The Relationship Between Cervicovaginal Infection, Human Papillomavirus Infection and Cervical Intraepithelial Neoplasia in Romanian Women

Diseases, Journal Year: 2025, Volume and Issue: 13(1), P. 18 - 18

Published: Jan. 16, 2025

Cervical intraepithelial neoplasia (CIN) is a premalignant cervical condition closely linked to persistent high-risk HPV infection, major risk factor for cancer. This study aims investigate the relationship between cervicovaginal infections, and CIN development in 94 Romanian women with lesions. Comprehensive assessments included genotyping, cytology, colposcopy, histopathology. In 53.20% of cases, vaginal infections were identified, Candida albicans most frequently associated HPV. Histopathology revealed 48.94% low-grade CIN, 42.55% high-grade 8.51% invasive carcinoma. There was strong correlation types (especially 16 18), colposcopic findings, histopathology, age. emphasizes mutual effect infection increasing developing cancer among women. Persistent types, particularly 18, has been confirmed as primary driver progression.

Language: Английский

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Oral Mycobiota: A Narrative Review

Dentistry Journal, Journal Year: 2024, Volume and Issue: 12(4), P. 115 - 115

Published: April 19, 2024

Numerous studies have proven the important role of oral microbiota in health and disease. The dysfunctionality microbiota, known as dysbiosis, is incriminated dental caries, periodontal disease, infectious diseases, cancer, systemic lesser-known component mycobiota, now assiduously investigated. Recent technological developments helped foster identification new fungal species based on genomic research. Next-generation sequencing has expanded our knowledge about diversity, architecture, relationships microorganisms within cavity. mycobiome structure with bacteriome been studied to identify a mycobiotic signature. This review aimed emphasize latest mycobiome.

Language: Английский

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Lactococcus lactis in Dairy Fermentation—Health-Promoting and Probiotic Properties

Fermentation, Journal Year: 2023, Volume and Issue: 10(1), P. 16 - 16

Published: Dec. 25, 2023

The use of lactic acid bacteria (LAB) in the fermentation process to produce fermented foods has a long history. Furthermore, LAB are beneficial microorganisms known for their health-promoting characteristics. During fermentation, have capacity significant amounts bioactive substances, such as peptides, bacteriocins, acid, exopolysaccharides (EPSs), enzymes, and others. Lactococcus lactis one best-known well-characterized species serves model organism studying LAB. For very time, L. been used milk both well-monitored industrial settings on small scale traditional operations. is vital microorganism dairy food industry due its role acidification, flavor development, creation various products, including cheese, butter, novelty this review comprehensive organized presentation main benefits processes technological safety features relevant industry, probiotic potential, ability compounds (e.g., GABA), recent development research methods like whole genome sequencing (WGS).

Language: Английский

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Micrognathia as a Diagnosis Marker for the Prenatal Identification of Edwards Syndrome

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 573 - 573

Published: Feb. 25, 2025

Background/Objectives: Edwards syndrome, or trisomy 18, is a severe chromosomal disorder marked by numerous congenital anomalies, including micrognathia. This study evaluated the diagnostic significance of micrognathia as prenatal indicator for 18 through case series involving five confirmed instances. Methods: Ultrasound assessments concentrated on inferior facial angle (IFA) and jaw index, supplemented Non-Invasive Prenatal Testing (NIPT) karyotyping. Results: Micrognathia was consistently identified alongside other reinforcing its reliability an ultrasound marker 18. Conclusions: The findings highlight critical nature early detection informed parental counseling effective pregnancy management.

Language: Английский

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One-Stage Surgical Management of an Asymptomatic Maxillary Sinus Mucocele with Immediate Lateral Sinus Lift and Simultaneous Implant Placement: A Case Report

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(6), P. 1946 - 1946

Published: March 13, 2025

Background: The relationship between dental implants and sinus mucoceles is an area of growing interest in oral maxillofacial surgery, as therapeutic approaches for these conditions remain controversial. This case report presents a 48-year-old male with no significant medical history who sought care due to recurrent abscesses on the distal abutment five-unit maxillary bridge. Clinical radiographic evaluations, including Cone-Beam Computed Tomography (CBCT), revealed pathologic lesion associated second molar, insufficient alveolar bone height posterior maxilla, radiopaque mass floor. Methods: A one-stage surgical approach was planned, involving molar extraction, cyst removal, floor elevation, simultaneous implant placement. prosthetic restoration completed six months postoperatively. Results: Over 88-month follow-up period, complications were observed, patient reported high satisfaction restoration’s function aesthetics. Conclusions: highlights single-stage strategy’s feasibility long-term success managing asymptomatic while optimizing placement rehabilitation.

Language: Английский

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The Role of Vitamin B Complex in Periodontal Disease: A Systematic Review Examining Supplementation Outcomes, Age Differences in Children and Adults, and Aesthetic Changes

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1166 - 1166

Published: March 27, 2025

Background and Objectives: Among nutritional factors implicated in periodontal health, the vitamin B complex-particularly folate (vitamin B9), cobalamin (B12), thiamine (B1), riboflavin (B2)-has gained attention for its role immunomodulation tissue repair. This systematic review aims to synthesize current evidence on whether adequate complex intake or status is associated with improved outcomes. Methods: A search was performed PubMed, Scopus, Web of Science observational studies investigating relation disease indicators. Articles were screened according PRISMA guidelines, five met inclusion criteria. Results: Five included. In older adults, each standard deviation increase serum an approximate 26% reduction odds ratio (OR = 0.74, 95% confidence interval (CI) 0.58-0.93). young adult women, inadequate (B2) pyridoxine (B6) correlated higher community index (CPI) scores (p < 0.05). a large NHANES-based cohort, insufficient (B1) yielded 33% likelihood severe periodontitis 0.05), while protective 0.90). Another dose-response analysis (n 8959) indicated up 30% risk moderate B1 intake, but no extra benefit excessive intake. Finally, UK Biobank 9476) showed that those highest quartile "high micronutrient" dietary pattern-including vitamins B6 folate-had 24% lower self-reported 0.76, CI 0.65-0.90) compared lowest quartile. Conclusions: Across diverse populations, intake-especially folate-was consistently linked worse

Language: Английский

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Impact of Malocclusions on Periodontopathogenic Bacterial Load and Progression of Periodontal Disease: A Quantitative Analysis

Microorganisms, Journal Year: 2024, Volume and Issue: 12(8), P. 1553 - 1553

Published: July 29, 2024

(1) Periodontal disease (PD) is a globally prevalent chronic inflammatory condition, exacerbated by the dysbiosis of oral microbiota. This study aims to evaluate bacterial load specific periodontopathogenic bacteria in patients with malocclusions (MAL) compared those without. (2) Methods: Conducted at "Carol Davila" University Medicine and Pharmacy, Bucharest, Romania, this pilot involved two groups: MAL PD, PD but without MAL. We included 20 patients: 10 (9 crowding 1 an open bite) Gingival crevicular fluid was collected for DNA extraction quantified using real-time PCR, focusing on 12 across different complexity classes. (3) Results: The identified significantly higher concentrations

Language: Английский

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Targeted Photodynamic Therapy using a Vectorized Photosensitizer coupled to Folic Acid Analog induces Ovarian Tumor Cell Death and inhibits IL-6-mediated Inflammation

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 371, P. 351 - 370

Published: June 5, 2024

Ovarian cancer (OC) is one of the most lethal cancers among women. Frequent recurrence in peritoneum due to presence microscopic tumor residues justifies development new therapies. Indeed, our main objective develop a targeted photodynamic therapy (PDT) treatment peritoneal carcinomatosis from OC improve life expectancy patients. Herein, we propose targeted-PDT using vectorized photosensitizer (PS) coupled with newly folic acid analog (FAA), named PSFAA, order target folate receptor alpha (FRα) overexpressed on metastasis. This PSFAA was result coupling pyropheophorbide-a (Pyro-a), as PS, synthesized FAA via polyethylene glycol (PEG) spacer. The selectivity and PDT efficacy evaluated two human cell lines overexpressing FRα compared fibrosarcoma cells underexpressing FRα. Final including synthesis its conjugation Pyro-a, obtained after 10 steps, an overall yield 19%. Photophysical properties EtOH were performed showed similarity those free such fluorescence singlet oxygen quantum yields (Φf = 0.39 ΦΔ 0.53 for Φf 0.26 0.41 PSFAA). Any toxicity noticed. After light illumination, dose-dependent effect PS concentration dose shown. Furthermore, secretome detected inducing decrease pro-inflammatory cytokine secretion (IL-6). has shown promising biological highlighting opening perspectives therapeutic impasse.

Language: Английский

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Prenatal Diagnosis of Cleft Lip and Palate: A Retrospective Study

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(16), P. 4804 - 4804

Published: Aug. 15, 2024

Cleft lip and/or palate are prevalent congenital anomalies. Early and accurate diagnosis allows proper case management. The Objective: This retrospective cohort study aimed to investigate the association between cleft other Methods: analyzed 17 pregnancies prenatally diagnosed with palate. investigations consisted of ultrasound examination, fetal karyotyping through amniocentesis, family tree analysis. In presence an abnormal karyotype, parental karyotype was also indicated. Results: Of cases identified, 9 (52.94%) were syndromic 8 (47.06%) non-syndromic. genetic syndromes identified in this included translocation syndrome (one case), Patau syndrome, trisomy 13 (seven cases), Edwards mosaic 18 case). Conclusions: A comprehensive approach ensures a thorough assessment diagnosis. detection multidisciplinary allow appropriate

Language: Английский

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An Update on Drug–Nutrient Interactions and Dental Decay in Older Adults

Nutrients, Journal Year: 2023, Volume and Issue: 15(23), P. 4900 - 4900

Published: Nov. 23, 2023

In recent decades, the global demographic landscape has undergone a discernible shift that been characterised by progressive increase in proportion of elderly individuals, indicative an enduring inclination toward extended lifespans. The aging process, accompanied physiological changes and dietary patterns, contributes to detrimental deviations micronutrient consumption. This vulnerable population faces heightened risks, including dental caries, due structural functional modifications resulting from insufficient nutritional sustenance. Factors such as changes, inadequate nutrition, prevalence multiple chronic pathologies leading polypharmacy contribute challenge maintaining optimal status. scenario increases likelihood drug interactions, both between medications with nutrients microbiome, triggering complications decay other pathologies. Since industry is evolving new types food, supplements, are being designed, there need for further research on mechanisms which drugs interfere certain affect homeostasis, exemplified caries mouths older adults. Infectious diseases, among them exert serious impacts health overall quality life demographic. comprehensive review endeavours elucidate intricate interplay drugs, nutrients, oral cavity environment, overarching objective mitigating potential hazards posed general well-being By scrutinising optimising these multifaceted this examination aims proactively minimise susceptibility spectrum health-related issues consequences associated decay.

Language: Английский

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