Life,
Journal Year:
2023,
Volume and Issue:
13(8), P. 1730 - 1730
Published: Aug. 11, 2023
Quercetin
is
a
flavonoid
present
in
apples,
onions,
tea,
red
wines,
and
berries,
it
has
shown
different
beneficial
effects,
such
as
providing
cardiovascular
protection,
possessing
anti-inflammatory
properties,
demonstrating
anticancer
activity,
among
others.
These
diseases
are
related
to
oxidizing
molecules
ROS
because
these
species
react
induce
the
oxidation
of
cellular
biomolecules,
proteins,
lipids,
DNA,
or
carbohydrates,
which
alters
homeostasis.
Regarding
induces
lipid
hydroperoxides
which,
if
not
decreased,
particularly
by
GPX4,
produce
highly
reactive
aldehydes
4HNE
MDA.
oxidative
conditions
ferroptosis,
type
cell
death
associated
with
that
differs
from
other
types
death,
apoptosis,
necrosis,
autophagy.
The
induction
ferroptosis
desired
some
diseases,
cancer,
but
others,
this
wanted.
possible
effects
quercetin
reducing
inducing
have
been
reviewed.
Thus,
review
focuses
on
ability
cancer
treatment
option
and,
conversely,
its
role
deactivating
alleviate
diseases.
Archives of Toxicology,
Journal Year:
2024,
Volume and Issue:
98(5), P. 1323 - 1367
Published: March 14, 2024
Abstract
Reactive
oxygen
species
(ROS)
and
reactive
nitrogen
(RNS)
are
well
recognized
for
playing
a
dual
role,
since
they
can
be
either
deleterious
or
beneficial
to
biological
systems.
An
imbalance
between
ROS
production
elimination
is
termed
oxidative
stress,
critical
factor
common
denominator
of
many
chronic
diseases
such
as
cancer,
cardiovascular
diseases,
metabolic
neurological
disorders
(Alzheimer’s
Parkinson’s
diseases),
other
disorders.
To
counteract
the
harmful
effects
ROS,
organisms
have
evolved
complex,
three-line
antioxidant
defense
system.
The
first-line
mechanism
most
efficient
involves
enzymes
superoxide
dismutase
(SOD),
catalase
(CAT),
glutathione
peroxidase
(GPx).
This
line
plays
an
irreplaceable
role
in
dismutation
radicals
(O
2
·−
)
hydrogen
peroxide
(H
O
).
removal
by
SOD
prevents
formation
much
more
damaging
peroxynitrite
ONOO
−
+
NO
·
→
maintains
physiologically
relevant
level
nitric
oxide
(NO
),
important
molecule
neurotransmission,
inflammation,
vasodilation.
second-line
pathway
exogenous
diet-derived
small-molecule
antioxidants.
third-line
ensured
repair
oxidized
proteins
biomolecules
variety
enzyme
review
briefly
discusses
endogenous
(mitochondria,
NADPH,
xanthine
oxidase
(XO),
Fenton
reaction)
(e.g.,
smoking,
radiation,
drugs,
pollution)
sources
(superoxide
radical,
peroxide,
hydroxyl
peroxyl
hypochlorous
acid,
peroxynitrite).
Attention
has
been
given
system
provided
SOD,
CAT,
GPx.
chemical
molecular
mechanisms
enzymes,
enzyme-related
(cancer,
cardiovascular,
lung,
metabolic,
GPx4)
cellular
processes
ferroptosis
discussed.
Potential
therapeutic
applications
mimics
recent
progress
metal-based
(copper,
iron,
cobalt,
molybdenum,
cerium)
nonmetal
(carbon)-based
nanomaterials
with
enzyme-like
activities
(nanozymes)
also
Moreover,
attention
action
low-molecular-weight
antioxidants
(vitamin
C
(ascorbate),
vitamin
E
(alpha-tocopherol),
carotenoids
β-carotene,
lycopene,
lutein),
flavonoids
quercetin,
anthocyanins,
epicatechin),
(GSH)),
activation
transcription
factors
Nrf2,
protection
against
diseases.
Given
that
there
discrepancy
preclinical
clinical
studies,
approaches
may
result
greater
pharmacological
success
therapies
subject
discussion.
Acta Pharmaceutica Sinica B,
Journal Year:
2023,
Volume and Issue:
13(10), P. 3988 - 4024
Published: July 16, 2023
In
recent
years,
growing
awareness
of
the
role
oxidative
stress
in
brain
health
has
prompted
antioxidants,
especially
dietary
to
receive
attention
as
possible
treatments
strategies
for
patients
with
neurodegenerative
diseases
(NDs).
The
most
widely
studied
antioxidants
include
active
substances
such
vitamins,
carotenoids,
flavonoids
and
polyphenols.
Dietary
are
found
usually
consumed
foods
fresh
fruits,
vegetables,
nuts
oils
gaining
popularity
due
recently
their
potential
preventive
protective
agents
against
NDs,
well
abundant
natural
sources,
generally
non-toxic
nature,
ease
long-term
consumption.
This
review
article
examines
development
explores
‘two-sidedness’
blood–brain
barrier
(BBB)
a
nervous
system
an
impeding
use
drug
medicinal
products
and/or
supplements
prevention
therapy
reviews
BBB
permeability
common
suplements
efficacy
treatment
NDs.
Finally,
current
challenges
future
directions
NDs
using
discussed,
useful
information
on
is
provided.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(19), P. 14876 - 14876
Published: Oct. 4, 2023
SARS-CoV-2
infection,
discovered
and
isolated
in
Wuhan
City,
Hubei
Province,
China,
causes
acute
atypical
respiratory
symptoms
has
led
to
profound
changes
our
lives.
COVID-19
is
characterized
by
a
wide
range
of
complications,
which
include
pulmonary
embolism,
thromboembolism
arterial
clot
formation,
arrhythmias,
cardiomyopathy,
multiorgan
failure,
more.
The
disease
caused
worldwide
pandemic,
despite
various
measures
such
as
social
distancing,
preventive
strategies,
therapeutic
approaches,
the
creation
vaccines,
novel
coronavirus
infection
(COVID-19)
still
hides
many
mysteries
for
scientific
community.
Oxidative
stress
been
suggested
play
an
essential
role
pathogenesis
COVID-19,
determining
free
radical
levels
patients
with
may
provide
insight
into
severity.
generation
abnormal
oxidants
under
COVID-19-induced
cytokine
storm
irreversible
oxidation
macromolecules
subsequent
damage
cells,
tissues,
organs.
Clinical
studies
have
shown
that
oxidative
initiates
endothelial
damage,
increases
risk
complications
post-COVID-19
or
long-COVID-19
cases.
This
review
describes
radicals
mediation
mitochondrial
dysfunction.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(4), P. 942 - 942
Published: April 17, 2023
Major
depressive
disorder
(MDD)
is
currently
the
main
cause
of
disability
worldwide,
but
its
pathophysiology
remains
largely
unknown,
especially
given
high
heterogeneity
in
terms
clinical
phenotypes
and
biological
characteristics.
Accordingly,
management
still
poor.
Increasing
evidence
suggests
that
oxidative
stress,
measured
on
various
matrices
such
as
serum,
plasma
or
erythrocytes,
has
a
critical
role
MDD.
The
aim
this
narrative
review
to
identify
erythrocyte
biomarkers
stress
MDD
patients
according
disease
stage
features.
Sixty-three
articles
referenced
PubMed
Embase
between
1
January
1991,
31
December
2022,
were
included.
Modifications
antioxidant
enzymes
(mainly
glutathione
peroxidase
superoxide
dismutase)
highlighted.
Non-enzymatic
antioxidants
uric
acid)
decreased
depressed
compared
healthy
controls.
These
changes
associated
with
an
increase
reactive
oxygen
species.
Therefore,
increased
damage
products
(principally
malondialdehyde,
protein
carbonyl
content
8-hydroxy-2′-deoxyguanosine)
present
patients.
Specific
modifications
could
be
identified
stages
Interestingly,
antidepressant
treatment
corrected
these
changes.
remission
from
depression,
markers
globally
normalized.
This
particular
interest
for
care
may
contribute
provide
opportunity
find
new
therapeutic
targets.
Biology,
Journal Year:
2023,
Volume and Issue:
12(8), P. 1139 - 1139
Published: Aug. 17, 2023
Traumatic
brain
injury
(TBI)
is
one
of
the
leading
causes
long-lasting
morbidity
and
mortality
worldwide,
being
a
devastating
condition
related
to
impairment
nervous
system
after
an
external
traumatic
event
resulting
in
transitory
or
permanent
functional
disability,
with
significant
burden
healthcare
system.
Harmful
events
underlying
TBI
can
be
classified
into
two
sequential
stages,
primary
secondary,
which
are
both
associated
breakdown
tissue
homeostasis
due
blood–brain
barrier,
osmotic
imbalance,
inflammatory
processes,
oxidative
stress,
excitotoxicity,
apoptotic
cell
death,
ultimately
loss
functionality.
The
present
study
provides
updated
review
concerning
roles
edema,
inflammation,
stress
on
changes
from
TBI.
proper
characterization
phenomena
contribute
improvement
care,
rehabilitation
quality
life
affected
people.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(5), P. 2600 - 2600
Published: Feb. 23, 2024
Free
radicals
(FRs)
are
unstable
molecules
that
cause
reactive
stress
(RS),
an
imbalance
between
oxygen
and
nitrogen
species
in
the
body
its
ability
to
neutralize
them.
These
generated
by
both
internal
external
factors
can
damage
cellular
lipids,
proteins,
DNA.
Antioxidants
prevent
or
slow
down
oxidation
process
interrupting
transfer
of
electrons
substances
agents.
This
is
particularly
important
at
level
because
reactions
lead
formation
FR
contribute
various
diseases.
As
we
age,
RS
accumulates
leads
organ
dysfunction
age-related
disorders.
Polyphenols;
vitamins
A,
C,
E;
selenoproteins
possess
antioxidant
properties
may
have
a
role
preventing
treating
certain
human
diseases
associated
with
RS.
In
this
review,
explore
current
evidence
on
potential
benefits
dietary
supplementation
investigate
intricate
connection
SIRT1,
crucial
regulator
aging
longevity;
transcription
factor
NRF2;
polyphenols,
vitamins,
selenium.
Finally,
discuss
positive
effects
molecules,
such
as
reducing
RS,
their
slowing
several
Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
2024, P. 1 - 21
Published: May 31, 2024
Absorption
of
free
radicals
in
the
body
cannot
be
done
by
antioxidant
compounds
originating
from
human
body,
so
exogenous
antioxidants
are
required
to
help
their
natural
action.
Oxidative
stress
can
caused
an
imbalance
radical
inhibitors
and
accumulation
that
enter
cellular
structures.
Synthetic
found
external
not
primary
choice
because
they
harmful
carcinogenic.
Therefore,
using
ingredients
provides
a
necessary
alternative
constructing
novel
antioxidants.
Recent
studies
have
highlighted
critical
analysis
evaluation
flavonoids
unique
class
secondary
metabolites
plants
used
communities
as
traditional
therapeutics
with
proven
bioactivity.
This
could
support
new
discoveries
based
on
various
herbal
medicines
addition,
functional
effectiveness
against
radicals.
In
this
review,
there
several
strengths
discussion.
First,
study
takes
comprehensive
approach
covering
aspects,
including
properties
sources
radicals,
oxidative
relation
different
diseases,
defense
mechanisms,
specific
mechanisms
flavonoids.
Second,
focus
antioxidants,
especially
flavonoids,
also
discussion
about
clinical
applications
studies,
limitations,
global
perspectives,
future
research
directions
become
references
selection
medicines.
But,
constraints
should
considered
when
interpreting
findings
review.
mechanism
is
only
discussed
general
one
example
compound
(flavonoid)
has
potential
antioxidant.
lack
regarding
relationship
between
diseases
Third,
limited
number
investigated
some
discussed.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(5), P. 1071 - 1071
Published: May 10, 2023
Obesity
is
a
chronic
low-grade
inflammatory
condition
that
induces
the
generation
of
oxidative
stress
and
inflammation.
This
inflammation
stimulate
brain
atrophy
some
morphological
changes
in
eventually
result
cognitive
impairments.
However,
there
no
exact
study
has
summarized
role
obesity
its
impact
on
Thus,
objective
this
review
to
recapitulate
current
decline
based
vivo
evidence.
A
comprehensive
search
was
performed
Nature,
Medline
Ovid,
ScienceDirect,
PubMed,
limited
past
10
years
publication.
From
search,
we
identified
27
articles
be
further
reviewed.
The
outcome
indicates
greater
amount
fat
stored
individual
adipocytes
formation
reactive
oxygen
species
will
lead
stress,
which
may
cause
brain,
suppress
endogenous
antioxidant
system,
promote
neuroinflammation
and,
eventually,
neuronal
apoptosis.
impair
normal
function
specific
regions
are
involved
learning,
as
well
memory.
shows
strong
positive
correlation
with
Hence,
summarizes
mechanism
induce
memory
loss
animal
model
In
conclusion,
serve
an
insight
into
therapeutic
development
focusing
pathways
manage
obesity-induced
future.
