Viruses,
Journal Year:
2024,
Volume and Issue:
16(1), P. 77 - 77
Published: Jan. 3, 2024
Enhancing
cross-protections
against
diverse
influenza
viruses
is
desired
for
vaccinations.
Neuraminidase
(NA)-specific
antibody
responses
have
been
found
to
independently
correlate
with
a
broader
protection
spectrum.
Here,
we
report
sequential
immunization
regimen
that
includes
priming
NA
protein
followed
by
boosting
peptide
nanoclusters,
which
targeted
enhancement
of
in
BALB/c
mice
certain
cross-protective
B-cell
epitopes
was
achieved.
The
nanoclusters
were
fabricated
via
desolvation
absolute
ethanol
and
only
composed
composite
peptides.
Unlike
KLH
conjugates,
would
not
induce
influenza-unrelated
immunity.
We
the
incorporation
hemagglutinin
H2-d
class
II
restriction
into
peptides
could
be
beneficial
enhancing
peptide-specific
response.
Of
note,
boosters
N2
induced
stronger
serum
cross-reactivities
heterologous
even
heterosubtypic
N7
N9
than
triple
immunizations
prototype
recombinant
tetrameric
(rt)
N2.
mouse
challenge
experiments
HK68
H3N2
also
demonstrated
strong
effectiveness
nanocluster
conferring
protection.
Polymer-Plastics Technology and Materials,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 23
Published: Dec. 16, 2024
Polymers
have
become
a
versatile
tool
in
pharmaceutical
chemistry
through
techniques
and
new
formulation.
This
review
presents
an
overview
of
the
general
topic
drug
delivery
polymers,
places
particular
focus
on
their
specific
contributions,
discusses
significant
issues
like
biocompatibility,
controlled
release
targeted
delivery.
Unlike
previous
reviews,
it
captures
recent
development
biodegradable,
smart
stimuli-responsive
abilities
to
improve
therapy
outcomes
patient
adherence
treatments.
Furthermore,
this
work
also
has
enhanced
understanding
advanced
polymer-based
systems
such
as
polymeric
nanoparticles,
bioconjugation
strategies
natural
with
examples
various
therapeutic
areas.
The
stands
for
itself
by
expanding
discussion
regulatory
clinical
realism
difficulties
well
safety,
efficacy,
acceptance
considerations.
In
addition,
emphasizes
role
interdisciplinary
intersectoral
cooperation
cross-country
collaborations
developing
polymers-based
applications
precision
medicine.
way,
provides
fresh
view
both
present
advancements
future
possibilities
technologies
dedicated
achievements
globally
inspire
researchers
practitioners.
Current Pain and Headache Reports,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 10, 2024
Abstract
Purpose
of
Review
Intervertebral
disc
degeneration
(IVDD)
is
a
common
orthopaedic
disease
and
an
important
cause
lower
back
pain,
which
seriously
affects
the
work
life
patients
causes
large
economic
burden
to
society.
The
traditional
treatment
IVDD
mainly
involves
early
pain
relief
late
surgical
intervention,
but
it
cannot
reverse
pathological
course
IVDD.
Current
studies
suggest
that
related
imbalance
between
anabolic
catabolic
functions
extracellular
matrix
(ECM).
Anti-inflammatory
drugs,
bioactive
substances,
stem
cells
have
all
been
shown
improve
ECM,
injection
methods
face
short
half-life
leakage
problems.
Recent
Findings
good
biocompatibility
slow-release
function
polymer
hydrogels
are
being
noticed
explored
combine
with
drugs
or
substances
treat
Summary
This
paper
introduces
pathophysiological
mechanism
IVDD,
discusses
advantages,
disadvantages
development
prospects
for
so
as
provide
guidance
future
breakthroughs
in
Viruses,
Journal Year:
2024,
Volume and Issue:
16(1), P. 77 - 77
Published: Jan. 3, 2024
Enhancing
cross-protections
against
diverse
influenza
viruses
is
desired
for
vaccinations.
Neuraminidase
(NA)-specific
antibody
responses
have
been
found
to
independently
correlate
with
a
broader
protection
spectrum.
Here,
we
report
sequential
immunization
regimen
that
includes
priming
NA
protein
followed
by
boosting
peptide
nanoclusters,
which
targeted
enhancement
of
in
BALB/c
mice
certain
cross-protective
B-cell
epitopes
was
achieved.
The
nanoclusters
were
fabricated
via
desolvation
absolute
ethanol
and
only
composed
composite
peptides.
Unlike
KLH
conjugates,
would
not
induce
influenza-unrelated
immunity.
We
the
incorporation
hemagglutinin
H2-d
class
II
restriction
into
peptides
could
be
beneficial
enhancing
peptide-specific
response.
Of
note,
boosters
N2
induced
stronger
serum
cross-reactivities
heterologous
even
heterosubtypic
N7
N9
than
triple
immunizations
prototype
recombinant
tetrameric
(rt)
N2.
mouse
challenge
experiments
HK68
H3N2
also
demonstrated
strong
effectiveness
nanocluster
conferring
protection.
