Bone‐Targeted Exosomes: Strategies and Applications

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(18)

Published: March 7, 2023

Abstract As the global population ages, bone‐related diseases have increasingly become a major social problem threatening human health. Exosomes, as natural cell products, been used to treat due their superior biocompatibility, biological barrier penetration, and therapeutic effects. Moreover, modified exosomes exhibit strong bone‐targeting capabilities that may improve efficacy avoid systemic side effects, demonstrating promising translational potential. However, review of bone‐targeted is still lacking. Thus, recently developed for applications in this are focused. The biogenesis regulatory functions exosomes, constructive strategies bone‐targeting, effects introduced. By summarizing developments challenges It striven shed light on selection exosome different bone highlight potential future clinical orthopedics.

Language: Английский

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Significance of Melatonin in the Regulation of Circadian Rhythms and Disease Management

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(8), P. 5541 - 5571

Published: Jan. 11, 2024

Language: Английский

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ARTIFICIAL EMOTIONAL INTELLIGENCE MANAGEMENT SYSTEM: DIAGNOSTICS AND REHABILITATION

Published: Dec. 11, 2024

The authors consider the growing role of transport corridors and logistics interaction between RIC countries -Russia, India China, which is especially becoming relevant in light expansion BRICS to + format India's attempt build, together with United States, its own route Africa, Middle East Europe.

Language: Английский

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DNA-Based Hydrogels for Bone Regeneration: A Promising Tool for Bone Organoids

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101502 - 101502

Published: Jan. 19, 2025

DNA-based hydrogels stand out for bone regeneration due to their exceptional biocompatibility and programmability. These facilitate the formation of spatial structures through bulk hydrogel fabricating, microsphere formatting, 3D printing. Furthermore, microenvironment can be finely tuned by leveraging degradation products, nanostructure, targeting, delivery capabilities inherent materials. In this review, we underscore advantages hydrogels, detailing composition, gelation techniques, structure optimization. We then delineate three critical elements in promotion using hydrogels: (i) osteogenesis driven phosphate ions, plasmids, oligodeoxynucleotides (ODNs) that enhance mineralization promote gene protein expression; (ii) vascularization facilitated tetrahedral DNA nanostructures (TDNs) aptamers, which boosts expression targeted release; (iii) immunomodulation achieved loaded factors, TDNs, bound ions stimulate macrophage polarization exhibit antibacterial properties. With these properties, used construct organoids, providing an innovative tool disease modeling therapeutic applications tissue engineering. Finally, discuss current challenges future prospects, emphasizing potential impacts regenerative medicine.

Language: Английский

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Natural Compounds for Preventing Age-Related Diseases and Cancers

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7530 - 7530

Published: July 9, 2024

Aging is a multifaceted process influenced by hereditary factors, lifestyle, and environmental elements. As time progresses, the human body experiences degenerative changes in major functions. The external internal signs of aging manifest various ways, including skin dryness, wrinkles, musculoskeletal disorders, cardiovascular diseases, diabetes, neurodegenerative cancer. Additionally, cancer, like aging, complex disease that arises from accumulation genetic epigenetic alterations. Circadian clock dysregulation has recently been identified as an important risk factor for cancer development. Natural compounds herbal medicines have gained significant attention their potential preventing age-related diseases inhibiting progression. These demonstrate antioxidant, anti-inflammatory, anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects well circadian regulation. This review explores cancers, specific natural targeting key features these conditions.

Language: Английский

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The role of melatonin in the development of postmenopausal osteoporosis

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 7, 2022

Melatonin is an important endogenous hormone that modulates homeostasis in the microenvironment. Recent studies have indicated serum melatonin levels are closely associated with occurrence and development of osteoporosis postmenopausal women. Exogenous could also improve bone mass increase skeletal strength. To determine underlying mechanisms prevention treatment osteoporosis, we performed this review to analyze role metabolism according its physiological functions. Serum related mass, measurement which a potential method for diagnosis osteoporosis. has direct effect on remodeling by promoting osteogenesis suppressing osteoclastogenesis. regulates biological rhythm tissue, benefits osteogenic effect. Additionally, participates modulation attenuates damage induced oxidative stress inflammation osteoblasts prevents osteolysis from reactive oxygen species inflammatory factors. As alternative drug can gut ecology, remodel microbiota composition, regulate substance absorption maintain metabolic balance, all beneficial health structure. In conclusion, our systematically demonstrates effects metabolism. Based evidence review, will play more diagnosis,

Language: Английский

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The Role of Inflammasome NLPR3 in the Development and Therapy of Periodontitis

International Journal of Medical Sciences, Journal Year: 2022, Volume and Issue: 19(10), P. 1603 - 1614

Published: Jan. 1, 2022

Periodontitis is a chronic inflammatory disease that affects tooth-supporting tissues and even leads to tooth loss.NLRP3 inflammasomes play critical role in periodontitis pathogenesis.Aberrant activation or overexpression of NLRP3 cellular players, including osteoclasts, osteoblasts, periodontal ligament fibroblasts, leukocytes often contributes dysfunction environment abnormality, thus resulting the disorganization alveolar bone.In this review, we mainly focus on negative regulation inflammasome highlight importance as candidate therapeutic target treatment.Then elucidate development status inhibitors show their application potential for treating periodontitis.In summary, review reveals recent progress perspectives periodontitis.

Language: Английский

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Daytime administration of melatonin has better protective effects on bone loss in ovariectomized rats

Journal of Orthopaedic Surgery and Research, Journal Year: 2023, Volume and Issue: 18(1)

Published: March 23, 2023

Abstract Objective To explore the difference in protective effects of intraperitoneal injection exogenous melatonin daytime or nighttime on bone loss ovariectomized (OVX) rats. Methods After bilateral ovariectomy and sham surgery, 40 rats were randomly divided into four groups: operation group (Sham), (OVX), (OVX + DMLT, 9:00, 30 mg/kg/d) NMLT, 22:00, mg/kg/d). 12 weeks treatment, sacrificed. The distal femur, blood femoral marrow cavity contents saved. rest samples tested by Micro-CT, histology, biomechanics molecular biology. Blood was used for metabolism marker measurements. CCK-8, ROS, Cell apoptosis are performed using MC3E3-T1 cells. Results Compared with treatment at night, mass OVX significantly increased after administration. All microscopic parameters trabecular increased, only Tb.Sp decreased. Histologically, microarchitecture DMLT also more dense than LMLT. In biomechanical experiment, femur day able to withstand greater loads deformation. biology experiments, formation-related molecules while resorption-related administration expression MT-1β cell cells treated low-dose MLT had higher viability efficiency inhibiting ROS production high-dose MLT, which turn effectively inhibited apoptosis. Conclusion Daytime acquires better night

Language: Английский

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Melatonin and bone-related diseases: an updated mechanistic overview of current evidence and future prospects

Osteoporosis International, Journal Year: 2023, Volume and Issue: 34(10), P. 1677 - 1701

Published: July 2, 2023

Language: Английский

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The short-term and long-term adverse effects of melatonin treatment in children and adolescents: a systematic review and GRADE assessment

EClinicalMedicine, Journal Year: 2023, Volume and Issue: 61, P. 102083 - 102083

Published: July 1, 2023

Summary

Background

Currently, melatonin is used to treat children and adolescents with insomnia without knowing the full extent of short-term long-term consequences. Our aim was provide clinicians guideline panels a systematic assessment serious—and non-serious adverse events seen in continuation treatment impact on pubertal development bone health following administration chronic insomnia.

Methods

We searched PubMed, Embase, Cinahl PsycINFO via Ovid, up March 17, 2023, for studies among (aged 5–20 years) The language restricted English, Danish, Norwegian, Swedish. Outcomes were serious assessed 2–4 weeks after initiating health, no restriction definition or time measurement. Observational included outcomes, randomised studies. certainty evidence using Grades Recommendation, Assessment, Development Evaluation (GRADE). protocol registered Danish Health Authority.

Findings

identified 22 1350 patients reporting four observational total 105 development. Melatonin not associated events, yet number experiencing increased (Relative risk 1.56, 95% CI 1.01–2.43, 17 studies, I² = 47%). Three reported little influence years treatment, whereas one study potential delay longer durations (>7 years). These findings need further evaluation due several methodological limitations.

Interpretation

Children who use are likely experience actual which leads consequences remain uncertain. This major gap knowledge safety calls caution against complacent more research inform this key issue.

Funding

Parker Institute, Bispebjerg Frederiksberg Hospital, supported by Oak Foundation.

Language: Английский

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