Giant,
Journal Year:
2024,
Volume and Issue:
19, P. 100323 - 100323
Published: July 10, 2024
Inspired
by
the
extracellular
matrix
(ECM),
biomaterials
have
emerged
as
promising
strategies
in
biomedical
research
and
engineering
domain,
offering
unique
characteristics
for
tissue
regeneration,
drug
delivery,
therapeutic
interventions,
cellular
investigations.
The
ECM,
a
dynamic
network
structure
secreted
various
cells,
primarily
comprises
diverse
proteins
capable
of
facilitating
tissue-ECM
signaling
regulatory
functions
through
its
rich
array
bioactive
substances
multi-level
structural
properties.
Drawing
inspiration
from
intricate
biochemical
composition
natural
researchers
developed
to
encapsulate
these
features
create
biomimetic
microenvironments,
such
electrospinning,
hydrogels/hydrogel
microspheres,
decellularized
ECM(dECM),
ECM-mimicking
peptides.
Furthermore,
mimicking
ECM
components,
ECM-inspired
exhibit
varying
degrees
functionalization,
including
providing
support,
cell
adhesion,
signal
transduction,
mitigating
immune
responses,
remodeling.
In
summary,
advancements
offer
significant
promise
addressing
key
challenges
fields
engineering,
regenerative
medicine,
delivery.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(10)
Published: Jan. 1, 2023
Abstract
Diabetic
foot
ulcer
(DFU)
is
one
of
the
most
common
complications
diabetes,
bringing
physical
and
mental
challenges
for
patients
due
to
lack
efficient
curative
therapy.
Despite
considerable
advances
in
pharmacological
surgical
approaches,
clinical
trials
DFU
remain
disappointing
local
overactive
excessive
inflammation.
Immunomodulatory
hydrogels
has
significant
advantages
overcome
challenge
DFUs
Here,
recent
fabrication
regenerative
utilization
functional
altering
immune
microenvironment
are
comprehensively
reviewed.
The
pathological
features
healing
processes
DFUs,
followed
by
summarizing
physicochemical
properties
essential
design
immunomodulation
briefly
introduced.
Then,
potential
immuno‐therapeutic
modalities
emerging
trends
used
treat
via
multitherapeutic
approaches
enhanced
efficacy
safety
discussed.
Taken
together,
linking
structural
their
functions
therapy
with
a
particular
focus
on
immunomodulatory
stimuli,
this
review
can
promote
further
designing
advanced
resulting
improved
diabetic
wound
repair
through
translation
into
setting
near
future.
BMEMat,
Journal Year:
2023,
Volume and Issue:
1(3)
Published: June 30, 2023
Abstract
Diabetic
foot
ulcers
(DFU)
are
a
common
and
often
debilitating
complication
of
diabetes
that
can
result
in
lower
limb
amputations
if
left
untreated.
Hydrogel
dressings
three‐dimensional
networks
hydrophilic
polymers
absorb
retain
large
amounts
water,
have
been
shown
to
possess
excellent
biocompatibility,
low
toxicity,
fluid
handling
properties.
In
addition,
hydrogels
create
moist
wound
environment
promotes
healing
by
supporting
cell
proliferation,
migration,
angiogenesis.
Hydrogels,
therefore,
emerged
as
promising
for
promoting
DFU
healing.
this
review,
we
attempt
chart
the
landscape
emerging
field
hydrogel
dressing
treatment.
We
will
explicitly
review
assorted
preparation
methods
well
detailed
discussion
various
types
deployed
study.
also
crystallize
key
findings,
identify
remaining
challenges,
present
an
outlook
on
future
development
enticing
field.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(8), P. 4086 - 4153
Published: Jan. 1, 2024
This
review
critically
analyzes
degradable
biomedical
elastomers,
focusing
on
their
degradation,
synthesis,
microstructure,
and
role
in
tissue
repair.
It
guides
experts
balancing
degradation
with
repair
for
improved
applications.
Nano-Micro Letters,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Feb. 6, 2024
Inflammatory
skin
disorders
can
cause
chronic
scarring
and
functional
impairments,
posing
a
significant
burden
on
patients
the
healthcare
system.
Conventional
therapies,
such
as
corticosteroids
nonsteroidal
anti-inflammatory
drugs,
are
limited
in
efficacy
associated
with
adverse
effects.
Recently,
nanozyme
(NZ)-based
hydrogels
have
shown
great
promise
addressing
these
challenges.
NZ-based
possess
unique
therapeutic
abilities
by
combining
benefits
of
redox
nanomaterials
enzymatic
activity
water-retaining
capacity
hydrogels.
The
multifaceted
effects
include
scavenging
reactive
oxygen
species
other
inflammatory
mediators
modulating
immune
responses
toward
pro-regenerative
environment
enhancing
regenerative
potential
triggering
cell
migration
differentiation.
This
review
highlights
current
state
art
NZ-engineered
(NZ@hydrogels)
for
regeneration
applications.
It
also
discusses
underlying
chemo-mechano-biological
mechanisms
behind
their
effectiveness.
Additionally,
challenges
future
directions
this
ground,
particularly
clinical
translation,
addressed.
insights
provided
aid
design
engineering
novel
hydrogels,
offering
new
possibilities
targeted
personalized
skin-care
therapies.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(4), P. 1982 - 1982
Published: Feb. 6, 2024
The
skin
is
subject
to
damage
from
the
surrounding
environment.
repair
of
wounds
can
be
very
challenging
due
several
factors
such
as
severe
injuries,
concomitant
infections,
or
comorbidities
diabetes.
Different
drugs
and
wound
dressings
have
been
used
treat
wounds.
Tissue
engineering,
a
novel
therapeutic
approach,
revolutionized
treatment
regeneration
tissue
damage.
This
field
includes
use
synthetic
natural
biomaterials
that
support
growth
tissues
organs
outside
body.
Accordingly,
demand
for
polymer-based
strategies
defects
significantly
increasing.
Among
various
3D
scaffolds
in
hydrogel
gained
special
significance
their
unique
properties
mimicry
extracellular
matrix
(ECM),
moisture
retention,
porosity,
biocompatibility,
biodegradability,
biocompatibility
properties.
First,
this
article
delineates
process
healing
conventional
methods
treating
It
then
presents
an
examination
structure
manufacturing
hydrogels,
followed
by
analysis
crucial
characteristics
most
recent
advancements
using
purpose.
Finally,
it
discusses
potential
future
materials
within
realm
healing.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(7), P. 3849 - 3849
Published: March 29, 2024
This
state-of-the-art
review
explores
the
emerging
field
of
regenerative
hydrogels
and
their
profound
impact
on
treatment
skin
wounds.
Regenerative
hydrogels,
composed
mainly
water-absorbing
polymers,
have
garnered
attention
in
wound
healing,
particularly
for
Their
unique
properties
make
them
well
suited
tissue
regeneration.
Notable
benefits
include
excellent
water
retention,
creating
a
crucially
moist
environment
optimal
facilitating
cell
migration,
proliferation.
Biocompatibility
is
key
feature,
minimizing
adverse
reactions
promoting
natural
healing
process.
Acting
as
supportive
scaffold
growth,
mimic
extracellular
matrix,
aiding
attachment
proliferation
cells
like
fibroblasts
keratinocytes.
Engineered
controlled
drug
release,
enhance
by
angiogenesis,
reducing
inflammation,
preventing
infection.
The
demonstrated
acceleration
process,
beneficial
chronic
or
impaired
wounds,
adds
to
appeal.
Easy
application
conformity
various
shapes
practical,
including
irregular
challenging
areas.
Scar
minimization
through
regeneration
crucial,
especially
cosmetic
functional
regions.
Hydrogels
contribute
pain
management
protective
barrier,
friction,
fostering
soothing
environment.
Some
with
inherent
antimicrobial
properties,
aid
infection
prevention,
which
crucial
aspect
successful
healing.
flexibility
ability
conform
contours
ensure
contact,
enhancing
overall
effectiveness.
In
summary,
present
promising
approach
improving
outcomes
across
diverse
clinical
scenarios.
provides
comprehensive
analysis
benefits,
mechanisms,
challenges
associated
use
this
review,
authors
likely
delve
into
rational
design
principles
efficacy
performance
Through
an
exploration
methodologies
approaches,
paper
poised
highlight
how
these
been
instrumental
refining
potentially
revolutionizing
therapeutic
potential
addressing
By
synthesizing
current
knowledge
highlighting
avenues
future
research,
aims
advancement
medicine
ultimately
improve
patients
