A vivid outline demonstrating the benefits of exosome-mediated drug delivery in CNS-associated disease environments

Archives of Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 753, P. 109906 - 109906

Published: Jan. 23, 2024

Language: Английский

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Beneficial Effects of Human Schwann Cell-Derived Exosomes in Mitigating Secondary Damage After Penetrating Ballistic-Like Brain Injury

Journal of Neurotrauma, Journal Year: 2024, Volume and Issue: 41(21-22), P. 2395 - 2412

Published: March 6, 2024

There is a growing body of evidence that the delivery cell-derived exosomes normally involved in intracellular communication can reduce secondary injury mechanisms after brain and spinal cord improve outcomes. Exosomes are nanometer-sized vesicles released by Schwann cells may have neuroprotective effects reducing posttraumatic inflammatory processes as well promoting tissue healing functional recovery. The purpose this study was to evaluate beneficial human Schwann-cell (hSC-Exos) severe model penetrating ballistic-like (PBBI) rats investigate on multiple Human cell processing protocols followed Current Good Manufacturing Practices (cGMP) with exosome extraction purification steps approved FDA for an expanded access single ALS patient IND. Anesthetized male Sprague-Dawley (280-350g) underwent PBBI surgery or sham procedures starting 30 min received either dose hSC-Exos PBS through jugular vein. At 48hrs PBBI, flow cytometry analysis cortical revealed administration reduced number activated microglia levels caspase-1, marker inflammasome activation. Neuropathological at 21 days showed treatment significantly overall contusion volume decreased frequency Iba-1 positive amoeboid immunocytochemical analysis. This systemic TBI reduces histopathological damage. represents clinically relevant cell-based therapy limit detrimental neurotrauma other progressive neurological injuries impacting pathophysiological events

Language: Английский

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The complexity of extracellular vesicles: Bridging the gap between cellular communication and neuropathology

Journal of Neurochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: April 22, 2024

Abstract Brain‐derived extracellular vesicles (EVs) serve a prominent role in maintaining homeostasis and contributing to pathology health disease. This review establishes crucial link between physiological processes leading EV biogenesis their impacts on EVs are involved the clearance transport of proteins nucleic acids, responding changes cellular associated with neurodegeneration, including autophagic disruption, organellar dysfunction, aging, other cell stresses. In neurodegenerative disorders (e.g., Alzheimer's disease, Parkinson's etc.), contribute spread pathological like amyloid β, tau, ɑ‐synuclein, prions, TDP‐43, exacerbating neurodegeneration accelerating disease progression. Despite evidence for both neuropathological neuroprotective effects EVs, mechanistic switch functions remains elusive, warranting further research into involvement Moreover, owing innate ability traverse blood–brain barrier ubiquitous nature, emerge as promising candidates novel diagnostic therapeutic strategies. The uniquely positions itself at intersection biology, neurophysiology, neuropathology, offering insights diverse biological roles

Language: Английский

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Innovative drug delivery strategies to the CNS for the treatment of multiple sclerosis

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 364, P. 435 - 457

Published: Nov. 8, 2023

Language: Английский

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Diabetes-related perturbations in the integrity of physiologic barriers

Journal of Diabetes and its Complications, Journal Year: 2023, Volume and Issue: 37(8), P. 108552 - 108552

Published: June 20, 2023

Language: Английский

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