Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Aug. 19, 2024
In
the
present
study,
single-walled
carbon
nanotubes
(SWCNTs)
incorporating
chitosan-graft-gelatin
(CS-g-GEL/SWCNTs)
hydrogels
were
fabricated
with
multiple
advantages,
including
cost-effectiveness,
high
efficiency,
biodegradability,
and
ease
of
separation
for
methylene
blue
(MB)
dye
from
aqueous
solution.
To
verify
successful
formulation
prepared
hydrogels,
various
characterization
methods
such
as
NMR,
FTIR,
XRD,
FE-SEM,
TGA,
BET,
EDX
employed.
The
removal
efficiency
CS-g-GEL/SWCNTs
nanocomposite
hydrogel
increased
significantly
to
98.87%
when
SWCNTs
percentage
was
20%.
highest
adsorption
observed
pH
=
9,
an
adsorbent
dose
1.5
g
L
Communications Chemistry,
Journal Year:
2023,
Volume and Issue:
6(1)
Published: Feb. 10, 2023
As
medical
research
progresses,
the
derivation
and
development
of
biological
materials
such
as
hydrogels
have
steadily
gained
more
interest.
The
biocompatibility
non-toxicity
chitosan
make
potential
carriers
for
drug
delivery.
This
work
aims
to
develop
two
multi-reactive,
safe,
highly
swellable
bio-hydrogels
consisting
chitosan-graft-glycerol
(CS-g-gly)
carboxymethyl
(CMCS-g-gly),
sustained
controlled
release,
improved
bioavailability
along
with
entrapment
in
nanocarriers,
which
reduces
side
effects
vincristine
sulphate.
CS-g-gly
CMCS-g-gly
are
successfully
prepared
fully
characterized
using
analytical
techniques.
Under
various
conditions,
exhibit
a
high
swelling
ratio.
Vincristine-loaded
(VCR/CS-g-gly),
(VCR/CMCS-g-gly)
show
encapsulation
efficiency
between
72.28-89.97%,
56.97-71.91%,
respectively.
VCR/CS-g-gly
release
behavior,
maximum
VCR
from
reached
82%
after
120
h
incubation.
MCF-7
(breast
cancer
cell
line)
MCF-10
(normal
breast
evaluated
viability
apoptosis
induction.
in-vitro
anti-tumor
efficacy
is
investigated
flow
cytometry.
tetrazolium-based
MTT
assay
shows
no
evidence
significant
cytotoxicity
cells.
According
these
findings,
can
effectively
deliver
drugs
other
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: March 29, 2024
Abstract
Addressing
the
increasing
drug
resistance
in
pathogenic
microbes,
a
significant
threat
to
public
health,
calls
for
development
of
innovative
antibacterial
agents
with
versatile
capabilities.
To
enhance
antimicrobial
activity
non-toxic
biomaterials
this
regard,
study
focuses
on
novel,
cost-effective
chitosan
(CS)-based
hydrogels,
crosslinked
using
gelatin
(GEL),
formaldehyde,
and
metallic
salts
(Ag
+
,
Cu
2+
Zn
).
These
hydrogels
are
formed
by
mixing
CS
GEL
creating
iminium
ion
crosslinks
without
hazardous
crosslinkers.
Characterization
techniques
like
FTIR,
XRD,
FESEM,
EDX,
rheological
tests
were
employed.
FTIR
analysis
showed
metal
ions
binding
amino
hydroxyl
groups
CS,
enhancing
hydrogelation.
FESEM
revealed
that
freeze-dried
possess
crosslinked,
porous
structure
influenced
various
ions.
Antibacterial
testing
against
gram-negative
gram-positive
bacteria
demonstrated
bacterial
growth
inhibition.
CS-based
containing
reduced
MIC
MBC
values
Staphylococcus
aureus
(0.5,
8,
16
µg/mL)
Escherichia
coli
(1,
16,
8
CS-g-GEL-Ag
CS-g-GEL-Cu
CS-g-GEL-Zn
.
MTT
assay
results
confirmed
high
biocompatibility
(84.27%,
85.24%,
84.96%
viability
at
10
towards
HFF-1
cells
over
48
h.
Therefore,
due
their
nature,
these
promising
applications.
Giant,
Journal Year:
2024,
Volume and Issue:
19, P. 100301 - 100301
Published: June 6, 2024
The
global
community
has
encountered
numerous
challenges
concerning
environmental
sustainability,
encompassing
issues
like
waste
generation,
depletion
of
natural
resources,
air
pollution,
and
other
threats
to
human
well-being.
Consequently,
the
pursuit
an
eco-friendly
environment
emerged
as
a
critical
concern
in
recent
years.
Polysaccharides,
being
biopolymers,
have
garnered
significant
attention
owing
their
distinctive
properties
that
make
them
versatile
for
various
applications.
Numerous
sustainable
environmentally
friendly
polysaccharides,
such
chitosan,
cellulose,
starch,
hyaluronic
acid,
alginate,
inulin,
been
identified.
This
article
highlights
characteristics
renewable
categorization,
potential
contribute
sustainability.
It
introduces
extraction
methods
aimed
at
minimizing
chemical
pollution.
Through
careful
selection
diverse
polysaccharides
application
functionalization
techniques,
suggests
possibility
obtaining
suitable
superabsorbent
hydrogels,
appropriate
nanocomposites,
effective
scaffolds.
significance
utilizing
polysaccharide-based
materials
is
explored
detail,
emphasizing
exceptional
properties.
Additionally,
discusses
applications
polymers,
including
agriculture,
biomedicine,
food
packaging.
Polymers,
Journal Year:
2023,
Volume and Issue:
15(4), P. 986 - 986
Published: Feb. 16, 2023
There
is
a
growing
concern
about
wound
care,
since
traditional
dressings
such
as
bandages
and
sutures
can
no
longer
meet
existing
needs.
To
address
the
demanding
requirements,
naturally
occurring
polymers
have
been
extensively
exploited
for
use
in
modern
management.
Polysaccharides,
being
most
abundant
biopolymers,
some
distinct
characteristics,
including
biocompatibility
biodegradability,
which
render
them
ideal
candidates
healing
applications.
Combining
with
inorganic
organic
moieties
produce
effective
multifunctional
composites
desired
mechanical
properties,
high
efficiencies
excellent
antibacterial
behavior.
Recent
research
endeavors
focus
on
development
of
stimuli-responsive
polysaccharide
biomedical
Polysaccharide
composites,
sensitive
to
local
environment,
changes
solution
temperature,
pH,
etc.,
sense
react
conditions,
thus
promoting
an
interaction
wound.
This
review
highlights
recent
advances
hydrogels
their
The
synthetic
approaches,
physical,
chemical,
biochemical
properties
well
function
will
be
discussed.
Journal of Functional Biomaterials,
Journal Year:
2023,
Volume and Issue:
14(2), P. 115 - 115
Published: Feb. 18, 2023
Skin
wounds
have
imposed
serious
socioeconomic
burdens
on
healthcare
providers
and
patients.
There
are
just
more
than
25,000
burn
injury-related
deaths
reported
each
year.
Conventional
treatments
do
not
often
allow
the
re-establishment
of
function
affected
regions
structures,
resulting
in
dehydration
wound
infections.
Many
nanocarriers,
such
as
lipid-based
systems
or
biobased
biodegradable
polymers
their
associated
platforms,
favorable
healing
due
to
ability
promote
cell
adhesion
migration,
thus
improving
reducing
scarring.
Hence,
many
researchers
focused
developing
new
dressings
based
compounds
with
desirable
effects.
However,
when
applied
healing,
some
problems
occur,
high
cost
public
health,
novel
emphasizing
reduced
costs,
increasing
quality
treatment
outcomes.
The
integrated
hybrid
nanocarriers
(LNCs)
polymer-based
can
be
promising
solution
for
above
process.
Furthermore,
drug
delivery
showed
effective
release
therapeutic
agents,
suitable
mimicking
physiological
environment,
improvement
single
system.
This
review
highlights
recent
advances
role
carriers
healing.
