The
abnormal
levels
of
pH
and
oxygen
(O2)
in
the
wound
microenvironment
impeded
healing,
their
regulation
remains
a
challenge.
Thus,
dressing
with
O2-regulating
capacity
is
urgently
desired.
Here,
we
designed
prepared
fluorinated
peptide
hydrogel
to
regulate
O2
site.
Fluorinated
peptides
(naphthalene-2-ly)-Gly-5fPhe-5fPhe-Tyr-Arg-Gly-Asp
sequence
(F5–Pep)
could
self-assemble
nanofiber
network
weak
acidic
buffer
(pH
=
6.0),
which
similar
human
skin.
F5–Pep
can
maintain
at
6.0–7.3
for
24
h
continuously
release
4
h.
blood
coagulation
hemostasis
assay
showed
that
significantly
accelerated
clotting
speed
vitro
rapidly
controlled
hemorrhage
mouse
liver
model.
In
cell
migration
assays
vivo
animal
experiments
confirmed
promote
healing.
summary,
this
work
might
provide
an
effective
treatment
strategy
wounds
develop
advanced
wound-healing
materials.
Materials,
Journal Year:
2024,
Volume and Issue:
17(2), P. 278 - 278
Published: Jan. 5, 2024
Effective
wound
treatment
has
become
one
of
the
most
important
challenges
for
healthcare
as
it
continues
to
be
leading
causes
death
worldwide.
Therefore,
care
technologies
significantly
evolved
in
order
provide
a
holistic
approach
based
on
various
designs
functional
dressings.
Among
them,
hydrogels
have
been
widely
used
due
their
biocompatibility
and
similarity
extracellular
matrix.
The
hydrogel
formula
offers
control
an
optimal
moisture
level
its
ability
absorb
excess
fluid
from
or
release
needed.
Additionally,
can
successfully
integrated
with
plethora
biologically
active
components
(e.g.,
nanoparticles,
pharmaceuticals,
natural
extracts,
peptides),
thus
enhancing
performance
resulting
composite
healing
applications.
In
this
review,
the-state-of-the-art
discoveries
related
stimuli-responsive
hydrogel-based
dressings
summarized,
taking
into
account
antimicrobial,
anti-inflammatory,
antioxidant,
hemostatic
properties,
well
other
effects
re-epithelialization,
vascularization,
restoration
tissue)
use.
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(5), P. 2660 - 2676
Published: May 9, 2024
Wound
healing,
particularly
for
chronic
wounds,
presents
a
considerable
difficulty
due
to
differences
in
biochemical
and
cellular
processes
that
occur
different
types
of
wounds.
Recent
technological
breakthroughs
have
notably
advanced
the
understanding
diagnostic
therapeutic
approaches
wound
healing.
The
evolution
care
has
seen
transition
from
traditional
textile
dressings
variety
alternatives,
including
self-healing
hydrogels,
hydrofibers,
foams,
hydrocolloids,
environment
responsive
dressings,
growth
factor-based
therapy,
bioengineered
skin
substitutes,
stem
cell
gene
therapy.
Technological
advancements,
such
as
3D
printing
electronic
(e-skin)
contribute
customization
Despite
these
effectively
managing
wounds
remains
challenging.
This
necessitates
development
treatments
consider
performance,
risk–benefit
balance,
cost-effectiveness.
review
discusses
innovative
strategies
healing
Incorporating
biomarkers
into
coupled
with
corresponding
biosensors
drug
delivery
formulations,
enables
theranostic
approach
treatment
Furthermore,
integrating
power
sources
user
interfaces
like
near-field
communication,
radio
frequency
identification,
Bluetooth
enhances
real-time
monitoring
on-demand
delivery.
It
also
provides
thorough
evaluation
advantages,
patient
compliance,
costs,
durability
emphasizing
smart
formulations
their
preparation
methods.
Gels,
Journal Year:
2024,
Volume and Issue:
10(9), P. 547 - 547
Published: Aug. 23, 2024
Regenerative
hydrogels
from
natural
polymers
have
come
forth
as
auspicious
materials
for
use
in
regenerative
medicine,
with
interest
attributed
to
their
intrinsic
biodegradability,
biocompatibility,
and
ability
reassemble
the
extracellular
matrix.
This
review
covers
latest
advances
used
wound
healing,
focusing
on
chemical
composition,
cross-linking
mechanisms,
functional
properties.
Key
carbohydrate
polymers,
including
alginate,
chitosan,
hyaluronic
acid,
polysaccharide
gums,
agarose,
carrageenan,
xanthan
gum,
are
discussed
terms
of
sources,
structures
specific
properties
suitable
applications.
The
further
explores
categorization
based
ionic
charge,
response
physiological
stimuli
(i.e.,
pH,
temperature)
particularized
roles
tissue
self-healing.
Various
methods
enhance
mechanical
biological
performance
these
also
examined.
By
highlighting
recent
innovations
ongoing
challenges,
this
article
intends
give
a
detailed
understanding
potential
revolutionize
medicine
improve
patient
healing
outcomes.
Frontiers in Neuroscience,
Journal Year:
2023,
Volume and Issue:
17
Published: May 31, 2023
Spinal
cord
injury
(SCI)
is
a
disease
of
the
central
nervous
system
often
caused
by
accidents,
and
its
prognosis
unsatisfactory,
with
long-term
adverse
effects
on
patients’
lives.
The
key
to
treatment
lies
in
improvement
microenvironment
at
reconstruction
axons,
tissue
repair
promising
therapeutic
strategy.
Hydrogel
three-dimensional
mesh
structure
high
water
content,
which
has
advantages
biocompatibility,
degradability,
adjustability,
can
be
used
fill
pathological
defects
injectable
flowing
hydrophilic
material
situ
accurately
adapt
size
shape
injury.
Hydrogels
mimic
natural
extracellular
matrix
for
cell
colonization,
guide
axon
extension,
act
as
biological
scaffold,
an
excellent
carrier
participate
SCI.
addition
different
materials
make
composite
hydrogel
scaffolds
further
enhance
their
performance
all
aspects.
In
this
paper,
we
introduce
several
typical
hydrogels
review
research
progress
SCI
provide
reference
clinical
application
therapy
