Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(11), P. 2720 - 2736
Published: Jan. 1, 2024
Advances in bioactive regenerative polymeric scaffolds continue to be made with new materials and methods of characterization.
Language: Английский
Microorganisms, Journal Year: 2023, Volume and Issue: 11(6), P. 1541 - 1541
Published: June 9, 2023
Bacterial exopolysaccharides (EPS) are essential natural biopolymers used in different areas including biomedicine, food, cosmetic, petroleum, and pharmaceuticals also environmental remediation. The interest them is primarily due to their unique structure properties such as biocompatibility, biodegradability, higher purity, hydrophilic nature, anti-inflammatory, antioxidant, anti-cancer, antibacterial, immune-modulating prebiotic activities. present review summarizes the current research progress on bacterial EPSs properties, biological functions, promising applications various fields of science, industry, medicine, technology, well characteristics isolation sources EPSs-producing strains. This provides an overview latest advances study important industrial xanthan, cellulose, levan. Finally, limitations future directions discussed.
Language: Английский
Citations
61
Polymers, Journal Year: 2022, Volume and Issue: 14(21), P. 4670 - 4670
Published: Nov. 2, 2022
Bacterial cellulose (BC) is currently one of the most popular environmentally friendly materials with unique structural and physicochemical properties for obtaining various functional a wide range applications. In this regard, literature reporting on bacterial nanocellulose has increased exponentially in past decade. Currently, extensive investigations aim at promoting manufacturing BC-based nanocomposites other components such as nanoparticles, polymers, biomolecules, that will enable to develop advanced novel functionalities. However, commercial production limited by high cost low yield BC, lack highly efficient industrial technologies well. Therefore, present review aimed studying current data field BC purpose its further usage obtain polymer nanocomposites. The highlights progress synthesizing their applications biomedical fields, wound healing, drug delivery, tissue engineering. nanocellulose-based biosensors adsorbents were introduced herein.
Language: Английский
Citations
42
Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(24), P. 5469 - 5482
Published: Jan. 1, 2023
Calcium phosphate (CaP) bioceramics are broadly employed for bone regeneration due to their excellent biocompatibility and osteoconductivity. However, they not capable of repairing healing-impaired defects such as with conditions ischemia or infection restricted bioactivities. In this study, we synthesized single-phased strontium-zinc-phosphate (SZP, SrZn2(PO4)2) via a solution combustion method further fabricated SZP scaffolds using three-dimensional (3D) printing technique. Compared 3D printed β-tricalcium (β-TCP) scaffolds, the presented comparable porosity, compressive strength, Young's modulus, but increased ability osteogenesis, angiogenesis, immunomodulation anti-bacterial activity. Specifically, only led significantly higher osteogenic differentiation MC3T3-E1 cells pro-angiogenesis human umbilical vein endothelial (HUVECs) directly through macrophage-mediated immunomodulation, also inhibited growth Staphylococcus aureus (S. aureus) Escherichia coli (E. coli). The in vivo study rat cranial defect model confirmed better vascularized 3D-printed scaffolds. These findings indicate that proposed might be versatile candidate tissue engineering.
Language: Английский
Citations
23
Materials Today Bio, Journal Year: 2023, Volume and Issue: 23, P. 100858 - 100858
Published: Nov. 11, 2023
Bone is one of the most vascular network-rich tissues in body and system essential for development, homeostasis, regeneration bone. When segmental irreversible damage occurs to bone, restoring its by means other than autogenous bone grafts with pedicles a therapeutic challenge. By pre-generating network scaffold vivo or vitro, pre-vascularization technique enables an abundant blood supply after implantation. However, techniques are time-consuming, can be damaging body. Critical deficiencies may filled quickly immediate implantation supporting tissue engineered scaffold. scaffolds generally lack vascularization, which requires modification aid enhancing internal vascularization. In this review, we summarize relationship between osteogenesis use it as basis further discuss surgical cytotechnology-based strategies describe preparation vascularized that implanted immediately. We anticipate study will serve inspiration future construction achievement clinical
Language: Английский
Citations
23
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(26)
Published: Feb. 22, 2024
Abstract Bioceramics are vital for treating bone defects, and bioactive glasses (exemplified by 45S5) calcium phosphate ceramics (CaPs, exemplified tricalcium [β‐TCP]) extensively explored. β‐TCP exhibits superior biocompatibility, degradability, osteoconductive properties than 45S5; however, it lacks bioactivity, such as mineralization capability. To harness the synergies of both, four 3D printing bioceramic scaffolds: 45S5, 70% 45S5 + 30% TCP, manufactured. Furthermore, investigation elucidates correlation between their in situ capabilities intracellular oscillations within macrophages determines how they impact macrophage phenotypic transitions. Notably, during degradation, there is an initial rise followed a decline ion concentration, which results macrophages. In TCP group, early release ions promotes M1 polarization. Subsequently, rapid causes decrease extracellular ions, thus accelerating transition to M2 facilitating repair. The present study reveals novel mechanism through bioceramics modulate polarization, offers new insights into foreign body response presents perspective on expeditious progression toward tissue
Language: Английский
Citations
14
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5916 - 5916
Published: May 29, 2024
Adipose-derived stem cells (ADSCs) are mesenchymal with a great potential for self-renewal and differentiation. Exosomes derived from ADSCs (ADSC-exos) can imitate their functions, carrying cargoes of bioactive molecules that may affect specific cellular targets signaling processes. Recent evidence has shown ADSC-exos mediate tissue regeneration through the regulation inflammatory response, enhancement cell proliferation, induction angiogenesis. At same time, they promote wound healing as well remodeling extracellular matrix. In combination scaffolds, present future cell-free therapies promising adjuncts to reconstructive surgery diverse tissue-specific functions minimal adverse effects. this review, we address main characteristics functional properties in explore most recent clinical application healing, musculoskeletal regeneration, dermatology, plastic engineering.
Language: Английский
Citations
13
Ceramics International, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
1
Regenerative Engineering and Translational Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 13, 2025
Language: Английский
Citations
1
Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113716 - 113716
Published: Feb. 1, 2025
Language: Английский
Citations
1
Biomimetics, Journal Year: 2024, Volume and Issue: 9(7), P. 386 - 386
Published: June 25, 2024
In order to ensure improved and accelerated bone regeneration, nano-hydroxyapatite scaffolds are often enriched with different bioactive components further accelerate improve healing. this review, we critically examined whether the enrichment of nHAp/polymer growth factors, hormones, polypeptides, microRNAs exosomes new formation in vivo.
Language: Английский
Citations
8