Carcinogenetic mechanisms employed by the oral microbiome: a narrative review

The American Journal of the Medical Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Mechanisms and Potential Clinical Implications of Oral Microbiome in Oral Squamous Cell Carcinoma

Current Oncology, Journal Year: 2023, Volume and Issue: 31(1), P. 168 - 182

Published: Dec. 28, 2023

Microorganisms in the oral cavity are abundant human body. At present, more than 700 species of microorganisms have been identified. Recently, a lot literature has indicated that microbiota plays an important role occurrence, development, and prognosis squamous cell carcinoma (OSCC) through various mechanisms. And researchers now trying to utilize cancer diagnosis treatment. However, few articles systematically summarize effects microbes diagnosis, treatment, disease outcomes cancer. Herein, we made summary microbial changes at cancerous sites placed emphasis on mechanisms by which microbiome promotes cancerization. Moreover, aimed find out clinical value OSCC.

Language: Английский

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Microbial Signatures in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma: Implications of Tobacco and Betel Quid Consumption

Journal of Oral Biosciences, Journal Year: 2025, Volume and Issue: unknown, P. 100656 - 100656

Published: March 1, 2025

Language: Английский

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Pathological primary tumor status, rather than adjuvant therapy, predicts survival outcomes in pT1–3N1M0 oral cavity squamous cell carcinoma: A nationwide cohort study

Oral Oncology, Journal Year: 2025, Volume and Issue: 164, P. 107289 - 107289

Published: April 5, 2025

Language: Английский

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Gut microbiota and oral cavity cancer: a two-sample bidirectional Mendelian randomization study

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: May 30, 2024

This study employs a two-sample bidirectional Mendelian randomization (MR) approach to systematically evaluate the causal relationship between gut microbiota and oral cavity cancer (OCC). Objective To address challenge in establishing OCC, we applied systematic MR analysis. Methods Utilizing GWAS data from MiBioGen consortium (18,340 individuals) UK Biobank (n = 264,137), selected instrumental variables employed MR-Egger, weighted median, IVW, mode analyses. Heterogeneity pleiotropy were assessed using Cochran’s Q test MR-Egger intercept test. Results Our findings indicate, at order level, Bacteroidales (OR 0.9990, 95% CI 0.9980–1.0000, P 0.046 ), Burkholderiales 1.0009, 1.0001–1.0018, 0.033 Victivallales 0.9979, 0.9962–0.9995, 0.037 ) exhibit causality on OCC Weighted analyses, respectively. At family Alcaligenaceae 1.0012, 1.0004–1.0019, 0.002 Clostridiaceae1 0.9970, 0.9948–0.9992, 0.027 show IVW genus Clostridiumsensustricto1 (IVW, OR 0.9987, 0.9980–0.9995, 0.001 ; 0.9978, 0.035 Desulfovibrio 1.0008, 1.0001–1.0015, 0.016 Eggerthella 0.9995, 0.9990–1.0000, 0.048 Eubacterium fissicatena group 1.0005, 1.0000–1.0009, 0.032 Holdemanella 0.9994, 0.9989–0.9999, 0.018 are implicated causing related Conclusion identifies order, family, genus, as causally increasing risk. In contrast, associated with decreased However, further investigations essential delineate an optimal composition unravel underlying mechanisms of specific bacterial taxa pathophysiology.

Language: Английский

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The role of the microbiome in head and neck squamous cell cancers

European Archives of Oto-Rhino-Laryngology, Journal Year: 2024, Volume and Issue: 282(2), P. 623 - 637

Published: Sept. 21, 2024

Language: Английский

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