Design, synthesis of amide derivatives of scutellarin and their antileukemia and neuroprotective activities DOI
Tong Han, Chunyu Jiang, Xing Wei

et al.

Medicinal Chemistry Research, Journal Year: 2022, Volume and Issue: 31(6), P. 905 - 915

Published: April 19, 2022

Language: Английский

Comparative studies of immobilized polysaccharide derivatives chiral stationary phases for enantioseparation of furanocoumarins and dihydroflavones and discussion on chiral recognition mechanism DOI

Luhuan Tang,

Yanyan Chen,

Mengru Wu

et al.

Journal of Separation Science, Journal Year: 2023, Volume and Issue: 46(20)

Published: Aug. 17, 2023

Enantiomeric separation of furanocoumarins and dihydroflavones compounds were systematically studied in the normal-phase mode using four different polysaccharide-type chiral stationary phases, namely, Chiralpak IA, IC, IG, IK-3 by high-performance liquid chromatography. The effect alcohol modifiers content on enantiomeric was evaluated for dihydroflavones. All eight have achieved baseline with resolutions ranging between 1.52 23.11. For a better insight into enantiorecognition mechanisms, thermodynamic analysis carried out. mechanisms recognition been discussed. Among columns, IG exhibited most universal best enantioseparation ability toward when used n-hexane-isopropanol n-hexane-ethanol as mobile phase, respectively. steric hindrance, hydrogen bonding, π-π interaction played major roles IG. By comparing this work analyzed methods first time reported some active ingredients traditional Chinese medicine that never separated, which provided further phases.

Language: Английский

Citations

2
Stereoselective separation, configuration determination, and quantification of flavanone glycosides in Citrus using chiral HPLC-UV in combination with CD spectra DOI

Bingtong Jiang,

Zhaokun Wang,

Xuejiao Shi

et al.

Analytical Methods, Journal Year: 2023, Volume and Issue: 15(46), P. 6444 - 6450

Published: Jan. 1, 2023

A efficient method for simultaneous separation of the C-2 diastereomers naringin, neohesperidin, hesperidin and narirutin was developed, used determination each epimer them in traditional Chinese medicine Zhiqiao Zhishi.

Language: Английский

Citations

2
Engineering of Microbial Substrate Promiscuous CYP105A5 for Improving the Flavonoid Hydroxylation DOI Open Access
Pradeep Subedi, Jong Kook Park, Tae‐Jin Oh

et al.

Catalysts, Journal Year: 2022, Volume and Issue: 12(10), P. 1157 - 1157

Published: Oct. 1, 2022

Bacterial cytochrome P450 (CYP) enzymes are versatile biocatalysts that responsible for the biotransformation of diverse endogenous substances. CYP105A5 from Streptomyces sp. showed substrate flexibility with different flavonoids and was able to catalyze O-demethylation biochanin A, regioselective C3′-hydroxylation daidzein, genistein, naringenin, additional C8-hydroxylation daidzein using heterologous redox partners putidaredoxin reductase. By rational design substrate-binding pocket based on experimental data, homology modeling, molecular docking analysis, we enhanced product formation rate flavonoids. The double mutant L100A/I302A L100A/I408N exhibited greatly in vivo conversion rates flavonoid hydroxylation. Particularly, mutant’s kcat/Km values increased by 1.68-fold 2.57-fold, respectively, naringenin. Overall, our result might facilitate potential use future modification application whole-cell production valuable polyphenols.

Language: Английский

Citations

3
Flavopiridol inhibits oocyte maturation, reduces oocyte quality and blocks cumulus cell function DOI

Xiaozhen Li,

Li‐Tao Yi,

Qing‐Yuan Sun

et al.

Toxicology Letters, Journal Year: 2024, Volume and Issue: 401, P. 44 - 54

Published: Sept. 13, 2024

Language: Английский

Citations

0
Design, synthesis of amide derivatives of scutellarin and their antileukemia and neuroprotective activities DOI
Tong Han, Chunyu Jiang, Xing Wei

et al.

Medicinal Chemistry Research, Journal Year: 2022, Volume and Issue: 31(6), P. 905 - 915

Published: April 19, 2022

Language: Английский

Citations

2