Published: Jan. 1, 2025
Language: Английский
Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10
Published: June 21, 2023
Dietary medicinal plants are among the most sought-after topics in alternative medicine today due to their preventive and healing properties against many diseases.This study aimed extract determine polyphenols from indigenous extracts, i.e., Mentha longifolia, M. arvensis, Tinospora cordifolia, Cymbopogon citratus, Foeniculum vulgare, Cassia absus, Camellia sinensis, Trachyspermum ammi, C. sinensis then evaluate antioxidant, cytotoxicity, antimicrobial properties, besides enzyme inhibition of isolated polyphenols.The antioxidant activity was evaluated by DPPH, Superoxide radical, Hydroxyl radical (OH.), Nitric oxide (NO.) scavenging activity; antidiabetic enzymatic methods, anticancer using MTT assay, while antibacterial activity.The results showed that tested plants' polyphenolic extracts (MPPE) exhibited significant hydroxyl, nitric oxide, superoxide methods because considerable amounts total polyphenol flavonoid contents. UHPLC profile twenty-five complexes eight plant categorized into phenolic acids, flavonoids, alkaloids. The main 3-Feroylquinic acid (1,302 mg/L), also found has a higher content, rosmarinic acid, vanillic chlorogenic p-coumaric ferulic gallic catechin, luteolin, 7-O-neohesperideside, quercetin 3,7-O-glucoside, hesperidin, rutin, quercetin, caffeine range (560-780 mg/L). At same time, other compounds medium content (99-312 phenolics were 20-116% more abundant than those plants. While T. cordifolia is rich alkaloids, ammi lower content. assay Caco-2 cells citratus had maximum cytotoxicity. F. vulgare activity, minor α-amylase. Furthermore, S. aureus, B. cereus, E. coli, enterica.The principal component analysis demonstrated clear separation based on functional properties. These findings prove therapeutic effectiveness highlight importance as natural reserves phytogenic with untapped potential needs be discovered through advanced analytical methods.
Language: Английский
Citations
49
Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 320 - 320
Published: Jan. 17, 2025
With the improvement of living standards, alcoholic liver disease caused by long-term drinking has been a common multiple disease. Probiotic interventions may help mitigate damage alcohol intake, but mechanisms need more investigation. This study involved 70 drinkers (18-65 years old, consumption ≥20 g/day, lasting for than one year) who were randomly assigned to either BC99 group or placebo group. Two groups given (3 1 × 1010 CFU) g/day) 60 days, respectively. Before and after intervention, blood routine indicators, function, renal inflammatory factors intestinal flora evaluated. The results showed that intervention with Weizmannia coagulans reduced levels alanine aminotransferase, aspartate glutamyl transpeptidase, serum total bilirubin, urea nitrogen, uric acid 'blood nitrogen/creatinine'. also pro-inflammatory TNF-α IL-6 increased anti-inflammatory factor IL-10. analysis regulated imbalance flora, beneficial bacteria abundance (Prevotella, Faecalibacterium Roseburia) conditionally pathogenic (Escherichia-Shigella Klebsiella). Both LEfSe random forest indicated increase in Muribaculaceae induced was key alleviating alcohol-induced damage. These findings demonstrate potential alleviate injury provide an effective strategy protection drinkers.
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 947 - 947
Published: Jan. 23, 2025
Recently, previously known viruses have changed their pathogenicity and encompassed new types of host populations. An example such an infection is that caused by SARS-CoV, belonging to the “well-known” coronavirus family. Another group are great importance human population herpes viruses. Due increasing viral resistance existing antiviral drugs, plant extracts attracting interest due complex composition simultaneous attack different targets. Based on above, we tested potential water–alcoholic extract obtained from a commercial sample Cistus incanus L. against enveloped SvHA1, SvHA2 (ACV resistant) HCoV 229E. The results showed both complete inhibition intracellular stages replication strong effect extracellular virions in three models. In study SvHA 2, calculated selectivity index was over 10. From experiments virucidal effects two viruses, it found titer samples decreased about 4 lg compared control sample. for introduction into practice.
Language: Английский
Citations
1
Published: Feb. 2, 2025
Because of its long history use in traditional medicine, Flemingia macrophylla has attracted a lot attention from the fields phytochemistry and pharmacology. However, comprehensive research data on pharmacological roles have not been found literature. This review combines abundance information regarding application, phytochemical makeup, properties, demonstrating critical role Chinese medicine. Examining past uses many cultural contexts treating gastrointestinal issues to dermatological conditions highlights extraordinary adaptability. article reveals generations-long development as reliable medicine through an examination ethnobotanical records. Its composition is carefully examined this review, which complex array chemicals including flavonoids, alkaloids, terpenoids that are crucial comprehending plant's potential Determining consequences bioactive components plant requires thorough structural clarification. Pharmacological studies demonstrate range actions, antiinflammatory, antioxidant, cardiovascular benefits, consistent with conventional applications. antifungal function particular how useful it against microbial dangers general. Throughout, paper knowledge contemporary pharmacology convergent, emphasizing mutually beneficial interaction between legacy evidence-based treatment. Encapsulating historical significance current relevance integration into modern healthcare practices, compilation could be invaluable resource for researchers, herbalists, practitioners.
Language: Английский
Citations
1
Molecules, Journal Year: 2023, Volume and Issue: 28(6), P. 2470 - 2470
Published: March 8, 2023
Natural products and plant extracts exhibit many biological activities, including that related to the defense mechanisms against parasites. Many studies have investigated functions of secondary metabolites reported evidence antiviral activities. The pandemic emergencies further increased interest in finding agents, efforts are oriented investigate possible activities human viruses their potential application treating or preventing SARS-CoV-2 infection. In this review, we performed a comprehensive analysis through silico vitro investigations, also vivo applications clinical trials, evaluate state knowledge on infection, with particular focus natural compounds present food plants. Although some seem be useful prevention as therapeutic management SARS-CoV-2, up now, no molecules can used treatment for COVID-19; however, more research is needed.
Language: Английский
Citations
17
Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14
Published: Feb. 29, 2024
Flavonoids, a diverse group of polyphenolic compounds found in various plant-based foods, have garnered attention for their potential combating Hepatitis B Virus (HBV) infection. Flavonoids demonstrated promising anti-HBV activities by interfering with multiple stages the HBV life cycle, making them candidates novel antiviral agents. Certain plant families, such as Theaceae , Asteraceae Lamiaceae and Gentianaceae are particular interest flavonoid-rich members activities. Evidences, both vitro vivo supports flavonoids. These subsets compound exert effects through mechanisms, including inhibiting viral entry, disrupting replication, modulating transcription factors, enhancing immune response, inducing autophagy. The antioxidant properties flavonoids play crucial role oxidative stress associated Several like epigallocatechin gallate (EGCG), proanthocyanidin (PAC), hexamethoxyflavone, wogonin, baicalin shown significant potential, holding promise therapeutic Synergistic between existing therapies offer approach to enhance efficacy reduce drug resistance. Challenges, limited bioavailability, translation from preclinical studies clinical practice, understanding precise targets, need be addressed. Future research should focus on trials, combination therapies, development flavonoid derivatives improved optimizing effectiveness managing chronic infections.
Language: Английский
Citations
8
Viruses, Journal Year: 2024, Volume and Issue: 16(2), P. 218 - 218
Published: Jan. 31, 2024
Most plants have developed unique mechanisms to cope with harsh environmental conditions compensate for their lack of mobility. A key part coping is the synthesis secondary metabolites. In addition role in plants' defense against pathogens, they also possess therapeutic properties diseases, and use by humans predates written history. Viruses are a class submicroscopic agents, incapable independent existence outside living host. Pathogenic viruses continue pose significant threat global health, leading innumerable fatalities on yearly basis. The medicinal as natural source antiviral agents has been widely reported literature past decades. Metabolomics powerful research tool identification plant metabolites potentials. It can be used isolate compounds capacities study biosynthetic pathways involved viral disease progression. This review discusses special focus metabolomics evidence supporting efficacy. Suggestions made optimization various methods characterizing bioactive subsequently understanding operation.
Language: Английский
Citations
7
Revista Brasileira de Farmacognosia, Journal Year: 2022, Volume and Issue: 32(2), P. 147 - 159
Published: Feb. 18, 2022
Language: Английский
Citations
28
Heliyon, Journal Year: 2022, Volume and Issue: 8(9), P. e10702 - e10702
Published: Sept. 1, 2022
The COVID-19 pandemic caused by SARS-CoV-2 remains an international concern. Although there are drugs to fight it, new natural alternatives such as polyphenols essential due their antioxidant activity and high antiviral potential. In this context, review reports the main findings on effect of phenolic compounds (PCs) against virus. First, proven PCs different human viruses is briefly detailed, which serves a starting point study anti-COVID-19 targets (its proteins) defined. Findings from in silico, vitro vivo studies wide variety shown, emphasizing mechanism action, fundamental for drug design. Furthermore, clinical trials have demonstrated effectiveness prevention possible therapeutic management COVID-19. results were complemented with information influence strengthening/modulating immune system. It recommended investigate vitamins, minerals, alkaloids, triterpenes fatty acids, synergistic use PCs, many been successful SARS-CoV-2. Based other viruses, evaluation accepted also suggested. Other recommendations limitations useful professionals involved development efficient, safe low-cost strategies based plant matrices rich PCs. To authors' knowledge, manuscript first evaluate relationship between immunomodulatory (including anti-inflammatory effects) underlying mechanisms relation interest general population be informed about importance consuming foods bioactive health benefits.
Language: Английский
Citations
28
Journal of environmental chemical engineering, Journal Year: 2024, Volume and Issue: 12(3), P. 112713 - 112713
Published: April 5, 2024
Language: Английский
Citations
6