Molecules,
Journal Year:
2024,
Volume and Issue:
29(24), P. 5973 - 5973
Published: Dec. 18, 2024
Single
and
dual-drug
delivery
systems
(DDSs)
based
on
linear
choline
polymers
were
designed
through
the
controlled
polymerization
of
a
pharmaceutically
functionalized
monomer,
i.e.,
[2-(methacryloyloxy)ethyl]trimethylammonium,
with
counterions
cloxacillin
(TMAMA/CLX),
or
its
copolymerization
[2-(methacryloyloxy)ethyl]trimethylammonium
ampicillin
(TMAMA/AMP),
providing
antibiotic
properties.
This
strategy
was
effective
in
attaining
well-defined
copolymers
38–93
mol.
%
TMAMA
content,
which
regulated
by
initial
ratio
to
methyl
methacrylate
comonomer.
The
polymer
compositions
total
monomer
conversion
(40–75%),
resulting
variable
degree
(DPn
=
160–300)
pharmaceutical
anion
contents
(CLX−
51–80%
AMP−
78–87%).
In
aqueous
solution,
formed
particles
sizes
ranging
between
274
380
nm
for
CLX−
288–348
CLX−/AMP−
systems.
vitro
drug
release,
driven
exchange
anions
phosphate
ions
phosphate-buffered
saline
(PBS),
imitating
physiological
fluid,
demonstrated
release
efficiencies
58–76%
(10.5–13.6
µg/mL)
single
systems,
91–100%
(12.9–15.1
97–100%
(21.1–23.3
dual
Compared
conventional
delivering
antibiotics
without
carrier,
choline-based
DDS
attained
satisfactory
levels
loading
content
(co-)release
from
carriers,
offering
promising
alternative
delivery.
Polymers,
Journal Year:
2023,
Volume and Issue:
15(23), P. 4563 - 4563
Published: Nov. 28, 2023
Polymeric
drug
delivery
technology,
which
allows
for
medicinal
ingredients
to
enter
a
cell
more
easily,
has
advanced
considerably
in
recent
decades.
Innovative
medication
strategies
use
biodegradable
and
bio-reducible
polymers,
progress
the
field
been
accelerated
by
future
possible
research
applications.
Natural
polymers
utilized
polymeric
systems
include
arginine,
chitosan,
dextrin,
polysaccharides,
poly(glycolic
acid),
poly(lactic
hyaluronic
acid.
Additionally,
poly(2-hydroxyethyl
methacrylate),
poly(N-isopropyl
acrylamide),
poly(ethylenimine),
dendritic
bioabsorbable
as
well
biomimetic
bio-related
drug-free
macromolecular
therapies
have
employed
delivery.
Different
synthetic
natural
biomaterials
are
clinical
phase
mitigate
different
diseases.
Drug
methods
using
becoming
increasingly
common
pharmaceutical
industry,
with
biocompatible
copolymers
dendrimers
having
helped
cure
cancer
systems.
This
review
discusses
all
above
components
how,
combining
biological
approaches,
micro-
nano-drug
can
result
revolutionary
gene
devices.
Drugs and Drug Candidates,
Journal Year:
2023,
Volume and Issue:
2(4), P. 898 - 922
Published: Nov. 22, 2023
This
review
article
emphasizes
the
current
enlargements
in
formation
and
properties
of
various
nanostructured
aggregates
resulting
from
self-assembly
a
variety
block
copolymers
(BCPs)
an
aqueous
solution.
The
development
different
polymerization
techniques
which
produce
polymers
with
desired
predetermined
molecular
weight
low
polydispersity
is
investigated
regard
to
their
technological
biomedical
applications;
particular,
applications
as
vehicles
for
drug
delivery
systems
are
considered.
solution
behavior
amphiphilic
BCPs
double-hydrophilic
(DHBCs),
one
or
both
blocks
being
responsive
any
stimulus,
discussed.
Polyion
complex
micelles
(PICMs)/polymersomes
obtained
electrostatic
interaction
polyelectrolyte-neutral
BCP
oppositely
charged
species
also
detailed.
Lastly,
polymerization-induced
(PISA),
forms
nanoscale
micellar
controlled
size/shape/surface
functionality,
crystallization-driven
semicrystalline
facilitated
when
crystallizable,
revealed.
scalability
copolymeric
pharmaceutical
formations
that
currently
used
clinical
trials,
research,
preclinical
testing
emphasized
these
could
be
future
create
novel
nanomedicines.
updated
literature
perspectives
AIChE Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 8, 2025
Abstract
This
study
presents
the
successful
mechanically
mediated
bulk
atom
transfer
radical
polymerization
(mechano‐ATRP)
of
methyl
acrylate
(MA)
using
high‐performance
piezoelectric
material
Bi
0.5
Na
TiO
3
(BNT)
under
ultrasonic
conditions.
Compared
to
widely
used
BaTiO
in
mechano‐ATRP,
BNT
demonstrates
superior
performance,
enhancing
carrier
generation,
separation,
and
interfacial
transfer.
The
strong
interaction
between
Cu
catalysts
facilitates
rapid
capture
mechano‐induced
electrons,
leading
formation
I
/L
efficient
initiation.
Factors
such
as
loading,
catalyst
targeted
degrees
polymerization,
sonication
power
were
systematically
evaluated.
living
nature
ATRP
was
confirmed
by
polymers
with
predetermined
molecular
weights
low
dispersitis
(<1.2).
work
broadens
application
offers
valuable
insights
into
design
catalytic
materials
for
mechano‐ATRP.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(10), P. 1315 - 1315
Published: May 8, 2024
A
hybrid
synthetic-natural,
thermoresponsive
graft
copolymer
composed
of
poly(N-isopropyl
acrylamide)
(PNIPAM)
side
chains,
prepared
via
RAFT
polymerization,
and
a
chitosan
(Chit)
polysaccharide
backbone,
was
synthesized
radical
addition-fragmentation
reactions
using
the
“grafting
to”
technique,
in
aqueous
solution.
ATR-FTIR,
TGA,
polyelectrolyte
titrations
1H
NMR
spectroscopy
were
employed
order
to
validate
Chit-g-PNIPAM
chemical
structure.
Additionally,
spectra
back
conductometric
titration
utilized
quantify
content
grafted
PNIPAM
chains.
The
resulting
contains
dual
functionality,
namely
both
pH
responsive
free
amino
groups,
with
electrostatic
complexation/coordination
properties,
Particle
size
measurements
dynamic
light
scattering
(DLS)
used
study
behavior
copolymer.
Thermal
properties
examined
by
TGA
showed
that,
grafting
modification
PNIPAM,
Chit
structure
became
more
thermally
stable.
lower
critical
solution
temperature
(LCST)
determined
DLS
at
25–45
°C.
Furthermore,
electrophoretic
demonstrated
that
is
suitable
binding
DNA
molecules
forms
nanosized
polyplexes
different
phosphate
groups
ratios,
potential
application
as
gene
delivery
systems.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(20), P. 15170 - 15170
Published: Oct. 14, 2023
New
amphiphilic
VP-(di)methacrylate
terpolymers
of
different
monomer
compositions
and
topologies
have
been
synthesized
by
radical
polymerization
in
toluene
without
any
growth
regulator
polymer
chains.
Their
structures
properties
solid
state
water
solution
were
studied
double-detector
size-exclusion
chromatography;
IR-,
1H,
13C
NMR-spectroscopy;
DLS,
TEM,
TG,
DSC
methods.
The
composition
the
VP-AlkMA-TEGDM
mixture
has
established
to
regulate
topology
resulting
macromolecules.
presented
on
TEM
images
as
individual
low-contrast
particles
their
conglomerates
various
sizes
with
highly
ordered
regions;
general,
they
are
amorphous
structures.
None
demonstrated
cytotoxic
effects
for
noncancerous
Vero
tumor
HeLa
cells.
Hydrophobic
D-α-tocopherol
(TP)
was
encapsulated
terpolymer
nanoparticles
(NPs),
its
antioxidant
activity
evaluated
ABTS
(radical
monocation
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic
acid))
or
DPPH
(2,2'-diphenyl-1-picrylhydrazyl)
reaction
efficiency
depends
TP-NP
type.
IC50
values
decolorization
ABTS•+
inhibition
presence
initial
TP
obtained.
European Polymer Journal,
Journal Year:
2023,
Volume and Issue:
202, P. 112631 - 112631
Published: Nov. 29, 2023
Oxygen-tolerant
reversible
deactivation
radical
polymerization
(RDRP)
was
carried
out
utilizing
a
smartphone
flashlight.
Well-controlled
poly(oligo(ethylene
oxide)
monomethyl
ether
methacrylate)
(POEOMA500)
with
relatively
low
dispersity
(Đ
=
1.16–1.35)
obtained
employing
dual
catalysis
atom
transfer
(ATRP)
CuBr2/tris(2-pyridylmethyl)amine
(TPMA)
and
three
different
organic
photocatalytic
dyes
(i.e.
eosin
Y
(EY),
fluorescein
(FL),
riboflavin
(RF)).
The
flashlight
also
used
for
oxygen-tolerant
photoinduced
electron/energy
(PET)
addition–fragmentation
chain
(RAFT)
EY
dithioesters
RAFT
agents
photoiniferter
(PI)
trithiocarbonate
agent.
formation
of
crosslinked
gels
facile
measurement
gel
points
via
recording
the
gelation
process
by
in-built
camera
demonstrated.
