Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 621 - 632
Published: Jan. 1, 2024
Language: Английский
European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177523 - 177523
Published: March 1, 2025
Language: Английский
Citations
0
Journal of Parkinson s Disease, Journal Year: 2025, Volume and Issue: unknown
Published: April 4, 2025
Background Circular RNAs (circRNAs) constitute a distinctive subclass of that are known for their regulatory roles in fundamental cellular processes. Due to increased stability and ubiquitous expression, circular have been widely studied as potential molecular targets various diseases, including neurodegenerative diseases. While several studies found differentially expressed circRNAs associated with Parkinson's disease (PD), none has looked specifically into PD progression. Objective To elucidate the role progression by identifying dysregulated pinpoint downstream miRNAs gene targets. Methods In this study, we utilized large-scale, longitudinal, deep RNA-seq data from two independent cohorts, namely Progression Marker Initiative (PPMI) Disease Biomarker Program (PDBP), characterize circRNA expression patients early stage. Results We identified six significantly whole blood samples obtained over time. Additionally, were able map competing endogenous RNA (ceRNA) network miRNA-mRNA and, help co-expression analysis, identify genes Our findings provide compelling evidence interactome an indicator progression, changes these being UPDRS III scores patients. Conclusions results strongly indicate association emphasize its significance critical marker.
Language: Английский
Citations
0
Pharmacological Research, Journal Year: 2023, Volume and Issue: 196, P. 106874 - 106874
Published: Aug. 14, 2023
Tricin, a natural nontoxic flavonoid distributed in grasses and euphorbia plants, has been reported to scavenge free radicals, possess anti-inflammatory antioxidative effects. However, its autophagic effect on Parkinson's disease (PD) not elucidated. By adopting cellular C. elegans models of PD, the tricin was identified based level autophagy markers (LC3-II p62). Besides, pharmacological effects neurotransmitters (tyrosine hydroxylase dopamine), inflammatory cytokines (IFN γ, TNFα, MCP-1, IL-10, IL-6 IL-17A), histology (hematoxylin & eosin Nissl staining) behavioural pathology (open-field test, hindlimb clasping, Y-maze, Morris water-maze nest building test) were also confirmed A53T-α-transgenic PD mouse model. Further experiments demonstrated that induced flux lowered α-synuclein through AMPK-p70s6K- ATG7-dependent mechanism. Compared existing clinical drugs, mitigated pathogenesis symptoms with no observable side In summary, is proposed as potential adjuvant remedy or nutraceutical for prevention treatment PD.
Language: Английский
Citations
9
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8838 - 8838
Published: Aug. 14, 2024
Type 2 diabetes (T2D) and Parkinson’s disease (PD) are the two most frequent age-related chronic diseases. There many similarities between diseases: both diseases; result of a decrease in specific substance—insulin T2D dopamine PD; caused by destruction cells—beta pancreatic cells dopaminergic neurons PD. Recent epidemiological experimental studies have found that there common underlying mechanisms pathophysiology PD: inflammation, mitochondrial dysfunction, impaired protein handling ferroptosis. Epidemiological research has indicated is higher risk PD individuals with T2D. Moreover, clinical observed symptoms worsen significantly after onset This article provides an up-to-date review on intricate interplay oxidative stress, reactive oxygen species (ROS) ferroptosis By understanding shared molecular pathways how they can be modulated, we develop more effective therapies, or repurpose existing drugs to improve patient outcomes disorders.
Language: Английский
Citations
3
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10484 - 10484
Published: Sept. 29, 2024
The human brain is highly dependent on oxygen, utilizing approximately 20% of the body’s oxygen at rest. Oxygen deprivation to can lead loss consciousness within seconds and death minutes. Recent studies have identified regions with spontaneous episodic hypoxia, referred as “hypoxic pockets”. Hypoxia also result from impaired blood flow due conditions such heart disease, clots, stroke, or hemorrhage, well reduced intake excessive consumption caused by factors like low ambient pulmonary diseases, infections, inflammation, cancer. Severe hypoxia in manifest symptoms similar Parkinson’s disease (PD), including cerebral edema, mood disturbances, cognitive impairments. Additionally, development PD appears be closely associated hypoxic pathways. This review seeks investigate molecular interactions between PD, emphasizing pathological role pathways exploring their potential therapeutic targets.
Language: Английский
Citations
2
Current Bioactive Compounds, Journal Year: 2024, Volume and Issue: 20(5)
Published: June 1, 2024
Background:: Lack of control in voluntary movements, resting tremor, postural instability, and stiffness are the hallmarks Parkinson's disease (PD). Objective:: The current work's objective is to assess naringin isolated from Citrus aurantium L. peels as an anti-parkinsonism agent rats. Methods:: HPLC LC-ESI-MS analysis methanol extract was done. behavioral, biochemical, genetic, histopathological were evaluated parkinsonism Results:: Fourteen phenolics nine flavonoids found extract, according analysis, while revealed presence twenty-six flavonoids. dominant flavonoid subclasses 4 aglycones, 11 monoglycosides, 5 diglycosides, 6 polymethoxy flavonoids, beside coumarines, alkaloids a limonin triterpene. Adenosine A2A receptor (A2AR) gene expression, malondialdehyde (MDA), interleukin-6 (IL-6), caspase-3 (Cas-3) DNA fragmentation levels significantly increased rotenone-treated Dopamine (DA), norepinephrine (NE), serotonin (5-HT), reduced glutathione (GSH), succinate, lactate dehydrogenase (SDH &LDH) all decreased. Treatment with A2AR antagonists enhanced animals’ behavior improved selected parameters. brain hippocampal features confirmed our results. Conclusion:: Naringin could be considered nutraceutical by attenuating neurodegeneration associated PD via blocking adenosine A2AR.
Language: Английский
Citations
2
Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 917 - 917
Published: July 29, 2024
Parkinson's disease is one of the most prevalent neurological disorders affecting millions people worldwide. There a growing demand for novel and natural substances as complementary therapies. Essential oils their various compounds are highly investigated plant-based products potential treatment options common human diseases, such microbial infections, chronic neurodegenerative disorders. The present study focuses on beneficial effects linalool geraniol, major lavender (
Language: Английский
Citations
2
Database, Journal Year: 2023, Volume and Issue: 2023
Published: Jan. 1, 2023
Abstract Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder, yet effective treatments able to stop or delay progression remain elusive. The aggregation of a presynaptic protein, α-synuclein (aSyn), primary neurological hallmark PD and, thus, promising target for therapeutic intervention. However, lack consensus on molecular properties required specifically bind toxic species formed during aSyn has hindered development molecules. Recently, we defined and experimentally validated peptide architecture that demonstrated high affinity selectivity in binding oligomers fibrils, effectively preventing pathogenic aggregation. Human peptides with such may have neuroprotective activities hold huge interest. Driven by this idea, here, developed discriminative algorithm screening human endogenous neuropeptides, antimicrobial diet-derived bioactive potential inhibit We identified over 100 unique biogenic candidates ensembled comprehensive database (aSynPEP-DB) collects their physicochemical features, source datasets additional therapeutic-relevant information, including sites expression associated pathways. Besides, provide access extend its application artificial new datasets. aSynPEP-DB repository modulate aggregation, serving as platform identification previously unexplored agents. Database URL: https://asynpepdb.ppmclab.com/
Language: Английский
Citations
4
Neuroscience, Journal Year: 2024, Volume and Issue: 544, P. 104 - 116
Published: Jan. 18, 2024
Our recent study revealed that fluorescent lamp light can penetrate deep into the brain of mice and rats leading to development typical histological characteristics associated with Parkinson's disease such as loss dopamine neurons in substantia nigra. Monochromatic LED lights were thus used this work deepen our knowledge on effects major wavelength peaks mouse human dopaminergic cells. In particular, we exposed immortalized MN9D neuronal cells, primary cultures mesencephalic cells differentiated from induced pluripotent stem (hiPSC) different wavelengths. We found chronic exposure reduced overall undifferentiated cell number, most significant observed at wavelengths 485 nm 610 nm. Moreover, especially was able negatively impact survival derived hiPSC. Notably, which closely resemble mature phenotype, acutely for 3h nm, showed a clear increase ROS production cytotoxicity compared controls These increases even more pronounced by co-treatment oxidative agent H2O2. Collectively, these findings suggest specific wavelengths, particularly those capable penetrating brain, could potentially pose an environmental hazard relation disease.
Language: Английский
Citations
1
Vaccines, Journal Year: 2024, Volume and Issue: 12(9), P. 973 - 973
Published: Aug. 28, 2024
Neurodegenerative diseases (ND) give rise to significant declines in motor, autonomic, behavioral, and cognitive functions. Of these conditions, Alzheimer's disease (AD) Parkinson's (PD) are the most prevalent, impacting over 55 million people worldwide. Given staggering financial toll on global economy their widespread manifestation, NDs represent a critical issue for healthcare systems Current treatment options merely seek provide symptomatic relief or slow rate of functional decline remain financially inaccessible many patients. Indeed, no therapy has yet demonstrated potential halt trajectory NDs, let alone reverse them. It is now recognized that brain accumulation pathological variants AD- PD-associated proteins (i.e., amyloid-β, Tau, α-synuclein) begins years decades before onset clinical symptoms. Accordingly, there an urgent need pursue therapies prevent neurodegenerative processes associated with protein aggregation long diagnosis can be made. These must safe, convenient, affordable ensure broad coverage at-risk populations. Based intervene symptoms appear, this review, we present rationale greater investment support development active immunotherapy prevention two common based safety profile, ability specifically target proteins, as well significantly lower costs manufacturing distribution, which stands expand accessibility millions globally.
Language: Английский
Citations
1