Advances in chitosan-based drug delivery systems: A comprehensive review for therapeutic applications

European Polymer Journal, Journal Year: 2024, Volume and Issue: 210, P. 112983 - 112983

Published: March 26, 2024

Language: Английский

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Chitosan: An overview of biological activities, derivatives, properties, and current advancements in biomedical applications

Carbohydrate Research, Journal Year: 2024, Volume and Issue: 542, P. 109199 - 109199

Published: June 27, 2024

Language: Английский

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Chitosan-based nanofibrous scaffolds for biomedical and pharmaceutical applications: A comprehensive review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 264, P. 130683 - 130683

Published: March 6, 2024

Language: Английский

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Advances in chitosan-based blends as potential drug delivery systems: A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 273, P. 132916 - 132916

Published: June 5, 2024

Language: Английский

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Folate-engineered chitosan nanoparticles: next-generation anticancer nanocarriers

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Oct. 31, 2024

Chitosan nanoparticles (NPs) are well-recognized as promising vehicles for delivering anticancer drugs due to their distinctive characteristics. They have the potential enclose hydrophobic molecules, thereby enhancing solubilities, permeabilities, and bioavailabilities; without use of surfactant, i.e., through surfactant-free solubilization. This allows higher drug concentrations at tumor sites, prevents excessive toxicity imparted by surfactants, could circumvent resistance. Moreover, biomedical engineers formulation scientists can also fabricate chitosan NPs slowly release agents. keeps site longer, makes therapy more effective, lowers frequency dosing. Notably, some types cancer cells (fallopian tube, epithelial tumors ovary, primary peritoneum; lung, kidney, ependymal brain, uterus, breast, colon, malignant pleural mesothelioma) overexpression folate receptors (FRs) on outer surface, which lets folate-drug conjugate–incorporated target kill them effectively. Strikingly, there is evidence suggesting that excessively produced FR&αgr (isoforms FR) stays consistent throughout treatment in ovarian endometrial cancer, indicating resistance conventional treatment; this regard, folate-anchored overcome it improve therapeutic outcomes. Interestingly, overly expressed FRs present only certain types, a biomarker predicting effectiveness FR-targeted therapy. On other hand, folate-modified enhance oral absorption medicines, especially drugs, pave way effective long-term low-dose metronomic scheduling poorly soluble permeable drugs. In review, we talked briefly about techniques used create, characterize, tailor chitosan-based NPs; delved deeper into applications folate-engineered treating various types. Schematic illustration ligand-drug incorporated its advantage cancer. Figure created with BioRender.Com.

Language: Английский

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Understanding the journey of biopolymeric nanoformulations for oral drug delivery: Conventional to advanced treatment approaches

European Polymer Journal, Journal Year: 2024, Volume and Issue: 218, P. 113338 - 113338

Published: July 26, 2024

Language: Английский

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Drug Loading in Chitosan-Based Nanoparticles

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 1043 - 1043

Published: Aug. 6, 2024

Chitosan nanoparticles (CSNPs) are promising vehicles for targeted and controlled drug release. Recognized their biodegradability, biocompatibility, low toxicity, ease of production, CSNPs represent an effective approach to delivery. Encapsulating drugs within (NPs) provides numerous benefits compared free drugs, such as increased bioavailability, minimized toxic side effects, improved delivery, the incorporation additional features like release, imaging agents, combination therapies with multiple drugs. Keys parameters in nanomedicines loading content efficiency. Most current NP systems struggle loading, presenting a significant challenge field. This review summarizes recent research on developing high capacity, focusing various synthesis strategies. It examines CSNP using different materials providing details methods, loadings, encapsulation efficiencies, release profiles, stability, applications Additionally, discusses factors affecting valuable guidelines future CSNPs’ development.

Language: Английский

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Selective Adsorption to Pathogenic Bacteria Augments Antibacterial Activity via Adjusting the Physicochemical Property of Nanoparticles

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract Oral antibiotics are the primary method used to treat bacterial infections in clinical practice. However, non‐selectivity of reduces efficacy treatment while also tending damage normal flora and cause dysbiosis. Obviously, it is crucial enhance selectivity against bacteria. It possible modulate physicochemical properties orally administered nanosystems achieve selective adsorption bacteria, thereby achieving improving bactericidal effects. A series nanoparticles examined adhesion characteristics focusing on five aspects: particle size, shape, charge, surface hydrophilicity, modification. Selective investigated pathogenic bacteria ( S. aureus as an example), E. coli probiotic faecium example). The results show that ≈50 nm chitosan‐modified spherical Poly(lactide‐co‐glycolide) (PLGA) exhibit a stronger capacity for Staphylococcus ). After loading with amoxicillin, antibacterial able destroy without disrupting intestinal reducing typical side effects ecological disruption caused by broad‐spectrum antibiotics. Thus, this work presents convenient versatile strategy targeting current

Language: Английский

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Diosmin-loaded chitosan nanoparticles mitigate doxorubicin-evoked cardiotoxicity in rats by featuring oxidative imbalance mechanism, NF-κB, and Bcl-2/Bax pathways

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140991 - 140991

Published: Feb. 1, 2025

Language: Английский

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Metronidazole-Loaded Chitosan Nanoparticles with Antimicrobial Activity Against Clostridium perfringens

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 294 - 294

Published: Feb. 24, 2025

Background/Objectives: Even with improvements in surgical techniques and the application of appropriate antibiotic prophylaxis, wound infections are still major public health problems low- middle-income countries. This study proposes design new particulate polymeric matrices based on chitosan (CS) for controlled release Metronidazole (MTZ), order it to be used treatment Clostridium perfringens infections. Methods: The nanoparticles were prepared via inverse emulsion using tannic acid (TA) sodium tripolyphosphate (TPP) as cross-linking agents. ratio CS TPP, concentration solution, TA varied optimize synthesis procedure. Nanoparticles have been characterized several points view correctly correlate their properties parameters. Results: FTIR spectra analyzed confirmed both formation hydrogen bonds between ionic TPP. average diameters ranged from 70 170 nm, whereas zeta potential values around 8 mV. Their swelling degree a weak basic environment, well drug loading/release capacity was influenced, expected, by obtained tested vitro evaluate behavior blood cytotoxic effect, antimicrobial activity loaded MTZ against cultures. Conclusions: results demonstrate that these non-hemolytic non-cytotoxic particles can efficient delivery systems

Language: Английский

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