Current Opinion in Biotechnology, Journal Year: 2023, Volume and Issue: 83, P. 102969 - 102969
Published: July 24, 2023
Language: Английский
Nanomaterials, Journal Year: 2023, Volume and Issue: 13(3), P. 489 - 489
Published: Jan. 25, 2023
Broad-spectrum antibiotics from the fluoroquinolone family have emerged as prominent water contaminants, among other pharmaceutical pollutants. In present study, an antibacterial magnetic molecularly imprinted polymer (MMIP) composite was successfully fabricated using carboxy methyl dextrin grafted to poly(aniline-co-meta-phenylenediamine) in presence of Fe3O4/CuO nanoparticles and ciprofloxacin antibiotic. The characteristics obtained materials were investigated FTIR, XRD, VSM, TGA, EDX, FE-SEM, zeta potential, BETanalyses. Afterward, MMIP’s activity adsorption effectiveness for removing aqueous solutions explored. results tests showed that MMIP had effect against Escherichia coli, a Gram-negative pathogen (16 mm), Staphylococcus aureus, Gram-positive (22 mm). Adsorption efficacy evaluated under variety experimental conditions, including solution pH, adsorbent dosage, contact time, initial concentration. maximum capacity (Qmax) determined be 1111.1 mg/g 3 mg MMIP, with concentration 400 mg/L at pH 7, within 15 min, agitated 25 °C, well-described by Freundlich isotherm model. kinetic data well represented pseudo-second-order Electrostatic interaction, cation exchange, π-π interactions, hydrogen bonding mostly able adsorb majority onto MMIP. Adsorption–desorption experiments revealed could retrieved reused no noticeable reduction after three consecutive cycles.
Language: Английский
Citations
17
Bio-Design and Manufacturing, Journal Year: 2024, Volume and Issue: 7(2), P. 181 - 205
Published: March 1, 2024
Abstract Three-dimensional (3D) printing and bioprinting have come into view for a plannable standardizable generation of implantable tissue-engineered constructs that can substitute native tissues organs. These structures are intended to integrate with the patient’s body. Vascular tissue engineering (TE) is relevant in TE because it supports sustained oxygenization nutrition all constructs. Bioinks specific role, representing necessary medium printability vascular cell growth. This review aims understand requirements design bioinks. First, an in-depth analysis interaction their environment must be gained. A physiological bioink suitable graft (TEVG) not only ensure good but also induce cells behave like vessel, including self-regenerative growth functions. describes general structure walls wall-specific extracellular matrix (ECM) components biomechanical properties Furthermore, role ECM mode introduced. Diverse currently available or imaginable bioinks described from proteins nonphysiologically occurring natural chemical compounds useful bioprinting. The performance these evaluated regard postprinting, current animal studies 3D printed structures. Finally, main challenges further development, create self-assembly concept, future strategies outlined. concepts discussed terms suitability part TEVG high potential later clinical use.
Language: Английский
Citations
7
ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(8), P. 8377 - 8391
Published: April 8, 2024
Nosocomial infections are a significant threat to public health that leads substantial morbidity and mortality. The emergence spread of antibiotic-resistant organisms have compounded the complexity managing these infections, highlighting urgent need for innovative effective strategies combat them. Photostimuli-responsive nanomaterials emerged as promising tools coating biomedical devices against nosocomial due their ability selectively target kill pathogenic bacteria fungi. It is feasible develop antibacterial surfaces by integrating photothermal agents (PTAs), photodynamic (PDAs), both PTAs PDAs into coatings. When exposed light, generate heat can be used bacteria, while emit reactive oxygen species (ROS) also bacteria. combination therapies produces synergistic effect in which death boosted comparison with use each individual therapy. These coatings potential provide enhanced bacterial control number devices, including implants, catheters, meshes, wound dressings. utilization antimicrobial offers approach reducing risk associated devices.
Language: Английский
Citations
7
Alexandria Engineering Journal, Journal Year: 2024, Volume and Issue: 95, P. 1 - 13
Published: March 29, 2024
The growth of the world population has led to an increase in demand for fresh water. Water pollution is often caused by hasty urbanization without proper management hazardous waste. Therefore, it vital implement new methods remove pollutants from In current study, antimicrobial nanocomposite adsorbent composed Arabic gum-grafted-poly(para phenylene diamine) (AG-g-PpPA) decorated with metal-organic framework and copper nanoparticles (AG-g-PpPA@MOF(Fe)/Cu) was synthesized via in-situ copolymerization. utilized eliminating antibiotic cloxacillin water solutions. effects different factors were analyzed, including pH, quantity adsorbent, contact time, preliminary concentrations. Ideal parameters pH 7, 5 mg dosage, 10 min initial 500 mg/L concentration. adsorption process followed Freundlich isotherm equation, a maximum ability 400 mg/g. kinetics information appropriately fits pseudo-second-order model. Thermodynamic calculation showed occurred spontaneously. also displayed antibacterial action contradiction Escherichia coli Staphylococcus aureus. Additionally, could be recovered reused effectively. excellent highlights potential AG-g-PpPA@MOF(Fe)/Cu pharmaceutical wastewater.
Language: Английский
Citations
6
Environmental Science Nano, Journal Year: 2024, Volume and Issue: 11(7), P. 2771 - 2802
Published: Jan. 1, 2024
This review examines the intersection of self-healing materials, biomedicine, and circular economy, focusing on challenges, advantages, future perspectives associated with their implementation.
Language: Английский
Citations
6
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 273, P. 133189 - 133189
Published: June 15, 2024
Language: Английский
Citations
6
Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(2), P. 275 - 275
Published: Feb. 11, 2023
Candida parapsilosis is the major non-C. albicans species involved in colonization of central venous catheters, causing bloodstream infections. Biofilm formation on medical devices considered one main causes healthcare-associated infections and represents a global public health problem. In this context, development new nanomaterials that exhibit anti-adhesive anti-biofilm properties for coating crucial. work, we aimed to characterize antimicrobial activity two different coated-surfaces, graphene oxide (GO) curcumin-graphene (GO/CU) first time, against C. parapsilosis. We report capacity GO bind stabilize CU molecules, realizing homogenous coated surface. tested anti-planktonic GO/CU by growth curve analysis quantification Reactive Oxigen Species( ROS) production. Then, antibiofilm adhesion assay, crystal violet live dead assay; moreover, inhibition mature biofilm was investigated viability test use specific dyes visualization cells extra-polymeric substances. Our data has anti-planktonic, anti-adhesive, properties, showing 72% cell reduction decrease 85% secretion extra-cellular substances (EPS) after 72 h incubation. conclusion, show conjugate promising material are refractory microbial colonization, thus leading impact biofilm-related
Language: Английский
Citations
14
Carbohydrate Polymer Technologies and Applications, Journal Year: 2024, Volume and Issue: 7, P. 100489 - 100489
Published: March 19, 2024
Antibiotics, widely used in human and animal medicine, pose a significant threat to water quality due their persistent presence even after use. Their insolubility resistance conventional removal methods exacerbate environmental impact. This study aimed develop an antimicrobial composite, alginate-grafted-poly(3-aminophenol)/silver-decorated metal-organic framework (SA-g-P3AP@MOF(Fe)/Ag) via in-situ copolymerization technique. composite proved effective removing neomycin from contaminated water. Characterization FTIR, XRD, BET, TGA analyses confirmed the composite's structure properties. Under optimized conditions (pH = 7, 30-minute contact time, 5 mg adsorbent amount, 25°C temperature, 700 mg/L pollutant concentration), removed 87% of samples. The interaction between aligned with Freundlich isotherm, exhibiting maximum adsorption capacity (Qmax) 625 mg/g, adhered pseudo-second-order kinetic. Thermodynamic analysis indicated exothermic spontaneous nature onto synthesized composite. proposed mechanism centered on intermolecular interactions amine, alcohol, imine functional groups SA-g-P3AP@MOF(Fe)/Ag antibiotic. incorporation MOF(Fe)/Ag its highly porous significantly bolstered adsorption, enhancing antibacterial effectiveness SA-g-P3AP@MOF(Fe)/Ag.
Language: Английский
Citations
6
Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 3, 2025
The global crisis of antimicrobial resistance (AMR) is escalating due to the misuse and overuse antibiotics, slow development new therapies, rise multidrug-resistant (MDR) infections. Traditional antibiotic treatments face limitations, including resistance, disruption microbiota, adverse side effects, environmental impact, emphasizing urgent need for innovative alternative antibacterial strategies. This review critically examines naturally derived biopolymers with intrinsic (essential feature) properties as a sustainable, next-generation traditional antibiotics. These may address bacterial uniquely by disrupting membranes rather than cellular functions, potentially reducing microbiota interference. Through comparative analysis mechanisms applications antibiotics biopolymers, this highlights potential such AMR while supporting human health.
Language: Английский
Citations
0
Multiscale and Multidisciplinary Modeling Experiments and Design, Journal Year: 2025, Volume and Issue: 8(3)
Published: Feb. 18, 2025
Language: Английский
Citations
0