PARP1 inhibitor niraparib exerts synergistic antimyeloma effect with bortezomib through inducing DNA damage and inhibiting DNA repair DOI Creative Commons
Haiyan Zhang,

Mengdi Cheng,

Qingshan Zhao

et al.

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Paeoniflorin protects hepatocytes from APAP-induced damage through launching autophagy via the MAPK/mTOR signaling pathway DOI Creative Commons
Xinyu Deng, Yubing Li, Yuan Chen

et al.

Cellular & Molecular Biology Letters, Journal Year: 2024, Volume and Issue: 29(1)

Published: Sept. 7, 2024

Language: Английский

Citations

12
Antioxidant effects of Paeoniflorin and relevant molecular mechanisms as related to a variety of diseases: A review DOI Open Access

Yansong Lu,

Lu Yin, Wei Yang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116772 - 116772

Published: May 28, 2024

Paeoniflorin (PF), which is the main component of Paeonia lactiflora Pall extract, one traditional Chinese medicines. The pharmacological effects associated with PF include antioxidant, immunomodulatory, anti-inflammatory, anticancer, antidepressant-like and neuroprotective effects. Our previous studies had revealed that protected melanocytes inhibited photodamage through suppression oxidative stress (OS). As OS plays a vital role in progression variety diseases, capacity for to suppress may exert important upon them. However, no review exists on these antioxidant as related various diseases. Therefore, this we summarized involved examining molecular mechanisms PF. Through its inhibit OS, has been shown beneficial several systems including nervous, cardiac/vascular, digestive, respiratory well specific diseases such diabetes, autoimmune, pregnancy related, ocular, kidney, dermatology, along distal flap necrosis, postoperative adhesions, hearing loss. Such findings provide new insights directions future research directed at development natural treatment clinical

Language: Английский

Citations

5
Jianwei Xiaoyan granule ameliorates chronic atrophic gastritis by regulating HIF-1α-VEGF pathway DOI
Jia Liu, Mengyu Li, Guobao Chen

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 334, P. 118591 - 118591

Published: July 17, 2024

Language: Английский

Citations

5
Mechanisms of Traditional Chinese Medicine in the Treatment and Prevention of Gastric Cancer DOI Creative Commons
Yanyang Liu, Xuefei Yu,

Huize Shen

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156003 - 156003

Published: Sept. 8, 2024

Language: Английский

Citations

5
Analysis of the correlation between the dose exposure intensity and apatinib in advanced gastric cancer: a retrospective cohort study DOI Creative Commons
Xiao Ma,

Lan Gao,

Shunan Che

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 5, 2025

Background Apatinib is a small molecule anti-angiogenesis targeted drug that has demonstrated significant efficacy as late-line treatment in advanced gastric cancer phase 3 clinical trials. This study amid to evaluate the correlation between dose exposure intensity and safety of apatinib cancer. Methods We conducted an observational, retrospective cohort patients with who received therapy Beijing Friendship Hospital affiliated Capital Medical University June 1, 2018, 30, 2021. Dose (DEI) was defined product continuous medication time. Patients were assigned high-dose (HDEI) low-dose (LDEI) cohorts. The primary endpoint progression-free survival (PFS), secondary endpoints overall (OS) safety. relationship HDEI LDEI outcomes analyzed by using Kaplan-Meier curve χ 2 test. Results 61 enrolled into two median PFS (mPFS) 6.50 months (95% confidence interval (CI) [4.80-9.20]) 4.10 CI [3.70-5.20]), OS (mOS) 10.70 [9.20-18.50]) 7.50 [6.80-9.30]) for cohorts, respectively. mPFS 5.85 [5.00-7.00]) 4.60 [4.10-5.90]), mOS 9.60 [9.10-12.40]) 7.60 [7.20-10.20]) 250 mg 500 6.65 [5.90-9.20]) [3.90-5.20]), 11.20 [7.20-9.60])for long time short most common TRAEs any grade hypertension, proteinuria, neutrophil count decreased. incidence 3-4 adverse reactions higher than (P=0.0016). Conclusion significantly positively correlated intensity, can prolong OS. Early application (250 mg/d) improve patients’ tolerability, are controllable.

Language: Английский

Citations

0
The active components and potential mechanisms of Li-Chong-Xiao-Zhen granules in the treatment of ovarian cancer: An integrated metabolomics, proteomics, network pharmacology and experimental validation DOI Creative Commons
Yiliu Chen, Rina Su, Guilin Hu

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119474 - 119474

Published: Feb. 1, 2025

Language: Английский

Citations

0
Plant polyphenols in gastric cancer: Nature's healing touch DOI
Chengu Niu, Jing Zhang, Patrick Okolo

et al.

Seminars in Oncology, Journal Year: 2025, Volume and Issue: 52(2), P. 152333 - 152333

Published: March 11, 2025

Language: Английский

Citations

0
The role of reactive oxygen species in gastric cancer DOI Creative Commons
Yuqi Wang,

Jingli Xu,

Zhenjie Fu

et al.

Cancer Biology and Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 14

Published: July 9, 2024

Gastric cancer (GC) ranks fifth in incidence and fourth cancer-related mortality worldwide. Reactive oxygen species (ROS) are highly oxidative oxygen-derived products that have crucial roles cell signaling regulation maintaining internal balance. ROS closely associated with the occurrence, development, treatment of GC. This review summarizes recent findings on sources bidirectional regulatory effects GC discusses various modalities for related to induction. In addition, by natural small molecule compounds highest potential development applications anti-GC research is summarized. The aim accelerate clinical application modulating levels as a therapeutic strategy

Language: Английский

Citations

2
The synergistic protective effects of paeoniflorin and β-ecdysterone against cardiac hypertrophy through suppressing oxidative stress and ferroptosis DOI

Peimei Yan,

Xue Li,

Yuhui He

et al.

Cellular Signalling, Journal Year: 2024, Volume and Issue: unknown, P. 111509 - 111509

Published: Nov. 1, 2024

Language: Английский

Citations

2
Modulating Endoplasmic Reticulum Stress in Gastrointestinal Cancers: Insights from Traditional Chinese Medicine DOI Creative Commons

Qinyi Li,

Xiaohong Zhao, Huan Yang

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(12), P. 1599 - 1599

Published: Nov. 27, 2024

Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) play critical roles in tumorigenesis, cancer progression, drug resistance. Persistent activation of ER system enhances survival capacities malignant tumor cells, including increased proliferation, invasion, resistance to treatment. Dysregulation function resultant is a common cellular therapies may lead cell death. Currently, growing evidence suggests that Traditional Chinese medicine (TCM), either as monotherapy or combination with other treatments, offers significant advantages preventing cancer, inhibiting growth, reducing surgical complications, improving sensitivity, mitigating drug-induced damage. Some these natural products have even entered clinical trials primary complementary anticancer agents. In this review, we summarize effects TCM monomers/natural on gastrointestinal (GI) tumors explore their mechanisms through modulation. We believe ongoing laboratory research development TCM-based hold considerable potential for advancing future treatments.

Language: Английский

Citations

1