Amelioration of Cancer Employing Chitosan, Its Derivatives, and Chitosan-Based Nanoparticles: Recent Updates

Polymers, Journal Year: 2023, Volume and Issue: 15(13), P. 2928 - 2928

Published: July 1, 2023

The limitations associated with the conventional treatment of cancer have necessitated design and development novel drug delivery systems based mainly on nanotechnology. These include various kinds nanoparticles, such as polymeric solid lipid nanostructured carriers, hydrogels, micelles. Among systems, chitosan-based nanoparticles attracted attention researchers to treat cancer. Chitosan is a polycationic polymer generated from chitin characteristics biocompatibility, biodegradability, non-toxicity, mucoadhesiveness, making it an ideal fabricate systems. However, chitosan poorly soluble in water acidic aqueous solutions. Furthermore, owing presence reactive amino groups, can be chemically modified improve its physiochemical properties. derivatives employed which are used most frequently pharmaceutical sector due their possession nanosize, appropriate pharmacokinetic pharmacodynamic properties, non-immunogenicity, improved stability, loading capacity. capable delivering nucleic acids, chemotherapeutic medicines, bioactives using chitosan. derivative-based targeted specific sites via active passive mechanisms. Based many anticancer drugs now better effectiveness, potency, cytotoxicity, or biocompatibility. tailored derivatives, well use therapy, will examined this review.

Language: Английский

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Food liposomes: Structures, components, preparations, and applications

Food Chemistry, Journal Year: 2023, Volume and Issue: 432, P. 137228 - 137228

Published: Aug. 21, 2023

Language: Английский

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“Review of strategic methods for encapsulating essential oils into chitosan nanosystems and their applications”

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 259, P. 129212 - 129212

Published: Jan. 5, 2024

Language: Английский

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Curcumin, its derivatives, and their nanoformulations: Revolutionizing cancer treatment

Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(1)

Published: Jan. 1, 2024

Abstract Curcumin is a natural compound derived from turmeric and can target malignant tumor molecules involved in cancer propagation. It has potent antioxidant activity, but its effectiveness limited due to poor absorption rapid elimination the body. Various curcumin derivatives have also shown anticancer potential in‐vitro in‐vivo models. multiple signaling pathways development/progression or induce cell death through apoptosis. In addition, could enhance of conventional chemotherapy, radiation therapy reduce their associated side effects. Lately, nanoparticle‐based delivery systems are being developed/explored overcome challenges with curcumin's delivery, increasing overall efficacy. The use an imaging system track these formulations give beneficial information about bioavailability distribution nano‐curcumin complex. conclusion, holds significant promise fight against cancer, especially nanoform, provide precise cells without affecting normal healthy cells.

Language: Английский

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Novel Nose-to-brain delivery of carbenoxolone via mucoadhesive solid lipid nanoparticles for Parkinson’s symptoms management: In vitro and in vivo evaluation in a rotenone-induced rat model

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 670, P. 125197 - 125197

Published: Jan. 8, 2025

Language: Английский

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Chitosan-coated nanoliposomes for efficient delivery of betanin with enhanced stability and bioavailability

Food Hydrocolloids, Journal Year: 2022, Volume and Issue: 132, P. 107871 - 107871

Published: June 14, 2022

Language: Английский

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Green Management of Postharvest Anthracnose Caused by Colletotrichum gloeosporioides

Journal of Fungi, Journal Year: 2023, Volume and Issue: 9(6), P. 623 - 623

Published: May 28, 2023

Fruits and vegetables are constantly affected by postharvest diseases, of which anthracnose is one the most severe caused diverse Colletotrichum species, mainly C. gloeosporioides. In last few decades, chemical fungicides have been primary approach to control. However, recent trends regulations sought limit use these substances. Greener management includes a group sustainable alternatives that natural substances microorganisms control fungi. This comprehensive review contemporary research presents various gloeosporioides in vitro situ, ranging from biopolymers, essential oils, antagonistic cultivar resistance. Strategies such as encapsulation, biofilms, coatings, compounds secreted, antibiotics, lytic enzyme production revised. Finally, potential effects climate change on disease explored. can provide possible replacement for conventional using It methodologies not mutually exclusive be tune with needs interests new consumers environment. Overall, developing or has strong improving sustainability addressing challenges generated change.

Language: Английский

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Exploring the emulsification potential of chitosan modified with phenolic acids: Emulsifying properties, functional activities, and application in curcumin encapsulation

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 263, P. 130450 - 130450

Published: Feb. 25, 2024

Language: Английский

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Lipid core-chitosan shell hybrid nanoparticles for enhanced oral bioavailability of sorafenib

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 299, P. 140030 - 140030

Published: Jan. 21, 2025

Language: Английский

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Enhancing the in vivo efficacy of anthrax vaccine using trimethylchitosan covalently coated chitosomes in a single-step microfluidic synthesis

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140689 - 140689

Published: Feb. 1, 2025

Language: Английский

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