Metabolite profiling, antioxidant, and in vitro wound healing activities of Citrus medica L. and Citrus x microcarpa Bunge peels and leaves essential oils DOI Creative Commons

Elidahanum Husni,

Dachriyanus Dachriyanus,

Dean Pavvellin

et al.

Prospects in Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 22(4), P. 122 - 130

Published: Dec. 26, 2024

Wound care is still dominated by the use of synthetic chemicals such as anti-inflammatory drugs, corticosteroids and antibiotics which have many shortcomings. One potential alternative to be developed essential oils. Citrus are members Rutaceae family contain medica L. x microcarpa Bunge distributed in West Sumatra research on wound healing activity lacking. Therefore, this study aims identify metabolite profiles oils two species citrus using FTIR spectroscopy GC-MS well evaluate their antioxidant determine activity. Essential were obtained hydrodistillation method. Metabolite fingerprinting profiling carried out methods. Antioxidant was determined ABTS FRAP methods while used MTT Assay Scratch Assay. The result showed secondary metabolites peels (LPEO) leaves (LLEO) oil contained D-limonene citral. Meanwhile (MLEO) β-pinene, germacrene D, elemol (MPEO) consists D-limonene, D. MLEO has stronger than MPEO, LPEO with method IC50 197.051 µg/mL 8.04 Fe (II)/mg sample followed LLEO. Testing assay that MPEO significantly increased cell proliferation. Meanwhile, highest closure found at a concentration 0.1 for 77.54% 73.71% scratch It can concluded increase proliferation migration so they an healing.

Language: Английский

Withania somnifera (L.) Dunal, a Potential Source of Phytochemicals for Treating Neurodegenerative Diseases: A Systematic Review DOI Creative Commons

Valentina Lerose,

Maria Ponticelli,

Nadia Benedetto

et al.

Plants, Journal Year: 2024, Volume and Issue: 13(6), P. 771 - 771

Published: March 8, 2024

Withania somnifera (L.) Dunal is a medicinal plant belonging to the traditional Indian medical system, showing various therapeutic effects such as anti-cancer, anti-inflammatory, anti-microbial, anti-diabetic, and hepatoprotective activity. Of great interest W. somnifera’s potential beneficial effect against neurodegenerative diseases, since authorized treatments can only delay disease progression provide symptomatic relief are not without side effects. A systematic search of PubMed Scopus databases was performed identify preclinical clinical studies focusing on applications in preventing diseases. Only English articles those containing keywords (Withania AND “neurodegenerative diseases”, “neuroprotective effects”, “Huntington”, “Parkinson”, “Alzheimer”, “Amyotrophic Lateral Sclerosis”, “neurological disorders”) title or abstract were considered. Reviews, editorials, letters, meta-analyses, conference papers, short surveys, book chapters Selected grouped by pathologies summarized, considering mechanism action. The quality assessment risk bias using Cochrane Handbook for Systematic Reviews Interventions checklist. This review uses approach summarize results from 60 investigations highlight role its specialized metabolites treating

Language: Английский

Citations

12
Nutritional immunological effects and mechanisms of chemical constituents from the homology of medicine and food DOI
Great Iruoghene Edo, Winifred Ndudi,

Raghda Makia

et al.

Phytochemistry Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 2, 2024

Language: Английский

Citations

9
Integrated HS-GC–IMS and UPLC-Q-Orbitrap HRMS-based metabolomics revealed the characteristics and differential volatile and nonvolatile metabolites of different citrus peels DOI Creative Commons

Haifan Wang,

Peng Wang, Fu Wang

et al.

Current Research in Food Science, Journal Year: 2024, Volume and Issue: 8, P. 100755 - 100755

Published: Jan. 1, 2024

Citrus is an important genus in the Rutaceae family, and citrus peels can be used both food herbal medicine. However, bulk of are discarded as waste by fruit processing industry, causing environmental pollution. This study aimed to provide guidelines for rational effective use elucidating volatile nonvolatile metabolites within them using metabolomics based on headspace-gas chromatography–ion mobility spectrometry ultra-high-performance liquid chromatography–Q-Orbitrap high-resolution mass spectrometry. In addition, antioxidant activities were evaluated DPPH radical scavenging, ABTS ferric reducing power. total, 103 53 identified characterized. Alcohols, aldehydes, terpenes constituted 87.36% metabolites, while flavonoids carboxylic acids accounted 85.46% metabolites. Furthermore, (Z)-2-penten-1-ol, L-pipecolinic acid, limonin characteristic components reticulata Blanco cv. Ponkan (PK), C. 'Unshiu' (CLU), 'Wo Gan' (WG), respectively. Principal component analysis partial least squares discriminant indicated that 'Chun Jian' (CJ), PK, CLU, 'Dahongpao' (DHP) clustered together. DHP a traditional Chinese medicine documented Pharmacopoeia, suggesting chemical compositions CJ, CLU may also have medicinal values similar those DHP. Moreover, DHP, 'Ai Yuan 38'(AY38), 'Gan Ping'(GP), 'Qing Jian'(QJ) displayed better activities, recommending their additives cosmetics food. Correlation suggested some polyphenols including tangeritin, nobiletin, skullcapflavone II, genistein, caffeic isokaempferide potential compounds peel. The results this deepen our understanding differences different peel varieties ultimately guidance full peels.

Language: Английский

Citations

6
Comparative Evaluation of Anticancer Efficacy and Molecular Mechanism of Silver Nanoparticles Synthesized from Methanolic and Ethanolic Extracts of Citrus medica DOI

Ejaj Ahmad,

Mohammed Sajid,

Alina Athar

et al.

Published: April 18, 2025

Abstract The development of biosynthesized and cost-efficient nanomedicine is a promising strategy in cancer therapeutics. Herein, we have synthesized highly potent silver nanoparticles (AgNPs) using methanolic ethanolic extracts Citrus medica fruit, unraveling the significance different solvents. Fourier transform Infrared spectroscopy confirmed occurrence secondary metabolites on AgNPs’ surface. Zetasizer analysis showed no significant particle-size differences between both solvents based-synthesized AgNPs; however, zeta potential particle surface charge. high-resolution transmission electron microscopy predominantly spherical morphology AgNPs. Notably, AgNPs from exhibited smaller sizes (5-7 nm) more uniform distribution compared to their counterparts. X-ray diffraction demonstrated polycrystalline nature with face-centered cubic structure. Functional assays increase anticancer efficacy extract-derived against breast cells (MCF-7 MDA-MB-231), accompanied by extensive DNA fragmentation enhanced induction apoptosis. Mechanistically, induce upregulation pro-apoptotic gene expression (e.g., TP53, BAX, CYCS) downregulation anti-apoptotic BCL2). flow cytometry substantial extract-based late-stage apoptotic cells, which was further morphological changes treated MCF-7 cells. This study reveals pivotal influence selection solvent synthesis potency AgNPs, significantly impacting ability apoptosis Our findings introduce novel for optimizing green AgNPs-based therapies, offering avenues advancing nanoparticle-driven treatments potentially transforming future therapeutic approaches oncology.

Language: Английский

Citations

0
Unlocking the Potential of Citrus medica L.: Antioxidant Capacity and Phenolic Profile across Peel, Pulp, and Seeds DOI Creative Commons
Ana Rita Soares Mateus, João David Teixeira, Sílvia Cruz Barros

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(15), P. 3533 - 3533

Published: July 27, 2024

L. is a traditional citrus fruit that rich in bioactive compounds and has the potential to be used as natural source of food additives. This study aims evaluate antioxidant capacity characterize phenolic present peels (including flavedo albedo), pulp, seeds citron. The results showed that, compared other parts, pulp had substantially higher Antioxidant Activity Coefficient (AAC) 168.2. albedo significantly lower AAC values, while green yellow noteworthy results.

Language: Английский

Citations

3
When sustainability meets health and innovation: The case of Citrus by-products for cancer chemoprevention and applications in functional foods DOI
Teresa D’Amore, Moufida Chaari, Geppino Falco

et al.

Biocatalysis and Agricultural Biotechnology, Journal Year: 2024, Volume and Issue: 58, P. 103163 - 103163

Published: April 15, 2024

Language: Английский

Citations

2
Reviews on Asian citrus species: Exploring traditional uses, biochemistry, conservation, and disease resistance DOI
Piumi Chathurika Palangasinghe, Wasantha Kumara Liyanage, Manupa Pabasara Wickramasinghe

et al.

Ecological Genetics and Genomics, Journal Year: 2024, Volume and Issue: 32, P. 100269 - 100269

Published: May 29, 2024

Language: Английский

Citations

1
Boosting the anti-tumor activity of natural killer cells by caripe 8 – A Carapichea ipecacuanha isolated cyclotide DOI Creative Commons
Julia List,

Jasmin Gattringer,

Sophie Huszarek

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 117057 - 117057

Published: July 7, 2024

Language: Английский

Citations

1
Sedative-Hypnotic Effect and Mechanism of Carbon Nanofiber Loaded with Essential Oils of Ligusticum chuanxiong (Ligusticum chuanxiong Hort.) and Finger Citron (Citrus medica L. var. sarcodactylis) on Mice Models of Insomnia DOI Creative Commons
Yue Hu,

Xiaofang He,

Yuanyuan Wu

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1102 - 1102

Published: Sept. 2, 2024

(1) Background: Insomnia is a neurological illness that poses significant threat to both physical and mental health. It results in the activation of neuroglial cells, heightened neuroinflammation, oxidative stress, disruptions Hypothalamic-Pituitary-Adrenal (HPA) axis. Ligusticum Chuanxiong (CX) Finger citron (FC) are frequently utilized botanicals for addressing sleeplessness. Both herbs possess notable anti-inflammatory properties their volatile oils. However, effectiveness hindered by nasal mucosal irritation instability they exhibit. (2) Methods: This study involved preparation nanofiber composite system using carbon (CNF) suspensions containing essential oils chuanxiong-Finger (CXEO-FCEO-CNF). The effects mechanisms these improving insomnia were investigated an mouse model after encapsulation. (3) Results: CXEO-FCEO-CNF had average particle size 103.19 ± 1.64 nm. encapsulation rates chuanxiong (CXEO) (FCEO) 44.50% 46.15%, respectively. resulted considerable improvement stability over period 30 days. effectively decreased mucosa following Furthermore, enhanced voluntary activity sleep mice with insomnia, notably boosted superoxide dismutase (SOD), reduced concentration lipoxidized malondialdehyde (MDA), levels hormones associated HPA axis, regulated neurotransmitters, resulting beneficial therapeutic outcome. contains total 23 active ingredients, such as alpha-Asarone, (E)-methyl isoeugenol, Senkyunolide. These ingredients primarily work modulating Janus kinase-signal transducer activator transcription (JAK-STAT) signaling decrease stress inflammatory reactions. (4) Conclusions: presented initial evidence combination CXEO FCEO formulations reduces it demonstrated potential anti-neuroinflammatory treating insomnia. Overall, this provides theoretical foundation developing new oil derived from herbs.

Language: Английский

Citations

1
Analysis of genetic diversity and environmental associations of wild citron (Citrus medica L.) in northeast India DOI
Aakash Maurya,

Bhavya Priyadarshini Mishra,

Ram Mohan

et al.

Scientia Horticulturae, Journal Year: 2024, Volume and Issue: 338, P. 113690 - 113690

Published: Oct. 4, 2024

Language: Английский

Citations

1