Decreased susceptibility to vancomycin and other mechanisms of resistance to antibiotics in Staphylococcus epidermidis as a therapeutic problem in hospital treatment DOI Creative Commons
Magdalena Szemraj, Paulina Glajzner, Monika Sienkiewicz

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Aug. 21, 2023

Multidrug-resistant coagulase-negative staphylococci represent a real therapeutic challenge. The aim of the study was to emphasize importance heteroresistance vancomycin presence in methicillin-resistant strains S. epidermidis. research comprised 65 Heteroresistance detected with use agar screening method Brain Heart Infusion and population profile analysis (PAP test). In addition, types cassettes genes responsible for resistance antibiotics 22 multidrug resistant were determined. Our investigations showed that 56 epidermidis phenotypically methicillin. tested mostly erythromycin, gentamicin, clindamycin, ciprofloxacin. Six decreased susceptibility their heterogeneous profiles confirmed PAP test. All multi-resistant exhibited mecA gene. More than half them possessed type IV cassettes. ant(4')-Ia aac(6')/aph(2''), ermC tetK most commonly found. described phenomenon bacteria Staphylococcus genus effectively inhibits effect treatment this antibiotic. That is why it so important search markers will enable identify under laboratory conditions.

Language: Английский

Look Who’s Talking: Host and Pathogen Drivers of Staphylococcus epidermidis Virulence in Neonatal Sepsis DOI Open Access
I.A. Joubert, Michaël Otto, Tobias Strunk

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(2), P. 860 - 860

Published: Jan. 13, 2022

Preterm infants are at increased risk for invasive neonatal bacterial infections. S. epidermidis, a ubiquitous skin commensal, is major cause of late-onset sepsis, particularly in high-resource settings. The vulnerability preterm to serious infections commonly attributed their distinct and developing immune system. While developmentally immature defences play large role facilitating invasion, this fails explain why only subset develop with low-virulence organisms when exposed similar factors the ICU. Experimental research has explored potential virulence mechanisms contributing pathogenic shift commensal epidermidis strains. Furthermore, comparative genomics studies have yielded insights into emergence spread nosocomial strains, genetic functional characteristics implicated disease neonates. These highlighted multifactorial nature traits relating pathogenicity commensalism. In review, we discuss known host pathogen drivers sepsis provide future perspectives close gap our understanding as morbidity mortality.

Language: Английский

Citations

27
Exploring the potential of metal-doped perovskite-oxides as oxygen reduction catalyst for enhancing the performance of microbial desalination cells DOI
Richa Tomar, Tahseena Naaz, Soumya Pandit

et al.

Fuel, Journal Year: 2023, Volume and Issue: 356, P. 129451 - 129451

Published: Aug. 23, 2023

Language: Английский

Citations

13
Staphylococcus epidermidis: Antimicrobial Resistance Profiles of Biofilm‐Forming Isolates From Pediatric Bacteremia in Pakistan DOI Creative Commons

Maleeha Nisar,

Hazir Rahman, Saghir Ahmad

et al.

Journal of Tropical Medicine, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Background: Staphylococcus epidermidis is an important cause of nosocomial infections in children. The study undertaken identified antibiotic resistance markers among biofilm‐forming S. epidermidis. Methods: A total 105 bacteremia‐positive samples from hospitalized children were processed for identification using species‐specific rdr gene. Phenotypic was checked through Kirby–Bauer disc diffusion method. 96‐well microtiter plate assays and PCR used biofilm production antibiotic‐resistant genes, respectively. Results: Among clinical isolates, gene detected 34 (32.38%) isolates. isolates exhibited formation ( n = 34; 100%). Multidrug‐resistant (MDR) pattern observed , while the frequency MDR higher very strong 18; 52.9%, p ≤ 0.002) as compared to weak 6; 17.6%). All strains resistant cefoxitin, penicillin, augmentin High against erythromycin 29; 85.29%) ciprofloxacin 25; 73.5%). displayed complete susceptibility 100%) toward vancomycin, tetracycline, linezolid. methicillin mecA 85.2%, 0.000), msrA 19; 55.7%) beta‐lactamase blaZ 17; 50%) detected. Detection 94.4%), 8; 44.4%) 11; 61.1%) significantly 0.0052) correlated with . Conclusion: Biofilm associated resistance. study’s result will help understand molecular mechanism antimicrobial pediatric patients.

Language: Английский

Citations

0
The complexity of Staphylococcus epidermidis molecular epidemiology in neonatal intensive care units (NICU) as revealed by genomic approaches DOI

Roberta Filipini Rampelotto,

Nuno A. Faria,

Rosmari Hörner

et al.

Journal of Hospital Infection, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Frequency and Molecular Characterization of Staphylococcus aureus from Placenta of Mothers with Term and Preterm Deliveries DOI Creative Commons
Hafiz Muhammad Umer Farooqi, Kyung Hwan Kim, Farzana Kausar

et al.

Life, Journal Year: 2022, Volume and Issue: 12(2), P. 257 - 257

Published: Feb. 9, 2022

Globally, prematurity is the leading cause of neonatal mortality (babies in first four weeks life) and now second after pneumonia children under age five. The gut microbial colonization crucial human life cycle. Placental microbiota transmits from plays a significant role association with kinship. Simultaneously, this transition being made mother to infant. This comparative study explored diversity associated term preterm neonates by evaluating placental samples. found that 16/68 (23.5%) full-term samples were positive for S. aureus; on other hand, 4/16 (25%) confirmed culture growth aureus. Antimicrobial susceptibility patterns showed Staphylococcusaureus (S. aureus) isolates both types resistant Ofloxacin, Trimethoprim-sulfamethoxazole, Oxacillin, Cefoxitin. However, Methicillin-Resistant Staphylococcus aureus (MRSA) detection was 43.75% 75% Moreover, two mecA PVL virulent genes, rest only gene. Interestingly few lacked characteristic MRSA PVL. Notably, resistances more inclined towards antimicrobial screening. It may be concluded there presence placenta mothers deliveries which might responsible deliveries. Therefore, judicious use antibiotics during pregnancies help prevent births.

Language: Английский

Citations

13
A new approach to overcoming antibiotic-resistant bacteria: Traditional Chinese medicine therapy based on the gut microbiota DOI Creative Commons
Peng Xue, Rui Sang, Nan Li

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: April 6, 2023

With the irrational use of antibiotics and increasing abuse oral antibiotics, drug resistance gastrointestinal pathogens has become a prominent problem in clinical practice. Gut microbiota plays an important role maintaining human health, change also affects activity pathogenic bacteria. Interfering with antibiotic resistant bacteria by affecting gut regulatory signal. In application, due to unique advantages traditional Chinese medicine sterilization resistance, it is possible for improve microbial microenvironment. This review discusses strategies treatment drug-resistant bacterial infections changing microenvironment, unlocking interaction between

Language: Английский

Citations

7
Decreased susceptibility to vancomycin and other mechanisms of resistance to antibiotics in Staphylococcus epidermidis as a therapeutic problem in hospital treatment DOI Creative Commons
Magdalena Szemraj, Paulina Glajzner, Monika Sienkiewicz

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Aug. 21, 2023

Multidrug-resistant coagulase-negative staphylococci represent a real therapeutic challenge. The aim of the study was to emphasize importance heteroresistance vancomycin presence in methicillin-resistant strains S. epidermidis. research comprised 65 Heteroresistance detected with use agar screening method Brain Heart Infusion and population profile analysis (PAP test). In addition, types cassettes genes responsible for resistance antibiotics 22 multidrug resistant were determined. Our investigations showed that 56 epidermidis phenotypically methicillin. tested mostly erythromycin, gentamicin, clindamycin, ciprofloxacin. Six decreased susceptibility their heterogeneous profiles confirmed PAP test. All multi-resistant exhibited mecA gene. More than half them possessed type IV cassettes. ant(4')-Ia aac(6')/aph(2''), ermC tetK most commonly found. described phenomenon bacteria Staphylococcus genus effectively inhibits effect treatment this antibiotic. That is why it so important search markers will enable identify under laboratory conditions.

Language: Английский

Citations

3