The potential roles of gossypol as anticancer agent: advances and future directions DOI Creative Commons
Danijela Paunović, Jovana Rajković, R Novaković

et al.

Chinese Medicine, Journal Year: 2023, Volume and Issue: 18(1)

Published: Dec. 15, 2023

Gossypol, a polyphenolic aldehyde derived from cottonseed plants, has seen transformation in its pharmaceutical application male contraceptive to candidate for cancer therapy. This shift is supported by recognized antitumor properties, which have prompted investigation the treatment of various cancers and related inflammatory conditions. review synthesizes current understanding gossypol as an anticancer agent, focusing on pharmacological mechanisms, strategies enhance clinical efficacy, status ongoing evaluations.The methodological approach this involved systematic search across several scientific databases including National Center Biotechnology Information (NCBI), PubMed/MedLine, Google Scholar, Scopus, TRIP. Studies were meticulously chosen cover aspects gossypol, chemical structure natural sources pharmacokinetics confirmed efficacy. Specific MeSH terms keywords gossypol's antineoplastic applications guided strategy.Results selected studies indicate that inhibits Bcl-2 family anti-apoptotic proteins, promoting apoptosis tumor cells. Clinical trials, particularly phase I II, reveal promise demonstrating efficacy manageable toxicity profiles. The identifies development derivatives novel carriers avenues therapeutic outcomes mitigate adverse effects.Conclusively, represents promising agent with considerable potential. However, further research needed refine gossypol-based therapies, explore combination treatments, verify their effectiveness types. trials continue support potential, suggesting future where could play significant role protocols.

Language: Английский

Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications DOI Creative Commons
Xinyang Zhong, Xuefeng He, Yaxian Wang

et al.

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: Nov. 1, 2022

Colorectal cancer (CRC) is the third most common and second leading cause of cancer-related death worldwide. Countless CRC patients undergo disease progression. As a hallmark cancer, Warburg effect promotes metastasis remodels tumor microenvironment, including promoting angiogenesis, immune suppression, cancer-associated fibroblasts formation drug resistance. Targeting metabolism would be promising method for treatment CRC. In this review, we summarize information about roles in microenvironment to elucidate mechanisms governing identify novel targets therapy.

Language: Английский

Citations

154
Bcl-2 pathway inhibition in solid tumors: a review of clinical trials DOI Creative Commons
Ioanna Ploumaki, Efthymios Triantafyllou, Ioannis‐Alexios Koumprentziotis

et al.

Clinical & Translational Oncology, Journal Year: 2023, Volume and Issue: 25(6), P. 1554 - 1578

Published: Jan. 13, 2023

Abstract Due to their key role in the pathogenesis of cancer through regulation apoptosis, B-cell leukemia/lymphoma-2 (BCL-2) family proteins have been an attractive target for therapy past decades. Throughout years, many Bcl-2 inhibitors developed, with Venetoclax being now successfully used treating hematological malignancies. Although effectiveness treatment solid tumors is yet be established, some preclinical evidence indicates possible clinical application. This review aims summarize current data from completed trials that protein as monotherapy or combination other agents We managed include various phases which analyze pharmacokinetics and pharmacodynamics drugs, well adverse effects. Active recruiting are also briefly presented future prospects challenges discussed.

Language: Английский

Citations

53
Lactate and lactylation in cancer DOI Creative Commons
Jie Chen, Ziyue Huang,

Ya Chen

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 11, 2025

Abstract Accumulated evidence has implicated the diverse and substantial influence of lactate on cellular differentiation fate regulation in physiological pathological settings, particularly intricate conditions such as cancer. Specifically, been demonstrated to be pivotal molding tumor microenvironment (TME) through its effects different cell populations. Within cells, impacts signaling pathways, augments shuttle process, boosts resistance oxidative stress, contributes lactylation. In various populations, interplay between immune cells governs processes differentiation, response, surveillance, treatment effectiveness. Furthermore, communication stromal/endothelial supports basal membrane (BM) remodeling, epithelial-mesenchymal transitions (EMT), metabolic reprogramming, angiogenesis, drug resistance. Focusing production transport, specifically dehydrogenase (LDH) monocarboxylate transporters (MCT), shown promise Inhibitors targeting LDH MCT act both suppressors enhancers immunotherapy, leading a synergistic therapeutic effect when combined with immunotherapy. The review underscores importance progression provides valuable perspectives potential approaches that target vulnerability metabolism, highlighting Heel Achilles for cancer treatment.

Language: Английский

Citations

9
Historical perspective of tumor glycolysis: A century with Otto Warburg DOI
Giulia Bononi, Samuele Masoni, Valeria Di Bussolo

et al.

Seminars in Cancer Biology, Journal Year: 2022, Volume and Issue: 86, P. 325 - 333

Published: July 7, 2022

Language: Английский

Citations

49
Rationale for LDH-targeted cancer immunotherapy DOI Creative Commons

Tina B.S. Miholjcic,

Heloise M. Halse,

Mélodie Bonvalet

et al.

European Journal of Cancer, Journal Year: 2022, Volume and Issue: 181, P. 166 - 178

Published: Dec. 14, 2022

Language: Английский

Citations

40
Current Advances and Future Strategies for BCL-2 Inhibitors: Potent Weapons against Cancers DOI Open Access
Jiaxuan Xu, Xiaoqing Dong, David C.S. Huang

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(20), P. 4957 - 4957

Published: Oct. 12, 2023

Targeting the intrinsic apoptotic pathway regulated by B-cell lymphoma-2 (BCL-2) antiapoptotic proteins can overcome evasion of apoptosis in cancer cells. BCL-2 inhibitors have evolved into an important means treating cancers inducing tumor cell apoptosis. As most extensively investigated inhibitor, venetoclax is highly selective for and effectively inhibit survival. Its emergence development significantly influenced therapeutic landscape hematological malignancies, especially chronic lymphocytic leukemia acute myeloid leukemia, which it has been clearly incorporated recommended treatment regimens. In addition, considerable efficacy combination with other agents demonstrated relapsed refractory multiple myeloma certain lymphomas. Although plays a prominent antitumor role preclinical experiments clinical trials, large individual differences outcomes characterized real-world patient populations, reduced drug sensitivity will lead to disease recurrence or progression. The may vary widely patients different molecular characteristics, key genetic mutations potentially result differential sensitivities venetoclax. identification validation more novel biomarkers are required accurately predict effectiveness inhibition therapy. Furthermore, we summarize recent research progress relating use solid demonstrate that wealth models shown promising results through therapies. applications tumors warrant further investigation define its prospects.

Language: Английский

Citations

25
Tumor lactic acid: a potential target for cancer therapy DOI
Jun‐Kyu Byun

Archives of Pharmacal Research, Journal Year: 2023, Volume and Issue: 46(2), P. 90 - 110

Published: Feb. 1, 2023

Language: Английский

Citations

23
Exploring the mystery of tumor metabolism: Warburg effect and mitochondrial metabolism fighting side by side DOI
Yongxin Yu,

Yulang Jiang,

Christian Glandorff

et al.

Cellular Signalling, Journal Year: 2024, Volume and Issue: 120, P. 111239 - 111239

Published: May 28, 2024

Language: Английский

Citations

14
Lactate’s impact on immune cells in sepsis: unraveling the complex interplay DOI Creative Commons
Tao Zhang, Linjian Chen,

Gatkek Kueth

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 20, 2024

Lactate significantly impacts immune cell function in sepsis and septic shock, transcending its traditional view as just a metabolic byproduct. This review summarizes the role of lactate biomarker influence on dynamics, emphasizing critical modulating responses during sepsis. Mechanistically, key transporters like MCT1, MCT4, receptor GPR81 are crucial mediating these effects. HIF-1α also plays significant lactate-driven modulation. Additionally, affects through post-translational modifications such lactylation, acetylation, phosphorylation, which alter enzyme activities protein functions. These interactions between cells central to understanding sepsis-associated dysregulation, offering insights that can guide future research improve therapeutic strategies enhance patient outcomes.

Language: Английский

Citations

9
Metabolic changes during prostate cancer development and progression DOI Creative Commons

Alicia-Marie K. Beier,

Martin Puhr, Matthias B. Stope

et al.

Journal of Cancer Research and Clinical Oncology, Journal Year: 2022, Volume and Issue: 149(5), P. 2259 - 2270

Published: Sept. 23, 2022

Abstract Metabolic reprogramming has been recognised as a hallmark in solid tumours. Malignant modification of the tumour’s bioenergetics provides energy for tumour growth and progression. Otto Warburg first reported these metabolic biochemical changes 1927. In prostate cancer (PCa) epithelial cells, metabolism also during development progress. These alterations are partly driven by androgen receptor, key regulator PCa development, progress, survival. contrast to other cells different entities, glycolytic sustains physiological citrate secretion normal prostatic epithelium. early stages PCa, is utilised power oxidative phosphorylation fuel lipogenesis, enabling advanced incurable castration-resistant shift towards choline, amino acid, fueling progression described. Therefore, even if not fully understood, altered may provide opportunities novel therapeutic strategies, especially stages. This review focuses on main differences PCa’s tumourigenesis highlighting glutamine’s role PCa.

Language: Английский

Citations

38