Harnessing photocatalytic and electrochemical approaches for C–H bond trifluoromethylation and fluoroalkylation

Organic Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 11(3), P. 954 - 1014

Published: Dec. 14, 2023

The review summarises various photo- and electrochemical strategies for trifluoromethylation fluoroalkylation of different C(sp 3 )–H, 2 C(sp)–H bonds in several classes organic molecules.

Language: Английский

---

Recent Advances in Visible‐Light‐Enabled C3‐H Fluoroalkylation of Quinoxalin‐2(1H)‐ones

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(12)

Published: March 1, 2025

Abstract In light of the extensive application fluoroalkyl‐containing molecules and functionalized quinoxalin‐2(1 H )‐ones in medicinal chemistry functional materials, visible‐light‐enabled C3‐H fluoroalkylation has garnered significant attention. this review, we provide a detailed overview latest advancements rapidly evolving research area. We cover utilization various fluoroalkyl sources under conditions photocatalyst or without photocatalyst, discuss pertinent reaction conditions, mechanisms, substrate scope. Our objective is to help more chemists comprehend challenges opportunities within field, thereby fostering its development.

Language: Английский

---

Electrochemical Access to Difluoromethyl Groups: An Overview of Scope, Mechanisms, and Challenges

ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 6826 - 6851

Published: April 14, 2025

Language: Английский

---

Visible-Light Photoredox-Catalyzed Three-Component Reaction of Carbazoles with Alkenes and S-(Difluoromethyl)sulfonium Salt: A Practical Approach to Access Difluoroalkyl-Functionalized Carbazoles

The Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 88(15), P. 10711 - 10720

Published: July 19, 2023

A mild and elegant multicomponent protocol for construction of CF2H-containing carbazoles was accomplished by visible-light photoredox catalysis with formation two new C-C bonds in a single step to deliver wide variety structurally diverse difluoroalkylated moderate good yields, featuring reaction conditions, synthetic simplicity, broad substrates, functional group tolerance.

Language: Английский

---

Photochemical Difluoromethylation of Quinoxalin-2(1H)-ones with Difluoroacetic Anhydride and Pyridine N-Oxide

The Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 89(2), P. 1199 - 1208

Published: Dec. 28, 2023

A novel photochemical difluoromethylation of quinoxalin-2(1H)-ones under catalyst-free conditions was achieved with difluoroacetic anhydride and pyridine N-oxide. The green mild reaction as well readily attainable provide a useful protocol to prepare C3-difluoromethylated quinoxalin-2(1H)-ones.

Language: Английский

---

Visible-light photoredox-catalyzed radical aryldifluoromethylation of N-arylacrylamides with S-(difluoromethyl)sulfonium salt

Organic & Biomolecular Chemistry, Journal Year: 2023, Volume and Issue: 21(19), P. 4013 - 4017

Published: Jan. 1, 2023

A facile and efficient visible-light photoredox-catalyzed protocol for aryldifluoromethylation of N -arylacrylamides was developed showed good to excellent yields, a broad substrate scope, tolerance functional groups, mild conditions.

Language: Английский

---

Visible light–driven organic synthesis under iridium (IrIII)-complex photocatalysis

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 221 - 300

Published: Aug. 16, 2024

Language: Английский

---