MGM Journal of Medical Sciences,
Journal Year:
2024,
Volume and Issue:
11(4), P. 738 - 754
Published: Oct. 1, 2024
Abstract
It
has
become
increasingly
apparent
that
cardiac
tissue
engineering
applications
can
be
employed
to
repair
heart
injuries.
The
primary
purpose
of
the
present
research
is
examine
use
biomaterials
and
bioengineering
methods
create
functioning
tissue.
Techniques
for
maturation,
scaffold
design,
cell
sources,
biomaterial
selection
are
important
subjects.
proper
growth
dependent
upon
these
factors.
assessment
emphasizes
further
development
areas
discusses
field’s
challenges
potential
solutions.
In
conclusion,
this
article
highlights
significant
advancements
in
engineering.
Regardless
its
challenges,
medical
discipline
cardiology
left
tremendous
prospects
future
generations.
progress
critically
area
regenerative
medicine,
biomaterials,
research,
innovation
necessary.
Stem Cell Research & Therapy,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: June 18, 2024
Abstract
Fibrosis
is
a
pathological
process,
that
could
result
in
permanent
scarring
and
impairment
of
the
physiological
function
affected
organ;
this
condition
which
categorized
under
term
organ
failure
affect
various
organs
different
situations.
The
involvement
major
organs,
such
as
lungs,
liver,
kidney,
heart,
skin,
associated
with
high
rate
morbidity
mortality
across
world.
Fibrotic
disorders
encompass
broad
range
complications
be
traced
to
illnesses
impairments;
these
from
simple
skin
scars
beauty
issues
severe
rheumatologic
or
inflammatory
systemic
sclerosis
well
idiopathic
pulmonary
fibrosis.
Besides,
overactivation
immune
responses
during
any
causing
tissue
damage
contribute
pathogenic
fibrotic
events
accompanying
healing
response;
for
instance,
inflammation
resulting
engraftment
cause
formation
grafted
tissue,
even
cases
where
system
deals
hard
clear
infections,
follow
adverse
effects.
A
good
example
complication
post-Covid19
lung
fibrosis
impair
life
individuals
extensive
involvement.
However,
effective
therapies
halt
slow
down
progression
are
missing
current
clinical
settings.
Considering
immunomodulatory
regenerative
potential
distinct
stem
cell
types,
their
application
an
anti-fibrotic
agent,
capable
attenuating
has
been
investigated
by
many
researchers.
Although
majority
studies
addressing
effects
cells
indicated
potent
capabilities,
underlying
mechanisms,
pathways
impact
processes
remain
poorly
understood.
Here,
we
first,
review
properties
types
utilized
so
far
treatments
discuss
challenges
limitations
applications
settings;
then,
will
summarize
general
organ-specific
mechanisms
contributing
fibrosis;
finally,
describe
considered
employed
exerting
events.
Polymers,
Journal Year:
2025,
Volume and Issue:
17(5), P. 620 - 620
Published: Feb. 26, 2025
Heart
failure
functions
as
one
of
the
leading
global
causes
death
because
it
falls
under
cardiovascular
disease
categories.
Cardiac
tissue
engineering
advances
by
developing
new
tissues
to
rebuild
heart
in
individuals
with
damaged
structures
gives
medical
treatment
possibilities
patients
reaching
their
final
stage.
Most
consists
cardiomyocytes
which
make
up
between
80
90
percent
total
organ
space.
The
retain
specialized
cell
structure
includes
elongation,
but
they
align
produce
contractions
span
into
length.
After
myocardial
infarction,
doctors
need
elastic
soft
platforms
heal
mimic
its
natural
attributes.
Special
consideration
must
be
paid
material
selection
for
appropriate
mechanical
properties,
given
that
different
substances
have
separate
qualities.
Stem
survival
becomes
higher,
and
differentiation
develops
more
efficiently
when
a
proper
scaffold
design
is
implemented,
thus
enabling
repair.
Conductive
biomaterials
demonstrate
best
candidate
status
cardiac
due
ability
both
convey
electrical
signals
boost
biological
actions
well
promote
cellular
communication.
Scientists
conduct
life
science
research
on
stem
cells
present
unique
characteristics.
Biomaterials
conductive
properties
within
help
body
recover
while
improving
functionality
myocardium.
This
article
analyzes
various
used
biomedical
practices
healing
applications.
