Polymers,
Journal Year:
2023,
Volume and Issue:
15(15), P. 3183 - 3183
Published: July 27, 2023
To
guide
therapeutic
strategies
and
to
monitor
the
state
changes
in
disease,
a
low-cost,
portable,
easily
fabricated
microfluidic-chip-integrated
three-dimensional
(3D)
microchamber
was
designed
for
capturing
analyzing
breast
cancer
cells.
Optimally,
colorimetric
sensor
array
integrated
into
microfluidic
chip
discriminate
metabolites
of
The
ultraviolet
polymerization
characteristic
poly(ethylene
glycol)
diacrylate
(PEGDA)
hydrogel
utilized
rapidly
fabricate
three-layer
with
structure
under
noninvasive
365
nm
laser
irradiation.
2-Hydroxyethyl
methacrylate
(HEMA)
added
prepolymer
order
increase
adhesive
capacity
microchip’s
surface
1-Vinyl-2-pyrrolidone
(NVP)
improve
toughness
reduce
swelling
composite.
A
non-toxic
3D
microarray
(60
mm
×
20
3
mm)
low
immunogenicity
high
hydrophilicity
created
simulate
real
physiological
microenvironment
tissue.
crisscross
channels
were
ensure
homogeneous
seeding
density.
This
material
displayed
excellent
biocompatibility
tunable
physical
properties
compared
traditional
materials
can
be
directly
processed
obtain
most
desirable
microstructure.
feasibility
using
PEGDA
real-time
online
detection
cells’
metabolism
confirmed
specifically
16
kinds
porphyrin,
porphyrin
derivatives,
indicator
dyes.
results
principal
component
analysis
(PCA),
hierarchical
cluster
(HCA),
linear
discriminant
(LDA)
suggest
that
metabolic
liquids
different
cells
distinguished
developed
chip.
has
potential
practicable
applicability
distinguishing
normal
cancerous
Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
12(20), P. 5134 - 5149
Published: Jan. 1, 2024
This
review
discusses
the
application
of
microneedle
technology
in
biomedical
detection,
emphasizing
advantages
painless
and
minimally
invasive
testing,
points
out
future
prospects
healthcare.
Gels,
Journal Year:
2024,
Volume and Issue:
10(11), P. 719 - 719
Published: Nov. 7, 2024
Microneedle
(MN)
technology
has
emerged
as
a
promising
approach
for
delivering
therapeutic
agents
to
the
skin,
offering
significant
potential
in
treating
various
dermal
conditions.
Among
these
technologies,
hydrogel-forming
microneedles
(HFMNs)
represent
transformative
advancement
management
of
diseases
through
non-invasive
drug
delivery.
These
innovative
devices
consist
micrometer-sized
needles
made
native
or
crosslinked
hydrophilic
polymers,
capable
penetrating
stratum
corneum
without
damaging
underlying
tissues.
Upon
insertion,
HFMNs
rapidly
absorb
interstitial
fluid,
swelling
form
hydrogel
conduit
that
enables
efficient
transport
directly
into
microcirculation.
The
nature
enhances
patient
compliance
by
eliminating
pain
and
discomfort
associated
with
traditional
hypodermic
needles.
This
allows
delivery
wide
range
drugs,
including
macromolecules
biomacromolecules,
which
are
often
difficult
administer
dermally
due
their
size
polarity.
Moreover,
provide
controlled
regulated
release
profiles,
enabling
sustained
effects
while
minimizing
systemic
side
effects.
Additionally,
can
be
used
both
real-time
fluid
monitoring,
valuable
insights
disease
states
treatment
responses.
dual
functionality
positions
versatile
dermatology
tool
effectively
addressing
complications.
review
explores
use
polymeric
biomaterials
HFMN
fabrication
application
major
disorders,
such
acne,
psoriasis,
other
skin
Furthermore,
highlights
MN-based
treatments,
underscoring
reduce
improve
adherence,
supported
recent
literature.
Micromachines,
Journal Year:
2024,
Volume and Issue:
15(12), P. 1433 - 1433
Published: Nov. 28, 2024
The
rapid
advancement
of
3D
printing
technology
has
revolutionized
the
fabrication
microneedle
arrays
(MNAs),
which
hold
great
promise
in
biomedical
applications
such
as
drug
delivery,
diagnostics,
and
therapeutic
interventions.
This
review
uniquely
explores
advanced
materials
used
production
3D-printed
MNAs,
including
photopolymer
resins,
biocompatible
materials,
composite
designed
to
improve
mechanical
properties,
biocompatibility,
functional
performance.
Additionally,
it
introduces
emerging
trends
4D
for
programmable
MNAs.
By
analyzing
recent
innovations,
this
identifies
critical
challenges
proposes
future
directions
advance
field
Unlike
previous
reviews,
paper
emphasizes
integration
innovative
with
techniques
enhance
both
performance
sustainability
Polymers,
Journal Year:
2023,
Volume and Issue:
15(15), P. 3183 - 3183
Published: July 27, 2023
To
guide
therapeutic
strategies
and
to
monitor
the
state
changes
in
disease,
a
low-cost,
portable,
easily
fabricated
microfluidic-chip-integrated
three-dimensional
(3D)
microchamber
was
designed
for
capturing
analyzing
breast
cancer
cells.
Optimally,
colorimetric
sensor
array
integrated
into
microfluidic
chip
discriminate
metabolites
of
The
ultraviolet
polymerization
characteristic
poly(ethylene
glycol)
diacrylate
(PEGDA)
hydrogel
utilized
rapidly
fabricate
three-layer
with
structure
under
noninvasive
365
nm
laser
irradiation.
2-Hydroxyethyl
methacrylate
(HEMA)
added
prepolymer
order
increase
adhesive
capacity
microchip’s
surface
1-Vinyl-2-pyrrolidone
(NVP)
improve
toughness
reduce
swelling
composite.
A
non-toxic
3D
microarray
(60
mm
×
20
3
mm)
low
immunogenicity
high
hydrophilicity
created
simulate
real
physiological
microenvironment
tissue.
crisscross
channels
were
ensure
homogeneous
seeding
density.
This
material
displayed
excellent
biocompatibility
tunable
physical
properties
compared
traditional
materials
can
be
directly
processed
obtain
most
desirable
microstructure.
feasibility
using
PEGDA
real-time
online
detection
cells’
metabolism
confirmed
specifically
16
kinds
porphyrin,
porphyrin
derivatives,
indicator
dyes.
results
principal
component
analysis
(PCA),
hierarchical
cluster
(HCA),
linear
discriminant
(LDA)
suggest
that
metabolic
liquids
different
cells
distinguished
developed
chip.
has
potential
practicable
applicability
distinguishing
normal
cancerous
