Role of exosomes in the pathogenesis of inflammation in Parkinson’s disease

Neural Regeneration Research, Journal Year: 2022, Volume and Issue: 17(9), P. 1898 - 1898

Published: Jan. 1, 2022

Inflammatory responses, including glial cell activation and peripheral immune infiltration, are involved in the pathogenesis of Parkinson’s disease (PD). These inflammatory responses appear to be closely related release extracellular vesicles, such as exosomes. However, relationships among different forms activation, synuclein dysregulation, mitochondrial dysfunction, exosomes complicated. This review discusses multiple roles played by PD-associated inflammation concludes that can transport toxic α-synuclein oligomers immature neurons into environment, inducing oligomerization normal neurons. Misfolded causes microglia astrocytes activate secrete Glial cell-derived participate communications between cells neurons, triggering anti-stress anti-inflammatory addition axon growth. The production vesicles establish a new mechanism for linking dysfunction systemic associated with PD. Given relevance mediators neuron-glia communication neuroinflammation neuropathogenesis, targeted treatment strategies currently being developed use these types drug carriers. Exosome-mediated may promising target intervention PD patients.

Language: Английский

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Liposomes or Extracellular Vesicles: A Comprehensive Comparison of Both Lipid Bilayer Vesicles for Pulmonary Drug Delivery

Polymers, Journal Year: 2023, Volume and Issue: 15(2), P. 318 - 318

Published: Jan. 7, 2023

The rapid and non-invasive pulmonary drug delivery (PDD) has attracted great attention compared to the other routes. However, nanoparticle platforms, like liposomes (LPs) extracellular vesicles (EVs), require extensive reformulation suit requirements of PDD. LPs are artificial composed lipid bilayers capable encapsulating hydrophilic hydrophobic substances, whereas EVs natural secreted by cells. Additionally, novel LPs-EVs hybrid may confer best both. preparation methods distinguished from since they rely mainly on extraction purification, synthesized their basic ingredients. Similarly, loading into/onto whereby cell- or non-cell-based, loaded via passive active approaches. This review discusses progress in as well with a special focus It also provides perspective comparison between various aspects (composition, preparation/extraction, loading, large-scale manufacturing) future prospects for inhaled therapeutics. In addition, it challenges that be encountered scaling up production presents our view regarding clinical translation laboratory findings into commercial products.

Language: Английский

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Purposing plant-derived exosomes-like nanovesicles for drug delivery: patents and literature review

Expert Opinion on Therapeutic Patents, Journal Year: 2023, Volume and Issue: 33(2), P. 89 - 100

Published: Feb. 1, 2023

Introduction How can biotechnology and organic agriculture be fused promoted simultaneously to overcome the main challenges in drug delivery systems. The role of future human health treatment still represents a binary organic–conventional question. However, exosomes-like nanoparticles define new path that plants vegetables release. In this review, we concisely propose plant-derived exosome-like nanovesicles discuss their most important biological pharmacological roles, representing tool for delivery.Areas covered Plant-derived nanovesicles; nature farming; green manufacturing practice; delivery; agriculture.Expert opinion There is growing interest potential use various diagnostic therapeutic applications should translate into supplement current nano‐pharmaceuticals. Despite clinical potential, lack sensitive preparatory analytical technologies poses barrier translation. An increasing number articles are recently published on platforms address these cross-comparison with conventional assay methods. This review also mentions two patents from ExoLab-Italia nanovesicles, respectively, nanovesicles' ability naturally deliver series potentially molecules novel approach upload them molecules.

Language: Английский

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Engineered exosomes for cancer theranostics: Next-generation tumor targeting

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 85, P. 104579 - 104579

Published: May 18, 2023

Exosomes are multivesicular bodies of which the plasma membrane fuse to release caring moiety into surrounding body fluids. They best known for their function in mediating intercellular connectivity by transferring various biomolecules, such as proteins, RNAs, and lipids, from one cell another. These "naturally equipped" nanovesicles could be therapeutically targeted or engineered drug delivery systems. The use exosomes cancer detection prognosis has attracted a great deal interest academics. In addition chemical, biological, genetic engineering approaches, other current exosomal alteration methodologies hold promise advancement therapeutic medicines cancer. this review, we highlight theranostic potential cancers.

Language: Английский

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Innovative Diagnosis and Therapeutic Modalities: Engineered Exosomes in Autoimmune Disease

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 3943 - 3956

Published: May 1, 2024

Autoimmune diseases refer to a group of conditions where the immune system produces an response against self-antigens, resulting in tissue damage. These have profound impacts on health patients. In recent years, with rapid development field biomedicine, engineered exosomes emerged as noteworthy class biogenic nanoparticles. By precisely manipulating cargo and surface markers exosomes, gained enhanced anti-inflammatory, immunomodulatory, reparative abilities, providing new prospects for treatment autoimmune diseases. Engineered not only facilitate efficient delivery bioactive molecules including nucleic acids, proteins, cytokines, but also possess capability modulate cell functions, suppress inflammation, restore homeostasis. This review mainly focuses applications several typical Additionally, this article comprehensively summarizes current approaches modification engineering outlines their clinical applications. conclusion, innovative therapeutic approach, hold promise management However, while significant progress has been made, further rigorous research is still needed address challenges that may encounter intervention process, order successful translation into practice ultimately benefit broader population

Language: Английский

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The emerging roles of exosomes in autoimmune diseases, with special emphasis on microRNAs in exosomes

Pharmacological Research, Journal Year: 2021, Volume and Issue: 169, P. 105680 - 105680

Published: May 16, 2021

Language: Английский

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Mesenchymal stem cells and their derived exosomes to combat Covid–19

Reviews in Medical Virology, Journal Year: 2021, Volume and Issue: 32(2)

Published: Aug. 7, 2021

Summary Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is causing an ongoing pandemic of disease 2019 (Covid‐19). Effective therapies are required for the treatment patients with severe stages disease. Mesenchymal stem cells (MSCs) have been evaluated in numerous clinical trials, but present challenges, such as carcinogenic risk and special storage conditions, coupled insufficient data about their mechanism action. The majority unique properties MSCs related to paracrine activity especially exosomes. impact MSCs‐derived exosomes (MSC‐Es) on complications Covid‐19 has investigated several studies. MSC‐Es may improve some cytokine storm, distress (ARDS) lung injury (ALI). Additionally, these can be applicable nano‐size carrier antiviral therapeutic agents. Herein, we consider potential applications derived Covid‐19.

Language: Английский

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Exosomes in Cardiovascular Disease: From Mechanism to Therapeutic Target

Metabolites, Journal Year: 2023, Volume and Issue: 13(4), P. 479 - 479

Published: March 27, 2023

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality globally. In recent decades, clinical research has made significant advances, resulting in improved survival recovery rates for patients with CVD. Despite this progress, there substantial residual CVD risk an unmet need better treatment. The complex multifaceted pathophysiological mechanisms underlying development pose a challenge researchers seeking effective therapeutic interventions. Consequently, exosomes have emerged as new focus because their role intercellular communicators gives them potential to act noninvasive diagnostic biomarkers nanocarriers. heart vasculature, cell types such cardiomyocytes, endothelial cells, vascular smooth muscle, cardiac fibroblasts, inflammatory resident stem cells are involved homeostasis via release exosomes. Exosomes encapsulate cell-type specific miRNAs, miRNA content fluctuates response setting heart, indicating that pathways affected by these differentially expressed miRNAs may be targets treatments. This review discusses number evidence supports relevance latest technologies applying exosomal vesicles cargo delivery vehicles gene therapy, tissue regeneration, repair described.

Language: Английский

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Biochemistry of exosomes and their theranostic potential in human diseases

Life Sciences, Journal Year: 2023, Volume and Issue: 315, P. 121369 - 121369

Published: Jan. 10, 2023

Language: Английский

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Exosomes as new generation vehicles for drug delivery systems

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 95, P. 105562 - 105562

Published: March 11, 2024

Language: Английский

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