Curcumin: Biological Activities and Modern Pharmaceutical Forms

Antibiotics, Journal Year: 2022, Volume and Issue: 11(2), P. 135 - 135

Published: Jan. 20, 2022

Curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione) is a natural lipophilic polyphenol that exhibits significant pharmacological effects in vitro and vivo through various mechanisms of action. Numerous studies have identified characterised the pharmacokinetic, pharmacodynamic, clinical properties curcumin. has an anti-inflammatory, antioxidative, antinociceptive, antiparasitic, antimalarial effect, it used as wound-healing agent. However, poor curcumin absorption small intestine, fast metabolism, systemic elimination cause bioavailability human beings. In order to overcome these problems, number formulations been developed. The aim this paper provide overview recent research biological pharmaceutical aspects curcumin, methods sample preparation for its isolation (Soxhlet extraction, ultrasound pressurised fluid microwave enzyme-assisted aided extraction), analytical (FTIR, NIR, FT-Raman, UV-VIS, NMR, XRD, DSC, TLC, HPLC, HPTLC, LC-MS, UPLC/Q-TOF-MS) identification quantification different matrices, techniques developing formulations. optimal use appropriate method will significantly improve evaluation activity

Language: Английский

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Curcumin and its uses in active and smart food packaging applications - a comprehensive review

Food Chemistry, Journal Year: 2021, Volume and Issue: 375, P. 131885 - 131885

Published: Dec. 17, 2021

Language: Английский

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Preventing Microbial Infections with Natural Phenolic Compounds

Future Pharmacology, Journal Year: 2022, Volume and Issue: 2(4), P. 460 - 498

Published: Nov. 2, 2022

The struggle between humans and pathogens has taken is continuing to take countless lives every year. As the misusage of conventional antibiotics increases, complexity associated with resistance mechanisms been evolving into gradually more clever mechanisms, diminishing effectiveness antibiotics. Hence, there a growing interest in discovering novel reliable therapeutics able infection, circumvent defend natural microbiome. In this regard, nature-derived phenolic compounds are gaining considerable attention due their potential safety therapeutic effect. Phenolic comprise numerous widely distributed groups different biological activities attributed mainly structure. Investigations have revealed that from sources exhibit potent antimicrobial activity against various clinically relevant microbial infection sensitize multi-drug strains bactericidal or bacteriostatic This review outlines current knowledge about sources, particular focus on structure-activity relationship actions each class compounds, including simple phenols, acids, coumarin, flavonoids, tannins, stilbenes, lignans, quinones, curcuminoids.

Language: Английский

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The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence

Antioxidants, Journal Year: 2022, Volume and Issue: 11(7), P. 1224 - 1224

Published: June 22, 2022

Cellular senescence is an irreversible state of cell cycle arrest occurring in response to stressful stimuli, such as telomere attrition, DNA damage, reactive oxygen species, and oncogenic proteins. Although beneficial protective several physiological processes, excessive senescent burden has been involved various pathological conditions including aging, tissue dysfunction chronic diseases. Oxidative stress (OS) can drive due a loss balance between pro-oxidant stimuli antioxidant defences. Therefore, the identification characterization compounds capable preventing or counteracting phenotype major interest. However, despite considerable number studies, comprehensive overview main molecules OS-induced still lacking. Here, besides brief description molecular mechanisms implicated OS-mediated we review discuss role enzymes, mitochondria-targeting compounds, vitamins, carotenoids, organosulfur nitrogen non-protein molecules, minerals, flavonoids, non-flavonoids with anti-aging potential, therefore offering insights into innovative lifespan-extending approaches.

Language: Английский

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Introduction to Traditional Medicine and Their Role in Prevention and Treatment of Emerging and Re-Emerging Diseases

Biomolecules, Journal Year: 2022, Volume and Issue: 12(10), P. 1442 - 1442

Published: Oct. 9, 2022

Infectious diseases have been a threat to human health globally. The relentless efforts and research enabled us overcome most of the through use antiviral antibiotic agents discovered employed. Unfortunately, microorganisms capability adapt mutate over time resistance ensues. There are many challenges in treating infections such as failure respond therapeutic agents, which has led more chronic infections, complications, preventable loss life. Thus, multidisciplinary approach collaboration is warranted create potent, effective, versatile therapies prevent eradicate old newly emerging diseases. In recent past, natural medicine proven its effectiveness against various illnesses. Most pharmaceutical currently used can trace their origin products one way, shape, or form. full potential yet be realized, numerous resources not explored analyzed. This merits continuous support analysis ancient treatment systems explore employ them an alternative principal therapy.

Language: Английский

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Curcumin a Natural Phenol and Its Therapeutic Role in Cancer and Photodynamic Therapy: A Review

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 639 - 639

Published: Feb. 14, 2023

Cancer continues to cause an alarming number of deaths globally, and its burden on the health system is significant. Though different conventional therapeutic procedures are exploited for cancer treatment, prevalence death rates remain elevated. These, therefore, insinuate that novel more efficient treatment needed cancer. Curcumin, a bioactive, natural, phenolic compound isolated from rhizome herbaceous plant turmeric, receiving great interest exciting broad pharmacological properties. Curcumin presents anticancer capacities can be utilized as photosensitizing drug in photodynamic therapy (PDT). Nonetheless, curcumin′s poor bioavailability related pharmacokinetics limit clinical utility treatment. This review looks at physical chemical properties, bioavailability, safety curcumin, while focusing curcumin agent photosensitizer PDT. The possible mechanisms cellular targets PDT highlighted. Furthermore, recent improvements curcumin’s using nanoformulations delivery systems presented.

Language: Английский

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Curcumin: Overview of Extraction Methods, Health Benefits, and Encapsulation and Delivery Using Microemulsions and Nanoemulsions

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(10), P. 8874 - 8874

Published: May 17, 2023

Curcumin is the principal curcuminoid found in rhizomes of turmeric. Due to its therapeutic action against cancer, depression, diabetes, some bacteria, and oxidative stress, it has been used widely medicine since ancient times. low solubility, human organism cannot completely absorb it. Advanced extraction technologies, followed by encapsulation microemulsion nanoemulsion systems, are currently being improve bioavailability. This review discusses different methods available for curcumin from plant material, identification resulting extracts, beneficial effects on health, techniques into small colloidal systems that have over past decade deliver this compound.

Language: Английский

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Receptor Tyrosine Kinases and Their Signaling Pathways as Therapeutic Targets of Curcumin in Cancer

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: Nov. 15, 2021

Receptor tyrosine kinases (RTKs) are transmembrane cell-surface proteins that act as signal transducers. They regulate essential cellular processes like proliferation, apoptosis, differentiation and metabolism. RTK alteration occurs in a broad spectrum of cancers, emphasising its crucial role cancer progression suitable therapeutic target. The use small molecule inhibitors however, has been crippled by the emergence resistance, highlighting need for pleiotropic anti-cancer agent can replace or be used combination with existing pharmacological agents to enhance treatment efficacy. Curcumin is an attractive mainly due potent effects, extensive range targets minimal toxicity. Out numerous documented curcumin, RTKs appear one main nodes curcumin-mediated inhibition. Many studies have found curcumin influences activation their downstream signaling pathways resulting increased decreased proliferation migration both vitro vivo. This review focused on how exhibits effects through inhibition MAPK, PI3K/Akt, JAK/STAT, NF-κB pathways. Combination were also analysed emphasis common molecular targets.

Language: Английский

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Effects of Quercetin and Curcumin Combination on Antibacterial, Antioxidant, In Vitro Wound Healing and Migration of Human Dermal Fibroblast Cells

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 23(1), P. 142 - 142

Published: Dec. 23, 2021

Wound healing impairment due to a postponed, incomplete, or uncoordinated process has been challenging clinical problem. Much research focused on wound care, particularly discovery of new therapeutic approaches for acute and chronic wounds. This study aims evaluate the effect combination quercetin curcuminoids at three different ratios antimicrobial, antioxidant, cell migration properties. The antioxidant activities quercetin, mixtures were tested by DPPH ABTS free radical scavenging assays. disc diffusion method was performed determine antibacterial against S. aureus P. aeruginosa. cytotoxicity migratory enhancing effects human dermal fibroblasts investigated MTT assay, scratch assay Transwell respectively. results showed synergism curcuminoid inhibit growth aeruginosa, with inhibition zone ranging from 7.06 ± 0.25 8.78 0.38 mm, demonstrated that yielded lower IC50 values (15.38-23.70 µg/mL) than alone (25.75 µg/mL). Quercetin 3:1 quercetin/curcuminoid mixture non-toxic concentrations ability stimulate across matrix, whereas only accelerated closure fibroblasts. In conclusion, ratio best formulations use in cell-migration-enhancing activities.

Language: Английский

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Curcumin supplementation in pediatric patients: A systematic review of current clinical evidence

Phytotherapy Research, Journal Year: 2021, Volume and Issue: 36(4), P. 1442 - 1458

Published: Dec. 14, 2021

Abstract This systematic review was designed to determine the clinical efficacy and safety of curcumin supplementation for pediatric patients based on trials in children. We systematically searched electronic databases including PubMed, EMBASE, Web Science, Scopus all studies that investigated administration population without any time frame limitation. Finally, we identified 16 this review. Clinical were assessed children with inflammatory immune disorders (including asthma, bowel disease (IBD), juvenile idiopathic arthritis (JIA)), metabolic disorders, autosomal dominant polycystic kidney (ADPKD), cystic fibrosis (CF), tetralogy Fallot (TOF), infectious diseases. Curcumin administered a wide range doses (45 mg–4,000 mg daily) durations (2–48 weeks). Overall, well tolerated improved severity However, more are needed clarify role among ADPKD, CF, TOF, Because substantial heterogeneity methodological quality, design, outcomes, dose, duration intake, formulations, study populations across studies, no quantitative analysis performed. Additional large‐scale, randomized, placebo‐controlled confirm results conducted studies.

Language: Английский

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