There
is
need
to
address
the
challenges
of
organ
shortage,
through
development
tissues
and
organs
with
alternatives
those
allograft-kind.
This
illustrates
quest
behind
novel
biofabrication
strategies
such
as
3D
bio-printing,
which
necessary
create
artificial
multi-cellular
tissues/organs.
Several
findings
have
been
reported
in
this
review.
First,
role
ECM
components
tissue
regenerative
medicine
presented.
Different
collagen,
gelatin,
elastin,
fibronectin,
laminins
glycosaminoglycans
are
concisely
examined
for
their
applications.
Next,
current
state
research
on
extrusion-based
bio-printing
techniques
limitations
reviewed.
For
example,
we
show
that
cell
viability
still
a
challenge
extrusion,
while
use
natural
polymers
collagen
improving
composites’
mechanical
properties
limited.
Lastly,
examine
unresolved
questions
advance
present
field.
Talanta Open,
Journal Year:
2023,
Volume and Issue:
8, P. 100243 - 100243
Published: July 8, 2023
Hydrogels
have
a
significant
impact
on
the
fields
of
biological
study
and
medical
diagnosis.
They
are
becoming
more
useful
in
bioanalytical
biosensing
applications.
The
intriguing
new
nanomaterials
quantum
dots-hydrogel
composites
gained
lot
interest
because
their
unmatched
biocompatibility
tolerable
biodegradability,
which
opens
up
wide
range
possible
Focusing
synthesis
techniques,
this
review
describes
current
developments
composites,
such
as
hydrogel
gelation
dots
(QDs)
solution,
inserting
prepared
QDs
into
hydrogels
after
gelation,
generating
situ
inside
preformed
gel,
cross-linking
through
QDs.
Biomedical
applications
bioimaging
specifically
examined,
then
inherent
problems
design
optimisation,
biocompatibility,
bimodal
applications,
well
potential
future
development,
discussed.
Journal of Tissue Engineering,
Journal Year:
2023,
Volume and Issue:
14
Published: Jan. 1, 2023
Fibrin
is
a
promising
natural
polymer
that
widely
used
for
diverse
applications,
such
as
hemostatic
glue,
carrier
drug
and
cell
delivery,
matrix
tissue
engineering.
Despite
the
significant
advances
in
use
of
fibrin
bioengineering
biomedical
some
its
characteristics
must
be
improved
suitability
general
use.
For
example,
hydrogels
tend
to
shrink
degrade
quickly
after
polymerization,
particularly
when
they
contain
embedded
cells.
In
addition,
their
poor
mechanical
properties
batch-to-batch
variability
affect
handling,
long-term
stability,
standardization,
reliability.
One
most
approaches
improve
has
been
modification
structure
composition
hydrogels.
this
review,
recent
composite
scaffolds,
chemically
modified
hydrogels,
interpenetrated
network
(IPN)
composed
other
synthetic
or
polymers
are
critically
reviewed,
focusing
on
Polymers,
Journal Year:
2022,
Volume and Issue:
14(5), P. 986 - 986
Published: Feb. 28, 2022
The
successful
design
of
a
hydrogel
for
tissue
engineering
requires
profound
understanding
its
constituents’
structural
and
molecular
properties,
as
well
the
proper
selection
components.
If
engineered
processes
are
in
line
with
procedures
that
natural
materials
undergo
to
achieve
best
network
structure
necessary
formation
desired
failure
rate
projects
will
be
significantly
reduced.
In
this
review,
we
examine
behavior
proteins
an
essential
effective
component
hydrogels,
describe
factors
can
enhance
protein-based
hydrogels’
structure.
Furthermore,
outline
fabrication
route
hydrogels
from
protein
microstructure
appropriate
according
recent
research
growth
factors,
crucial
members
family,
their
delivery
approaches.
Finally,
unmet
needs
current
challenges
developing
ideal
biomaterials
discussed,
emerging
strategies
area
highlighted.
Journal of Functional Biomaterials,
Journal Year:
2025,
Volume and Issue:
16(3), P. 79 - 79
Published: Feb. 22, 2025
The
use
of
blood
plasma,
fibrinogen
or
fibrin,
a
natural
biomaterial,
has
been
widely
studied
for
the
development
different
skin
tissue-engineered
products
and
other
dermatological
treatments.
This
systematic
review
reports
preclinical
clinical
studies
which
it
alone
combined
with
biomaterials
and/or
cells
treatment
several
conditions.
Following
PRISMA
2020
Guidelines,
147
have
revealed
that
this
biomaterial
as
wound
dressing
monolayer
(one
cell
type)
substitute
are
preferred
strategies,
mainly
excisional
surgical
wounds.
Moreover,
plasma
is
used
although
its
combination
such
agarose,
polyethylene
glycol
collagen
also
reported
to
increase
healing
potential.
However,
most
17
reviewed
evaluated
severely
burned
patients
bilayer
(two
types)
substitute.
Although
number
evaluating
increased
during
last
fifteen
years,
not
correlated
wide
variety
studies.
Its
safety
potential
proved;
however,
lack
standard
model
presence
approaches
meant
translation
environment
still
limited.
A
higher
should
be
carried
out
in
coming
years
set
strategy
each
disease.
Gels,
Journal Year:
2023,
Volume and Issue:
9(5), P. 376 - 376
Published: May 2, 2023
Hydrogels
are
three-dimensional
networks
with
a
variety
of
structures
and
functions
that
have
remarkable
ability
to
absorb
huge
amounts
water
or
biological
fluids.
They
can
incorporate
active
compounds
release
them
in
controlled
manner.
also
be
designed
sensitive
external
stimuli:
temperature,
pH,
ionic
strength,
electrical
magnetic
stimuli,
specific
molecules,
etc.
Alternative
methods
for
the
development
various
hydrogels
been
outlined
literature
over
time.
Some
toxic
therefore
avoided
when
obtaining
biomaterials,
pharmaceuticals,
therapeutic
products.
Nature
is
permanent
source
inspiration
new
functionalities
more
competitive
materials.
Natural
present
series
physico-chemical
characteristics
suitable
such
as
biocompatibility,
antimicrobial
properties,
biodegradability,
nontoxicity.
Thus,
they
generate
microenvironments
comparable
intracellular
extracellular
matrices
human
body.
This
paper
discusses
main
advantages
presence
biomolecules
(polysaccharides,
proteins,
polypeptides)
hydrogels.
Structural
aspects
induced
by
natural
their
properties
emphasized.
The
most
applications
will
highlighted,
including
drug
delivery,
self-healing
materials
regenerative
medicine,
cell
culture,
wound
dressings,
3D
bioprinting,
foods,
International Journal of Cosmetic Science,
Journal Year:
2023,
Volume and Issue:
45(6), P. 699 - 724
Published: July 4, 2023
Abstract
The
term
biopolymer
refers
to
materials
obtained
by
chemically
modifying
natural
biological
substances
or
producing
them
through
biotechnological
processes.
They
are
biodegradable,
biocompatible
and
non‐toxic.
Due
these
advantages,
biopolymers
have
wide
applications
in
conventional
cosmetics
new
trends
emerged
as
essential
ingredients
that
function
rheological
modifiers,
emulsifiers,
film‐formers,
moisturizers,
hydrators,
antimicrobials
and,
more
recently,
with
metabolic
activity
on
skin.
Developing
approaches
exploit
features
is
a
challenge
for
formulating
skin,
hair
oral
care
products
dermatological
formulations.
This
article
presents
an
overview
of
the
use
principal
used
cosmetic
formulations
describes
their
sources,
recently
derived
structures,
novel
safety
aspects
molecules.
Polymers,
Journal Year:
2023,
Volume and Issue:
15(17), P. 3648 - 3648
Published: Sept. 4, 2023
Wound
management
represents
a
well-known
continuous
challenge
and
concern
of
the
global
healthcare
systems
worldwide.
The
is
on
one
hand
related
to
accurate
diagnosis,
other
establishing
an
effective
treatment
plan
choosing
appropriate
wound
care
products
in
order
maximize
healing
outcome
minimize
financial
cost.
market
dressings
dynamic
field
which
grows
evolves
continuously
as
result
extensive
research
developing
versatile
formulations
with
innovative
properties.
Hydrogels
are
most
attractive
which,
many
aspects,
considered
ideal
for
widely
exploited
extension
their
advantages
process.
Smart
hydrogels
(SHs)
offer
opportunities
modulation
physico-chemical
properties
response
external
stimuli
(light,
pressure,
pH
variations,
magnetic/electric
field,
etc.)
achieve
behavior
three-dimensional
matrix
(gel–sol
transitions,
self-healing
self-adapting
abilities,
controlled
release
drugs).
SHs
different
triggers
depends
composition,
cross-linking
method,
manufacturing
process
approach.
Both
native
or
functionalized
natural
synthetic
polymers
may
be
used
develop
stimuli-responsive
matrices,
while
mandatory
characteristics
(biocompatibility,
water
permeability,
bioadhesion)
preserved.
In
this
review,
we
briefly
present
physiopathology
mechanisms
chronic
wounds,
well
current
therapeutic
approaches.
rational
using
traditional
healing,
directions
features,
addressed
discussed
along
limitations
perspectives
industrial-scale
manufacturing.
Biomacromolecules,
Journal Year:
2021,
Volume and Issue:
22(12), P. 4956 - 4966
Published: Nov. 9, 2021
Three-dimensional
(3D)
bioprinting
offers
a
great
alternative
to
traditional
techniques
in
tissue
reconstruction,
based
on
seeding
cells
manually
into
scaffold,
better
reproduce
organs'
complexity.
When
suitable
bioink
is
engineered
with
appropriate
physicochemical
properties,
such
process
can
advantageously
provide
spatial
control
of
the
patterning
that
improves
reconstruction.
The
design
an
adequate
must
fulfill
long
list
criteria
including
biocompatibility,
printability,
and
stability.
In
this
context,
we
have
developed
containing
precisely
controlled
recombinant
biopolymer,
namely,
elastin-like
polypeptide
(ELP).
This
material
was
further
chemoselectively
modified
cross-linkable
moieties
3D
network
through
photopolymerization.
ELP
chains
were
additionally
either
functionalized
peptide
sequence
Gly-Arg-Gly-Asp-Ser
(GRGDS)
or
combined
collagen
I
enable
cell
adhesion.
Our
ELP-based
bioinks
found
be
printable,
while
providing
excellent
mechanical
properties
as
stiffness
elasticity
their
cross-linked
form.
Besides,
they
demonstrated
biocompatible,
showing
viability
adhesion
dermal
normal
human
fibroblasts
(NHF).
Expressions
specific
extracellular
matrix
(ECM)
protein
markers
pro-collagen
I,
elastin,
fibrillin,
fibronectin
revealed
within
after
only
18
days
culture,
potential
for
engineering.
