First-year dynamics of the anaerobic microbiome and archaeome in infants’ oral and gastrointestinal systems DOI Creative Commons
Charlotte Neumann,

Rokhsareh Mohammadzadeh,

Pei Yee Woh

et al.

mSystems, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

ABSTRACT Recent research provides new insights into the early establishment of infant gut microbiome, emphasizing influence breastfeeding on development gastrointestinal microbiomes. In our study, we longitudinally examined taxonomic and functional dynamics oral tract (GIT) microbiomes healthy infants ( n = 30) in their first year, focusing often-over-looked aspects, archaeal anaerobic Breastfed (BF) exhibit a more defined transitional phase microbiome compared to non-breastfed (NBF) infants, marked by decrease Streptococcus emergence genera such as Granulicatella . This phase, characterized increased alpha-diversity significant changes beta-diversity, occurs earlier NBF (months 1–3) than BF 4–6), suggesting that supports later, maturation. We demonstrated presence archaea cavity GIT from infancy, with Methanobrevibacter being predominant genus. Still, transient patterns show no stable archaeome is formed. The exhibited gradual development, showing diversity complexity between third eighth months, microbial networks. showed complex co-occurrence start. These strong differences infants’ are less pronounced levels levels. Overall, differentiates stabilizes over playing crucial role shaping networks overall IMPORTANCE year life period for establishing human microbiome. Our study analyses obligate anaerobes specific focus impact this process. findings breastfed undergo distinct phases within life. contrast, mature month, leading steadier without year. Additionally, found signatures present under 1 age, but they do not form archaeome. contrast this, could track bacterial strains transitioning or persisting time.

Language: Английский

Nutrition for Optimal Lactation DOI Creative Commons
Otilia Perichart‐Perera

Annals of Nutrition and Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: Feb. 21, 2025

Background:: Breastfeeding is the ideal method of feeding for all newborns and associated with multiple positive health outcomes. Human milk provides essential nutrients bioactive molecules needed optimal infant development. Maternal nutrition during lactation plays an important role in supporting breastfeeding preventing metabolic imbalances. The aim this narrative review was to describe most prevalent issues lactating women provide a summary current diet recommendations as well controversies on supplementation, order facilitate information clinicians professionals. Summary:: nutritionally demanding stage adequate key avoid alterations maternal nutritional status, produce quantity good quality, programming diseases. Anemia vitamin D, A, iodine, iron deficiencies are common, while obesity diseases keep rising. Inadequate intake many also frequent stage.

Language: Английский

Citations

1
The role of antibiotic exposure and the effects of breastmilk and human milk feeding on the developing infant gut microbiome DOI Creative Commons
Meredith Brockway

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: June 6, 2024

The World Health Organization (WHO) recommends exclusive breastfeeding for the first 6 months of life followed by complementary foods and sustained at least 2 years, underscoring its pivotal role in reducing infant mortality preventing various illnesses. This perspective delves into intricate relationship between practices, early antibiotic exposure, gut microbiome development, highlighting their profound influence on child health outcomes. Antibiotics are extensively prescribed during pregnancy childhood, disrupting microbiome, related to increased risks allergies, obesity, neurodevelopmental disorders. Breastfeeding is a significant determinant healthier characterized higher levels beneficial bacteria such as Bifidobacterium lower potential pathogens. Despite widespread recognition benefits breastfeeding, gaps persist healthcare practices support mechanisms, exacerbating challenges faced families. highlights pressing need comprehensive research encompassing behaviors, human milk intake, impact Additionally, promoting awareness among providers families regarding detrimental effects unnecessary formula supplementation could facilitate informed decision-making bolster rates. Moreover, donor (DHM) promising alternative formula, potentially mitigating disruptions after exposure. Overall, prioritizing interventions bridging essential steps towards improving outcomes global scale.

Language: Английский

Citations

8
Comparative analysis of pectin and prebiotics on human microbiota modulation in early life stages and adults DOI
Janaina Lombello Santos Donadio, João Paulo Fabi

Food & Function, Journal Year: 2024, Volume and Issue: 15(13), P. 6825 - 6846

Published: Jan. 1, 2024

The gut microbiota is essential in human health, influencing various physiological processes ranging from digestion and metabolism to immune function mental health.

Language: Английский

Citations

5
The gut microbiome across the lifespan: how diet modulates our microbial ecosystem from infancy to the elderly DOI
Hazem Golshany, Shahinaz Helmy, Nashwa F. S. Morsy

et al.

International Journal of Food Sciences and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 27

Published: Dec. 19, 2024

This comprehensive review examines the impact of dietary patterns on gut microbiome composition and diversity from infancy to old age, linking these changes age-related health outcomes. It investigates how develops across life stages, focusing influence factors. The explores early-life feeding practices, including breastfeeding formula feeding, shape infant microbiota have lasting effects. In elderly individuals, alterations in are associated with increased susceptibility infections, chronic inflammation, metabolic disorders cognitive decline. critical role diet modulating throughout is emphasised, particularly potential benefits probiotics fortified foods promoting healthy ageing. By elucidating mechanisms connecting food systems health, this provides insights into interventions that could enhance resilience improve outcomes lifespan.

Language: Английский

Citations

5
Fecal Microbiome and Metabolomic Profiles of Mixed-Fed Infants Are More Similar to Formula-Fed than Breastfed Infants DOI Creative Commons
Mei Wang, Negin Valizadegan, Christopher J. Fields

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(1), P. 166 - 166

Published: Jan. 14, 2025

Many infants consume both human milk and infant formula (mixed-fed); however, few studies have investigated how mixed feeding affects the gut microbiome composition metabolic profiles compared to exclusive breastfeeding or feeding. Herein, delivery mode early nutrition affect metabolome of 6-week-old in STRONG Kids2 cohort was investigated. Fecal samples were collected from exclusively breastfed (BF; n = 25), formula-fed (FF; 25) mixed-fed (MF; participants. Within each group, either delivered vaginally (VD; 13) by Cesarean section (CS; 12). Feeding fecal diversity, composition, functional potential, as well metabolomic regardless mode. Alpha beta diversity MF differed that BF (p < 0.05) but comparable FF infants. Functional analyses shown 117 potential pathways between FF, 112 MF, 8 0.05, q 0.10). clustered together separated In total, 543 metabolites 517 3 Delivery affected overall microbial 0.022) at genus level 24 pathways, with 16 being higher VD than CS Metabolomic analysis identified 47 differential VD, 39 lower summary, microbiota function metabolite are closer

Language: Английский

Citations

0
Administration of probiotics and synbiotics and systemic inflammation in Kenyan infants: an open label, randomised, phase II trial DOI Creative Commons
Mary Iwaret Otiti,

Micah J. June,

Alloys K’Oloo

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Abstract Environmental enteric dysfunction (EED) in early life, caused by gut pathogen colonisation, contributes to chronic systemic inflammation (CSI) which impairs growth and organ development increases non-communicable disease risk. Pro/synbiotics may prevent or ameliorate EED, thereby reduce CSI, through boosting colonisation resistance against enteropathogens provide other intestinal immune benefits. We evaluated three pro/synbiotics consisting of live, multi-strain Bifidobacterium spp. Lactobacillaceae reducing CSI. In this open-label, randomised, four-arm, phase II trial, 600 healthy Kenyan newborns (1–3 days old, birthweight ≥2000g) were allocated 1:1:1:1, stratified HIV exposure, receive Labinic synbiotic, Lab4b synbiotic probiotic no intervention daily for ten days, then weekly until six months. The primary outcome was CSI (plasma α1-acid glycoprotein > 1g/L) at months with blinded laboratory assessments. At months, occurred 60/138 (43%) controls versus 4/144 (3%; relative risk (RR) 0.06, 95% CI 0.02–0.17; p < 0.0001) infants the 3/132 (2%; RR = 0.05, 0.02–0.16; P 3/141 0.02–0.15; arm. Serious adverse events mortality over 0–24 similar across study arms. safely markedly reduced disadvantaged population, warranting investigation health impacts.

Language: Английский

Citations

0
Transgenerational Gut Dysbiosis: Unveiling the Dynamics of Antibiotic Resistance through Mobile Genetic Elements from Mothers to Infants DOI
S. Farooq,

Absar Talat,

Achal Dhariwal

et al.

International Journal of Antimicrobial Agents, Journal Year: 2025, Volume and Issue: 65(5), P. 107458 - 107458

Published: Feb. 6, 2025

Language: Английский

Citations

0
Impact of diet on the gut mycobiome of Hong Kong Chinese infants DOI Creative Commons
Jordan Y. H. Fong, Kris Yuet Wan Lok,

Man Lung Yeung

et al.

Computational and Structural Biotechnology Journal, Journal Year: 2025, Volume and Issue: 27, P. 661 - 671

Published: Jan. 1, 2025

Despite extensive research on the gut bacteriome during infancy and its correlation with various chronic diseases, influence of diet mycobiome development in infants remains unexplored. To address this significant gap, we conducted a study 70 healthy Hong Kong Chinese who were either directly breastfed, expressed milk-fed, or formula-fed. Our analysis revealed that formula-fed had higher fungal diversity composition their compared to those breastfed milk-fed infants. The group exhibited richness, median 58.5, 34 (p = 0.04) 28.5 0.02). However, groups showed no differences. In terms compositions, increase relative abundance Pochonia (0 % breastmilk vs 0.5 formula milk, false discovery rate (FDR)-corrected p 0.05), Saccharomyces (0.95 2.7 FDR corrected 0.03), Tetrapisispora (0.6 3.0 0.002), whereas direct an increased Malassezia (breastmilk vs. milk 1.4 0.4 %, FDR-corrected 0.01). Overall, our results indicate can have varying impacts infants, providing new insights into diet-gut dynamic early life. Given small sample size group, findings should be considered preliminary exploratory. Further studies are thus necessary explore potential health implications these findings.

Language: Английский

Citations

0
Operationalizing Team Science at the Academic Cancer Center Network to Unveil the Structure and Function of the Gut Microbiome DOI Open Access
Kevin McDonnell

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(6), P. 2040 - 2040

Published: March 17, 2025

Oncologists increasingly recognize the microbiome as an important facilitator of health well a contributor to disease, including, specifically, cancer. Our knowledge etiologies, mechanisms, and modulation states that ameliorate or promote cancer continues evolve. The progressive refinement adoption “omic” technologies (genomics, transcriptomics, proteomics, metabolomics) utilization advanced computational methods accelerate this evolution. academic center network, with its immediate access extensive, multidisciplinary expertise scientific resources, has potential catalyze research. Here, we review our current understanding role gut in prevention, predisposition, response therapy. We underscore promise operationalizing network uncover structure function microbiome; highlight unique microbiome-related expert resources available at City Hope Comprehensive Cancer Center example team science achieve novel clinical discovery.

Language: Английский

Citations

0
Development of antibiotic resistome in premature infants DOI Creative Commons
Ayya Keshet, Ori Hochwald, Amit Lavon

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(4), P. 115515 - 115515

Published: April 1, 2025

Preterm birth is a major concern in neonatal care, significantly impacting infant survival and long-term health. The gut microbiome, essential for development, often becomes imbalanced preterm infants, making it crucial to understand the effects of antibiotics on its development. Our study analyzed weekly, 6-month, 1-year stool samples from 100 correlating clinical data antibiotic use feeding patterns. Comparing infants who received no with those given empirical post-birth treatment, we observed notable alterations microbiome's composition an increase resistance gene abundance early life. Although these diminished over time, their impacts remain unclear. Human milk was associated beneficial microbiota like Actinobacteriota reduced genes, underscoring protective role. This highlights importance judicious promoting human foster healthy microbiome infants.

Language: Английский

Citations

0