published: April 4, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major cause of chronic dysfunction worldwide, characterized by hepatic steatosis that may progress to nonalcoholic steatohepatitis and cirrhosis. Owing its strong association with metabolic disorders, current management focuses on weight reduction via lifestyle modifications. Recently, the very-low-calorie ketogenic diet (VLCKD) has emerged as promising intervention due potential for rapid loss in fat. This review aims evaluate clinical evidence regarding impact diets steatosis. We conducted an extensive MEDLINE literature search databases including PubMed, Scopus, Web Science up December 2024. Studies assessing effects or low-carbohydrate high-fat fat, evaluated imaging, histology, biochemical markers, were included. The analysis indicates significantly reduce fat content improve parameters, insulin sensitivity enzyme levels. Evidence further suggests substituting saturated fats unsaturated replacing carbohydrates proteins enhance these benefits. However, considerable variability exists among studies long-term data remain limited. Although short-term outcomes are encouraging, adverse such dyslipidaemia, gastrointestinal disturbances, transient 'keto flu' symptoms require careful monitoring. Future research should focus elucidating underlying mechanisms, optimizing dietary composition, safety establish robust strategy managing MASLD.

Language: Английский

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Problems and Opportunities in the use of Bioelectrical Impedance Analysis for Assessing Body Composition During Ketogenic Diets: A Scoping Review

Current Obesity Reports, Journal Year: 2024, Volume and Issue: 13(3), P. 496 - 509

Published: May 27, 2024

The use of bioelectrical impedance analysis (BIA) for monitoring body composition during the ketogenic diet has experienced a rapid surge. This scoping review aimed to assess validity procedures applying BIA in and suggest best practices optimizing its utilization.

Language: Английский

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Higher-Level Steatosis Is Associated with a Greater Decrease in Metabolic Dysfunction-Associated Steatoic Liver Disease after Eight Weeks of a Very Low-Calorie Ketogenic Diet (VLCKD) in Subjects Affected by Overweight and Obesity

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 874 - 874

Published: March 18, 2024

The most common form of chronic liver disease, recently defined as MASLD, is strongly linked to obesity and metabolic syndrome. Lifestyle changes are part MASLD prevention. very low-calorie ketogenic diet (VLCKD) a useful option for treating reducing steatosis in patients with obesity. We assessed whether greater degree could have positive or negative impact on how well 8 weeks using the VLCKD improve fibrosis patient population overweight obese individuals. Anthropometric parameters, along hormone biomarkers, were also both before after dietary change. study included 111 (14.41%) subjects (85.59%) aged between 18 64 years; 75 women 36 men involved not taking any medicine. In raw (0.37 95% CI 0.21; 0.52) multivariate models (model a: 0.439 0.26; 0.62; model b: 0.437 0.25; 0.63), there was statistically significant correlation CAP delta value VLCKD. Additionally, stiffness found be positively significantly correlated use models: 0.560 0.40; 0.71; 0.498 0.34; 0.65) (0.52 0.39; 0.65). Systolic diastolic blood pressure, insulin resistance (measured by HOMA-IR), insulin, HbA1c, fasting glucose, total cholesterol, LDL HDL cholesterol triglycerides, BMI, waist circumference, fat mass, all decreased (p < 0.001) following However, VLCKD, an increase vitamin D levels. 0.001). that has effect improving who initially more severe forms these conditions.

Language: Английский

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Beneficial Effects of the Ketogenic Diet on Nonalcoholic Fatty Liver Disease (NAFLD/MAFLD)

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(16), P. 4857 - 4857

Published: Aug. 17, 2024

The prevalence of nonalcoholic fatty liver disease (NAFLD) is likely to be approaching 38% the world's population. It predicted become worse and main cause morbidity mortality due hepatic pathologies. particularly worrying that NAFLD increasingly diagnosed in children closely related, among other conditions, insulin resistance metabolic syndrome. Against this background concern awareness patients with low; one study, almost 96% adult USA were not aware their disease. Thus, studies on therapeutic tools used treat are extremely important. One promising treatment a well-formulated ketogenic diet (KD). aim paper present review available publications current state knowledge effect KD NAFLD. This includes characteristics key factors (from point view regression), which exerts its effects, i.e., reduction body weight, elimination fructose monosaccharides, limitation total carbohydrate intake, anti-inflammatory ketosis state, or modulation gut microbiome metabolome. In context evidence for effectiveness regression NAFLD, also suggests important role taking responsibility one's own health through increasing self-monitoring self-education.

Language: Английский

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Dietary Influences on Gut Microbiota and Their Role in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 143 - 143

Published: Dec. 31, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major contributor to liver-related morbidity, cardiovascular disease, and metabolic complications. Lifestyle interventions, including diet exercise, are first line in treating MASLD. Dietary approaches such as the low-glycemic-index Mediterranean diet, ketogenic intermittent fasting, high fiber diets have demonstrated potential addressing dysfunction underlying this condition. The development progression of MASLD closely associated with taxonomic shifts gut microbial communities, relationship well-documented literature. Given importance primary treatment for MASLD, it important understand how microbiota their byproducts mediate favorable outcomes induced by healthy dietary patterns. Conversely, changes conferred unhealthy patterns Western may induce dysbiosis influence through promoting hepatic inflammation, up-regulating lipogenesis, dysregulating bile acid metabolism, increasing insulin resistance, causing oxidative damage hepatocytes. Although emerging evidence has identified links between microbiota, significant gaps remain understanding specific roles, metabolite pathways, host interactions, causal relationships. Therefore, review aims provide mechanistic insights into role microbiota-mediated processes analysis both contribution pathophysiology. By better elucidating interplay nutrients, processes, onset work identify new opportunities targeted interventions treat efficiently.

Language: Английский

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