Current Neuropharmacology,
Journal Year:
2022,
Volume and Issue:
21(3), P. 517 - 535
Published: July 7, 2022
Brain
disorders
are
a
prevalent
and
rapidly
growing
problem
in
the
medical
field
as
they
adversely
affect
quality
of
life
human.
With
an
increase
expectancy,
it
has
been
reported
that
diseases
like
Alzheimer's,
Parkinson's,
stroke
brain
tumors,
along
with
neuropsychological
disorders,
also
being
at
alarmingly
high
rate.
Despite
various
therapeutic
methods
for
treating
drug
delivery
to
challenging
because
very
complex
Blood
Barrier,
which
precludes
most
drugs
from
entering
effective
concentrations.
Nano-carrier-based
systems
have
widely
by
researchers
overcome
this
barrier
layer.
These
due
their
small
size,
offer
numerous
advantages;
however,
short
residence
time
body
owing
opsonization
hinders
success
vivo.
This
review
article
focuses
on
aspects
modifying
surfaces
these
nano-carriers
polymers,
surfactants,
protein,
antibodies,
cell-penetrating
peptides,
integrin
binding
peptides
glycoproteins
such
transferrin
&
lactoferrin
leading
enhanced
time,
desirable
characteristics
ability
cross
blood-brain
(BBB),
increased
bioavailability
regions
targeted
delivery.
Pharmaceutical Development and Technology,
Journal Year:
2022,
Volume and Issue:
27(5), P. 525 - 544
Published: May 28, 2022
The
bioavailability
of
drugs
is
dependent
on
several
factors
such
as
solubility
and
the
administration
route.
A
drug
with
poor
aqueous
solubility,
therefore,
poses
challenges
regards
to
its
pharmaceutical
advance
ultimately
biological
usage.
Lipid
nanoparticles
have
been
used
in
science
due
their
importance
green
chemistry.
Their
biochemical
properties
‘green’
materials
processes
mean
they
can
be
environmentally
sustainable.
Generally,
lipid
employed
carriers
for
both
lipophilic
hydrophilic
drugs.
proposed
route
present
advantages
disadvantages
which
should
considered
by
a
formulator.
Solid
(SLNs)
nanostructured
(NLCs)
are
attractive
delivery
systems
because
ease
manufacture,
biocompatibility,
biodegradability,
scale-up
capacity
formulation
constituents.
easy
simple
scalability
novel
SLNs
nano
carriers,
along
various
processing
procedures,
recent
developments,
limitation
toxicity,
optimization
approaches
manufacture
nanoparticles,
lyophilization
release
comprehensively
discussed
this
review.
This
review
also
summarizes
research
data
related
preparation
methods
excipients
NLCs
years.
Colloids and Surfaces B Biointerfaces,
Journal Year:
2022,
Volume and Issue:
221, P. 112999 - 112999
Published: Nov. 2, 2022
The
blood-brain
barrier
(BBB)
restricts
the
access
of
therapeutic
agents
to
brain,
complicating
treatment
neurological
diseases,
such
as
Alzheimer's
disease
(AD),
Parkinson's
(PD),
multiple
sclerosis
(MS),
glioma,
etc.
To
overcome
this
limitation
and
improve
drug
delivery
central
nervous
system
(CNS),
potential
nanocarriers,
including
lipid-based
nanosystems,
has
been
explored.
Through
active
targeting,
surface
nanocarriers
can
be
modified
with
ligands
that
interact
BBB,
enhancing
their
uptake
penetration
across
brain
endothelium
by
different
physiological
mechanisms,
receptor-
or
transporter-mediated
transcytosis.
This
review
seeks
provide
an
overview
targeting
in
delivery,
while
highlighting
functionalized
lipid
treat
diseases.
Therefore,
first
sections,
we
discuss
importance
CNS
present
commonly
used
for
functionalization,
well
summarize
state
art
most
recent
relevant
studies
surface-modified
nanosystems
developed
disorders.
Lastly,
challenges
hindering
clinical
translation
are
discussed,
critical
insights
future
perspectives
outlined.
Although
some
limitations
have
identified,
it
is
expected
upcoming
years
these
will
established
approach.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(15), P. 3482 - 3482
Published: July 25, 2024
Nanoparticles
are
structures
that
possess
unique
properties
with
high
surface
area-to-volume
ratio.
Their
small
size,
up
to
100
nm,
and
potential
for
modifications
have
enabled
their
use
in
a
wide
range
of
applications.
Various
factors
influence
the
applications
NPs,
including
synthesis
method
physical
attributes
such
as
size
shape.
Additionally,
materials
used
NPs
primary
determinants
application.
Based
on
chosen
material,
generally
classified
into
three
categories:
organic,
inorganic,
carbon-based.
These
categories
include
variety
materials,
proteins,
polymers,
metal
ions,
lipids
derivatives,
magnetic
minerals,
so
on.
Each
material
possesses
activity
application
NPs.
Consequently,
certain
typically
particular
areas
because
they
higher
efficiency
along
tenable
toxicity.
Therefore,
classification
base
NP
hold
significant
importance
both
research
In
this
paper,
we
discuss
these
classifications,
exemplify
most
major
categorize
them
according
preferred
area
This
review
provides
an
overall
application,
Polymers,
Journal Year:
2023,
Volume and Issue:
15(9), P. 2196 - 2196
Published: May 5, 2023
Neurodegenerative
diseases
are
common,
incurable
neurological
disorders
with
high
prevalence,
and
lead
to
memory,
movement,
language,
intelligence
impairments,
threatening
the
lives
health
of
patients
worldwide.
The
blood–brain
barrier
(BBB),
a
physiological
between
central
nervous
system
peripheral
blood
circulation,
plays
an
important
role
in
maintaining
homeostasis
intracerebral
environment
by
strictly
regulating
transport
substances
brain.
Therefore,
it
is
difficult
for
therapeutic
drugs
penetrate
BBB
reach
brain,
this
affects
their
efficacy.
Nanoparticles
(NPs)
can
be
used
as
drug
carriers
also
known
nanoparticle-based
delivery
systems
(NDDSs).
These
not
only
increase
stability
but
facilitate
crossing
through
improve
In
article,
we
provided
overview
types
administration
routes
NPs,
highlighted
preclinical
clinical
studies
NDDSs
neurodegenerative
diseases,
summarized
combined
strategies
management
diseases.
Finally,
prospects
challenges
recent
basic
research
were
discussed.
Above
all,
provide
inspiring
strategy
treatment
Membranes,
Journal Year:
2023,
Volume and Issue:
13(3), P. 343 - 343
Published: March 16, 2023
Over
the
past
few
years,
pharmaceutical
and
biomedical
areas
have
made
most
astounding
accomplishments
in
field
of
medicine,
diagnostics
drug
delivery.
Nanotechnology-based
tools
played
a
major
role
this.
The
implementation
this
multifaceted
nanotechnology
concept
encourages
advancement
innovative
strategies
materials
for
improving
patient
compliance.
plausible
usage
delivery
prompts
an
extension
lipid-based
nanocarriers
with
special
reference
to
barriers
such
as
skin
blood–brain
barrier
(BBB)
that
been
discussed
given
manuscript.
limited
permeability
these
two
intriguing
biological
restricts
penetration
active
moieties
through
brain,
resulting
futile
outcomes
several
related
ailments.
Lipid-based
provide
possible
solution
problem
by
facilitating
drugs
across
obstacles,
which
leads
improvements
their
effectiveness.
A
emphasis
review
is
placed
on
composition,
mechanism
recent
applications
carriers.
It
also
includes
research
latest
findings
form
patents
clinical
trials
field.
presented
data
demonstrate
capability
carriers
potential
systems
(referred
topical,
dermal
transdermal
delivery)
well
can
be
exploited
further
development
safe
efficacious
products.
Journal of Agricultural and Food Chemistry,
Journal Year:
2022,
Volume and Issue:
70(33), P. 10075 - 10089
Published: Aug. 15, 2022
Lactoferrin
(LF)
is
a
naturally
present
iron-binding
globulin
with
the
structural
properties
of
an
N-lobe
strongly
positively
charged
terminus
and
cage-like
structure
nano
self-assembly
encapsulation.
These
unique
give
it
potential
for
development
in
fields
electrostatic
spinning,
targeted
delivery
systems,
gut-brain
axis.
This
review
will
provide
overview
LF's
structure,
encapsulation,
transport
capabilities,
as
well
its
applications
immunity
gut
microbiota
regulation.
First,
microstructure
LF
summarized
compared
homologous
ferritin,
revealing
both
functional
similarities
differences
between
them.
Second,
interactions
application
spinning
are
summarized.
Its
positive
charge
can
be
applied
to
environmental
protection
packaging
materials
improving
drug
stability
antiviral
effects,
while
promote
bone
regeneration
anti-inflammatory
effects.
Then
behavior
exploited
protein
encapsulate
bioactive
substances
construct
systems
such
contrast
agents,
antibacterial
dressings,
anti-cancer
therapy,
gene
delivery.
In
addition,
some
covalent
noncovalent
Maillard
reaction
other
topics
briefly
discussed.
Finally,
may
affect
immunological
function
via
controlling
microbiota.
conclusion,
this
paper
reviews
research
advances
self-assembly,
immune
regulation,
aiming
reference
food
pharmaceutical
fields.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(9), P. 8053 - 8053
Published: April 29, 2023
Nanocarriers,
and
especially
nanostructured
lipid
carriers
(NLC),
represent
one
of
the
most
effective
systems
for
topical
drug
administration.
NLCs
are
biodegradable,
biocompatible
provide
a
prolonged
release.
The
glutamate
release
inhibitor
Riluzole
(RLZ)
is
currently
used
amyotrophic
lateral
sclerosis
(ALS),
with
anti-proliferative
effects
potentially
beneficial
diseases
excessive
cell
turnover.
However,
RLZ
possesses
low
water
solubility
high
light-sensibility.
We
present
here
optimized
loaded
(RLZ-NLCs)
as
potential
treatment.
RLZ-NLCs
were
prepared
by
hot-pressure
homogenization
method
using
active
essential
oils
liquid
lipids,
design
experiments
approach.
developed
obtaining
optimal
properties
dermal
application
(mean
size
below
200
nm,
negative
surface
charge
entrapment
efficacy).
In
vitro
study
demonstrates
that
allow
successful
delivery
in
sustained
manner.
Moreover,
not
angiogenic
able
to
inhibit
keratinocyte
proliferation.
Hence,
system
loading
combination
natural
constitutes
promising
strategy
against
hyperproliferative
conditions.
