Melatonin and its ubiquitous anticancer effects

Molecular and Cellular Biochemistry, Journal Year: 2019, Volume and Issue: 462(1-2), P. 133 - 155

Published: Aug. 26, 2019

Language: Английский

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Is Phytomelatonin a New Plant Hormone?

Agronomy, Journal Year: 2020, Volume and Issue: 10(1), P. 95 - 95

Published: Jan. 9, 2020

Melatonin (N-acetyl-5-methoxytryptamine) is of particular importance as a chronobiological hormone in mammals, acting signal darkness that provides information to the brain and peripheral organs. It an endogenous synchronizer for both endocrine (i.e., via neurotransmitter release) other physiological rhythms. In this work we will try add series scientific events discoveries made plants that, surprisingly, confirm great similarity action melatonin animals plants. The most relevant milestones on 25 years phytomelatonin studies are presented, from its discovery 1995 receptor 2018, suggesting it should be regarded new plant hormone.

Language: Английский

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Gut Microbiota’s Relationship with Liver Disease and Role in Hepatoprotection by Dietary Natural Products and Probiotics

Nutrients, Journal Year: 2018, Volume and Issue: 10(10), P. 1457 - 1457

Published: Oct. 8, 2018

A variety of dietary natural products have shown hepatoprotective effects. Increasing evidence has also demonstrated that gut microorganisms play an important role in the hepatoprotection contributed by products. Gut dysbiosis could increase permeability barrier, resulting translocated bacteria and leaked gut-derived products, which can reach liver through portal vein might lead to increased oxidative stress inflammation, thereby threatening health. Targeting microbiota modulation represents a promising strategy for hepatoprotection. Many protect from various injuries or mitigate hepatic disorders reverting dysbiosis, improving intestinal permeability, altering primary bile acid, inhibiting fatty acid accumulation. The mechanisms underlying their beneficial effects include reducing stress, suppressing attenuating fibrosis, decreasing apoptosis. This review discusses via modulating microbiota, mainly focusing on action.

Language: Английский

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Does Sars-Cov-2 threaten our dreams? Effect of quarantine on sleep quality and body mass index

Journal of Translational Medicine, Journal Year: 2020, Volume and Issue: 18(1)

Published: Aug. 18, 2020

Abstract Background COVID 19 - related quarantine led to a sudden and radical lifestyle changes, in particular eating habits. Objectives of the study were investigate effect on sleep quality (SQ) body mass index (BMI), if change SQ was working modalities. Materials We enrolled 121 adults (age 44.9 ± 13.3 years 35.5% males). Anthropometric parameters, modalities physical activity studied. Sleep evaluated by Pittsburgh Quality Index (PSQI) questionnaire. At baseline, subjects assessed outpatient clinic after 40 days quarantine/lockdown phone interview. Results Overall, 49.6% good sleepers (PSQI < 5) at baseline significantly decreased ( p 0.001). In detail, onset latency 0.001), efficiency = 0.03), disturbances daytime dysfunction 0.001) worsened. There also significant increase BMI values normal weight 0.023), grade I 0.027) II obesity 0.020). all cohort, 0.004). However, analyzing data according gender difference, males as well females which there only trend without reaching statistical significance (53.5% vs 25.6%; 0.015 50.0% 35.9%, 0.106; females, respectively). addition, smart resulted worsening SQ, particularly Conclusions Quarantine associated doing working, an values.

Language: Английский

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Melatonin Target Proteins: Too Many or Not Enough?

Frontiers in Endocrinology, Journal Year: 2019, Volume and Issue: 10

Published: Nov. 15, 2019

The neurohormone N-acetyl-5-methoxytryptamine, better known as melatonin, is a tryptophan derivative with wide range of biological effects that present in many organisms. These are believed to rely either on the chemical properties melatonin itself scavenger free radicals or binding protein targets. More than fifteen proteins, including receptors (MT1, MT2, Mel1c, CAND2, ROR, VDR), enzymes (QR2, MMP-9, pepsin, PP2A, PR-10 proteins), pores (mtPTP), transporters (PEPT1/2, Glut1) and other proteins (HBS, CaM, tubulin, calreticuline), have been suggested interact at sub-nanomolar millimolar concentrations. In this review we assemble for first time available information proposed targets discuss them comprehensive manner evaluate robustness these findings terms methodology, physiological relevance independent replication.

Language: Английский

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Impact of Melatonin on Skeletal Muscle and Exercise

Cells, Journal Year: 2020, Volume and Issue: 9(2), P. 288 - 288

Published: Jan. 24, 2020

Skeletal muscle disorders are dramatically increasing with human aging enormous sanitary costs and impact on the quality of life. Preventive therapeutic tools to limit onset progression frailty include nutrition physical training. Melatonin, indole produced at nighttime in pineal extra-pineal sites mammalians, has recognized anti-aging, anti-inflammatory, anti-oxidant properties. Mitochondria favorite target melatonin, which maintains them efficiently, scavenging free radicals reducing oxidative damage. Here, we discuss most recent evidence dietary melatonin efficacy age-related skeletal cellular, preclinical, clinical studies. Furthermore, analyze emerging activity. Finally, consider newest gut–muscle axis influence exercise probably microbiota. In our opinion, this review reinforces relevance as a safe nutraceutical that limits prolongs performance.

Language: Английский

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Functions of Melatonin during Postharvest of Horticultural Crops

Plant and Cell Physiology, Journal Year: 2021, Volume and Issue: 63(12), P. 1764 - 1786

Published: Dec. 14, 2021

Melatonin, a tryptophan-derived molecule, is endogenously generated in animal, plant, fungal and prokaryotic cells. Given its antioxidant properties, it involved myriad of signaling functions associated with various aspects plant growth development. In higher plants, melatonin (Mel) interacts regulators such as phytohormones, well reactive oxygen nitrogen species including hydrogen peroxide (H2O2), nitric oxide (NO) sulfide (H2S). It shows great potential biotechnological tool to alleviate biotic abiotic stress, delay senescence conserve the sensory nutritional quality postharvest horticultural products which are considerable economic importance worldwide. This review provides comprehensive overview biochemistry Mel, whose endogenous induction exogenous application can play an important role enhancing marketability hence earnings from crops.

Language: Английский

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Insight into the roles of melatonin in bone tissue and bone‑related diseases (Review)

International Journal of Molecular Medicine, Journal Year: 2021, Volume and Issue: 47(5)

Published: March 17, 2021

Bone‑related diseases comprise a large group of common diseases, including fractures, osteoporosis and osteoarthritis (OA), which affect number individuals, particularly the elderly. The progressive destruction loss alveolar bone caused by periodontitis is specific type loss, has high incidence markedly reduces quality life patients. With existing methods prevention treatment, mortality bone‑related are still gradually increasing, creating significant financial burden to societies worldwide. To prevent occurrence delay their progression or reverse injuries they cause, new alternative complementary treatments need be developed. Melatonin exerts numerous physiological effects, inducing anti‑inflammatory antioxidative functions, resetting circadian rhythms promoting wound healing tissue regeneration. also participates in health management cartilage. In present review, potential roles melatonin pathogenesis injury, osteoporosis, OA summarized. Furthermore, efficiency diversity regulatory effects highlighted benefits use for clinical treatment discussed.

Language: Английский

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Association Between Night-Shift Work and Cancer Risk: Updated Systematic Review and Meta-Analysis

Frontiers in Oncology, Journal Year: 2020, Volume and Issue: 10

Published: June 23, 2020

Background: Nightshift work introduces light at night and causes circadian rhythm among workers, who are considered to be increased risk of cancer. However, in the last two years, nine population-based studies reported insignificant associations between night-shift cancer risks. We aimed conduct an updated systematic review meta-analysis ascertain effect on incidence cancers. Methods: Our protocol was registered PROSPERO complied with Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA). Embase, PubMed Web Science databases were used comprehensively search published up May 31, 2019. The random-effect model (Der Simonian-Laird method) carried out combine estimates dose-response performed verify whether association a dose-dependent manner. Results: literature searching retrieved 1,660 publications. Included meta-analyses 57 eligible 8,477,849 participants (mean age 55 years; 2,560,886 men, 4,220,154 women 1,696,809 not mentioned). pooled results showed that associated breast (OR= 1.009, 95% CI=0.984-1.033), prostate (OR=1.027, CI=0.982-1.071), ovarian CI=0.942-1.113), pancreatic (OR=1.007, CI=0.910-1.104), colorectal (OR=1.016, CI=0.964-1.068), non-Hodgkin's lymph (OR=1.046, CI=0.994-1.098), stomach (OR=1.064, CI=0.971-1.157), while reduction lung (OR=0.949, CI=0.903-0.996), skin (OR=0.916, CI=0.879-0.953). found significantly elevated exposure night- shift work. Conclusion: This observational did find overall ever-exposure breast, ovarian, pancreatic, colorectal, Non-Hodgkin's lymph,

Language: Английский

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Recent advances in the utilization of tea active ingredients to regulate sleep through neuroendocrine pathway, immune system and intestinal microbiota

Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 63(25), P. 7598 - 7626

Published: March 10, 2022

Sleep disorders have received widespread attention nowadays, which been promoted by the accelerated pace of life, unhealthy diets and lack exercise in modern society. The chemical medications to improve sleep has shown serious side effects risks with high costs. Therefore, it is urgent develop efficient nutraceuticals from natural sources ensure quality as a sustainable strategy. As second most consumed beverage worldwide, health-promoting tea long widely recognized. However, modulatory effect teas on much less attention. Tea contains various sleep-modulating active ingredients such L-theanine (LTA), caffeine, polyphenols (TPP), pigments, polysaccharides (TPS) γ-aminobutyric acid (GABA). This review focuses potential influence main regulating mechanisms different sleep, including being absorbed small intestine then cross blood-brain barrier act neurons brain neurotransmitters, manipulating immune system further affect sleep-wake cycle levels cytokines, controlling gut microbes maintain homeostasis circadian rhythm. Current research progress limitations are summarized several future development directions also proposed. hopes provide new insights into elucidation sleep-regulating their tea-based functional foods for alleviating disorders. Highlights• Natural summarized.• Influences drinking or reviewed.• Three explained.• associations among nervous system, intestinal microbiota investigated.• developing delivery carriers

Language: Английский

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